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| 1 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 2 | The MDM2-p53 pathway revisited显示文摘The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important defense mechanism against cancer onset and progression, and is negatively regulated by interaction with the oncoprotein MDM2. In human cancers, the TP53 gene is frequently mutated or deleted, or the wild-type p53 function is inhibited by high levels of MDM2, leading to downregulation of tumor suppressive p53 pathways. Thus, the inhibition of MDM2-p53 interaction presents an appealing therapeutic strategy for the treatment of cancer. However, recent studies have revealed the MDM2-p53 interaction to be more complex involving multiple levels of regulation by numerous cellular proteins and epigenetic mechanisms, making it imperative to reexamine this intricate interplay from a holistic viewpoint. This review aims to highlight the multifaceted network of molecules regulating the MDM2-p53 axis to better understand the pathway and exploit it for anticancer therapy. | Subhasree Nag Jiangjiang Qin Kalkunte S.Srivenugopal Minghai Wang Ruiwen Zhang | 2013 | The Journal of Biomedical Research2013，27，4： | 13 |
| 3 | Novel natural product therapeutics targeting both inflammation and cancer显示文摘Inflammation is recently recognized as one of the hallmarks of human cancer. Chronic inflammatory response plays a critical role in cancer development, progression, metastasis, and resistance to chemotherapy. Conversely, the oncogenic aberrations also generate an inflammatory microenvironment, enabling the development and progression of cancer. The molecular mechanisms of action that are responsible for inflammatory cancer and cancer-associated inflammation are not fully understood due to the complex crosstalk between oncogenic and pro-inflammatory genes. However, molecular mediators that regulate both inflammation and cancer, such as NF-κB and STAT have been considered as promising targets for preventing and treating these diseases. Recent works have further demonstrated an important role of oncogenes(e.g., NFAT1, MDM2) and tumor suppressor genes(e.g., p53) in cancer-related inflammation. Natural products that target these molecular mediators have shown anticancer and anti-inflammatory activities in preclinical and clinical studies. Sesquiterpenoids(STs), a class of novel plant-derived secondary metabolites have attracted great interest in recent years because of their diversity in chemical structures and pharmacological activities. At present, we and other investigators have found that dimeric sesquiterpenoids(DSTs) may exert enhanced activity and binding affinity to molecular targets due to the increased number of alkylating centers and improved conformational flexibility and lipophilicity. Here, we focus our discussion on the activities and mechanisms of action of STs and DSTs in treating inflammation and cancer as well as their structure-activity relationships. | Jiangjiang QIN Wei WANG Ruiwen ZHANG | 2017 | Chinese Journal of Natural Medicines2017，15，6： | 8 |
| 4 | Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine显示文摘The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest,apoptosis,senescence,and DNA repair.The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability.MDM2,p53,and the p53-MDM2 pathway represent welldocumented targets for preventing and/or treating cancer.Natural products,especially those from medicinal and food plants,are a rich source for the discovery and development of novel therapeutic and preventive agents against human cancers.Many natural product-derived MDM2 inhibitors have shown potent efficacy against various human cancers.In contrast to synthetic small-molecule MDM2 inhibitors,the majority of which have been designed to inhibit MDM2-p53 binding and activate p53,many natural product inhibitors directly decrease MDM2 expression and/or MDM2 stability,exerting their anticancer activity in both p53-dependent and p53-independent manners.More recently,several natural products have been reported to target mutant p53 in cancer.Therefore,identification of natural products targeting MDM2,mutant p53,and the p53-MDM2 pathway can provide a promising strategy for the development of novel cancer chemopreventive and chemotherapeutic agents.In this review,we focus our discussion on the recent advances in the discovery and development of anticancer natural products that target the p53-MDM2 pathway,emphasizing several emerging issues,such as the efficacy,mechanism of action,and specificity of these natural products. | Jiang-Jiang Qin Xin Li Courtney Hunt Wei Wang Hui Wang Ruiwen Zhang | 2018 | Genes & Diseases2018，5，3： | 7 |
| 5 | Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy显示文摘There is an increasing interest in development of novel anticancer agents that target oncogenes.We have recently discovered that nuclear factor of activated T cells 1(NFAT1) is a novel regulator of the Mouse Double Minute 2(MDM2) oncogene and the NFAT1-MDM2 pathway has been implicated in human cancer development and progression,justifying that targeting the NFAT1-MDM2 pathway could be a novel strategy for discovery and development of novel cancer therapeutics.The present study was designed to examine the anticancer activity and underlying mechanisms of action of lineariifolianoid A(LinA),a novel natural product inhibitor of the NFAT1-MDM2 pathway.The cytotoxicity of LinA was first tested in various human cancer cell lines in comparison with normal cell lines.The results showed that the breast cancer cells were highly sensitive to LinA treatment.We next demonstrated the effects of LinA on cell proliferation,colony formation,cell cycle progression,and apoptosis in breast cancer MCF7 and MDA-MB-231 cells,in dose-dependent and p53-independent manners.LinA also inhibited the migration and invasion of these cancer cells.Our mechanistic studies further indicated that its anticancer activities were attributed to its inhibitory effects on the NFAT1-MDM2 pathway and modulatory effects on the expression of key proteins involved in cell cycle progression,apoptosis,and DNA damage.In summary,LinA is a novel NFAT1-MDM2 inhibitor and may be developed as a preventive and therapeutic agent against human cancer. | Jiang-Jiang Qin Sushanta Sarkar Sukesh Voruganti Rajesh Agarwal Wei Wang Ruiwen Zhang | 2016 | The Journal of Biomedical Research2016，30，4： | 5 |
| 6 | 大推力液体火箭发动机推力调节技术综述显示文摘Throttling of large-thrust liquid rocket engines,which can improve mission adaptability of a carrier rocket,reduce risk and facilitate rocket recovery,is a key technology for current and future space development.This paper summarizes the state of the art and trends of throttling technology for large-thrust liquid rocket engines at home and abroad.According to the working principles of propulsion for rocket engines,throttling the propellant flow rate is a major way of adjusting thrust,and regulation devices along with adjustable injectors are primary measures of throttling propellant flow rates.This paper clarifies the working principles of typical regulation devices and adjustable injectors,introduces the regulation schemes of typical large-thrust engines such as YF-100,RD-170,and SSME,and summarizes the main characteristics of current throttleable large-thrust engines.Finally,critical technologies and development trends of throttling are discussed,including combustion stability and reliable cooling of thrust chambers at low thrust levels,turbopump stability,and stable regulation and precise control in a wide range of operating conditions. | LI Bin ZHANG Ruiwen ZHANG Miao WANG Haiyan LI Chunhong WANG Kai | 2021 | Aerospace China2021，22，2： | 5 |
| 7 | Scalable and ultrafast epitaxial growth of single-crystal graphene wafers for electrically tunable liquid-crystal microlens arrays显示文摘The scalable growth of wafer-sized single-crystal graphene in an energy-efficient manner and compatible with wafer process is critical for the killer applications of graphene in high-performance electronics and optoelectronics. Here, ultrafast epitaxial growth of single-crystal graphene wafers is realized on singlecrystal Cu90Ni10(1 1 1) thin films fabricated by a tailored two-step magnetron sputtering and recrystallization process. The minor nickel(Ni) content greatly enhances the catalytic activity of Cu, rendering the growth of a 4 in. single-crystal monolayer graphene wafer in 10 min on Cu90Ni10(1 1 1), 50 folds faster than graphene growth on Cu(1 1 1). Through the carbon isotope labeling experiments, graphene growth on Cu90Ni10(1 1 1) is proved to be exclusively surface-reaction dominated, which is ascribed to the Cu surface enrichment in the Cu Ni alloy, as indicated by element in-depth profile. One of the best benefits of our protocol is the compatibility with wafer process and excellent scalability. A pilot-scale chemical vapor deposition(CVD) system is designed and built for the mass production of single-crystal graphene wafers, with productivity of 25 pieces in one process cycle. Furthermore, we demonstrate the application of single-crystal graphene in electrically controlled liquid-crystal microlens arrays(LCMLA), which exhibit highly tunable focal lengths near 2 mm under small driving voltages. By integration of the graphene based LCMLA and a CMOS sensor, a prototype camera is proposed that is available for simultaneous light-field and light intensity imaging. The single-crystal graphene wafers could hold great promising for highperformance electronics and optoelectronics that are compatible with wafer process. | Bing Deng Zhaowei Xin Ruiwen Xue Shishu Zhang Xiaozhi Xu Jing Gao Jilin Tang Yue Qi Yani Wang Yan Zhao Luzhao Sun Huihui Wang Kaihui Liu Mark H. Rummeli Lu-Tao Weng Zhengtang Luo Lianming Tong Xinyu Zhang Changsheng Xie Zhongfan Liu Hailin Peng | 2019 | Science Bulletin2019，64，10： | 4 |
| 8 | Ordovician radiolarians from the Yinisala ophiolitic melange and their significance in western Junggar, Xinjiang, NW China显示文摘The Yinisala ophiolitic mélange is located in the southern part of the Xiemisitai Mountains in western Junggar(NW China), and is composed of mafic-ultra mafic rocks, siliceous blocks, marble(marbleized limestone) and pyroclastic rocks, which all crop out as faulted blocks. Rich radiolarian and sponge spicule fossils are found in the siliceous rock for the first time. There are six genera of radiolarians(including one gen. et sp. Indet.) belonging to two families: Inaniguttid gen. et sp. Indet., Inanigutta sp., Inanibigutta sp., Inanihella bakanasensis(Nazarov), Triplococcus acanthicus(Danelian and Popov), Antygopora sp., which are identified to be of late Early to Middle Ordovician age, representing the upper limit of the formation age of the Yinisala ophiolite mélange. The ophiolites were developed in the Early Cambrian-Middle Ordovician oceanic environment, probably an important part of the early Paleozoic Paleo-Asian Ocean, based on the composition and structure of the siliceous rock and associated deep-water fossils. The Yinisala, Taerbahatai, and Hongguleleng ophiolitic mélange belts can be correlated as a suite of unified subduction accretionary complex, which extends eastward to the eastern Junggar. We consider that there existed an ancient ocean connecting the east and west of northern Junggar in the Early Cambrian-Middle Ordovician. | ZONG RuiWen WANG ZiZhang GONG YiMing WANG GuoCan XIAO Long WANG ZhiHong FAN RuoYing | 2015 | Science China Earth Sciences2015，58，5： | 4 |
| 9 | Orderly defective superstructure for enhanced pseudocapacitive storage in titanium niobium oxide显示文摘Artificial defect engineering in transition metal oxides is of important terms for numerous applications.In the present work,we proposed an in-situ gas reduction strategy to introduce ordered defects into titanium niobium oxide embedding on vapor grew carbon fibers(Ti_(2)Nb_(10)O_(29-x)@VGCFs).High-resolution transmission electron microscopy(HRTEM)and fast Fourier transform(FFT)simulation indicate that the ordered oxygen defects locate at interval layers,which leads to a new superstructure in Ti_(2)Nb_(10)O_(29).The ordered defects could provide extra active sites for lithium-ion storage and modulate ionic migration,resulting an enhanced pseudocapacitive performance.In addition,the excellent structural stability of the superstructure was proved by in-situ HRTEM under a harsh electrochemical process.Our work provides a directly observation of orderly defective superstructure in transition metal oxide,and its functionality on electrochemistry was revealed. | Le Yang Jinfeng Zeng Lei Zhou Ruiwen Shao Wellars Utetiwabo Muhammad Khurram Tufail Saisai Wang Wen Yang Jiatao Zhang | 2022 | Nano Research2022，15，2： | 4 |
| 10 | Construction of three-dimensional hierarchical porous nitrogen-doped re duce d graphene oxide/hollow cobalt ferrite composite aerogels toward highly efficient electromagnetic wave absorption显示文摘The development of graphene-based composites with low density,robust absorption,wide bandwidth and thin thickness remained a great challenge in the field of electromagnetic(EM)absorption.In this work,nitrogen-doped reduced graphene oxide/hollow cobalt ferrite(NRGO/hollow CoFe_(2)O_(4))composite aerogels were constructed by a solvothermal and hydrothermal two-step route.Results demonstrated that the as-fabricated composite aerogels had the ultralow density and a unique three-dimensional(3D)network structure,and lots of hollow CoFe_(2)O_(4)microspheres were almost homogeneously distributed on the wrinkled surfaces of lamellar NRGO.Moreover,superior EM absorbing capacity could be achieved by modulating the ferrite structure,addition amounts of hollow CoFe_(2)O_(4)and thicknesses.It was noteworthy that the NRGO/hollow CoFe_(2)O_(4)composite aerogel with the addition amount of ferrite of 15.0 mg pos-sessed the minimum reflection loss of-44.7 dB and maximum absorption bandwidth of 5.2 GHz(from 12.6 to 17.8 GHz)at a very thin thickness of 1.8 mm and filling ratio of 15.0 wt.%.Furthermore,the possible EM attenuation mechanism had been proposed.The results of this work would be helpful for developing RGO-based 3D composites as lightweight,thin and highly efficient EM wave absorbers. | Jing Xu Ruiwen Shu Zongli Wan Jianjun Shi | 2023 | Journal of Materials Science & Technology2023，，1： | 4 |
| 11 | Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction显示文摘The RON receptor tyrosine kinase,a member of the MET proto-oncogene family,is a pathogenic factor implicated in tumor malignancy.Specifically,aberrations in RON signaling result in increased cancer cell growth,survival,invasion,angiogenesis,and drug resistance.Biochemical events such as ligand binding,receptor overexpression,generation of structure-defected variants,and point mutations in the kinase domain contribute to RON signaling activation.Recently,functional crosstalk between RON and signaling proteins such as MET and EFGR has emerged as an additional mechanism for RON activation,which is critical for tumorigenic development.The RON signaling crosstalk acts either as a regulatory feedback loop that strengthens or enhances tumorigenic phenotype of cancer cells or serves as a signaling compensatory pathway providing a growth/survival advantage for cancer cells to escape targeted therapy.Moreover,viral oncoproteins derived from Friend leukemia or Epstein-Barr viruses interact with RON to drive viral oncogenesis.In cancer cells,RON signaling is integrated into cellular signaling network essential for cancer cell growth and survival.These activities provide the molecular basis of targeting RON for cancer treatment.In this review,we will discuss recent data that uncover the mechanisms of RON activation in cancer cells,review evidence of RON signaling crosstalk relevant to cancer malignancy,and emphasize the significance of the RON signaling addiction by cancer cells for tumor therapy.Understanding aberrant RON signaling will not only provide insight into the mechanisms of tumor pathogenesis,but also lead to the development of novel strategies for molecularly targeted cancer treatment. | Ming-Hai Wang Ruiwen Zhang Yong-Qing Zhou Hang-Ping Yao | 2013 | The Journal of Biomedical Research2013，27，5： | 4 |
| 12 | Improved method for subsystems performance trade-off in system-of-systems oriented design of UAV swarms显示文摘For the rapidly developing unmanned aerial vehicle(UAV)swarm,the system-of-systems(SoS)oriented design is a prospective conceptual design methodology due to the competence for complex mission requirements and subsystems interactions.In the SoS oriented design,the subsystems performance trade-off is the basis of design decisions.In the trade-off for surveillance missions,most previous works do not consider track reporting and mainly focus on the design of platforms.An improved method for the subsystems performance trade-off in the SoS oriented UAV swarm design is proposed.Within an improved design framework with subsystems disaggregation,this method is characterized by treating platforms,sensors,and communications as equally important subsystems,integrating operational strategies into the trade-off,and enabling the trade-off for track reporting.Those advantages are achieved by a behavior-based modular model structure for agent-based operational modeling and simulation.In addition,a method of analyzing the bounds of the communication range is also presented.Simulation experiments are conducted by using precision-based simulation replication rules and surrogate modeling methods.The results demonstrate the effectiveness of the proposed method,and show that the configuration of area partitioning changes the trade space of subsystems performances,indicating the necessity of integrating operational strategies into the conceptual design. | ZHANG Ruiwen SONG Bifeng PEI Yang YUN Qijia | 2019 | Journal of Systems Engineering and Electronics2019，30，4： | 3 |
| 13 | Regulation of pathological BBB restoration via nanostructured ROS-responsive glycolipid-like copolymer entrapping siVEGF for glioblastoma targeted therapeutics显示文摘Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative treatments.Abnormally elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)with an increased permeability,resulting in poor outcome and prognosis.RNAi interference has shown strong potential to inhibit VEGF expression,thus it is necessary to development an effective and safe gene delivery system possessing the ability to cross the BBB and target GBM cells.This study aims to explore the anti-GBM effect of angiopep-2(Ap)peptide modified reactive oxygen species(ROS)cleavable thioketal(TK)linked glycolipid-like nanocarrier(CSTKSA)delivering anti-VEGF siRNA(R),termed as Ap-CSTKSA/R complexes.Ap functionalized modification produced an enhanced cellular uptake and a stronger bio-distribution of Ap-CSTKSA/R complexes in U87 MG cells and brain tumor tissues,respectively.Ap-CSTKSA/R complexes exhibited great superiority in GBM growth inhibition and finally translated into the longest survival period mainly via receptor-mediated targeting delivery,VEGF gene silencing accompanied with remarkable angiogenesis inhibition,and suppressed expression of caveolin-1 which is involved in BBB functional regulation in the occurrence and treatment of GBM.The study indicated that Ap functionalization on ROS-responsive glycolipid-like copolymer exhibits a promising and effective gene delivery platform for GBM targeted treatment. | Lijuan Wen Yu Peng Kai Wang Zhihua Huang Shiying He Ruiwen Xiong Longping Wu Fengtian Zhang Fuqiang Hu | 2022 | Nano Research2022，15，2： | 2 |
| 14 | A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance显示文摘Overexpression of the MDM2 oncogene and mutations in the p53 tumor suppressor commonly occur in hepatocellular carcinoma(HCC)and are associated with increased mortality due to this disease.Inhibiting MDM2 has been demonstrated to be a valid approach for the treatment of HCC.However,most of the MDM2 inhibitors evaluated to date have been designed to block the MDM2 and p53 binding,and have limited efficacy against tumors with mutant or deficient p53.In the present study,we developed a novel MDM2 inhibitor(termed SP141)that has direct effects on MDM2 and exerts anti-HCC activity independent of the p53 status of the cancer cells.We demonstrate that SP141 inhibits cell growth and prevents cell migration and invasion,independent of p53.Mechanistically,SP141 directly binds the MDM2 protein and promotes MDM2 degradation.The inhibition of MDM2 by SP141 also increases the sensitivity of HCC cells to sorafenib.In addition,in orthotopic and patient-derived xenograft models,SP141 inhibits MDM2 expression and suppresses tumor growth and metastasis,without any host toxicity.Furthermore,the inhibition of MDM2 by SP141 is essential for its anti-HCC activities.These results provide support for the further development of SP141 as a lead candidate for the treatment of HCC. | Wei Wang Bo Hu Jiang-Jiang Qin Jian-Wen Cheng Xin Li Mehrdad Rajaei Jia Fan Xin-Rong Yang Ruiwen Zhang | 2019 | Genes & Diseases2019，6，4： | 2 |
| 15 | Nitric oxide enhances the sensitivity of alpaca melanocytes to respond to α-melanocyte-stimulating hormone by up-regulating melanocortin-1 receptor显示文摘 | Yanjun Dong Jing Cao Haidong Wang Jie Zhang Zhiwei Zhu Rui Bai HuanQing Hao Xiaoyan He Ruiwen Fan Changsheng Dong | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 2 |
| 16 | Microstructural evolution and hardness of as-cast Be-Al-Sc-Zr alloy processed by laser surface remelting显示文摘As-cast beryllium-aluminum(Be-Al)alloy exhibits a coarse microstructure with pore defects due to a large solidification interval,greatly limiting its mechanical properties.In this research,the relationship between laser surface remelting process and microstructure and hardness of as-cast Be-Al-Sc-Zr alloy was established.The experimental results demonstrated that a pore-free refined microstructure of remelted layer was obtained by controlling the parameter of effective laser energy input.The microstructure of as-cast Be-Al-Sc-Zr alloy consisted of equiaxed grains with Al phase forming a continuous frame wrapping Be phase,which was significantly refined in the remelted zone(from 25μm to 2μm).The Vickers hardness in the remelted zone(approximately 210 HV)was approximately 3 times that of as-cast Be-Al-Sc-Zr alloy.Analysis of the Vickers hardness and the Be phase size showed a good agreement with a Hall-Petch equation.In addition,transmission electron microscopy(TEM),auger electron spectroscopy(AES)and X-ray diffraction(XRD)analysis evidenced that Sc and Zr elements formed a single blocky phase Be13(Scx,Zr1-x),which was also greatly refined from 8μm to 1.5μm in the remelted zone.The results obtained in this study indicate that the laser surface remelting allowed refining the microstructure and further strengthening the Vickers hardness of Be-Al-Sc-Zr alloy. | Qingdong XU Yu LUO Xiangdong LIU Lei YANG Shixiong HE Xin WANG Wenyuan WANG Tao SHI Ruiwen LI Pengcheng ZHANG | 2021 | Chinese Journal of Aeronautics2021，34，8： | 2 |
| 17 | Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ,a novel anticancer makaluvamine analog,and application in a pharmacokinetic study in rats显示文摘We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers.Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog,TCBA-TPQ,and conducted a pharmacokinetic study in laboratory rats.Our results indicated that the HPLC-MS/MS method was precise,accurate,and specific.Using this method,we carried out in vitro and in vivo evaluations of the pharmacological properties of TCBA-TPQ and plasma pharmacokinetics in rats.Our results provide a basis for future preclinical and clinical development of this promising anticancer marine analog. | YU Jun-Xian Sukesh Voruganti LI Dan-Dan Jiang-Jiang Qin Subhasree Nag Su Xu Sadanandan E.Velu Wei Wang Ruiwen ZHANG | 2015 | Chinese Journal of Natural Medicines2015，13，7： | 2 |
| 18 | Non-Hermitian Skin Effect in a Non-Hermitian Electrical Circuit显示文摘The conventional bulk-boundary correspondence directly connects the number of topological edge states in a finite system with the topological invariant in the bulk band structure with periodic boundary condition(PBC).However,recent studies show that this principle fails in certain non-Hermitian systems with broken reciprocity,which stems from the non-Hermitian skin effect(NHSE)in the finite system where most of the eigenstates decay exponentially from the system boundary.In this work,we experimentally demonstrate a 1D non-Hermitian topological circuit with broken reciprocity by utilizing the unidirectional coupling feature of the voltage follower module.The topological edge state is observed at the boundary of an open circuit through an impedance spectra measurement between adjacent circuit nodes.We confirm the inapplicability of the conventional bulk-boundary correspondence by comparing the circuit Laplacian between the periodic boundary condition(PBC)and open boundary condition(OBC).Instead,a recently proposed non-Bloch bulk-boundary condition based on a non-Bloch winding number faithfully predicts the number of topological edge states. | Shuo Liu Ruiwen Shao Shaojie Ma Lei Zhang Oubo You Haotian Wu Yuan Jiang Xiang Tie Jun Cui Shuang Zhang | 2021 | Research2021，，1： | 2 |
| 19 | Low-density extraction solvent-based solvent terminated dispersive liquid–liquid microextraction combined with gas chromatography-tandem mass spectrometry for the determination of carbamate pesticides in water samples显示文摘 | Hao Chen Ruiwen Chen Shengqing Li | 2009 | Journal of Chromatography A2009，，8： | 1 |
| 20 | In situ TEM revealing the effects of dislocations on lithium-ion migration in transition metal dichalcogenides显示文摘The two-dimensional (2D) structure of layered transition metal dichalcogenides (TMDs) provides unusual physical properties [1,2]and chemical reactivity [3,4], which can be influenced by defects such as dislocations [5,6]. For example, dislocations can act as nucleation sites for the onset of deformation when subjected to stress [7]. | Ruiwen Shao Chengkai Yang Chen Yang Shulin Chen Weikang Dong Bairong Li Xiumei Ma Jing Lu Lixin Dong Peng Gao Dapeng Yu | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
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