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| 1 | Characteristics of volatile organic compounds,NO_2,and effects on ozone formation at a site with high ozone level in Chengdu显示文摘Chengdu is a megacity in the southwest of China with high ozone(O_3) mixing ratio.Observation of volatile organic compounds(VOCs), NO_2 and O_3 with high temporal resolution was conducted in Chengdu to investigate the chemical processes and causes of high O_3 levels. The hourly mixing ratios of VOCs, NO2, and O_3 were monitored by an online system from 28 August to 7 October, 2016. According to meteorological conditions,Chengdu, with relative warm weather and low wind speed, is favorable to O_3 formation.Part of the O_3 in Chengdu may be transported from the downtown area. In O_3 episodes,the average mixing ratios of NO_2 and O_3 were 20.20 ppbv and 47.95 ppbv, respectively. In non-O_3 episodes, the average mixing ratios of NO_2 and O_3 were 16.38 ppbv and 35.15 ppbv,respectively. The average mixing ratio of total VOCs(TVOCs) was 40.29 ppbv in non-O_3 episodes, which was lower than that in O_3 episodes(53.19 ppbv). Alkenes comprised51.7% of the total O_3 formation potential(OFP) in Chengdu, followed by aromatics which accounted for 24.2%. Ethylene, trans-pentene, propene, and BTEX(benzene, ethylbenzene,toluene, m/p-xylene, o-xylene) were also major contributors to the OFP in Chengdu. In O_3 episodes, intensive secondary formations were observed during the campaign. Oxygenated VOCs(OVOCs), such as acetone, Methylethylketone(MEK), and Methylvinylketone(MVK)were abundant. Isoprene rapidly converted to MVK and Methacrolein(MACR) during O_3 episodes. Acetone was mainly the oxidant of C3-C5 hydrocarbons. | Yuanyuan Deng Jing Li Yaqi Li Rongrong Wu Shaodong Xie | 2019 | Journal of Environmental Sciences2019，31，1： | 29 |
| 2 | Effect of scraping therapy on Interleukin-1 in serum of rats with lumbar disc herniation显示文摘OBJECTIVE:To explore the effect of scraping therapy on the Interleukin-1 (IL-1) levels of rats with lumbar disc herniation (LDH). METHODS: Fifty male rats were devided into a blank group (A), a sham operation group (B), a model group (C), a scraping group (D), and a drug group (E). The rats in the group B were treated with sham operation, and groups C, D and E were made into the LDH model by operation. After operation group C were treated with no interventions, D were given scraping and E were fed with azathioprine Then the IL-1 levels of different groups were detected by enzyme-linked immuno sorbent assay method. And the transplanted coccygeal vertebra discs were observed by pathological section. RESULTS: The IL-1 levels in the groups C, D, and E were significantly higher than those in the groups A and B (all P<0.01), which proved the operationwas successful.The IL-1 levels in the groups D and E at different periods had statistical significance (F= 414.158, P<0.01). The treatment periods and interventions have interation (F=46.613, P<0.01). Multiple comparison results showed that the IL-1 levels in the groups D and E was significantly lower than that in the group C (P<0.01), while the IL-1 levels between the groups D and E had no statistical significance (P>0.05). Moreover, pathological section indicated that immuno-inflammatory response was hardly found in coccygeal vertebra discs in the groups A and B, while local immuno-inflammatory responses of the groups D and E were much lighter than that of the group C. CONCLUSION: Scraping therapy could inhibit the immuno-inflammatory responses in the rats with LDH caused by transplantation of autologous nu cleus pulposus. | Rongrong Jiang Guihua Xu Hua Chen Jie Li Tao Yang Yang Guo | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 23 |
| 3 | Trends in particulate matter and its chemical compositions in China from 2013–2017显示文摘Accurate determination of the atmospheric particulate matter mass concentration and chemical composition is helpful in exploring the causes and sources of atmospheric enthalpy pollution and in evaluating the rationality of environmental air quality control strategies.Based on the sampling and chemical composition data of PM2.5 in different key regions of China in the CARE-China observation network,this research analyzes the environmental air quality data released by the China National Environmental Monitoring Centre during the studied period to determine the changes in the particulate matter mass concentration in key regions and the evolution of the corresponding chemical compositions during the implementation of the Action Plan for Prevention and Control of Air Pollution from 2013-2017.The results show the following.(1)The particulate matter mass concentration in China showed a significant downward trend;however,the PM2.5 annual mass concentration in 64%of cities exceeds the New Chinese Ambient Air Quality Standard(CAAQS)GradeⅡ(GB3095-2012).The region to the east of the Taihang Mountains,the Fenhe and Weihe River Plain and the Urumqi-Changji regions in Xinjiang,all have PM2.5 concentration loading that is still high,and heavy haze pollution occurred frequently in the autumn and winter.(2)During the heavy pollution in the autumn and winter,the concentrations of sulfate and organic components decreased significantly.The mean SO42-concentration in PM2.5 decreased by 76%,12%,81%and 38%in Beijing-Tianjin-Hebei(BTH),the Pearl River Delta(PRD),the Sichuan-Chongqing region(SC)and the Fenhe and Weihe River Plain,respectively.The mean organic matter(OM)concentration decreased by 70%,44%,48%and 31%,respectively,and the mean concentration of NH4+decreased by 68%,1.6%,38%and 25%,respectively.The mean elemental carbon(EC)concentration decreased by 84%and 20%in BTH and SC,respectively,and it increased by 61%and 11%in the PRD and Fenhe and Weihe River Plain,respectively.The mean concentration of mineral and unresolved chemical components(MI)dropped by 70%,24%and 13%in BTH,the PRD and the Fenhe and Weihe River Plain,respectively.The change in the PM2.5 chemical composition is consistent with the decrease of the PM2.5mass concentration.(3)In 2015,the mean OM concentration contributions to fine particles and coarse particles were 13-46%and 46-57%,respectively,and the mean MI concentration contributions to fine particles and coarse and particles were 31-60%and 39-73%,respectively;these values are lower than the 2013 values from the key regions,which is the most important factor behind the decrease of the particulate matter mass concentration.From 2013 to 2015,among the chemical components of different particle size fractions,the peak value of the coarse particle size fraction decreased significantly,and the fine particle size fractions of SO42-,NO3-,and NH4+decreased with the decrease of the particulate matter mass concentration in different particle size fractions.The fine-particle size peaks of SO42-,NO3-and NH4+shifted from 0.65-1.1μm to the finer size range of0.43-0.65μm during the same time frame. | Yuesi WANG Wenjie LI Wenkang GAO Zirui LIU Shili TIAN Rongrong SHEN Dongsheng JI Shuai WANG Lili WANG Guiqian TANG Tao SONG Mengtian CHENG Gehui WANG Zhengyu GONG Jiming HAO Yuanhang ZHANG | 2019 | Science China Earth Sciences2019，62，12： | 23 |
| 4 | Size,composition,and mixing state of individual aerosol particles in a South China coastal city显示文摘Aerosol samples were collected in summer in Macao,a coastal city of the Pearl River Delta Region in China.Morphology,size,elemental composition,and mixing state of individual aerosol particles were determined by scanning electron microscopy coupled energy dispersive X-ray(SEM/EDX) and transmission electron microscopy(TEM).Based on the morphologies of 5711 aerosol particles,they consist of soot(32%),mineral(17%),secondary(22%),and unknown fine particles(29%).The sizes of these particles were mostly distributed between 0.1 and 0.4 μm.Compositions of 202 mineral particles were obtained by SEM/EDX.Mineral particles were mainly classified into three types:Si-rich,Ca-rich,and Na-rich.The compositions of typical mineral particles can indicate their sources in sampling location.For example,mineral particles,collected along the main street,were associated with trace amounts of heavy metals,such as Zn,Ti,Mn,Ba,Pb,and As.TEM observations indicate that most Na-rich particles were aged sea salt particles(e.g.,Na2SO4 and NaNO3) which formed through heterogeneous chemical reactions between sea salt and acidic gases.Additionally,aging time of soot was short in Macao due to high humidity,high temperature,and high levels of sunlight in Macao.Most of soot and fine mineral dust particles were internally mixed with secondary particles. | Weijun Li Longyi Shao Zhishi Wang Rongrong Shen Shusheng Yang Uwa Tang | 2010 | Journal of Environmental Sciences2010，22，4： | 21 |
| 5 | Petrogenesis of Indosinian Granitoids in Middle-Segment of South Qinling Tectonic Belt:Constraints from Sr-Nd Isotopic Systematics显示文摘南方 Qinling 构造的带(SQTB ) 在 Shangzhou-Danfeng 和 Mianxian-Lueyang 缝术之间被定位。在它的中间的片断有很多早中生代 granitoid plutons,包括在在西南的东北,在中央部分的 Huayang-Wulong-Laocheng granitoid plutons,在西北的 Xiba granitoid pluton 和 Guangtoushan-Liuba granitoid plutons 的 Dongjiangkou-Zhashui granitoid plutons。这些 Indonisian granitoids 包含各种各样的规模 mafic 被外国领地包围的土地的一个团,它与他们的主人 granitoids 显示出有时清楚的边界和有时过渡的边界。这些 granitoids 也从 low-K tholeiite 系列展出 metaluminous 到 peraluminous 系列,通常更高的 Mg# 和大量石油化学,通过 mid-K 和 high-K,到 shoshonite 系列的计算碱的系列和支配的样品被归因于 mid-K 和 high-K 计算碱的系列。在 Sr-Nd 同位素的 systematics 和石油化学的详细分析表明可以有 Indonisian granitoid plutons 的地区性起始的 granitoid 岩浆,包括 Dongjiangkou-Zhashui , Huayang-Wulong-Laocheng , Xiba ,和 Guangtoushan-Liuba granitoid plutons ,它被岩浆的混血儿在各种各样的度生产,并且起始的岩浆在 SQTB 从披风和更低的大陆人外壳( LCC )来源被导出。起始的 granitoid 岩浆进一步在他们的炮兵阵地期间与上面的外壳的材料从 LCC,结晶化分别,和吸收做了与岩浆混合的岩浆在 SQTB 生产这些 granitoid plutons。这些 magmatism 过程是最可能的发生在大陆下面边缘的弧和 syn 碰撞到碰撞以后的构造背景。 | LIU Shuwen LI Qiugen TIAN Wei WANG Zongqi YANG Pengtao WANG Wei BAI Xiang GUO Rongrong | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 20 |
| 6 | Using Fuzzy Theory and Variable Weights for Water Quality Evaluation in Poyang Lake, China显示文摘Achieving water purity in Poyang Lake has become a major concern in recent years, thus appropriate evaluation of spatial and temporal water quality variations has become essential. Variations in 11 water quality parameters from 15 sampling sites in Poyang Lake were investigated from 2009 to 2012. An integrative fuzzy variable evaluation(IFVE) model based on fuzzy theory and variable weights was developed to measure variations in water quality. Results showed that: 1) only chlorophyll-a concentration and Secchi depth differed significantly among the 15 sampling sites(P < 0.01), whereas the 11 water quality parameters under investigation differed significantly throughout the seasons(P < 0.01). The annual variations of all water quality variables except for temperature, electrical conductivity, suspended solids and total phosphorus were considerable(P < 0.05). 2) The IFVE model was reasonable and flexible in evaluating water quality status and any possible ′bucket effect′. The model fully considered the influences of extremely poor indices on overall water quality. 3) A spatial analysis indicated that anthropogenic activities(particularly industrial sewage and dredging) and lake bed topography might directly affect water quality in Poyang Lake. Meanwhile, hydrological status and sewage discharged into the lake might be responsible for seasonal water quality variations. | LI Bing YANG Guishan WAN Rongrong ZHANG Lu ZHANG Yanhui DAI Xue | 2017 | Chinese Geographical Science2017，27，1： | 15 |
| 7 | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. | Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 10 |
| 8 | The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells显示文摘几研究证明了有自然产品和化疗代理人的联合治疗能改进化疗代理人的 sensitivityand cytotoxicity。Resveratrol,一个自然产品,包括 antitumor andantiviral 活动,以及脉管的保护的效果有许多生物效果。这研究的目的是与 cisplatin 和涉及 A549 房间的潜在的 anticancer 机制在联合调查 resveratrol 的 synergistic anticancereffect。从数 Kit-8 和 isobolographic 分析的房间的 resultsobtained 表明了 resveratrol 和 cisplatin resultedin synergistic 的那联合在 A549 房间的细胞毒素的效果。从染色的 Hoechst 的结果,流动 cytometry 和西方的污点分析 suggestedthat resveratrol 提高了调停 cisplatin 的 apoptosis。同时, LC3-II 和 P62 层次和在有 cisplatin 的联合的 resveratrol 触发了的 autophagosomesuggested 的形成的变化 autophagy。更重要地,由 3-methyladeninemarkedly 禁止 autophagy 稀释了 resveratrol 和 cisplatin 的联合在 A549 房间引起的 apoptosis。一起拿,我们的 studyprovides resveratrol synergistically 与 cisplatin 相结合的第一条证据在 A549 房间经由 modulating autophagiccell 死亡导致 apoptosis。这些调查结果也帮助我们在肺癌症与 chemotherapyagents 在联合理解自然产品的角色。 | Song Hu Xiaolin Li Rongrong Xu Lingyun Ye Hui Kong Xiaoning Zeng Hong Wang Weiping Xie | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 9 |
| 9 | Damage on lining concrete in highway tunnels under combined sulfate and chloride attack显示文摘 | Rongrong YIN Chenchen ZHANG Qing WU Baocheng LI He XIE | 2018 | Frontiers of Structural and Civil Engineering2018，12，3： | 7 |
| 10 | Plane-Wave Least-Squares Reverse Time Migration for Rugged Topography显示文摘We present a method based on least-squares reverse time migration with plane-wave encoding(P-LSRTM) for rugged topography.Instead of modifying the wave field before migration,we modify the plane-wave encoding function and fill constant velocity to the area above rugged topography in the model so that P-LSRTM can be directly performed from rugged surface in the way same to shot domain reverse time migration.In order to improve efficiency and reduce I/O(input/output) cost,the dynamic encoding strategy and hybrid encoding strategy are implemented.Numerical test on SEG rugged topography model show that P-LSRTM can suppress migration artifacts in the migration image,and compensate amplitude in the middle-deep part efficiently.Without data correction,P-LSRTM can produce a satisfying image of near-surface if we could get an accurate near-surface velocity model.Moreover,the pre-stack PLSRTM is more robust than conventional RTM in the presence of migration velocity errors. | Jianping Huang Chuang Li Rongrong Wang Qingyang Li | 2015 | Journal of Earth Science2015，26，4： | 6 |
| 11 | Geometric morphometric analysis of Eysarcoris guttiger,E.annamita and E.ventralis(Hemiptera:Pentatomidae)显示文摘The genus Eysarcoris can be easily distinguished from other genera through the two spots in the basal angle of the scutellum.Nevertheless,Eysarcoris species show complex variances.Geometric morphometric methods have been increasingly applied to distinguish species and to define the boundary of genera among insects.In the present study,geometric morphometric approach was firstly employed to evaluate the shape variation of three characters(fore wing,hind wing and pygophore) of E.guttiger,E.annamita and E.ventralis using E.aeneus as outgroup to ascertain whether this approach is a reliable method for the taxonomy of Eysarcoris.Analysis was conducted on the landmarks of the three characters of these species.Multivariate regression of procrustes coordinates against centroid size was conducted to test the presence of allometry.Principal component analysis(PCA),canonical variate analysis(CVA) and cluster analysis were utilized to describe variations in shapes among the studied species.For all of the three characters,though PCA analysis showed some overlap among species,p-values for procrustes distance and mahalanobis distance were all less than 0.0001.The distribution of the three studied species corresponds with their species status.This study demonstrates that the geometric morphometrics of both the fore wing and the hind wing might represent a possible tool for the identification of species within this genus. | Rongrong Li Hufang Zhang Shengcai Li Ming Bai | 2017 | Zoological Systematics2017，42，1： | 6 |
| 12 | Real-time pressure mapping smart insole system based on a controllable vertical pore dielectric layer显示文摘Real-time monitoring of plantar pressure has significant applications in wearable biosensors,sports injury detection,and early diagnostics.Herein,an all-in-one insole composed of 24 capacitive pressure sensors(CPSs)with vertical pores in an elastic dielectric layer is fabricated by laser cutting.Optimized CPSs with a hexagonal configuration and a pore size of 600μm possess good linearity over a wide detection range of 0–200 kPa with a sensitivity of 12×10^(–3) kPa−1.Then,a smart system including the all-in-one insole with the 24 CPS array,a data acquisition system with a wireless transmitter and a PC terminal with a wireless receiver is established for real-time monitoring to realize static and dynamic plantar pressure mapping.Based on this smart insole system,various standing and yoga postures can be distinguished,and variations in the center of gravity during walking can be recognized.This intelligent insole system provides great feasible supervision for health surveillance,injury prevention,and athlete training. | Juan Tao Ming Dong Li Li Chunfeng Wang Jing Li Yue Liu Rongrong Bao Caofeng Pan | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 13 | Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes显示文摘Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles(SPIO) was prepared for drug delivery and magnetic resonance imaging(MRI). Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L-1. Doxorubicin(DOX) and a cluster of the manganese-doped iron oxide nanoparticles(Mn-SPIO)nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplatform for the delivery of anticancer drug DOX with a loading content(DLC) of 16 %. Confocal laser scanning microscopyreveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with free DOXáHCl. Under a 3.0-T MRI scanner, Mn-SPIO/DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation(T2) rate is also significantly higher than that of the control cells(33.9 versus 2.3 s-1). Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability. | Bingbing Lin Hongying Su Rongrong Jin Danyang Li Changqiang Wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai | 2015 | Science Bulletin2015，60，14： | 6 |
| 14 | Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a global pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).SARS-Co V-2 infection was first detected in Wuhan,China in late December 2019.The virus was spreading rapidly to other cities of China and accumulating cases had been reported(Li et al.2020). | Xiaoping Chen Qunqun Jiang Zhiyong Ma Jiaxin Ling Wenjia Hu Qian Cao Pingzheng Mo Lei Yao Rongrong Yang Shicheng Gao Xien Gui Wei Hou Yong Xiong Jinlin Li Yongxi Zhang | 2020 | Virologica Sinica2020，35，6： | 6 |
| 15 | Pd/C modified with Sn catalyst for liquid-phase selective hydrogenation of maleic anhydride to gamma-butyrolactone显示文摘Pd catalysts suffered from poor selectivity and stability for liquid-phase hydrogenation of maleic anhydride(MA) to gamma-butyrolactone(GBL).Thus,Pd/C catalysts modified with different Sn loadings were synthesized,and characterized by XRD,XPS,TEM and elemental mapping.The types of alloy phase and the amounts of the surface Pd-SnOx sites altered along with Sn/Pd mass ratios from 0-1.0synthesized in the process of preparation.The maximum reaction rate was 0.57 mol-GBL/(mol-Pd min)and selectivity was 95.94%when the Sn/Pd mass ratio was 0.6.It might be attributed to the formation of Pd_2Sn alloy and less amounts of Pd-SnOx sites. | Rongrong Li Jia Zhao Deman Han Xiaonian Li | 2017 | Chinese Chemical Letters2017，28，6： | 5 |
| 16 | A novel PTEN gene promoter mutation and untypical Cowden syndrome显示文摘Cowden syndrome (CS), an autosomal dominant disorder, is one of a spectrum of clinical disorders that have been linked to germline mutations in the phosphatase and tensin homolog (PTEN) gene. Although 70-80% of patients with CS have an identifiable germline PTEN mutation, the clinical diagnosis presents many challenges because of the phenotypic and genotypic variations. In the present study, we sequenced the exons and the promoter of PTEN gene, mutations and variations in the promoter and exons were identified, and a PTEN protein expression negative region was determined by immunohistochemistry (IHC). In conclusion, a novel promoter mutation we found in PTEN gene may turn off PTEN protein expression occasionally, leading to the disorder of PTEN and untypical CS manifestations. | Chen Liu Guangbing Li Rongrong Chen Xiaobo Yang Xue Zhao Haitao Zhao | 2013 | Chinese Journal of Cancer Research2013，25，3： | 5 |
| 17 | Reduction of polyethylenimine-coated iron oxide nanoparticles induced autophagy and cytotoxicity by lactosylation显示文摘Superparamagnetic iron oxide(SPIO)nanoparticles are excellent magnetic resonance contrast agents and surface engineering can expand their applications.When covered with amphiphilic alkyl-polyethyleneimine(PEI),the modified SPIO nanoparticles can be used as MRI visible gene/drug delivery carriers and cell tracking probes.However,the positively charged amines of PEI can also cause cytotoxicity and restricts their further applications.In this study,we used lactose to modify amphiphilic low molecular weight polyethylenimine(C_(12-)PEI_(2K))at different lactosylation degree.It was found that the N-alkyl-PEI-lactobionic acid wrapped SPIO nanocomposites show better cell viability without compromising their labelling efficacy as well as MR imaging capability in RAW 264.7 cells,comparing to the unsubstituted ones.Besides,we found the PEI induced cell autophagy can be reduced via lactose modification,indicating the increased cell viability might rely on down-regulating autophagy.Thus,our findings provide a new approach to overcome the toxicity of PEI wrapped SPIO nanocomposites by lactose modification. | Jiuju Du Wencheng Zhu Li Yang Changqiang Wu Bingbing Lin Jun Wu Rongrong Jin Taipeng Shen Hua Ai | 2016 | Regenerative Biomaterials2016，3，4： | 5 |
| 18 | Research on Testing Technology of Relay Protection for Intelligent Substations显示文摘Intelligent substations adopt various kinds of new technologies, including information sharing technology based on IEC61850, digital sampling technology, synchronization technology, and network transmission technology. Relay protection equipment faces all the challenges brought by the application of these new technologies. After analyzing the demand for test, the authors propose testing methods and technical requirements targeting the test items in great need, including ICD model file test, digital interface performance test, coordination performance test with merging unit and smart terminal, network pressure test. And the problems occurring during the tests are summarized. | Zhan Rongrong Li Yanjun Zhang Xiaoli Zhan Zhihua Yu Yue Chen Zhengguang | 2014 | Electricity2014，25，5： | 5 |
| 19 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 20 | Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury显示文摘Spinal cord injury(SCI)involves diverse injury responses in different cell types in a temporally and spatially specific manner.Here,using single-cell transcriptomic analyses combined with classic anatomical,behavioral,electrophysiological analyses,we report,with single-cell resolution,temporal molecular and cellular changes in crush-injured adult mouse spinal cord.Data revealed pathological changes of 12 different major cell types,three of which infiltrated into the spinal cord at distinct times post-injury.We discovered novel microglia and astrocyte subtypes in the uninjured spinal cord,and their dynamic conversions into additional stage-specific subtypes/states.Most dynamic changes occur at 3-days post-injury and by day-14 the second wave of microglial activation emerged,accompanied with changes in various cell types including neurons,indicative of the second round of attacks.By day-38,major cell types are still substantially deviated from uninjured states,demonstrating prolonged alterations.This study provides a comprehensive mapping of cellular/molecular pathological changes along the temporal axis after SCI,which may facilitate the development of novel therapeutic strategies,including those targeting microglia. | Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 4 |
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