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| 1 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 2 | Fighting against fall armyworm by using multiple genes pyramiding and silencing(MGPS) technology显示文摘The pest Fall Armyworm(FAW),Spodoptera frugiperda belonging to the order Lepidoptera,is one of the most devastating insect pests resulting in severe economic losses to maize,rice,wheat,cotton and soybean in South America,Africa and Asia.It consists of two morphologically indistinguishable strains:the“corn strain”feeding mainly on maize,cotton and sorghum;the“rice strain”mostly feeding on rice and various grasses(Gouin et al.,2017).Adults of FAW have strong migration ability to fly 100 km per night.In 2018 it was detected in India and then spreads to Bangladesh,Thailand,Myanmar,and China in 2019(http://www.fao.org/fall-armyworm/en/).It is a polyphagous lepidopteran herbivore,attacks more than 350 plant species,and causes destructive damage to many economically important crops.The FAW causes up to 30%-60% yield losses. | Maozhi Ren Muhammad Mubashar Zafar Huijuan Mo Zhaoen Yang Fuguang Li | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 3 | The Arabidopsis catalase triple mutant reveals important roles of catalases and peroxisome-derived signaling in plant development显示文摘Hydrogen peroxide(H_2O_2)is generated in many metabolic processes.As a signaling molecule,H_2O_2plays important roles in plant growth and development,as well as environmental stress response.In Arabidopsis,there are three catalase genes,CAT1,CAT2,and CAT3.The encoded catalases are predominately peroxisomal proteins and are critical for scavenging H_2O_2.Since CAT1 and CAT3 are linked on chromosome 1,it has been almost impossible to generate cat1/3 and cat1/2/3 mutants by traditional genetic tools.In this study,we constructed cat1/3 double mutants and cat1/2/3 triple mutants by CRISPR/Cas9 to investigate the role of catalases.The cat1/2/3 triple mutants displayed severe redox disturbance and growth defects under physiological conditions compared with wild-type and the cat2/3 double mutants.Transcriptome analysis showed a more profound transcriptional response in the cat1/2/3 triple mutants compared to the cat2/3 mutants.These differentially expressed genes are involved in plant growth regulation as well as abiotic and biotic stress responses.In addition,expression of OXI1(OXIDATIVE SIGNAL INDUCIBLE 1)and several MAPK cascade genes were changed dramatically in the catalase triple mutant,suggesting that H_2O_2produced in peroxisomes could serve as a peroxisomal retrograde signal. | Tong Su Pingping Wang Huijuan Li Yiwu Zhao Yao Lu Peng Dai Tianqi Ren Xiaofeng Wang Xuezhi Li Qun Shao Dazhong Zhao Yanxiu Zhao Changle Ma | 2018 | Journal of Integrative Plant Biology2018，60，7： | 3 |
| 4 | Contributing to local policy making on GHG emission reduction through inventorying and attribution: A case study of Shenyang, China显示文摘 | Fengming Xi Yong Geng Xudong Chen Yunsong Zhang Xinbei Wang Bing Xue Huijuan Dong Zhu Liu Wanxia Ren Tsuyoshi Fujita Qinghua Zhu | 2011 | Energy Policy2011，，10： | 1 |
| 5 | Interference control in 6–11 year-old children with and without ADHD: behavioral and ERP study显示文摘 | Jian Cao Suhong Wang Yanling Ren Yili Zhang Jing Cai Wenjuan Tu Huijuan Shen Xuan Dong Ying Xia | 2013 | International Journal of Developmental Neuroscience2013，，5： | 1 |
| 6 | Spatial-temporal patterns and driving factors for industrial wastewater emission in China显示文摘 | Yong Geng Meiling Wang Joseph Sarkis Bing Xue Lin Zhang Tsuyoshi Fujita Xiaoman Yu Wanxia Ren Liming Zhang Huijuan Dong | 2014 | Journal of Cleaner Production2014，，： | 1 |
| 7 | Synthesis and characterization of terbium-trimesic acid luminescent complex in polyvinylpyrrolidone matrix 显示文摘 | Cui Zhenfeng Ren Huijuan Liu Guixia Hong Guangyan | 2006 | Journal of Rare Earths2006，24，5： | 1 |
| 8 | An Integrated “Energy Wire” for both Photoelectric Conversion and Energy Storage显示文摘 | Tao Chen Longbin Qiu Zhibin Yang Zhenbo Cai Jing Ren Houpu Li Huijuan Lin Xuemei Sun Huisheng Peng | 2012 | Angew Chem Int Ed2012，，48： | 1 |
| 9 | Investigation of Nanosecond Pulsed Discharge and Its Audio Characteristics in Atmospheric-pressure Air显示文摘There was no well-resolved mechanism of audible noise caused by corona discharge on UHV transmission lines. Hence we measured the sound pressure of pulsed discharges between needle-plane electrodes under different discharge conditions in air, for revealing the intrinsic relationship between discharge and its audible noise(AN). The relationship between discharge parameters and audio characte- ristics was drawn from the analysis of the electric and sound signals obtained in experiments. Experiment results showed that nanosecond pulsed discharges produce the sound pressure with a microsecond pulse lagging behind the discharge pulse in their waveforms. The peak value of the sound pulse decreases and its high frequency component gradually attenuates, when the measuring distance from discharges increases. The sound pulses correlate with the discharge current and voltage significantly, especially the current. The audible noise produced by repetitive pulsed discharge increases with the strength, duration, and pulse repetition rate of discharge. | REN Chengyan | 2013 | 高电压技术2013，39，8： | 1 |
| 10 | Genetic variability for yield and fiber related traits in genetically modified cotton显示文摘Background:Cotton(Gossypium hirsutum L.)is grown for fiber and oil purposes in tropical and sub-tropical areas of the world.Pakistan is the 4th largest producer of cotton.It has a significant contribution in the GDP of Pakistan.Therefore,the present study was performed to assess the genetic variations and genetic diversity of yield and fiber quality traits in cotton and to analyze the associations present among them.Results:Analysis of variance exhibited significant variation for all studied traits except total number of nodes and the height to node ratio.The phenotypic coefficient of variation was higher than the genotypic coefficient of variation for all studied traits.Plant height,monopodial branches,total number of bolls,lint index,seed index,and seed cotton yield displayed high heritabilities in a broad sense with maximum genetic advanee.Correlation analysis revealed that seed cotton yield had a significant positive association with plant height,the nu mber of monopodial branches,the nu mber of sympodia I branches,ginning outturn(GOT),the number of bolls,seed per boll,seed index,uniformity index,the number of sympodial branches,reflectance,and seed index at the genotypic level while a significant positive relationship was observed with plant height,the number of sympodial branches,boll number,and GOT.Plant height,monopodial branches,GOT,boll weight,seeds per boll,and short fiber index exerted direct positive effects on seed cotton yield.The first 6 principal component analysis(PCs)out of the total fourteen PCs displayed eigenvalues(>1)and had maximum share to total variability(82.79%).The attributes that had maximum share to total divergence in eluded plant height,uniformity index,the nu mber of sympodial branches,seed per boll,GOT,seed cotton yield,and short fiber index.Conclusion:The genotype AA-802,IUB-13,FH-159,FH-458,and CIM-595 were genetically diverse for most of the yield and fiber quality traits and could be utilized for the selection of better performing genotypes for further improvement. | SAHAR Adeela ZAFAR Muhammad Mubashar RAZZAQ Abdul MANAN Abdul HAROON Muhammad SAJID Sunaina REHMAN Abdul MO Huijuan ASHRAF Muhammad REN Maozhi SHAKEEL Amir YUAN Youlu | 2021 | Journal of Cotton Research2021，4，3： | 1 |
| 11 | Twisted Aligned Carbon Nanotube/Silicon Composite Fiber Anode for Flexible Wire‐Shaped Lithium‐Ion Battery显示文摘 | Huijuan Lin Wei Weng Jing Ren Longbin Qiu Zhitao Zhang Peining Chen Xuli Chen Jue Deng Yonggang Wang Huisheng Peng | 2014 | Adv Mater2014，，8： | 1 |
| 12 | Novel Electric Double‐Layer Capacitor with a Coaxial Fiber Structure显示文摘 | Xuli Chen Longbin Qiu Jing Ren Guozhen Guan Huijuan Lin Zhitao Zhang Peining Chen Yonggang Wang Huisheng Peng | 2013 | Adv Mater2013，，44： | 1 |
| 13 | Pumping and sliding of droplets steered by a hydrogel pattern for atmospheric water harvesting显示文摘Atmospheric water harvesting is an emerging strategy for decentralized and potable water supplies.However,water nucleation and microdroplet coalescence on condensing surfaces often result in surface flooding owing to the lack of a sufficient directional driving force for shedding.Herein,inspired by the fascinating properties of lizards and catfish,we present a condensing surface with engineered hydrogel patterns that enable rapid and sustainable water harvesting through the directional pumping and drag-reduced sliding of water droplets.The movement of microscale condensed droplets is synergistically driven by the surface energy gradient and difference in Laplace pressure induced by the arch hydrogel patterns.Meanwhile,the superhydrophilic hydrogel surface can strongly bond inner-layer water molecules to form a lubricant film that reduces drag and facilitates the sliding of droplets off the condensing surface.Thus,this strategy is promising for various water purification techniques based on liquid-vapor phase-change processes. | Wei Zhang Qinghua Ji Gong Zhang Zhenao Gu Haozhi Wang Chengzhi Hu Huijuan Liu Zhiyong Jason Ren Jiuhui Qu | 2023 | National Science Review2023，10，12： | 0 |
| 14 | NAD+associated genes as potential biomarkers for predicting the prognosis of gastric cancer显示文摘Nicotinamide adenine dinucleotide(NAD+)plays an essential role in cellular metabolism,mitochondrial homeostasis,inflammation,and senescence.However,the role of NAD+-regulated genes,including coding and long non-coding genes in cancer development is poorly understood.We constructed a prediction model based on the expression level of NAD+metabolism-related genes(NMRGs).Furthermore,we validated the expression of NMRGs in gastric cancer(GC)tissues and cell lines;additionally,β-nicotinamide mononucleotide(NMN),a precursor of NAD+,was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation,cell cycle,apoptosis,and senescence-associated secretory phenotype(SASP).A total of 13 NMRGs-related lncRNAs were selected to construct prognostic risk signatures,and patients with high-risk scores had a poor prognosis.Some immune checkpoint genes were upregulated in the high-risk group.In addition,cell cycle,epigenetics,and senescence were significantly downregulated in the high-risk group.Notably,we found that the levels of immune cell infiltration,including CD8 T cells,CD4 naïve T cells,CD4 memory-activated T cells,B memory cells,and naïve B cells,were significantly associated with risk scores.Furthermore,the treatment of NMN showed increased proliferation of AGS and MKN45 cells.In addition,the expression of SASP factors(IL6,IL8,IL10,TGF-β,and TNF-α)was significantly decreased after NMN treatment.We conclude that the lncRNAs associated with NAD+metabolism can potentially be used as biomarkers for predicting clinical outcomes of GC patients. | XIANGDONG SUN HUIJUAN WEN FAZHAN LI IHTISHAM BUKHARI FEIFEI REN XIA XUE PENGYUAN ZHENG YANG MI | 2024 | Oncology Research2024，32，2： | 0 |
| 15 | Navigating Chinese cities to achieve sustainable development goals by 2030显示文摘Achieving the 17 United Nations sustainable development goals(SDGs)in China largely depends on the transition of cities toward sustainable development.However,significant knowledge gaps exist in evaluating the SDG index at the city scale and in understanding how to simulate pathways to achieve the 17 SDGs for Chinese cities by 2030.This study aimed to quantify the SDG index of 285 Chinese cities and developed a forecasting model to simulate the performance of each SDG in each city until 2030 using varied scenarios.The results indicated that although the SDG index in Chinese cities increased by 33.97%during 2005–2016,Chinese cities,which continued their past paths,achieved an average of only five SDGs by 2030.To promote the joint achievement of all SDGs,we designed different paths for all SDGs of each of the 285 cities and simulated their SDG index until 2030.Under the scenarios,216 Chinese cities(75.79%)could achieve 9–13 more SDGs in 2030 and the overall SDG index can improve from 74.57 in 2030 to 97.49(target score 100)by adopting more intensive path adjustment.We lastly determined a cost-effective path for each SDG of each city to promote joint achievement of all SDGs by 2030.The proposed simulation model and cost-effective path serve as a foundation for other countries to simulate SDG progress and develop pathways for achieving SDGs in the future. | Huijuan Xiao Zhenci Xu Jingzheng Ren Ya Zhou Ruojue Lin Sheng Bao Long Zhang Shengfang Lu Carman K.M.Lee Jianguo Liu | 2022 | The Innovation2022，3，5： | 0 |
| 16 | Insect resistance management in Bacillus thuringiensis cotton by MGPS(multiple genes pyramiding and silencing)显示文摘The introduction of Bacillus thuringiensis(Bt)cotton has reduced the burden of pests without harming the environment and human health.However,the efficacy of Bt cotton has decreased due to field-evolved resistance in insect pests over time.In this review,we have discussed various factors that facilitate the evolution of resistance in cotton pests.Currently,different strategies like pyramided cotton expressing two or more distinct Bt toxin genes,refuge strategy,releasing of sterile insects,and gene silencing by RNAi are being used to control insect pests.Pyramided cotton has shown resistance against different cotton pests.The multiple genes pyramiding and silencing(MGPS)approach has been proposed for the management of cotton pests.The genome information of cotton pests is necessary for the development of MGPS-based cotton.The expression cassettes against various essential genes involved in defense,detoxification,digestion,and development of cotton pests will successfully obtain favorable agronomic characters for crop protection and production.The MGPS involves the construction of transformable artificial chromosomes,that can express multiple distinct Bt toxins and RNAi to knockdown various essential target genes to control pests.The evolution of resistance in cotton pests will be delayed or blocked by the synergistic action of high dose of Bt toxins and RNAi as well as compliance of refuge requirement. | ZAFAR Muhammad Mubashar RAZZAQ Abdul FAROOQ Muhammad Awais REHMAN Abdul FIRDOUS Hina SHAKEEL Amir MO Huijuan REN Maozhi | 2020 | Journal of Cotton Research2020，3，4： | 0 |
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