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| 1 | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection显示文摘(EV71 ) Entero 病毒 71 引起手,脚,和嘴疾病(HFMD ) 并且偶尔导致严重神经病学的复杂并发症甚至死亡。(SCARB2 ) Scavenger 受体班 B 成员 2 是为 EV71 的功能的受体,调停病毒的附件,成为主观,和 uncoating。然而, SCARB2 上的 EV71 的准确有约束力的地点是未知的。在这研究,我们产生了绑在人然而并非老鼠 SCARB2 的 monoclonal 抗体(mAb ) 。它被称为 JL2,并且它能有效地禁止目标房间的 EV71 感染。用人和老鼠 SCARB2 的一套怪物,我们鉴别包含人的 SCARB2 的残余 77-113 的区域显著地作出贡献到 JL2 绑定。SCARB2-JL2 建筑群的结构表明 JL2 绑在包含 -helices 的 SCARB2 的顶端的区域 2, 5,和 14。我们的结果在 SCARB2 和 EV71 入口的分子的机制上为 EV71 提供新卓见进潜在的有约束力的地点。 | Xuyuan Zhang Pan Yang Nan Wang Jialong Zhang Jingyun Li Hao Guo Xiangyun Yin Zihe Rao Xiangxi wang Liguo Zhang | 2017 | Protein & Cell2017，8，8： | 10 |
| 2 | Advanced data analytics for enhancing building performances: From data-driven to big data-driven approaches显示文摘Buildings have a significant impact on global sustainability.During the past decades,a wide variety of studies have been conducted throughout the building lifecycle for improving the building performance.Data-driven approach has been widely adopted owing to less detailed building information required and high computational efficiency for online applications.Recent advances in information technologies and data science have enabled convenient access,storage,and analysis of massive on-site measurements,bringing about a new big-data-driven research paradigm.This paper presents a critical review of data-driven methods,particularly those methods based on larger datasets,for building energy modeling and their practical applications for improving building performances.This paper is organized based on the four essential phases of big-data-driven modeling,i.e.,data preprocessing,model development,knowledge post-processing,and practical applications throughout the building lifecycle.Typical data analysis and application methods have been summarized and compared at each stage,based upon which in-depth discussions and future research directions have been presented.This review demonstrates that the insights obtained from big building data can be extremely helpful for enriching the existing knowledge repository regarding building energy modeling.Furthermore,considering the ever-increasing development of smart buildings and IoT-driven smart cities,the big data-driven research paradigm will become an essential supplement to existing scientific research methods in the building sector. | Cheng Fan Da Yan Fu Xiao Ao Li Jingjing An Xuyuan Kang | 2021 | Building Simulation2021，14，1： | 10 |
| 3 | Electrophoretic deposition of graphene-based materials:A review of materials and their applications显示文摘Recently,graphene-based materials have been successfully fabricated by the electrophoretic deposition(EPD)technique and exhibited various extraordinary properties.Here,research progress of the field of graphene-based materials prepared by the EPD process in recent 5 years is reviewed,including graphene films,graphene/non-metal composites,graphene/metal-based nanoparticles composites,graphene/polymer composites.We also summarize the experimental deposition conditions and the applications of the deposited graphene-based materials that have been reported.It can be concluded that EPD is a simple and reliable manipulation technique and promises a bright future for the production of graphenebased materials in the field of advanced nanocomposite materials.Finally the current issues and outlook of the development direction of EPD in future are also proposed. | Yifei Ma Jiemin Han Mei Wang Xuyuan Chen Suotang Jia | 2018 | Journal of Materiomics2018，4，2： | 7 |
| 4 | Response of soil respiration to nitrogen addition in two subtropical forest types显示文摘Anthropogenic activities have increased nitrogen(N)deposition in terrestrial ecosystems,which directly and indirectly affects soil biogeochemical processes,including soil respiration.However,the effects of the increases in N availability on soil respiration are not fully understood.In this study,soil respiration was measured using an infrared gas analyzer system with soil chambers under four N treatments(0,5,15,and 30 g Nm^-2 year^-1 as control,low N(LN),moderate N(MN),and high N(HN),respectively)in camphor tree and slash pine forests in subtropical China.Results showed that soil respiration rates decreased by 37% in the camphor tree forest and 27% in the slash pine forest on average on an annual base,respectively,in the N-fertilized treatments when compared with the control.No significant differences were found in the soil respiration rate among the LN,MN,and HN treatments in both forest types as these fertilized plots reached an adequate N content zone.In addition,soil microbial biomass carbon(C)content and fine root biomass declined in N-treated plots compared to the control.Our results indicated that elevated N deposition might alter the tree growth pattern,C partitioning,and microbial activity,which further affect soil C sequestration by reducing soil respiration in subtropical forests of China. | Wende YAN Xiaoyong CHEN Yuanying PENG Fan ZHU Wei ZHEN Xuyuan ZHANG | 2020 | Pedosphere2020，30，4： | 6 |
| 5 | TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope显示文摘Ebolavirus 能与 50%90% 的死亡率在人引起出血性的发烧。当前,没有同意的疫苗和抗病毒的治疗是可得到的。人的 TIM1 为 EBOV 被看作一个附件因素,提高通过和位于病毒的信封的 PS 的相互作用的病毒的感染。然而,推理由 filovirus 位于 hTIM-1,然而并非另外的 PS 有约束力的受体的更好的用法下面,未知的遗体。我们第一在 vitro 表明了在 hTIM-1 和 EBOV GP 之间的一个直接相互作用并且决定了 hTIM-1 和 hTIM-4 的 Ig V 领域的水晶结构。在到 EBOV GP 的 hTIM-1 的有约束力的区域被怪物和变化试金印射,它基于结构的分析被设计。象点异种一样用 hTIM-1 和它的相当或相同的事物执行的 Pseudovirion 感染试金在 EBOV 细胞的入口验证了 GP 有约束力的地点和 EBOV GP-hTIM-1 相互作用的重要性的地点。 | Shuai Yuan Lei Cao Hui Ling Minghao Dang Yao Sun Xuyuan Zhang Yutao Chen Liguo Zhang Dan Su Xiangxi Wang Zihe Rao | 2015 | Protein & Cell2015，6，11： | 6 |
| 6 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 7 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 8 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 9 | Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importinα7 is counteracted by TBK1-p62 axis-mediated autophagy显示文摘As a major component of the viral ribonucleoprotein(vRNP)complex in influenza A virus(IAV),nucleoprotein(NP)interacts with isoforms of importinαfamily members,leading to the import of itself and vRNP complex into the nucleus,a process pivotal in the replication cycle of IAV.In this study,we found that BinCARD1,an isoform of Bcl10-interacting protein with CARD(BinCARD),was leveraged by IAV for efficient viral replication.BinCARD1 promoted the nuclear import of the vRNP complex and newly synthesized NP and thus enhanced vRNP complex activity.Moreover,we found that BinCARD1 interacted with NP to promote NP binding to importinα7,an adaptor in the host nuclear import pathway.However,we also found that BinCARD1 promoted RIG-I-mediated innate immune signaling by mediating Lys63-linked polyubiquitination of TRAF3,and that TBK1 appeared to degrade BinCARD1.We showed that BinCARD1 was polyubiquitinated at residue K103 through a Lys63 linkage,which was recognized by the TBK1-p62 axis for autophagic degradation.Overall,our data demonstrate that IAV leverages BinCARD1 as an important host factor that promotes viral replication,and two mechanisms in the host defense system are triggered—innate immune signaling and autophagic degradation—to mitigate the promoting effect of BinCARD1 on the life cycle of IAV. | Xuyuan Wang Li Jiang Guangwen Wang Wenjun Shi Yuzhen Hu Bo Wang Xianying Zeng Guobin Tian Guohua Deng Jianzhong Shi Liling Liu Chengjun Li Hualan Chen | 2022 | Cellular & Molecular Immunology2022，19，10： | 3 |
| 10 | Parametric Simulation and Optimization of Cold-test Properties for a 220 GHz Broadband Folded Waveguide Traveling-wave Tube显示文摘 | ZHENG Ruilin CHEN Xuyuan | | 0，，09： | 1 |
| 11 | Parametric simulation and optimization of cold-test properties for a 220 GHz broadband folded waveguide trave-ling-wave tube显示文摘 | Zheng Ruilin Chen Xuyuan | 2009 | J Infrared Milli Terahz Waves2009，30，9： | 1 |
| 12 | Model Design of Wireless Sensor Network Based on Scale Free Network Theory显示文摘 | Zhang Xuyuan | 2009 | 5th International Conference on Wireless Communications Networking and Mobile Computing2009，，： | 1 |
| 13 | In vivo high-resolution magnetic resonance elastography of the uterine corpus and cervix显示文摘 | Xuyuan Jiang Patrick Asbach Kaspar-Josche Streitberger Anke Thomas Bernd Hamm Jürgen Braun Ingolf Sack Jing Guo | 2014 | European Radiology2014，，： | 1 |
| 14 | 显示文摘 | XuYuan(-嫒) SunKun(孙坤) ZiXingfa(自兴发)etal | 2011 | 稀有金属材料与工程2011，40，11： | 1 |
| 15 | Synthe- sis of electrochemically-reduced graphene oxide film with controllable size and thickness and its use in supereapacitor显示文摘 | Peng Xuyuan Liu Xiaoxia Dermot Diamond | 2011 | Carbon2011，49，11： | 1 |
| 16 | Parametric Simulation and Optimization of Cold-test Properties for a 220?GHz Broadband Folded Waveguide Traveling-wave Tube显示文摘 | Ruilin Zheng Xuyuan Chen | 2009 | Journal of Infrared Millimeter and Terahertz Waves2009，，9： | 1 |
| 17 | 显示文摘 | XUYuan YAOMing-yin LIUMu-hua etal(徐媛 姚明印 刘木华 等) | | 光学学报0，，： | 1 |
| 18 | Fabrication and Tests of a Novel Three Dimensional Micro Supercapacitor显示文摘 | Sun Wei Chen Xuyuan | 2009 | Journal of Mieroelectronic Engineering2009，，86： | 1 |
| 19 | 显示文摘 | SunKun(孙坤) XuYuan(徐媛) YeQing(叶青)etal | 2012 | 稀有金属材料与工程2012，41，3： | 1 |
| 20 | 显示文摘 | SunKun(孙坤) XuYuan(徐媛) ZiXingfa(自兴发)etal | 2011 | 稀有金属材料与工程2011，40，9： | 1 |
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