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| 1 | Distribution feature of terrestrial heat flow densities in the Bohai Basin,East China显示文摘Temperature logging curves at 8 boreholes and well-testing temperature data at 142 boreholes are used to determine geotemperature gradients in the Bohai Basin. The thermal conductivities of 86 rock samples are measured at laboratory and the effects of porosity and temperature are corrected to obtain conductivities in situ. Terrestrial heat flow densities at 76 wells are determined based on these data. The distribution of the heat flow indicates that the terrestrial heat flow in the Bohai Basin is relatively high with an average value of 65.8 mW/m2. This characteristic is caused by the tectonic evolution of the basin. During Cenozoic, the litho-sphere stretched intermittently and the crust thinned so that heat conducted from the mantle increased and formed thermal abnormity at depth beneath the basin. | WANG Liangshu LIU Shaowen XIAO Weiyong LI Cheng LI Hua GUO Suiping LIU Bo LUO Yuhui CAI Dongsheng | 2002 | Chinese Science Bulletin2002，47，10： | 10 |
| 2 | Clinical antiangiogenic effect of recombinant adenovirus-p53 combined with hyperthermia for advanced cancer显示文摘Objective:To assess the safety and clinical antiangiogenic effect of recombinant adenovirus-p53(rAd-p53)combined with hyperthermia plus or not plus radiotherapy in advanced cancer.Methods:Expression of Vascular epithelial growth factor(VEGF)after intratumoral injection of rAd-p53was assayed by immunohistochemistry(IHC)imaging.Forty-four patients with advanced cancer were enrolled into this clinical study.The patients were intratumorally injected with rAd-p53(Gendicine)at a dose of 1×1012vp once a week,with a total of 4-54(mean 7.7)times.Total of 4-29(mean 8.5)times of hyperthermia was given to the patients.Among the 44 patients,30 patients were concurrently added with radiotherapy of a total dose 30-76 Gy/15-38 f/3-8 w(mean 58 Gy).Results:Before and after intratumoral injection of rAd-p53,the VEGF IHC positive cell scores were 2.80and 1.50,respectively(P=0.031).The treatment of rAd-p53 combined with hyperthermia plus or not plus radiotherapy in advanced cancer achieved CR rate of 13.60%(6/44),and PR rate of 29.6%(13/44),and thus the effective rate was 43.2%.In addition to 6 patients with CR,19 patients(19/38,50.0%)had low density area(LDA)of more than 50%area on CT image within tumor indicating tumor tissue necrosis.Conclusions:Our data indicate that rAd-p53 inhibits VEGF expression and angiogenesis,and promotes tumor necrosis and shrinkage induced by hyperthermia plus or not plus radiotherapy in advanced cancer. | Xiaofan Li Shaowen Xiao Yongheng Li Shanwen Zhang | 2013 | Chinese Journal of Cancer Research2013，25，6： | 6 |
| 3 | The effects on antibiotic production in a hetrologous sys- tem by sare4854,a novel member of streptomyces act- ibiotic regulatory protein family (SARP)from a ma- rine microorganism Salinispora arenicola CNH643 DSM 44819显示文摘 | Xiao S H U Jinlong Y U Shaowen W U | 2014 | Journal of Huazhong Normal Univer- sity2014，48，1： | 1 |
| 4 | Haemophilus parasuis infection activates the NF-κB pathway in PK-15 cells through IκB degradation显示文摘 | Yushan Chen Hui Jin Ping Chen Zili Li Xianrong Meng Mei Liu Shaowen Li Deshi Shi Yuncai Xiao Xiliang Wang Zutao Zhou Dingren Bi Rui Zhou | 2012 | Veterinary Microbiology (-)2012，，1： | 1 |
| 5 | Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development显示文摘The maternal immune system is vital in maintaining immunotolerance to the semiallogeneic fetus for a successful pregnancy.Although studies have shown that myeloid-derived suppressor cells(MDSCs)play an important role in maintaining feto-maternal tolerance,little is known about the role of MDSCs in pregnancies with intrauterine growth retardation(IUGR).Here,we reported that the activation of polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)during pregnancy was closely associated with fetal growth.In humans,class E scavenger receptor 1(SR-E1),a distinct marker for human PMN-MDSCs,was used to investigate PMN-MDSC function during pregnancy.Continuous activation of SR-E1+PMN-MDSCs was observed in all stages of pregnancy,accompanied by high cellular levels of ROS and arginase-1 activity,mediated through STAT6 signaling.However,SR-E1+PMN-MDSCs in pregnancies with IUGR showed significantly lower suppressive activity,lower arginase-1 activity and ROS levels,and decreased STAT6 phosphorylation level,which were accompanied by an increase in inflammatory factors,compared with those in normal pregnancies.Moreover,the population of SR-E1+PMN-MDSCs was negatively correlated with the adverse outcomes of newborns from pregnancies with IUGR.In mice,decreases in cell population,suppressive activity,target expression levels,and STAT6 phosphorylation levels were also observed in the pregnancies with IUGR compared with the normal pregnancies,which were rescued by the adoptive transfer of PMN-MDSCs from pregnant mice.Interestingly,the growth-promoting factors(GPFs)secreted by placental PMN-MDSCs in both humans and mice play a vital role in fetal development.These findings collectively support that PMN-MDSCs have another new role in pregnancy,which can improve adverse neonatal outcomes. | Mengyu Shi Ziyang Chen Meiqi Chen Jingping Liu Jing Li Zhe Xing Xiaogang Zhang Shuaijun Lv Xinyao Li Shaowen Zuo Shi Feng Ying Lin Gang Xiao Liping Wang Yumei He | 2021 | Cellular & Molecular Immunology2021，18，7： | 1 |
| 6 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 7 | miR-200a suppresses glioma cell migration and invasion via directly targeting MAGED4显示文摘Melanoma-associated antigen D4(MAGED4)is overexpressed in glioma and has been associated with WHO grade and survival.Here we investigated the exact function of MAGED4 during glioma progression and its regulatory mechanism.Cell migration and invasion were evaluated following up-and down-regulation of MAGED4 expression in glioma cell lines U87MG,U251,A172 and SHG44.Furthermore,we combined bioinformatics tools with biological validation assays to determine the miRNA targeting MAGED4. | Zhang Qing mei Wu Huixcian Liu Chang Luo Xin Zhao Wenjing Ge Yingying Chen Fang Nong Weixia Xiao Shaowen Xie Xiaoxtun Luo Bin | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 8 | Light-driven directional ion transport for enhanced osmotic energy harvesting显示文摘Light-driven ion(proton)transport is a crucial process both for photosynthesis of green plants and solar energy harvesting of some archaea.Here,we describe use of a TiO_(2)/C_(3)N_(4)semiconductor heterojunction nanotube membrane to realize similar light-driven directional ion transport performance to that of biological systems.This heterojunction system can be fabricated by two simple deposition steps.Under unilateral illumination,the TiO_(2)/C_(3)N_(4)heterojunction nanotube membrane can generate a photocurrent of about 9μA/cm^(2),corresponding to a pumping stream of~5500 ions per second per nanotube.By changing the position of TiO_(2)and C_(3)N_(4),a reverse equivalent ionic current can also be realized.Directional transport of photogenerated electrons and holes results in a transmembrane potential,which is the basis of the light-driven ion transport phenomenon.As a proof of concept,we also show that this system can be used for enhanced osmotic energy generation.The artificial light-driven ion transport system proposed here offers a further step forward on the roadmap for development of ionic photoelectric conversion and integration into other applications,for example water desalination. | Kai Xiao Paolo Giusto Fengxiang Chen Ruotian Chen Tobias Heil Shaowen Cao Lu Chen Fengtao Fan Lei Jiang | 2021 | National Science Review2021，8，8： | 0 |
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