|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetic diversity of rice cultivars (Oryza sativa L.) in China and the temporal trends in recent fifty years显示文摘To understand geographical distribution of the genetic diversity of rice cultivars {Oryza sativa L.) and its trends in recent fifty years in China, 453 ’ accessions were analyzed by 36 microsatellites loci and 42 phenotypic traits. Results revealed that the genetic diversity by SSRs is highly consistent with that by phenotypic traits and the genetic diversity of indica cultivars was higher than that of japonica cultivars; the genetic diversity of cultivars declined from 1950s to 1980s and then increased greatly; among the six rice ecological zones (REZs), genetic diversity of REZTl was the highest and those of REZV and REZVT were the lowest at both DNA and phenotypic level. Jiangsu and Jiangxi provinces in the middle and lower reaches of Yangtze River and Sichuan province in southwest of China were the areas with the highest genetic diversity. Breeders in REZV which is an important japonica rice area but with very low genetic diversity should explore more gene resources to widen the genetic backgrounds of cultivars. | QI Yonawen ZHANG Dongling ZHANG Hongliang WANG Meixing SUN Junli WEI Xinghua QIU Zongen TANG Shengxiang CAO Yongsheng WANG Xiangkun LI Zichao | 2006 | Chinese Science Bulletin2006，51，6： | 27 |
| 2 | Temporal changes in SSR allelic diversity of major rice cultivars in China显示文摘Forty simple sequence repeats (SSRs) were used to assess the changes of diversity in 310 major Chinese rice cultivars grown during the 1950s-1990s. Of the 40 SSR loci, 39 were polymorphic. A total of 221 alleles were detected with an average of 5.7 alleles per locus (Na). The Nei’s genetic diversity index (He) varied drastically among the loci (0.207 to 0.874, mean 0.625). Comparing the temporal changes in Na and He, the cultivars from the 1950s had more alleles and higher He scores than the cultivars from the other four decades Analysis of molecular variance (AMOVA) indicated that the genetic differentiation among the five decades was not significant in the whole set, but significant within indica and japonica. More changes among the decades were revealed in indica cultivars than in japonica cultivars. Some alleles had been lost in current rice cultivars in the 1990s, occurring more frequently in indica. These results suggest that more elite alien genetic resources should be explored to widen the genetic backgrounds of rice cultivars currently grown in China. | Xinghua Wei Xiaoping Yuan Hanyong Yu Yiping Wang Qun Xu Shengxiang Tang | 2009 | Journal of Genetics and Genomics2009，36，6： | 16 |
| 3 | Microglial activation after ischaemic stroke显示文摘Ischaemic stroke can induce rapid activation of microglia.As the resident immune cells of the central nervous system,microglial activation is believed to play a central role in neuroinflammation and pathological progression of ischaemic tissue.The activation of microglia after ischaemia involves several stereotypical events including morphological transformation,proliferation and polarisation.Studies using confocal or two-photon imaging techniques have revealed that the degree of microglial activation is correlated with the degree of ischaemia.Activated microglia display diverse polarisation phenotypes.It remains largely unclear regarding whether activated microglia are beneficial or detrimental to poststroke recovery.This mini-review focuses on the morphological and functional aspects of microglial activation,with particular attention to progress in two-photon imaging studies. | Shengxiang Zhang | 2019 | Stroke & Vascular Neurology2019，4，2： | 10 |
| 4 | A Hybrid Immigrants Scheme for Genetic Algorithms in Dynamic Environments显示文摘动态优化问题是随着时间的过去包含变化的一种优化问题。自从球门不再是寻找一个固定问题的最佳的答案,但是随着时间的过去追踪动人的最佳,他们提出严肃的挑战到传统的优化方法以及常规基因算法。动态优化问题在最近的年里从基因算法社区吸引了成长兴趣。几条途径被开发了在动态环境提高基因算法的表演。一条途径是经由随机的移民维持人口的差异。这篇论文建议联合精英统治,两重性和随机的移民的概念让基因算法处理动态优化问题的一个混合移民计划。在这个混合计划,最好的个人,即,精英,作为底从以前的产生和它的双个人被检索经由传统的变化计划创造移民。和一些随机的移民的这些基于精英统治、基于两重性的移民被代替进当前的人口,代替在人口的最糟的个人。这些三种移民试图分别地探讨细微、中等、重要的度的环境变化并且高效地因此使基因算法适应服从于变化的不同严厉的动态环境。基于一系列系统地构造的动态测试问题,实验被执行与混合移民计划和传统的随机的移民计划调查基因算法的表演。试验性的结果为在动态环境改进基因算法的表演验证建议混合移民计划的效率。关键词基因算法 - 随机的移民 - 基于精英统治的移民 - 两重性 - 动态优化问题这个工作被英国 EPSRC 支持(没有。EP/E060722/01 ) 并且巴西 FAPESP (Proc。04/04289-6 ) 。杨胜祥收到了 B.Sc。并且 M.Sc。在自动控制的学位和在从东北大学设计的系统的博士学位, P. R。在 1993, 1996 和 1999 的中国分别地。他是在计算机科学系的一个博士后的研究伙伴,从 1999 年 10 月的国王鈥檚 学院伦敦到 2000 年 10 月。他当前是在在累斯特的大学的计算机科学系的一个讲师,英国。他在书,杂志和会议出版了超过 50 篇论文。他有 co-guest-edited 为基因编程和可发展的机器的杂志的一期特刊并且共同编辑一本书在动态、不明确的环境的进化计算,在 2007 年 3 月出版了。他的当前的研究兴趣包括进化、基因的算法,为组合优化问题的人工的神经网络,安排问题,动态优化问题,和网络流动问题和算法。杨博士担任区域编辑,伙伴编辑和三本国际杂志的编委的成员。他是在动态、不明确的环境的进化计算上的工作组的一个成员,进化计算技术委员会, IEEE 计算智力社会(CIS ) 。他是 IEEE 和 ACM SIGEVO 的一个成员。Renato 听贸 s 收到了 B.Sc。在从 S 的州立大学的电力工程的度 ? o Paulo (UNESP ) ,在 1994 的巴西,和 M.Sc。并且在来自 S 的大学的电力工程的博士学位 ? 在 S 的 o Paulo (USP )? o 卡洛斯,在 1999 和 2003 的巴西分别地。他然后在 S 加入了 USP 的计算机科学系 ? o 卡洛斯作为一个研究科学家。他当前是在物理的系和在 Ribeir 的 USP 的数学的一个助教 ? o Preto。他的研究兴趣包括进化算法,动态优化,机器人学,容错,和神经网络。 | Shengxiang Yang Renato Tinós | 2007 | International Journal of Automation and computing2007，4，3： | 9 |
| 5 | Differential Characteristics of the Upper Ordovician-Lower Silurian Wufeng-Longmaxi Shale Reservoir and its Implications for Exploration and Development of Shale Gas in/around the Sichuan Basin显示文摘The Upper Ordovician Wufeng-Lower Silurian Longmaxi shale is widely distributed in the Sichuan Basin and its periphery,which is the key stratum for marine shale gas exploration and development(E&D)in China.Based on sedimentary environment,material basis,storage space,fracability and reservoir evolution data,the reservoir characteristics of the Wufeng-Longmaxi shale and their significance for shale gas E&D are systematically compared and analyzed in this paper.The results show that(1)the depocenter of the Wufeng(WF)-Longmaxi(LM)shale gradually migrates from east to west.The high-quality shale reservoirs in the eastern Sichuan Basin are mainly siliceous shales,which are primarily distributed in the graptolite shale interval of WF2-LM5.The high-quality reservoirs in the southern Sichuan Basin are mainly calcareous-siliceous and organic-rich argillaceous shales,which are distributed in the graptolite shale interval of WF2-LM7.(2)Deep shale gas(the burial depth>3500 m)in the Sichuan Basin has high-ultrahigh pressure and superior physical properties.The organic-rich siliceous,calcareous-siliceous and organic-rich argillaceous shales have suitable reservoir properties.The marginal area of the Sichuan Basin has a higher degree of pressure relief,which leads to the argillaceous and silty shales evolving into direct cap rocks with poor reservoir/good sealing capacity.(3)Combining shale gas exploration practices and impacts of lithofacies,depth,pressure coefficient and brittle-ductile transition on the reservoir properties,it is concluded that the favorable depth interval of the Wufeng-Longmaxi shale gas is 2200~4000 m under current technical conditions.(4)Aiming at the differential reservoir properties of the Wufeng-Longmaxi shale in the Sichuan Basin and its periphery,several suggestions for future research directions and E&D of shale gas are formulated. | WANG Ruyue HU Zongquan LONG Shengxiang LIU Guangxiang ZHAO Jianhua DONG Li DU Wei WANG Pengwei YIN Shuai | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 8 |
| 6 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 7 | Visible calculation of mining index based on stope 3D surveying and block modeling显示文摘Aimed at the CMS laser scanning theory and characteristic, a combined actual situation of stope N4-5 of Fankou Lead-Zinc Mine and complementary monitoring of the stope were carried out by carefully choos- ing two measuring points. The cavity 3D visible model was created by large-scale mining industry soft- ware Surpac after changing the measured data. The stope mine design model, bottom structural model and backfill model of the south and north sides of the stope N4-5 were established according to the stope design data. On this basis, the stope block model was established, and then block attribute was estimated. The amount the ore remains, mullock, backfill and total mined ore were calculated through the solid model restrains. Finally, the stope mining dilution rate and loss rate reached 8.2% and 1.47%, respectively. The practice indicates that the mining index visible calculation method based on cavity 3D monitoring and stope block modeling can make up the deficiency of adopting the solid model to directly carry out the Boolean operation. The stope mining indexes obtained by this method are accurate and reliable, and can be used to guide the actual production management and estimate the mining quality. | Liu Xiaoming Luo Zhouquan Yang Biao Lu Guang Cao Shengxiang Jiang Xinjian | 2012 | International Journal of Mining Science and Technology2012，22，2： | 7 |
| 8 | CRISPR/Cas9-Mediated Adenine Base Editing in Rice Genome显示文摘Precise base editing is highly desired in plant functional genomic research and crop molecular breeding. In this study, we constructed a rice-codon optimized adenine base editor(ABE)-nC as9 tool that induced targeted A·T to G·C point mutation of a key single nucleotide polymorphism site in an important agricultural gene. Combined with the modified single-guide RNA variant, our plant ABE tool can efficiently achieve adenine base editing in the rice genome. | LI Hao QIN Ruiying LIU Xiaoshuang LIAO Shengxiang XU Rongfang YANG Jianbo WEI Pengcheng | 2019 | Rice science2019，26，2： | 7 |
| 9 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 10 | Uncommon EGFR mutations in a cohort of Chinese NSCLC patients and outcomes of first-line EGFR-TKIs and platinum-based chemotherapy显示文摘Objective: Data on the clinical activity of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in patients with non-small-cell lung cancer(NSCLC) and uncommon EGFR mutations remain insufficient.This study aimed to investigate the effect of first-line EGFR-TKIs or platinum-based chemotherapy in NSCLC patients with uncommon EGFR mutations.Methods: We retrospectively enrolled 504 patients with EGFR-mutant NSCLC.The clinical characteristics and treatment outcomes were collected and compared between patients with common and uncommon EGFR-mutant NSCLC.Results: Seventy patients(13.9%) harboring uncommon EGFR mutations were included.Thirty of these patients received EGFR-TKIs and 40 received platinum-based chemotherapy as first-line therapy.The objective response rate(ORR) and median progression-free survival(m PFS) of patients treated with TKIs in the uncommon mutation group was significantly inferior to that in the common mutation group(ORR: 23.3% vs.51.8%,P=0.003; m PFS:7.1 vs.10.9 months,P<0.001).In the uncommon group,m PFS was similar between first-line EGFR-TKIs treatment and platinum-based chemotherapy(7.1 vs.6.1 months,P=0.893).In patients with EGFR G719 X or L861 Q mutations,the m PFS was longer in the first-line EGFR-TKIs treatment group than in the chemotherapy group,but the difference was not statistically significant(G719 X: 8.2 vs.5.8 months,P=0.061; L861 Q: 7.6 vs.4.1 months,P=0.872).Multivariate analyses identified adenocarcinoma(P=0.003) as the independent predictive factor for PFS in patients with uncommon EGFR mutations who were treated with first-line EGFR-TKIs.Conclusions: The current study demonstrated that the effect of first-line EGFR-TKIs was similar to that of platinum-based chemotherapy in patients with uncommon EGFR-mutant NSCLC.Adenocarcinoma was the independent predictive factor for PFS in uncommon EGFR-mutant NSCLC patients treated with first-line EGFRTKIs. | Jinpeng Shi Hui Yang Tao Jiang Xuefei Li Chao Zhao Limin Zhang Sha Zhao Xiaozhen Liu Yijun Jia Yan Wang Lei Xi Shijia Zhang Chunxia Su Shengxiang Ren Caicun Zhou | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 11 | Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke显示文摘Stroke at the acute stage is a major cause of disability in adults, and is associated with dysfunction of brain networks. However, the mechanisms underlying changes in brain connectivity in stroke are far from fully elucidated. In the present study, we investigated brain metabolism and metabolic connectivity in a rat ischemic stroke model of middle cerebral artery occlusion(MCAO)at the acute stage using18 F-fluorodeoxyglucose positron emission tomography. Voxel-wise analysis showed decreased metabolism mainly in the ipsilesional hemisphere, and increased metabolism mainly in the contralesional cerebellum. We used further metabolic connectivity analysis to explore the brain metabolic network in MCAO.Compared to sham controls, rats with MCAO showed most significantly reduced nodal and local efficiency in the ipsilesional striatum. In addition, the MCAO group showed decreased metabolic central connection of the ipsilesional striatum with the ipsilesional cerebellum, ipsilesional hippocampus, and bilateral hypothalamus. Taken together,the present study demonstrated abnormal metabolic connectivity in rats at the acute stage of ischemic stroke, which might provide insight into clinical research. | Shengxiang Liang Xiaofeng Jiang Qingqing Zhang Shaofeng Duan Tianhao Zhang Qi Huang Xi Sun Hua Liu Jie Dong Weilin Liu Jing Tao Shujun Zhao Binbin Nie Lidian Chens Baoci Shan | 2018 | Neuroscience Bulletin2018，34，5： | 5 |
| 12 | Zonal Differences in Correlation Patterns Between Soil Organic Carbon and Climate Factors at Multi-extent显示文摘Studying the relationship between climate factors and soil organic carbon(SOC) is vitally important. However, how SOC responses to climate(temperature and precipitation) at cohesive extents is poorly studied. Two transects of approximately the same length(transect P and transect T) were selected to examine the variation of SOC content in relation to mean annual temperature(MAT) and mean annual precipitation(MAP). The coefficients of partial correlation between SOC density and MAT(Rt) and MAP(Rp) were determined to quantify the relationships between SOC density and the two climate factors. The results indicated that for transect T, Rt was statistically significant once the extent level was greater than or equal to two fundamental extent units, while for transect P, Rp showed statistical significance only at extent levels which were greater than two fundamental extent units. At the same extent levels but in different transects, Rts exhibited no zonal difference, but Rps did once the extent level was greater than two fundamental extent units. Therefore, to study the relationship between SOC density and different climate factors, different minimum extent levels should be examined. The results of this paper could deepen the understanding of the impacts that SOC pool has on terrestrial ecosystem and global carbon cycling. | QIN Falyu SHI Xuezheng XU Shengxiang YU Dongsheng WANG Dandan | 2016 | Chinese Geographical Science2016，26，5： | 5 |
| 13 | Genetic structure and diversity of Oryza sativa L. in Guizhou,China显示文摘Preserving many kinds of rice resources and rich variations, Guizhou Province is one of the districts with the highest genetic diversity of cultivated rice (Oryza sativa L.) in China. In the current research, genetic diversity and structure of 537 accessions of cultivated rice from Guizhou were studied using 36 microsatellite markers and 39 phenotypic characters. The results showed that the model-based genetic structure was the same as genetic-distance-based one using SSRs but somewhat different from the documented classification (mainly based on phenotype) of two subspecies. The accessions being classified into indica by phenotype but japonica by genetic structure were much more than that being classified into japonica by phenotype but indica by genetic structure. Like Ding Ying’s taxonomic sys- tem of cultivated rice, the subspecific differentiation was the most distinct differentiation within culti- vated rice. But the differentiation within indica or japonica population was different: japonica presented clearer differentiation between soil-watery ecotypes than indica, and indica presented clearer differen- tiation between seasonal ecotypes than japonica. Cultivated rices in Guizhou revealed high genetic diversity at both DNA and phenotypic levels. Possessing the highest genetic diversity and all the nec- essary conditions as a center of genetic diversity, region Southwestern of Guizhou was suggested as the center of genetic diversity of O. sativa L. from Guizhou. | ZHANG DongLing ZHANG HongLiang WEI XingHua QI YongWen WANG Meixing SUN JunLi DING Li TANG ShengXiang QIU Zong'En CAO YongSheng WANG XiangKun LI ZiChao | 2007 | Chinese Science Bulletin2007，52，3： | 5 |
| 14 | Elemental Geochemistry of the Interlayer Oxidation Zonein the Shihongtan Sandstone Type Uranium Deposit, Xinjiang显示文摘According to the oxidation intensity of ore-hosting sandstone, the interlayer oxidation zone of the Shihongtansandstone-type uranium deposit in the Turpan-Hami basin can be divided into 4 geochemical subzones, namely, intensely-oxidized, weakly-oxidized, redox and unoxidized primary subzones. The elemental geochemical characteristics of thefour subzones have been studied in detail, and the results show that U, together with other elements such as Re, Mo, Se, Sr,S, REE, Corganic etc., is enriched in the redox subzone. Re and U have similar geochemical properties in the reduction-oxidation process. The geochemical properties of Mo and Se are similar to those of U in the reduction condition, butdifferent from those of U in the oxidation condition. It is proposed that the ore-hosting layers can provide a curtain mountof uranium for uranium mineralization. | CAI Genqing ZHANG Zimin LI Shengxiang | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 4 |
| 15 | Review Expert Collaborative Recommendation Algorithm Based on Topic Relationship显示文摘The project review information plays an important role in the recommendation of review experts. In this paper, we aim to determine review expert’s rating by using the historical rating records and the final decision results on the previous projects, and by means of some rules, we construct a rating matrix for projects and experts. For the data sparseness problem of the rating matrix and the 'cold start' problem of new expert recommendation, we assume that those projects/experts with similar topics have similar feature vectors and propose a review expert collaborative recommendation algorithm based on topic relationship. Firstly, we obtain topics of projects/experts based on latent Dirichlet allocation(LDA) model, and build the topic relationship network of projects/experts. Then, through the topic relationship between projects/experts, we find a neighbor collection which shares the largest similarity with target project/expert,and integrate the collection into the collaborative filtering recommendation algorithm based on matrix factorization. Finally, by learning the rating matrix to get feature vectors of the projects and experts, we can predict the ratings that a target project will give candidate review experts, and thus achieve the review expert recommendation. Experiments on real data set show that the proposed method could predict the review expert rating more effectively, and improve the recommendation effect of review experts. | Shengxiang Gao Zhengtao Yu Linbin Shi Xin Yan Haixia Song | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，4： | 4 |
| 16 | Dynamic Geometry Monitoring System and Its Application in Sutong Bridge Construction显示文摘The construction period of large cable-stayed bridges is long, and the structure deformation is complicated. Any error during construction will potentially affect the cantilever alignments and the internal forces. In order to ensure safety during construction and exactly determine the cantilever alignments, dynamic deformation monitoring is needed immediately when the con struction of the superstructure starts. This paper aims at the requirement of deformation monitoring during the Sutong Bridge construction, and introduces the realization and observing schemes of the GPS and georobot based on remote real-time dynamic geometrical deformation monitoring system, then researches the data processing methods and enumerates some of the application achievements. Long-term operation during the Sutong Bridge construction indicates that the system runs steadily and the results are reliable. | ZHANG Hong YANG Baocen HUANG Shengxiang | 2010 | Geo-Spatial Information Science2010，13，2： | 3 |
| 17 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 18 | Increasing fidelity and efficiency by modifying cytidine base-editing systems in rice显示文摘The efficiency of plant cytidine base-editing systems is limited, and unwanted mutations frequently occur in transgenic plants. We increased the cytidine editing frequency and fidelity of the plant base editor 3(BE3) and targeted activation-induced cytidine deaminase(CDA)(target-AID) systems by coexpressing three copies of free uracil–DNA glycosylase(UDG) inhibitor(UGI). The editing efficiency of the improved BE3 and CDA systems reached as high as 88.9% and 85.7%, respectively, in regenerated rice plants, with a very low frequency of unwanted mutations. The low editing frequency of the BE3 system in the GC context could be overcome by the modified CDA system. These results provide a highfidelity and high-efficiency solution for rice genomic base editing. | Ruiying Qin Shengxiang Liao Juan Li Hao Li Xiaoshuang Liu Jianbo Yang Pengcheng Wei | 2020 | The Crop Journal2020，8，3： | 3 |
| 19 | Effect of Ultrasonic Vibration on Deformation in Micro-blanking Process with Copper Foil显示文摘Effect of ultrasonic vibration on deformation in micro-blanking was investigated with copper foils of different grain sizes using a developed device. It is found that maximum shearing strength is decreased by ultrasonic vibration, and this effect becomes bigger for coarse grain than that for fine grain, which can be attributed to acoustic softening effect considering the absorbed acoustic energy. Surface roughness R_a of smooth zone decreases for the polishing effect of vibration at the lateral contact surface. When ultrasonic vibration is applied, the sheared deformation area becomes relatively narrow, and it leads to the reduction of radius of rollover. The analysis of cross section in sheared deformation area shows that the crack initiation is inhabited for the existence of acoustic softening, and the proportion of smooth zone is increased. Also, angle of crack propagation becomes smaller because of periodic strain, and the angle of facture surface is decreased. As a result, the quality of micro-sheet parts is improved by applying ultrasonic vibration. | 王春举 LIU Yang WAN Shengxiang GUO Bin SHAN Debin ZHANG Bo | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，2： | 2 |
| 20 | An Automatic Method for Generating an Unbiased Intensity Normalizing Factor in Positron Emission Tomography Image Analysis After Stroke显示文摘Positron emission tomography(PET) imaging of functional metabolism has been widely used to investigate functional recovery and to evaluate therapeutic efficacy after stroke. The voxel intensity of a PET image is the most important indicator of cellular activity, but is affected by other factors such as the basal metabolic ratio of each subject. In order to locate dysfunctional regions accurately,intensity normalization by a scale factor is a prerequisite in the data analysis, for which the global mean value is most widely used. However, this is unsuitable for stroke studies.Alternatively, a specified scale factor calculated from a reference region is also used, comprising neither hyper-nor hypo-metabolic voxels. But there is no such recognized reference region for stroke studies. Therefore, we proposed a totally data-driven automatic method for unbiased scale factor generation. This factor was generated iteratively until the residual deviation of two adjacent scale factors was reduced by < 5%. Moreover, both simulated and real stroke data were used for evaluation, and these suggested that our proposed unbiased scale factor has better sensitivity and accuracy for stroke studies. | Binbin Nie Shengxiang Liang Xiaofeng Jiang Shaofeng Duan Qi Huang Tianhao Zhang Panlong Li Hua Liu Baoci Shan | 2018 | Neuroscience Bulletin2018，34，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员