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| 1 | Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis显示文摘Although it has been known that γδ T cells may play an important role in the immune response to infection of Mycobacterium tuberculosis (M. tb), the mechanisms by which the γδ T cells participate in the innate and/or acquired immunity to tuberculosis (TB) have not been full elucidated. In the present study, 27 patients with active pulmonary TB and 16 healthy donors (HD) were performed. We found that proportion of IL-17-producing cells among lymphocyte was similar between TB patients and HD, whereas the proportions of γδ T cells in IL-17-producing cells (59.2%) and IL-17-producing cells in γδ T cells (19.4%) in peripheral blood were markedly increased in TB patients when compared to those in HD (43.9% and 7.7%, respectively). In addition, the proportions of IFN-γ-producing γδ T cells in TB patients were obviously lower than that in HD. Upon re-stimulated with M. tb heat-treated antigen (M. tb-HAg) in vitro, fewer IL-17-producing γδ T cells were generated from HD and TB patients, whereas IFN-γ-producing γδ T cells were increased in TB patients compared to that in HD. Our findings in TB patients and healthy human were consistent with other murine investigation that the IL-17-producing γδ T cells were main source of IL-17 in mouse model of BCG infection, suggesting that γδ T cells might be involved in the formation of tubercular granuloma in pulmonary TB patients, but need further identification. | Meiyu Peng Zhaohua Wang Chunyan Yao Lina Jiang Qili Jin Jing Wang Baiqing Li | 2008 | Cellular & Molecular Immunology2008，5，3： | 28 |
| 2 | Buyang Huanwu Decoction fraction protects against cerebral ischemia/reperfusion injury by attenuating the inflammatory response and cellular apoptosis显示文摘Buyang Huanwu Decoction fraction extracted from Buyang Huanwu Decoction contains saponins of Astragalus, total paeony glycoside and safflower flavones. The aim of this study was to demonstrate the neuroprotective effect and mechanism of Buyang Huanwu Decoction fraction on ischemic injury both in vivo and in vitro. In vivo experiments showed that 50-200 mg/kg Buyang Huanwu Decoction fraction reduced infarct volume and pathological injury in ischemia/reperfusion rats, markedly inhibited expression of nuclear factor-κB and tumor necrosis factor-α and promoted nestin protein expression in brain tissue. Buyang Huanwu Decoction fraction (200 mg/kg) exhibited significant effects, which were similar to those of 100 mg/kg Ginkgo biloba extract. In vitro experimental results demonstrated that 10-100 mg/L Buyang Huanwu Decoction fraction significantly improved cell viability, decreased the release of lactate dehydrogenase and malondialdehyde levels, and inhibited the rate of apoptosis in HT22 cells following oxygen-glucose deprivation. Buyang Huanwu Decoction fraction (100 mg/L) exhibited significant effects, which were similar to those of 100 mg/L Ginkgo biloba extract. These findings suggest that Buyang Huanwu Decoction fraction may represent a novel, protective strategy against cerebral ischemia/reperfusion injury in rats and oxygen-glucose deprivation-induced damage in HT22 cells in vitro by attenuating the inflammatory response and cellular apoptosis. | Yulian Jin Liuyi Dong Changqing Wu Jiang Qin Sheng Li Chunyan Wang Xu Shao Dake Huang | 2013 | Neural Regeneration Research2013，8，3： | 11 |
| 3 | Genetic Analysis of Two Weak Dormancy Mutants Derived from Strong Seed Dormancy Wild Type Rice N22 (Oryza sativa)显示文摘Two weak dormancy mutants,designated Q4359 and Q4646,were obtained from the rice cultivar N22 after treatment with 400 Gy 60Co gamma-radiation.Compared to the N22 cultivar,the dormancy of the mutant seeds was more readily broken when exposed to a period of room temperature storage.The mutants also showed a reduced level of sensitivity to abscisic acid compared to the N22 cultivar,although Q4359 was more insensitive than Q4646.A genetic analysis indicated that in both mutants,the reduced dormancy trait was caused by a single recessive allele of a nuclear gene,but that the mutated locus was different in each case.The results of quantitative trait locus(QTL)mapping,based on the F2 population from Q4359 x Nanjing35,suggested that Q4359 lacks the QTL qSdn-1 and carries a novel allele at QTL qSdn-9, while a similar analysis of the Q4646 x Nanjing35 F2 population suggested that Q4646 lacks QTL qSdn-5, both qSdn-1 and qSdn-5 are major effect seed dormancy QTL in N22.Therefore,these two mutants were helpful to understand the mechanism of seed dormancy in N22. | Bingyue Lu KunXie Chunyan Yang Long Zhang Tao Wu Xi Liu Ling Jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，5： | 7 |
| 4 | Three-dimensional structure of a low salinity tongue in the southern Taiwan Strait observed in the summer of 2005显示文摘Cruise observations with CTD (conductivity-temperature-depth) profiler were carried out in the southern Taiwan Strait in the summer of 2005. Using the cruise data, two-dimensional maps of salinity and temperature distributions at depths of 5, 10, 15, 20, and 30 m were generated. The maps show a low salinity tongue sandwiched by low temperature and high salinity waters on the shallow water side and high temperature and high salinity waters on the deep water side. The further analysis indicates that the low salinity water has a nature of river-diluted water. A possible source of the diluted water is the Zhujiang (Pearl) Estuary. Meanwhile, the summer monsoon is judged as a possible driving force for this northeastward jet-like current. The coastal upwelling and the South China Sea Warm Current confine the low salinity water to flow along the central line of the strait. Previous investigations and a numerical model are used to verify that the upstream of the low salinity current is the Zhujiang Estuary. Thus, the low salinity tongue is produced by four major elements: Zhujinag Estuary diluted water, monsoon wind driving, coastal upwelling and South China Sea Warm Current modifications. | HONG Huasheng ZHENG Quanan HU Jianyu CHEN Zhaozhang LI Chunyan JIANG Yuwu WAN Zhenwen | 2009 | Acta Oceanologica Sinica2009，28，4： | 6 |
| 5 | Self-powered electrochromic devices with tunable infrared intensity显示文摘Triboelectric nanogenerator(TENG) is an efficient way to convert ambient mechanical energy into electricity to power up portable electronics.In this work,a flexible infrared electrochromical device(IR-ECD)with stable performances was assembled with a TENG for building self-powered infrared detector with tunable intensity.As driven by TENG,the electrochromic device could be operated in the mid-IR region due to the reversible electrochromic reactions.An average infrared reflectance contrast of 46% was achieved in 8–14 lm regions and as well a clear thermal image change can be observed.This work indicates that the TENG-driven infrared electrochromical device has potential for use in self-powered camouflage and thermal control. | Jiangman sun xiong pu Chunyan Jiang Chunhua Du Mengmeng Liu Yang Zhang Zhitian Liu Junyi Zhai Weiguo Hu Zhong Lin Wang | 2018 | Science Bulletin2018，63，12： | 6 |
| 6 | An event-related potential study of working memory in children显示文摘To examine the neural mechanisms o working memory in children, event-related potentials (ERPs) were recorded from the 12―13 year-old while they performed a delayed match-to-sample task. The ERP results revealed that new and studied objects both evoked a late positive ERP componen peaking around 350 ms during the working memory process. New objects evoke a more positive ERP waveform than the studied objects. The scalp distri bution showed that the frontal-central electrode sites were associated with object working memory proc esses. When tracking new or studied targets among visual distracters, ERPs of targets and distracters revealed differential responses as early as 150 ms The visual targets evoked larger and more positive ERP responses than the distracters. The typica old-new effect was observed between ERPs of stud ied and new distracters. However, ERPs of new and studied targets differed at about 250 ms, in which new targets evoked more positive-going and slightly earlier ERP responses. In addition, a P3a componen was found for new targets only, and was absent in ERPs of studied targets at frontal and central sites The present study results reveal the spatial and temporal characteristics of neural mechanisms un derlying working memory in children, some of which are distinct from those in adults. | LIU Rong GUO Chunyan JIANG Yang | 2006 | Chinese Science Bulletin2006，51，12： | 5 |
| 7 | An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair显示文摘Acute myocardial infarction(AMI)remains a dominant origin of morbidity,mortality and disability worldwide.Increases in reactive oxygen species(ROS)are key contributor to excessive cardiac injury after AMI.Here we developed an immobilized enzyme with Superoxide Dismutase(SOD)activity cross-link with Zr-based metal-organic framework(ZrMOF)(SOD-ZrMOF)for mitigate ROS-caused injury.In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility.By efficiently scavenging ROS and suppressing oxidative stress,SOD-ZrMOF can protect the function of mitochondria,reduce cell death and alleviate inflammation.More excitingly,long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area,protect cardiac function,promote angiogenesis and inhibit pathological myocardial remodeling.Therefore,SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI. | Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang | 2022 | Bioactive Materials2022，7，4： | 4 |
| 8 | New language outcome measures for Mandarin speaking children with hearing loss显示文摘Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM) was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland.Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM)was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland.Results:This paper summarizes the evidence-based item design process and validity and reliability results of DREAM.A pilot study reported here shows that DREAM provided detailed information about hearing impaired children's language abilities and can be used to aid intervention planning to maximize progress.Conclusion:DREAM represents an example of translational science,transferring methods from empirical studies of language acquisition in research environments into applied domains such as assessment and intervention.Research on outcomes in China will advance significantly with the availability of evidence-based comprehensive language tests that measure a sufficient age range of skills,are normed on Mandarin speaking children in China's Mainland,and are designed to capture features central to Mandarin language acquisition. | Xueman Liu Jill de Villiers Wendy Lee Chunyan Ning Eric Rolfhus Teresa Hutchings Fan Jiang Yiwen Zhang | 2016 | Journal of Otology2016，11，1： | 4 |
| 9 | DYNAMICS OF AN HIV-1 INFECTION MODEL WITH CELL-MEDIATED IMMUNE RESPONSE AND STOCHASTIC PERTURBATION显示文摘 | CHUNYAN JI DAQING JIANG | 2012 | International Journal of Biomathematics2012，5，5： | 4 |
| 10 | Chronic intermittent hypoxia promotes the development of experimental non-alcoholic steatohepatitis by modulating Treg/Th17 differentiation显示文摘The present study aims to characterize the effect of chronic intermittent hypoxia and HIF1α on the non-alcoholic steatohepatitis (NASH)process in mice,and to explore the role of the Treg/Th17 balance in the formation of NASH inflammation and fibrosis.To achieve this purpose,simple steatosis was induced in mice by high-fat diet administration.Subsequently,chronic intermittent hypoxia was simulated by intraperitoneally injecting sodium nitrite.The changes of inflammation, fibrosis,and Treg/Th17 balance in the liver were.quantified under chronic intermittent hypoxia condition and after tail vein injection of HIF1α-siRNA.In addition,T cells were cultured in vitro, and HIF1α expression was either blocked or overexpressed under chronic intermittent hypoxia or normal conditions.Then,the changes of Treg/Th17 balance,inflammatory factors,and cell pathways were measured in each group.Our results demonstrated that chronic intermittent hypoxia accelerates the NASH process,while tail vein injection of HIF1α-siRNA improves liver histology and function.Chronic intermittent hypoxia alters the ratio of Th17 and Treg cells through HIF1α and roTOR signaling,and increases the expressions of NF-κB,IL-6,and IL-17,but decreases IL-10 expression.Inhibition of the mTOR-HIF1α-TLR4-IL-6 pathway increases the ratio of Treg/Th17. Thus,chronic intermittent hypoxia modulates the Treg/Th17 balance by inducing HIF1α,resulting in the activation of the mTOR-HIF1α-TLR4-IL-6 pathway,which accelerates the formation of NASH and fibrosis. | Jiang Liu Weiping Li Weihua Zhu Weimei He Hui Zhao Yu Xiang Chunyan Liu Wei Wu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 4 |
| 11 | Precipitation Responses to Radiative Effects of Ice Clouds:A Cloud-Resolving Modeling Study of a Pre-Summer Torrential Precipitation Event显示文摘The precipitation responses to the radiative effects of ice clouds are investigated through analysis of five-day and horizontally averaged data from 2D cumulus ensemble model experiments of a pre-summer torrential precipitation event.The exclusion of the radiative effects of ice clouds lowered the precipitation rate through a substantial reduction in the decrease of hydrometeors when the radiative effects of water clouds were switched on,whereas it increased the precipitation rate through hydrometeor change from an increase to a decrease when the radiative effects of ice clouds were turned off.The weakened hydrometeor decrease was associated with the enhanced longwave radiative cooling mainly through the decreases in the melting of non-precipitating ice to non-precipitating water.The hydrometeor change from an increase to a decrease corresponded to the strengthened longwave radiative cooling in the upper troposphere through the weakened collection of non-precipitating water by precipitation water. | Xinyong SHEN Wenyan HUANG Chunyan GUO Xiaocen JIANG | 2016 | Advances in Atmospheric Sciences2016，33，10： | 3 |
| 12 | Carrier Cells for Delivery of Oncolytic Measles Virus into Tumors:Determinants of Efficient Loading显示文摘Oncolytic measles virus(OMV) is a promising antitumor agent. However, the presence of anti-measles neutralizing antibodies(NAbs) against the hemagglutinin(H) protein of OMV is a major barrier to the therapeutic application of OMV in clinical practice. In order to overcome this challenge, specific types of cells have been used as carriers for OMV.Differential loading strategies appear to result in different therapeutic outcomes; despite this, only few studies have reported practical ex vivo loading strategies required for effective treatment. To this end, we systematically evaluated the antitumor efficacy of OMV using different loading strategies; this involved varying the in vitro loading duration and loading dose of OMV. We found that improved oncolysis of carrier cells was achieved by a prolonged loading duration in the absence of NAbs. However, the enhanced oncolytic effect was abrogated in the presence of NAbs. Further, we found that the expression of H protein on the surface of carrier cells was predominantly determined by the loading duration rather than the loading dose. Finally, we showed that NAbs blocked viral transfer by targeting H protein prior to the occurrence of cell-to-cell interactions. Our results provide comprehensive information on the determinants of an effective loading strategy for carrier cell-based virotherapy; these results may be useful for guiding the application of OMV as an antitumor agent in clinical practice. | Chun Xu Mao Xia Gang Meng Chunyan Li Aiqin Jiang Jiwu Wei | 2018 | Virologica Sinica2018，33，3： | 3 |
| 13 | Role of nitric oxide and vascular endothelial growth factor in fluoride-induced goitrogenesis in rats显示文摘 | Guoyan Liu Weidong Zhang Peng Jiang Xinhong Li Chunyan Liu Chunyan Chai | 2012 | Environmental Toxicology and Pharmacology2012，，2： | 2 |
| 14 | Effect of Traditional Chinese Medicine plus narrow-band medium-wave ultraviolet B radiation on moderate-to-severe psoriasis vulgaris in a case series显示文摘OBJECTIVE: To investigate the efficacy and safety of Traditional Chinese Medicine (TCM) therapy combined with ultraviolet B light therapy in the treatment of moderate-to-severe psoriasis. METHODS: Patients with moderate-to-severe psoriasis (skin lesion area > 10% of the body surface area) for 2 consecutive years were treated with TCM (oral and external use of herbal medicines, acupuncture, and herbal bathing) and narrow-band medium-wave ultraviolet B light treatment for 12 weeks. The treatment effect was evaluated based on the Psoriasis Area Severity Index (PASI), the achievement of a 50% reduction in the PASI (PASI50), the achievement of a 75% reduction in the PASI (PASI75), pruritus score, Dermatology Life Quality Index, and safety. RESULTS: A total of 95 outpatients were enrolled, and 92 subjects (96.8%) completed the 12-week treatment course. At baseline, the average proportion of the body surface area covered by skin lesions was 12.4%, and the average PASI was 17.7. All patients had previously been treated with conventional medicine (89.1% of patients received ultraviolet light treatment, 50.0% received glucocorticoids, and 21.7% received acitretin). After the 12-week treatment course, 22 patients (23.9%) achieved PASI75, and 43 (46.7%) achieved PASI50. The post-treatment pruritus score and Dermatology Life Quality Index of all treated patients were significantly lower than the respective baseline values (P < 0.0001). No adverse effects were detected by the monitoring of blood, urine, stools, liver and kidney function, and echocardiography.CONCLUSION: Comprehensive therapy comprising TCM therapy combined with ultraviolet B light therapy achieved good outcomes for patients with moderate-to-severe psoriasis. | Li Tiantian Zhou Dongmei Xu Xuying Qu Jianhua Jiang Chunyan Lan Haibing Lou Weihai Chen Weiwen Jin Li Liu Rongqi Liu Zhiyong Zhang Cang Duan Lanhua Bohua Li Xu Jingna Zhou Tao Jiang Xi Cao Wei Zhang Guangzhong Liu Jianping Sun Liyun Wang Ping | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 15 | Expression and prognostic value of plasminogen activator inhibitor type 1 in node-negative breast cancer显示文摘Objective:To investigate the expressions of plasminogen activator inhibitor type 1 (PAI-1), C-erbB-2, VEGF and Ki-67 by immunohistostaining and then to evaluate the prognostic value of PAI-1 in node-negative breast cancer. Methods:The study included a retrospective series of 62 female patients with axillary lymph node-negative breast cancer. Expressions of PAI-1, C-erbB-2, VEGF and Ki-67 were determined by immunohistostaining on formalin-fixed paraffin-embedded tissue sections from these patients after a median follow-up of 69 months (range 22–117 months). Correlations with well known clinicopathologic factors were assessed and multivariate survival analyses were performed. Results: High PAI-1 level was positively associated with high histologic grade of the tumors. Disease-free survival (DFS) was significantly shorter for the patients with moderate to intensive expression of PAI-1 than for those with negative (χ2 = 25.46, P < 0.001; χ2 = 23.07, P < 0.001) to mild expression (χ2 = 19.75, P < 0.001; χ2 = 17.40, P < 0.001). Although on univariate analysis of the prognostic factors, tumor size, location of primary tumor and age as well as expressions of PAI-1, VEGF and Ki-67 were all significantly prognostic factors for DFS (P < 0.05), PAI-1 was the only independent prognostic factor on multivariate analysis (P<0.0001; hazard ratio [HR], 4.041; 95% confidence interval [CI], 1.928–8.468). Conclusion: These results of the current study indicate that intermediate or high expression of PAI-1 represents a strong and independent unfavorable prognostic factor for the de-velopment of recurrence or metastases in axillary node-negative breast cancer. | Bin Wang Ning Wang Chunyan Xue Bin Jiang Yajie Wang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 2 |
| 16 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 17 | Asymptotic behavior of global positive solution to a stochastic SIR model显示文摘 | Daqing Jiang Jiajia Yu Chunyan Ji Ningzhong Shi | 2011 | Mathematical and Computer Modelling2011，，1： | 2 |
| 18 | The ergodicity and extinction of stochastically perturbed SIR and SEIR epidemic models with saturated incidence显示文摘 | Qingshan Yang Daqing Jiang Ningzhong Shi Chunyan Ji | 2011 | Journal of Mathematical Analysis and Applications2011，，1： | 2 |
| 19 | Improving the ammonia synthesis activity of Ru/CeO_(2) through enhancement of the metal–support interaction显示文摘The metal–support interactions induced by high-temperature hydrogen reduction have a strong influence on the catalytic performance of ceria-supported Ru catalysts. However, the appearance of the strong metal–support interaction leads to covering of the Ru species by Ce suboxides, which is detrimental to the ammonia synthesis reaction that requires metallic species as active sites. In the present work, the interaction between Ru and ceria in the Ru/CeO_(2) catalyst was induced by NaBH_(4) treatment. NaBH_(4) treatment enhanced the fraction of metallic Ru, proportion of Ce^(3+), content of exposed Ru species, and amount of surface oxygen species. As a result, a larger amount of hydrogen species would desorb by the H_(2)-formation pathway and the strength of hydrogen adsorption would be weaker, weakening the inhibition effect of the hydrogen species on ammonia synthesis. In addition, the strong electronic metal–support interaction aids in nitrogen dissociation. Consequently, Ru/CeO_(2) with NaBH_(4) treatment showed higher ammonia synthesis rates than that with only hydrogen reduction. | Chunyan Li Yuying Shi Zecheng Zhang Jun Ni Xiuyun Wang Jianxin Lin Bingyu Lin Lilong Jiang | 2021 | Journal of Energy Chemistry2021，30，9： | 2 |
| 20 | Composition engineering of Sb_2S_3 film enabling high performance solar cells显示文摘Sb_2S_3 is a kind of stable light absorption materials with suitable band gap, promising for practical applications. Here we demonstrate that the engineering on the composition ratio enables significant improvement in the device performance. We found that the co-evaporation of sulfur or antimony with Sb_2S_3 is able to generate sulfur-or antimony-rich Sb_2S_3. This composition does not generate essential influence on the crystal structure, optical band and film formability, while the carrier concentration and transport dynamics are considerably changed. The device investigations show that sulfur-rich Sb_2S_3 film is favorable for efficient energy conversion, while antimony-rich Sb_2S_3 leads to greatly decreased device performance. With optimizations on the sulfur-rich Sb_2S_3 films, the final power conversion efficiency reaches5.8%, which is the highest efficiency in thermal evaporation derived Sb_2S_3 solar cells. | Yiwei Yin Chunyan Wu Rongfeng Tang Chenhui Jiang Guoshun Jiang Weifeng Liu Tao Chen Changfei Zhu | 2019 | Science Bulletin2019，64，2： | 2 |
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