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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Atmospheric HULIS and its ability to mediate the reactive oxygen species (ROS): A review显示文摘Atmospheric humic-like substances(HULIS) are not only an unresolved mixture of macroorganic compounds but also powerful chelating agents in atmospheric particulate matters(PMs); impacting on both the properties of aerosol particles and health effects by generating reactive oxygen species(ROS). Currently, the interests of HULIS are intensively shifting to the investigations of HULIS-metal synergic effects and kinetics modeling studies, as well as the development of HULIS quantification, findings of possible HULIS sources and generation of ROS from HULIS. In light of HULIS studies, we comprehensively review the current knowledge of isolation and physicochemical characterization of HULIS from atmospheric samples as well as HULIS properties(hygroscopic, surface activity, and colloidal) and possible sources of HULIS.This review mainly highlights the generation of reactive oxygen species(ROS) from PMs, HULIS and transition metals, especially iron. This review also summarized the mechanism of ironorganic complexation and recent findings of OH formation from HULIS-metal complexes. This review will be helpful to carry out the modeling studies that concern with HULIS-transition metals and for further studies in the generation of ROS from HULIS-metal complexes. | Myat Sandar Win Zhengyang Tian Hui Zhao Kai Xiao Jiaxian Peng Yu Shang Minghong Wu Guangli Xiu Senlin Lu Shinich Yonemochi Qingyue Wang | 2018 | Journal of Environmental Sciences2018，30，9： | 6 |
| 3 | Single atom and defect engineering of CuO for efficient electrochemical reduction of CO_(2) to C_(2)H_(4)显示文摘Electrochemical CO_(2) transformation to high‐value ethylene(C_(2)H_(4))at high currents and efficiencies is desired and yet remains a grand challenge.We show for the first time that coupling single Sb atoms and oxygen vacancies of CuO enable synergistic electrocatalytic reduction of CO_(2) to C_(2)H_(4) at low overpotentials.Highly dispersed Sb atoms occupying metal substitutional sites of CuO are synthesized under mild conditions.The overall CO_(2) reduction faradaic efficiency(FE)reaches 89.3±1.1%with an FE toward C_(2)H_(4) exceeding 58.4%at a high‐current density of 500 mA/cm^(2).Addition of the p‐block metal is found to induce transformation of CuO from flakes to nanoribbons rich in nanoholes and oxygen vacancies,greatly enhancing CO_(2) adsorption and activation while suppressing hydrogen evolution.Further density functional theory calculations with in situ X‐ray diffraction reveal that combining Sb sites and oxygen vacancies prominently lessen the dimerization energy of adsorbed CO intermediate,thus boosting the conversion of CO_(2) to produce C_(2)H_(4).This study provides a new perspective for promoting selective C-C coupling for electrochemical CO_(2) reduction. | Senlin Chu Changwoo Kang Woonghyeon Park Yu Han Song Hong Leiduan Hao Hao Zhang Tsz Woon Benedict Lo Alex W.Robertson Yousung Jung Buxing Han Zhenyu Sun | 2022 | SmartMat2022，3，1： | 3 |
| 4 | Analysis of the relationship between bile duct and duodenal microbiota reveals that potential dysbacteriosis is the main cause of primary common bile duct stones显示文摘Bacteria play an important role in the formation of primary Common Bile Duct(CBD)stones.However,the composition and function of the microbiota of bile duct in patients with primary CBD stones remained to be explored.We utilized the 16S rRNA gene high-throughput sequencing technology to analyze the microbial diversity and community composition of biliary and duodenal microbiota in 15 patients with primary CBD stones and 4 patients without biliary tract diseases.Alpha diversity analysis showed that the microbiota richness was similar in bile and intestinal fluid;Beta diversity analysis showed that there were differences in the composition between biliary microbiota and the duodenal microbiota,but the abundance of the main groups showed similarities.The composition of the biliary microbiota from gallstone patients was more complex,as was the duodenal microbiota.Proteobacteria and Firmicutes were the dominant bacteria at phylum level,accounting for at least 75%of the total reads in each subgroup.Pseudomonas and EscherichiaShigella were the major genus among subgroups,but Escherichia-Shigella had increased abundance in duodenal microbiota with primary choledocholithiasis,which may play an important role in stone formation.It is noteworthy that Clostridiumsensu_stricto,Lachnospiraceae_UCG-008,Butyrivibrio and Roseburia which could produce short chain fatty acids(SCFAs),were significantly decreased in biliary microbiota with primary CBD stones(p<0.05).Our study provided new insights into the compositional of normal biliary microbiota.The micro-ecology of biliary and duodenal in patients with stones is complex and closely related,and there is a potential for dysbacteriosis.The decrease in abundance of certain major acid-producing bacteria affects the health of the biliary tract and thus leads to the formation of stones. | Zhitang Lyu Tingting Yu Lichao Zhang Xiaona Xu Yijun Zhang Jihong Li Zhirong Li Wei Zhang Senlin Hou | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 2 |
| 5 | A low dose cell therapy system for treating osteoarthritis:In vivo study and in vitro mechanistic investigations显示文摘Mesenchymal stem cells(MSCs)can be effective in alleviating the progression of osteoarthritis(OA).However,low MSC retention and survival at the injection site frequently require high doses of cells and/or repeated injections,which are not economically viable and create additional risks of complications.In this study,we produced MSC-laden microcarriers in spinner flask culture as cell delivery vehicles.These microcarriers containing a low initial dose of MSCs administered through a single injection in a rat anterior cruciate ligament(ACL)transection model of OA achieved similar reparative effects as repeated high doses of MSCs,as evaluated through imaging and histological analyses.Mechanistic investigations were conducted using a co-culture model involving human primary chondrocytes grown in monolayer,together with MSCs grown either within 3D constructs or as a monolayer.Co-culture supernatants subjected to secretome analysis showed significant decrease of inflammatory factors in the 3D group.RNA-seq of co-cultured MSCs and chondrocytes using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed processes relating to early chondrogenesis and increased extracellular matrix interactions in MSCs of the 3D group,as well as phenotypic maintenance in the co-cultured chondrocytes.The cell delivery platform we investigated may be effective in reducing the cell dose and injection frequency required for therapeutic applications. | Bin Wang Wei Liu Jiao Jiao Li Senlin Chai Dan Xing Hongsheng Yu Yuanyuan Zhang Wenjin Yan Zhihong Xu Bin Zhao Yanan Du Qing Jiang | 2022 | Bioactive Materials2022，7，1： | 2 |
| 6 | Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: The role of quinones显示文摘 | Yu Shang Lanlan Fan Jialiang Feng Senlin Lv Minghong Wu Bing Li Yuan-Sheng Zang | 2013 | Toxicology in Vitro2013，，2： | 1 |
| 7 | Synthesis of nitrogen-doped carbon spheres using the modified Stober method for supercapacitors显示文摘Nitrogen-doped carbon spheres (NCSs) with uniform and regular morphology were facilely prepared by the modified Stober method. Hexamethylenetetramine (HMT) was selected as the starting material, which decomposed to provide nitrogen and carbon sources for the synthesis of NCSs. The decomposition product formaldehyde polymerized to form carbon skeleton with resorcinol after carbonization, and the in-situ nitrogen doping was achieved with the decomposed nitrogen source. NCSs were obtained with regular spherical morphology, high specific surface area, and suitable nitrogen doping. When used as the electrode material, NCSs exhibited good capacitance and electrochemical stability, indicating that NCSs be the promising candidate for the electrode material of high-performance supercapacitors. | Meng LIU Lei LIU Yifeng YU Haijun LV Aibing CHEN Senlin HOU | 2019 | Frontiers of Materials Science2019，13，2： | 1 |
| 8 | A USRP2 based reconfigurable multi-constellation multi-frequency GNSS software receiver front end显示文摘 | PENG Senlin YU Morton | 2013 | GPS Solutions2013，17，1： | 1 |
| 9 | Gd_(2)O_(3) nanoparticles modified g-C_(3)N_(4) with enhanced photocatalysis activity for degradation of organic pollutants显示文摘Gd_(2) O_(3) nanoparticles modified g-C_(3) N_(4) photocatalytic composites were synthesized by a simple one-step hydrothermal method.The structure,morphology,optical properties of the prepared photocatalyst were characterized by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),field emission transmission electron microscopy(FETEM) and X-ray photoelectron spectroscopy(XPS).The result demonstrates that gadolinium is mainly dispersed on the surface of g-C_(3) N_(4) in the form of Gd_(2) O_(3),and does not destroy the lattice structure of g-C_(3) N_(4).Besides,the gadolinium can cause the red shift of the absorption edge of light,narrow the band gap,and increase the separation efficiency of the photogenerated electron and hole of g-C_(3) N_(4).Especially,the specific surface area of g-C_(3) N_(4) can be significantly increased.Furthermore,g-C_(3) N_(4)/Gd-0.05 displays the highest photodegradation performance when it is used for degradation of methyl orange(MO),methylene blue(MB) and Rhodamine B(RhB).The photodegradation rate of g-C_(3) N_(4)/Gd-0.05 composites is 72.4% for MO,95.5% for RhB,100% for MB after120 min under visible light(λ> 420 nm) irradiation.Narrow band gap promotes the separation of photogenerated electron and hole,which enhances the photocatalytic activity of g-C_(3) N_(4).It is noted that g-C_(3) N_(4)/Gd-0.05 exhibits excellent photocatalytic stability by the photocurrent and the cyclic photodegradation of MO. | Yipeng Zhou Fanshan Zeng Chaoyang Sun Jun Wu Yu Xie Fayun Zhang Senlin Rao Fahui Wang Jinbing Zhang Jinsheng Zhao Shiqian Li | 2021 | Journal of Rare Earths2021，39，11： | 1 |
| 10 | Physicochemical properties and ability to generate free radicals of ambient coarse, fine, and ultrafine particles in the atmosphere of Xuanwei, China, an area of high lung cancer incidence显示文摘 | Senlin Lu Fei Yi Xiaojie Hao Shang Yu Jingjing Ren Minghong Wu Feng Jialiang Shinich Yonemochi Qingyue Wang | 2013 | Atmospheric Environment2013，，： | 1 |
| 11 | Physiological and biomass partitioning shifts to water stress under distinct soil types in Populus deltoides saplings显示文摘土壤类型是影响植物分布和生产力的重要环境因素,但有关土壤环境异质性对植物抗逆性效应的研究非常缺乏。本研究以美洲黑杨(Populus deltoids)为对象,以3种典型土壤类型(红壤、黄壤和黄棕壤)为栽培基质,在控制实验条件下,经过三个月的干旱胁迫(25%田间持水量)处理,测定了不同处理条件下美洲黑杨的气体交换速率、抗氧化能力、氮代谢特征、生物量积累与分配特征。研究结果表明,在红壤和黄壤条件下,与对照(75%田间持水量)相比,干旱胁迫显著降低了美洲黑杨各器官的生物量、光合速率、叶片氮同化酶的活性,显著增加了叶片中过氧化氢、丙二醛和无机氮的含量。在黄棕壤条件下,干旱对美洲黑杨总生物量、光合速率、氮同化酶以及质膜完整性的负面影响较小,这与其维持较高的超氧化物歧化酶,过氧化物酶和过氧化氢酶的活性相关,也与其生物量分配模式(如提高根冠比)密切相关。由此可见,生长在黄棕壤条件下的美洲黑杨表现出较强的抗旱能力,这可能与其土壤母质中较高的土壤养分和良好的通气状况相关。因此,就土壤类型而言,与红壤和黄壤相比,黄棕壤提供的土壤环境条件有利于美洲黑杨的抗逆表现和栽培利用。 | Senlin Yang Jian Shi Lianghua Chen Jian Zhang Danju Zhang Zhenfeng Xu Jiujin Xiao Peng Zhu Yang Liu Tiantian Lin Li Zhang Hanbo Yang Yu Zhong | 2020 | Journal of Plant Ecology2020，13，5： | 0 |
| 12 | ERCP combined with colonoscopy in the treatment of biliary-colonic fistula:case report and literature review显示文摘Introduction Internal biliary fistula is a potentially serious complication of laparoscopic cholecystectomy[1].Biliary-colonic fistula is a rare type of internal biliary fistula.Formation of a biliary-colonic fistula can occur as the result of surgical injury,stone obstruction,and biliary hypertension.More infrequent causes include intestinal ulcer and malignant tumor.The formation of a fistula also has the effect of infection and inflammation.While very few cases of biliary-colonic fistulas have been reported,these cases typically present with the aforementioned clinical presentations[2,3].In the present case,a biliary-colonic fistula resulting from bile-duct injury after laparoscopic cholecystectomy was identified by endoscopic retrograde cholangiopancreatography(ERCP).We innovatively adopted ERCP combined with colonoscopy to clamp the sinus tract for the patient. | Hongfei He Tingting Yu Yaoting Li Senlin Hou Lichao Zhang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 13 | A Pilot Protection Scheme of DC Lines for MMC-HVDC Grid Using Random Matrix显示文摘The over-current capacity of half-bridge modular multi-level converter(MMC)is quite weak,which requests protections to detect faults accurately and reliably in several milliseconds after DC faults.The sensitivity and reliability of the existing schemes are vulnerable to high resistance and data errors.To improve the insufficiencies,this paper proposes a pilot protection scheme by using the random matrix for DC lines in the symmetrical bipolar MMC high-voltage direct current(HVDC)grid.Firstly,the 1-mode voltage time-domain characteristics of the line end,DC bus,and adjacent line end are analyzed by the inverse Laplace transform to find indicators of fault direction.To combine the actual model with the data-driven method,the methods to construct the data expansion matrix and to calculate additional noise are proposed.Then,the mean spectral radiuses of two random matrices are used to detect fault directions,and a novel pilot protection criterion is proposed.The protection scheme only needs to transmit logic signals,decreasing the communication burden.It performs well in high-resistance faults,abnormal data errors,measurement errors,parameters errors,and different topology conditions.Numerous simulations in PSCAD/EMTDC confirm the effectiveness and reliability of the proposed protection scheme. | Senlin Yu Xiaoru Wang Chao Pang | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，3： | 0 |
| 14 | Novel per-oral cholangioscopy for treatment of occult accessory hepatic duct stones显示文摘Introduction The accessory hepatic duct is a variation of the biliary tree and is considered to be an important factor contributing to bile duct injury during surgery[1].Accessory hepatic duct stones are a rare form of cholelithiasis.The angle at which the accessory hepatic duct opens into the common bile duct makes it difficult to remove stones using conventional endoscopic retrograde cholangiopancreatography(ERCP).We reported a rare and insidious case of an accessory hepatic duct stone.The patient’s abdominal computed tomography(CT)did not reveal any abnormalities,but endoscopic ultrasound revealed a stone in the bile duct opening into a branch of the common bile duct.The patient underwent ERCP,and cholangiography showed no abnormalities.However,the accessory hepatic duct opening was found in the common bile duct and the accessory hepatic duct stones were successfully removed using the EyeMax Choledochoscope System Digital Controller(Nanjing,China). | Tingting Yu Yaoting Li Hongfei He Senlin Hou Lichao Zhang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 15 | Air pressure law of a reservoir constructed in karst sinkholes显示文摘Karst sinkholes with natural negative landform provide favorable conditions for the pumped storage reservoir construction for less excavation work.However,the construction of the reservoir would plug the natural karst channels for water and air,which would cause remarkable air pressure in karst channels when the groundwater level fluctuates.A large laboratory simulation test was carried out to study the air pressure variation of a reservoir built on the karst sinkhole.The air pressure in the karst channel and inside the model was monitored during the groundwater rising and falling process.Result showed that the variation of air pressure in the karst channel and the surrounding rock exhibited a high degree of similarity.The air pressure increased rapidly at the initial stage of water level rising,followed by a slight decrease,then the air pressure increased sharply when the water level approached the top of the karst cave.The initial peak of air pressure and the final peak of air pressure were defined,and both air pressure peaks were linearly increasing with the water level rising rate.The negative air pressure was also analyzed during the drainage process,which was linearly correlated with the water level falling rate.The causes of air pressure variation in karst channels of a pumped storage reservoir built on the karst sinkhole were discussed.The initial rapid increase,then slight decrease and final sudden increase of air pressure were controlled by the combined effects of air compression in karst channel and air seepage into the surrounding rock.For the drainage process,the instant negative air pressure and gradual recovering of air pressure were controlled by the combined effects of negative air pressure induced by water level falling and air supply from surrounding rock.This work could provide valuable reference for the reservoir construction in karst area. | YU Bo TAI Shengping ZHENG Kexun CHEN Shiwan HAN Xiao WANG Senlin ZUO Shuangying | 2024 | Journal of Mountain Science2024，21，3： | 0 |
| 16 | Improving luminescence and thermometric performance of Ba_(2)CaWO_(6):Er^(3+) by tri-doping with Yb^(3+) and Na^(+)显示文摘The Er3+doped double perovskite Ba_(2)CaWO_(6) crystal is a promising ratiometric thermometer based on the fluorescence intensity ratio(FIR) of transitions from ^(2)H_(11/2) and ^(4)S_(3/2) to the lowered ^(4)I_(15/2) level.However,the Ca^(2+) vacancy defect caused by the charge difference between rare-earth ions and the substituted alkaline-earth ions gives rise to the non-radiative probability and limits the thermal sensitivity.Here,the up-conversion luminescence and thermometric performance of Er^(3+),Yb^(3+) dopedBa_(2)CaWO_(6) are tuned by tri-doping with alkaline ions.The Ca^(2+) vacancy defect can be eliminated by the introduction of Na^(+),which occupies the Ca^(2+) site when it is doped into Ba_(2)CaWO_(6) with Er^(3+) and Yb^(3+).On the contrary,the doping of Cs^(+) into Ba_(2)CaWO_(6) with Er^(3+) and Yb^(3+) enhances the defect concentration because it occupies the site of Ba^(2+).Thus,the tri-doping of Na^(+) reduces the non-radiative probability and enhances the quantum efficiency of Er^(3+),leading to the improvement of the thermometric sensitivity of Ba_(2)CaWO_(6).As a result,we get an excellent thermometric Ba_(2)CaWO_(6):8%Yb^(3+),3.5%Er^(3+),6%Na^(+) powder with a luminescence lifetime of 515 μs and maximum thermal sensitivity(S_(r)) of 1.45%/K,which is more than three times higher than that of the BCWO:Er^(3+) powder. | Lingyun Li Ziwei Zhou Fazheng Huang Senlin Peng Yantang Huang Guoqiang Wang Xinxu Li Fei-Fei Chen Chengkai Yang Xin-Xiong Li Yan Yu | 2023 | Journal of Rare Earths2023，41，1： | 0 |
| 17 | Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study显示文摘Thoracic aortic dissection(TAD)without familial clustering or syndromic features is known as sporadic TAD(STAD).So far,the genetic basis of STAD remains unknown.Whole exome sequencing was performed in 223 STAD patients and 414 healthy controls from the Chinese Han population(N=637).After population structure and genetic relationship and ancestry analyses,we used the optimal sequence kernel association test to identify the candidate genes or variants of STAD.We found that COL3A1 was significantly relevant to STAD(P=7.35×10^(−6))after 10000 times permutation test(P=2.49×10^(−3)).Moreover,another independent cohort,including 423 cases and 734 non-STAD subjects(N=1157),replicated our results(P=0.021).Further bioinformatics analysis showed that COL3A1 was highly expressed in dissected aortic tissues,and its expression was related to the extracellular matrix(ECM)pathway.Our study identified a profile of known heritable TAD genes in the Chinese STAD population and found that COL3A1 could increase the risk of STAD through the ECM pathway.We wanted to expand the knowledge of the genetic basis and pathology of STAD,which may further help in providing better genetic counseling to the patients. | Yanghui Chen Yang Sun Zongzhe Li Chenze Li Lei Xiao Jiaqi Dai Shiyang Li Hao Liu Dong Hu Dongyang Wu Senlin Hu Bo Yu Peng Chen Ping Xu Wei Kong Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，3： | 0 |
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