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| 1 | Cancer incidence,mortality,and burden in China:a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020显示文摘Background:Cancer is one of the leading causes of death and a main economic burden in China.Investigating the differences in cancer patterns and control strategies between China and developed countries could provide reference for policy planning and contribute to improving cancer control measures.In this study,we reviewed the rates and trends of cancer incidence and mortality and disability-adjusted life year(DALY)burden in China,and compared them with those in the United States(US)and the United Kingdom(UK).Methods:Cancer incidence,mortality,and DALY data for China,US and UK were obtained fromtheGLOBOCAN2020 online database,Global Burden of Disease(GBD)2019 study,and Cancer Incidence in Five Continents plus database(CI5 plus).Trends of cancer incidence and mortality in China,US,and UK were analyzed using Joinpoint regression models to calculate annual percent changes(APCs)and identify the best-fitting joinpoints.Results:An estimated 4,568,754 newly diagnosed cancer cases and 3,002,899 cancer deaths occurred in China in 2020.Additionally,cancers resulted in 67,340,309 DALYs in China.Compared to the US and UK,China had lower cancer incidence but higher cancer mortality andDALY rates.Furthermore,the cancer spectrum of China was changing,with a rapid increase incidence and burden of lung,breast,colorectal,and prostate cancer in addition to a high incidence and heavy burden of liver,stomach,esophageal,and cervical cancer.Conclusions:The cancer spectrum of China is changing from a developing country to a developed country.Population aging and increase of unhealthy lifestyles would continue to increase the cancer burden of China.Therefore,the Chinese authorities should adjust the national cancer control program with reference to the practices of cancer control which have been well-established in the developed countries,and taking consideration of the diversity of cancer types by of different regions in China at the same time. | Haibo Qiu Sumei Cao Ruihua Xu | 2021 | Cancer Communications2021，41，10： | 194 |
| 2 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | Antibacterial evaporator based on reduced graphene oxide/polypyrrole aerogel for solar-driven desalination显示文摘Solar-driven water evaporation is a sustainable method to purify seawater.Nevertheless,traditional volumetric water-evaporation systems suffer from the poor sunlight absorption and inefficient light-to-thermal conversion.Also,their anti-bacterial and antifouling performances are crucial for the practical application.Herein,we introduce reduced graphene oxide(RGO)with broadband absorbance across the entire solar spectrum,and polypyrrole(PPy),an antibacterial polymer with efficient solar absorption and low thermal conductivity,to develop integrated RGO/PPy aerogel as both the solar absorber and evaporator for highly efficient solar-driven steam generation.As a result,the RGO/PPy aerogel shows strong absorption and good photothermal performance,leading to an evaporation rate of 1.44 kg·m^(−2)·h^(−1)and high salt rejection(up to 99.99%)for real seawater,with photothermal conversion efficiency>90%under one sun irradiation.The result is attributed to the localized heat at the air-water interface by the RGO/PPy and its porous nature with functional groups that facilitates the water evaporation.Moreover,the RGO/PPy demonstrates excellent durability and antibacterial efficiency close to 100%for 12 h,crucial characteristics for longterm application.Our well-designed RGO/PPy aerogel with efficient water desalination performance and antibacterial property provides a straightforward approach to improve the solar-driven evaporation performance by multifunctional materials integration,and offers a viable route towards practical seawater desalination. | Mengru Zhang Fan Xu Wenjie Liu Yaqi Hou Liyun Su Xin Zhang Ruihua Zhang Lijun Zhou Xiaomei Yan Miao Wang Xu Hou Yang Cao | 2023 | Nano Research2023，16，4： | 2 |
| 5 | Title Extraction from Bodies of HTML Documents and its Application to Web Page Retrieval 显示文摘 | Yunhua Hu Guomao Xin Ruihua Song Guoping Hu Shuming Shi Yunbo Cao and Hang Li | 2005 | The 28th Annual International ACM SIGIR Conference (SIGIR''2005)2005，2005，： | 1 |
| 6 | SDF-1α upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines显示文摘 | Feng Pan Shijie Ma Weike Cao Haining Liu Fengli Chen Xiaofei Chen Ruihua Shi | 2013 | Molecular Biology Reports2013，，7： | 1 |
| 7 | Metabolic features of the tumor microenvironment of gastric cancer and the link to the systemic macroenvironment显示文摘 | Jiye Aa Lianzhen Yu Min Sun Linsheng Liu Mengjie Li Bei Cao Jan Shi Jin Xu Liping Cheng Jun Zhou Tian Zheng Xinwen Wang Chunyan Zhao Rongrong Gu Fengyi Zhang Ruihua Shi Guangji Wang | 2012 | Metabolomics2012，，1： | 1 |
| 8 | The formation kinetics and control of biofilms by three dominant fungi species isolated from groundwater显示文摘Filamentous fungi can enter drinking water supply systems in various ways,and exist in suspended or sessile states which threatens the health of individuals by posing a high risk of invasive infections.In this study,the biofilms formation kinetics of the three genera of fungal spores,Aspergillus niger(A.niger),Penicillium polonicum(P.polonicum)and Trichoderma harzianum(T.harzianum)isolated fromthe groundwater were reported,as well as the effects of water quality parameters were evaluated.In addition,the efficiency of low-concentrations of chlorine-based disinfectants(chlorine,chlorine dioxide and chloramine)on controlling the formation of fungal biofilms was assessed.The results showed that the biofilms formation of the three genera of fungi could be divided into the following four phases:induction,exponential,stationary and sloughing off.The optimum conditions for fungal biofilms formation were found to be neutral or weakly acidic at 28°C with rich nutrition.In fact,A.niger,P.polonicum,and T.harzianum were not observed to form mature biofilms in actual groundwater within 120 hr.Carbon was found to have the maximum effect on the fungal biofilms formation in actual groundwater,followed by nitrogen and phosphorus.The resistance of fungal species to disinfectants during the formation of biofilms decreased in the order:A.niger>T.harzianum>P.polonicum.Chlorine dioxide was observed to control the biofilms formation with maximum efficiency,followed by chlorine and chloramine.Consequently,the results of this study will provide a beneficial understanding for the formation and control of fungal biofilms. | Xinyu Luo Xiangqian Xu Ruihua Cao Qiqi Wan Jingyi Wang Huining Xu Yingzi Lin Gang Wen Tinglin Huang | 2021 | Journal of Environmental Sciences2021，33，11： | 1 |
| 9 | A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate显示文摘Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was developed.The acylation reaction was completed in a continuous coil reactor at 160℃ in 20 min.And the high toxic solvent pyridine was replaced by acetonitrile.Furthermore,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer chip.Combining with the membrane phase separators,the residence time of the purification step was 30 s.The isolated yield of this sequential continuous process was 92%with 99%purity. | Liming Cao Maolin Sun Chaoming Liang Lei Yang Yueyue Ma Ruihua Cheng Yanxiong Ke Wei Yu Jinxing Ye | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 10 | Association of Remnant-like Particle Cholesterol with Major Adverse Cardiovascular Events in Subjects with Different Levels of Proprotein Convertase Subtilisin/Kexin 9:A 9.5-year Follow-up Study in a Beijing Community Population显示文摘Objective::The purpose of this study was to determine the relationship between remnant-like particle cholesterol(RLP-C)and major adverse cardiovascular events(MACEs)in patients with different levels of proprotein convertase subtilisin/kexin 9(PCSK9).Methods::From September 2007 to January 2009,1,859 subjects in Pingguoyuan communities in Beijing were initially screened.After excluding those with bedridden status,mental illness,severe systemic diseases,and missing data,1,680 subjects were recruited for follow up.All recruited subjects were followed up from February 2013 to September 2013(181 subjects were lost to follow-up)and from June 2017 to September 2018(174 subjects were lost to follow up).Finally,1,325 subjects were included in the study.General demographic characteristics,lifestyle and behaviors,disease history and use of medication was collected.Levels of total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,fast blood glucose,RLP-C,low-density lipoprotein triglycerides and PCSK9 were measured.The levels of RLP-C(low:RLP-C≤157 mg/L;high:RLP-C>157 mg/L)and PCSK9(low:PCSK9≤135.87μg/L;high:PCSK9>135.87μg/L)were represented using quartiles.Subjects were categorized into 4 groups according to their RLP-C and PCSK9 levels:Q4,high levels of RLP-C with high levels of PCSK9;Q3,high levels of RLP-C with low levels of PCSK9;Q2,low levels of RLP-C with high levels of PCSK9;and Q1,low levels of RLP-C with low levels of PCSK9.The association of RLP-C with MACEs in subjects with different PCSK9 levels was evaluated.Results::After a median follow-up of 9.5 years,1,325 subjects were included in the study and a total of 191 MACEs had occurred.The incidence of MACEs was higher in the RLP-C>157 mg/L group than the RLP-C≤157 mg/L group(18.40%vs.10.42%).Cox proportional hazards regression model analysis showed that increased RLP-C levels were associated with an increased risk of MACEs(hazard ratio:1.405;95%confidence interval:1.005-1.964;P<0.005).The incidence of MACEs was higher in the high RLP-C/PCSK9 group vs.the low RLP-C/PCSK9 group(20.68%vs.8.76%).Cox proportional hazards regression model analysis showed that RLP-C was associated with an increased risk of MACEs in subjects with high PCSK9 levels independent of traditional risk factors(hazard ratio:1.791;95%confidence interval:1.168-2.825;P=0.001),but not in those with low PCSK9 levels.Conclusions::RLP-C was identified as a risk factor for MACEs,particularly in subjects with high PCSK9 levels.Lowering PCSK9 levels may reduce residual risk in subjects with elevated plasma RLP-C levels. | Xiaona Wang Ruping Tie Ruihua Cao Xu Yang Wenkai Xiao Li Sheng Ping Ye | 2023 | Cardiology Discovery2023，3，3： | 0 |
| 11 | Inactivation and subsequent reactivation of Aspergillus species by the combination of UV and monochloramine: Comparisons with UV/chlorine显示文摘Ultraviolet(UV)/monochloramine(NHCl) as an advanced oxidation process was firstly applied for Aspergillus spores inactivation. This study aims to: i) clarify the inactivation and photoreactivation characteristics of UV/NHCl process, ii) compared with UV/Clin inactivation efficiency, photoreactivation and energy consumption. The results illustrated that UV/NHCl showed better inactivation efficiency than that of UV alone and UV/Cl, and could effectively control the photoreactivation. For instance, the inactivation rates for Aspergillus flavus, Aspergillus niger and Aspergillus fumigatus in the processes of UV/NHCl(2.0 mg/L) was 0.034, 0.030 and 0.061 cm^(2)/m J), respectively, which were higher than that of UV alone(0.027, 0.026 and 0.024 cm^(2)/m J) and UV/Cl(0.023, 0.026 and 0.031 cm^(2)/m J). However, there was no synergistic effect for Aspergillus flavus and Aspergillus fumigatus. As for Aspergillus niger, the best synergistic effect can reach 1.86-log 10. This may be due to their different resistance to disinfectants, which were related to the size, an outer layer of rodlets(hydrophobins) and pigments. After UV/NHCl inactivation, the degree of cell membrane damage and intracellular reactive oxygen species were higher than that of UV alone. UV/NHCl had the advantages of high inactivation efficiency and inhibition of photoreactivation, which provides a new entry point for the disinfection of waterborne fungi. | Gehui Wu Hui Zhao Qiqi Wan Xiangqian Xu Ruihua Cao Kai Li Jingyi Wang Tinglin Huang Jinsuo Lu Gang Wen | 2022 | Journal of Environmental Sciences2022，34，7： | 0 |
| 12 | Two-step continuous flow process of sodium tanshinone ⅡA sulfonate using a 3D circular cyclone-type microreactor显示文摘A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for STS production.We constructed a telescoped two-step continuous flow platform.This involved a continuous tanshinone IIA sulfonation and in-line salt formation.For the setup,we constructed a 3D circular cyclone-type microreactor using femtosecond laser micromachining.Compared to the 68%yield for 2 h in batch,the two-step continuous flow had an STS yield of 90%,achieved for a total residence time of<3.0 min under optimal conditions.The proposed continuous flow method vastly simplified the operation and improved procedural safety,while significantly reducing the required acid content and wastewater production. | Maolin Sun Chaoming Liang Liming Cao Yaguo Wang Jiasheng Yang Shiyu Hou Wei Yu Yueyue Ma Ruihua Cheng Jinxing Ye | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 13 | Conditions of Incipient Motion of Pebbles Based on Shape and the Equivalent Grain Size显示文摘Incipient motion of pebbles is an unsteady and random process,the main influence factors are pebble shape,non-uniformity,location in bed and flow condition.By virtue of the concept of the equivalent grain size,it is shown that d_ηfollows a normal distribution following a regression analysis of measured data.Consid- ering the influence of pebble shape and the relative exposure degree,formula of calculating the incipient veloc- ity for pebbles is deduced based on the equivalent grain size of pebble and the... | Nie, Ruihua Liu, Xingnian Li, Li Cao, Shuyou | 2005 | 四川大学学报(工程科学版)2005，37，S1： | 0 |
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