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| 1 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 2 | Lack of Cholecystokinin-A Receptor Enhanced Gallstone Formation: A Study in CCK-A Receptor Gene Knockout Mice显示文摘 | Norikazu Sato Kyoko Miyasaka Shinji Suzuki Setsuko Kanai Minoru Ohta Takako Kawanami Yuki Yoshida Soichi Takiguchi Tetsuo Noda Yutaka Takata Akihiro Funakoshi | 2003 | Digestive Diseases and Sciences2003，，10： | 2 |
| 3 | Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity显示文摘 | Ayumi Yoshizaki Kazuhiro Komura Yohei Iwata Fumihide Ogawa Toshihide Hara Eiji Muroi Motoi Takenaka Kazuhiro Shimizu Minoru Hasegawa Manabu Fujimoto Shinichi Sato | 2009 | Journal of Clinical Immunology2009，，2： | 1 |
| 4 | In Vivo klotho Gene Transfer Ameliorates Angiotensin II-Induced Renal Damage显示文摘 | Haruo Mitani Nobukazu Ishizaka Toru Aizawa Minoru Ohno Shin-ichi Usui Toru Suzuki Toshihiro Amaki Ichiro Mori Yasushi Nakamura Misako Sato Masaomi Nangaku Yasunobu Hirata Ryozo Nagai | 2002 | Hypertension: Journal of the American Heart Association2002，，4： | 1 |
| 5 | Aconstic characteristics of wheels with different webshapes显示文摘 | SATO Kiyoshi SASAKURA Minoru AKUTSU Katsunori | 2006 | Q Rep RTRI2006，47，1： | 1 |
| 6 | Dynamicity of the J-Wave in Idiopathic Ventricular Fibrillation With a Special Reference to Pause-Dependent Augmentation of the J-Wave显示文摘 | Yoshifusa Aizawa Akinori Sato Hiroshi Watanabe Masaomi Chinushi Hiroshi Furushima Minoru Horie Yoshiaki Kaneko Tsutomu Imaizumi Kimie Okubo Ichiro Watanabe Tsuyoshi Shinozaki Yoshiyasu Aizawa Keiichi Fukuda Kunitake Joo Michel Haissaguerre | 2012 | Journal of the American College of Cardiology2012，，22： | 1 |
| 7 | Production of the Blood Pressure Lowing Peptides from Brown Alga(Undaria pinnatifida)显示文摘Brown alga (Undaria pinnatifida) was treated with alginate lyase and hydrolyzed using 17 kinds of proteases andthe inhibitory activity of the hydrolysates for the angiotensin-I-converting enzyme (ACE) was measured. Four hydrolysateswith potent ACE-inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHRs). The sys-tolic blood pressure of SHRs decreases significantly after single oral administration of the brown alga hydrolysates by pro-tease S ’Amano’ (from Bacillus stearothermophilus) at the concentration of 10 (mg protein) (kg body weight)-1. In the 17weeks of feeding experiment, 7-week-old SHRs were fed standard diet supplemented with the brown alga hydrolysates for 10weeks. In SHRs fed 1.0 and 0.1% brown alga hydrolysates, elevating of systolic bloodpressure was significantly suppressedfor 7 weeks. To elucidate the active components, the brown alga hydrolysates were fractionated by 1-butanol extraction andHPLC on a reverse-phase column. Seven kinds of ACE-inhibitory peptides were isolated and identified by amino acid compo-sition analysis, sequence analysis, and LC-MS with the results Val-Tyr, Ile-Tyr, Ala-Trp, Phe-Tyr, Val-Trp, Ile-Trp, andLeu-Trp. Each peptide was determined to have an antihypertensive effect after a single oral administration in SHRs. Thebrown alga hydrolysates were also confirmed to decrease the blood pressure in humans. | Sato Minoru Oba Takashi Hosokawa Takao Yamaguchi Toshiyasu Nakano Toshiki Saito Tadao Muramoto Koji Kahara Takashi Funayama Katsura Kobayashi Akio Nakano Takahisa | 2005 | Journal of Ocean University of China2005，4，3： | 1 |
| 8 | Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，： | 1 |
| 9 | Electrical Storm in Idiopathic Ventricular Fibrillation is Associated with Early Repolarization显示文摘 | Yoshifusa Aizawa Masaomi Chinushi Kanae Hasegawa Nobu Naiki Minoru Horie Yoshiaki Kaneko Masahiko Kurabayashi Shogo Ito Tsutomu Imaizumi Yoshiyasu Aizawa Seiji Takatsuki Kunitake Joo Masahito Sato Katsuya Ebe Yukio Hosaka Michel Haissaguerre Keiichi Fukud | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 10 | Potentiation of antitumor effect of NKT cell ligand, α-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells1显示文摘 | Minoru Nakui Akio Ohta Masashi Sekimoto Marimo Sato Kenji Iwakabe Takashi Yahata Hidemitsu Kitamura Toshiaki Koda Tetsu Kawano Hiroyasu Makuuchi Masaru Taniguchi Takashi Nishimura | 2000 | Clinical and Experimental Metastasis2000，，2： | 1 |
| 11 | Association of the polymorphisms in the 5′-untranslated region of PTEN gene with type 2 diabetes in a Japanese population显示文摘 | Hajime Ishihara Toshiyasu Sasaoka Syota Kagawa Shihou Murakami Kazuhito Fukui Yukio Kawagishi Katsuya Yamazaki Akira Sato Minoru Iwata Masaharu Urakaze Manabu Ishiki Tsutomu Wada Saori Yaguchi Hiroshi Tsuneki Ikuko Kimura Masashi Kobayashi | 2003 | FEBS Letters2003，，3： | 1 |
| 12 | Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C显示文摘 | Junji Kato Koji Miyanishi Masayoshi Kobune Tokiko Nakamura Kohichi Takada Rishu Takimoto Yutaka Kawano Sho Takahashi Minoru Takahashi Yasushi Sato Tetsuji Takayama Yoshiro Niitsu | 2007 | Journal of Gastroenterology2007，，10： | 1 |
| 13 | Pitavastatin Reduces Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands in Hypercholesterolemic Humans显示文摘 | Tetsuya Matsumoto Masatoshi Fujita Tatsuya Sawamura Akemi Kakino Yuko Sato Yoshiko Fujita Haruo Matsuda Mamoru Nakanishi Kagehiro Uchida Izuru Nakae Hiroshi Kanda Akira Yoshida Kunihisa Miwa Hideki Hayashi Kenichi Mitsunami Minoru Horie | 2010 | Lipids2010，，4： | 1 |
| 14 | Hepatic portal venous gas associated with cholangitis following pancreaticoduodenectomy: Report of a case显示文摘 | Toshihiro Tsubono Kenij Sato Minoru Fukuda | 1994 | Surgery Today1994，，4： | 1 |
| 15 | Development of target protein-selective degradation inducer for protein knockdown显示文摘 | Yukihiro Itoh Minoru Ishikawa Risa Kitaguchi Shinichi Sato Mikihiko Naito Yuichi Hashimoto | 2011 | Bioorganic & Medicinal Chemistry2011，，10： | 1 |
| 16 | Phase II study of S-1 as first-line treatment for elderly patients over 75?years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 17 | A Mechanism of Lithium Storage in Disordered Carbons显示文摘 | Kenji Sato Minoru Noguchi | 1994 | Science1994，264，4： | 1 |
| 18 | Selective cancer cell cytotoxicity of enantiomeric 9-mer peptides derived from beetle defensins depends on negatively charged phosphatidylserine on the cell surface显示文摘 | Takashi Iwasaki Jun Ishibashi Hiromitsu Tanaka Mitsuru Sato Ai Asaoka DeMar Taylor Minoru Yamakawa | 2008 | Peptides2008，，： | 1 |
| 19 | Early changes induced by environmental stresses in insulin sensitivity-related genes显示文摘 | Masao Sato Satoshi Ishibashi Minoru Higashimoto Yoshito Kadota Takashige Kawakami Shinya Suzuki | 2011 | European Journal of Pharmacology2011，，3： | 1 |
| 20 | Host-Derived MCP-1 and MIP-1α Regulate Protective Anti-Tumor Immunity to Localized and Metastatic B16 Melanoma显示文摘 | Yuko Nakasone Manabu Fujimoto Takashi Matsushita Yasuhito Hamaguchi Doanh Le Huu Mizuki Yanaba Shinichi Sato Kazuhiko Takehara Minoru Hasegawa | 2012 | The American Journal of Pathology2012，，1： | 1 |
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