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| 1 | A Label-free Fluorescent Aptasensor for Turn-on Monitoring Ochratoxin A Based on AIE-active Probe and Graphene Oxide显示文摘 | MA Lian XU Bin LIU Leijing TIAN Wenjing | 2018 | Chemical Research in Chinese Universities2018，34，3： | 6 |
| 2 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 3 | Human rhinovirus C infection is associated with asthma in children determined by x TAG respiratory viral panel FAST显示文摘Dear Editor,Cumulative evidence supports the role of early-life viral infections,especially respiratory syncytial virus(RSV)and human rhinovirus(HRV),as major antecedents of childhood asthma(Lemanske,2002;Jackson et al.,2008).In this study,the x TAG respiratory viral panel FAST(RVP FAST)assay,a multiplex polymerase chain reaction(PCR)-based method(Arens et al.,2010;BaladaLlasat et al.,2011;Gharabaghi et al.,2011;Selvaraju,2012),was used to investigate the association of infec- | Dongmei Chen Qinwei Song Runan Zhu Yuan Qian Yu Sun Jie Deng Fang Wang Yaxin Ding Run Tian Chuanhe Liu Wenjing Zhu Linqing Zhao | 2017 | Virologica Sinica2017，32，2： | 5 |
| 4 | Small molecules in targeted cancer therapy:advances,challenges,and future perspectives显示文摘Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,targeted therapeutic drugs have become mainstream cancer treatments.Since the first tyrosine kinase inhibitor imatinib was approved to enter the market by the US Food and Drug Administration(FDA)in 2001,an increasing number of small-molecule targeted drugs have been developed for the treatment of malignancies.By December 2020,89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration(NMPA)of China.Despite great progress,small-molecule targeted anti-cancer drugs still face many challenges,such as a low response rate and drug resistance.To better promote the development of targeted anti-cancer drugs,we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification.We present all the approved drugs as well as important drug candidates in clinical trials for each target,discuss the current challenges,and provide insights and perspectives for the research and development of anti-cancer drugs. | Lei Zhong Yueshan Li Liang Xiong Wenjing Wang Ming Wu Ting Yuan Wei Yang Chenyu Tian Zhuang Miao Tianqi Wang Shengyong Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 5 |
| 5 | Mars Ion and Neutral Particle Analyzer (MINPA) for Chinese Mars Exploration Mission (Tianwen-1): Design and ground calibration显示文摘The main objective of the Mars Ion and Neutral Particle Analyzer(MINPA)aboard the Chinese Mars Exploration Mission(Tianwen-1)is to study the solar wind-Mars interaction by measuring the ions and energetic neutral atoms(ENAs)near Mars.The MINPA integrates ion and ENA measurements into one sensor head,sharing the same electronics box.The MINPA utilizes a standard toroidal top-hat electrostatic analyzer(ESA)followed by a time of flight(TOF)unit to provide measurement of ions with energies from 2.8 eV to 25.9 keV and ENAs from 50 eV to 3 keV with a base time resolution of 4 seconds.Highly polished silicon single crystal substrates with an Al2O3 film coating are used to ionize the ENAs into positive ions.These ions can then be analyzed by the ESA and TOF,to determine the energy and masses of the ENAs.The MINPA provides a 360°×90°field of view(FOV)with 22.5°×5.4°angular resolution for ion measurement,and a 360°×9.7°FOV with 22.5°×9.7°angular resolution for ENA measurement.The TOF unit combines a-15 kV acceleration high voltage with ultra-thin carbon foils to resolve H+,He2+,He+,O+,O2+and CO2+for ion measurement and to resolve H and O(≥16 amu group)for ENA measurement.Here we present the design principle and describe our ground calibration of the MINPA. | LingGao Kong AiBing Zhang Zhen Tian XiangZhi Zheng WenJing Wang Bin Liu Peter Wurz Daniele Piazza Adrian Etter Bin Su YaYa An JianJing Ding WenYa Li Yong Liu Lei Li YiRen Li Xu Tan YueQiang Sun | 2020 | Earth and Planetary Physics2020，4，4： | 4 |
| 6 | SARS-CoV-2 nsp12 attenuates type Ⅰ interferon production by inhibiting IRF3 nuclear translocation显示文摘SARS-CoV-2 is the pathogenic agent of COVID-19,which has evolved into a global pandemic.Compared with some other respiratory RNA viruses,SARS-CoV-2 is a poor inducer of type Ⅰ interferon(IFN).Here,we report that SARS-CoV-2 nsp12,the viral RNA-dependent RNA polymerase(RdRp),suppresses host antiviral responses.SARS-CoV-2 nsp12 attenuated Sendai virus(SeV)-or poly(I:C)-induced IFN-β promoter activation in a dose-dependent manner.It also inhibited IFN promoter activation triggered by RIG-I,MDA5,MAVS,and IRF3 overexpression.Nsp12 did not impair IRF3 phosphorylation but suppressed the nuclear translocation of IRF3.Mutational analyses suggested that this suppression was not dependent on the polymerase activity of nsp12.Given these findings,our study reveals that SARS-CoV-2 RdRp can antagonize host antiviral innate immunity and thus provides insights into viral pathogenesis. | Wenjing Wang Zhuo Zhou Xia Xiao Zhongqin Tian Xiaojing Dong Conghui Wang Li Li Lili Ren Xiaobo Lei Zichun Xiang Jianwei Wang | 2021 | Cellular & Molecular Immunology2021，18，4： | 4 |
| 7 | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca^(2+) ions and L-tryptophan显示文摘The human calcium-sensing receptor(CaSR)is a class C G protein-coupled receptor(GPCR)responsible for maintaining Ca^(2+)homeostasis in the blood.The general consensus is that extracellular Ca^(2+)is the principal agonist of CaSR.Aliphatic and aromatic L-amino acids,such as L-Phe and L-Trp,increase the sensitivity of CaSR towards Ca^(2+)and are considered allosteric activators.Crystal structures of the extracellular domain(ECD)of CaSR dimer have demonstrated Ca^(2+)and L-Trp binding sites and conformational changes of the ECD upon Ca^(2+)/L-Trp binding.However,it remains to be understood at the structural level how Ca^(2+)/L-Trp binding to the ECD leads to conformational changes in transmembrane domains(TMDs)and consequent CaSR activation.Here,we determined the structures of full-length human CaSR in the inactive state,Ca^(2+)-or L-Trp-bound states,and Ca^(2+)/L-Trp-bound active state using single-particle cryo-electron microscopy.Structural studies demonstrate that L-Trp binding induces the closure of the Venus flytrap(VFT)domain of CaSR,bringing the receptor into an intermediate active state.Ca^(2+)binding relays the conformational changes from the VFT domains to the TMDs,consequently inducing close contact between the two TMDs of dimeric CaSR,activating the receptor.Importantly,our structural and functional studies reveal that Ca^(2+)ions and L-Trp activate CaSR cooperatively.Amino acids are not able to activate CaSR alone,but can promote the receptor activation in the presence of Ca^(2+).Our data provide complementary insights into the activation of class C GPCRs and may aid in the development of novel drugs targeting CaSR. | Shenglong Ling Pan Shi Sanling Liu Xianyu Meng Yingxin Zhou Wenjing Sun Shenghai Chang Xing Zhang Longhua Zhang Chaowei Shi Demeng Sun Lei Liu Changlin Tian | 2021 | Cell Research2021，31，4： | 3 |
| 8 | A highly sensitive “turn-on” fluorescent probe for bovine serum albumin protein detection and quantification based on AIE-active distyrylanthracene derivative显示文摘A sulfonated 9,10-distyrylanthracene derivative with aggregation-induced emission (AIE) property is designed and synthesized. It shows a highly sensitive and selective fluorescence enhancement property for bovine serum albumin (BSA) protein detection and quantification. Analysis on the interaction between the probe molecule and BSA reveals the essential role of the hydrophobic cavities of the protein folding structure. | WANG ZiLong MA Ke XU Bin LI Xing TIAN WenJing | 2013 | Science China Chemistry2013，56，9： | 3 |
| 9 | A Satellite-borne Miniature Ion Mass Spectrometer for Space Plasma显示文摘The miniature design technology is an important trend in space exploration.Mass spectrometer is used extensively in the space environment detection.The miniature ion mass spectrometer utilizes a 127° cylindrical electrostatic analyzer accompanied with a Time of Flight(TOF)unit based on ultrathin carbon foil to measure the energy spectra and composition of space plasma.The Time of Flight technique has been used broadly in space plasma measurement.A new type of miniature method for the ion mass spectrometer is introduced.The total mass of the instrument is1.8 kg and the total power consumption is 2.0 W.The calibration results show that the energy measurement range is 8.71~43550eV,the energy resolution is 1.86%and the ion mass from 1 amu(1 amu= 1.67 × 10^(-27)kg) to 58 amu can be resolved by the miniature mass spectrometer.The miniature ion mass spectrometer also has a potential to be increased in the field of view by an electrostatic deflecting system to extend its application in space plasma detection.The miniature ion mass spectrometer has been selected for pre-study of Chinese Strategic Priority Research Program on Space Science. | KONG Linggao ZHANG Aibing ZHENG Xiangzhi AN Yaya WANG Wenjing TIAN Zhen GUAN Yibing LIU Chao DING Jianjing SUN Yueqiang | 2015 | 空间科学学报2015，35，6： | 2 |
| 10 | Down-regulation of lipocalin 2 suppresses the growth of human lung adenocarcinoma through oxidative stress involving Nrf2/HO-1 signaling显示文摘Lipocalin 2 (LCN2 ) ,作为嗜中性的联系 gelatinase 的 lipocalin (NGAL ) 知道的多功能的能分泌的蛋白质,在许多癌症被表示。然而,很少在肺腺癌的发展对 NGAL 的生物功能被知道。在现在的学习,我们首先发现那 NGAL 表情在人的肺腺癌纸巾是起来调整的。另外, NGAL 表示的弄空减少了房间增长和导致的房间 apoptosis 的能力。而且与 N-acetylcysteine 的增加,反应的氧种类(ROS ) 的 scavenger, NGAL 弄空是足够的由通过原子因素的抑制产生 ROS 引起肺腺癌细胞的 apoptosis,这被发现 E2 相关的因素 2/heme oxygenase-1 抗氧化剂小径。最后,人的肺腺癌的生长上的 NGAL 下面规定的效果在 BALB/c 裸体老鼠被决定。这些调查结果证明 NGAL 可以是为有肺腺癌的病人的一个潜在的治疗目标。 | Baoquan Song Hairui Zhang Lei Jiang Ying Chi Jianjian Tian Wenjing Du Bentong Yu Zhongchao Han | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 2 |
| 11 | The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis显示文摘The endoplasmic reticulum(ER) membrane protein complex(EMC) regulates the synthesis and quality control of membrane proteins with multiple transmembrane domains. One of the membrane spanning subunits, EMC3, is a core member of the EMC complex that provides essential hydrophilic vestibule for substrate insertion. Here, we show that the EMC subunit Emc3 plays critical roles in the retinal vascular angiogenesis by regulating Norrin/Wnt signaling. Postnatal endothelial cell(EC)-specific deletion of Emc3 led to retarded retinal vascular development with a hyperpruned vascular network, the appearance of bluntended, aneurysm-like tip endothelial cells(ECs) with reduced numbers of filopodia and leakage of erythrocytes at the vascular front. Diminished tube formation and cell proliferation were also observed in EMC3 depleted human retinal endothelial cells(HRECs). We then discovered a critical role for EMC3 in expression of FZD4 receptor of β-catenin signaling using RNA sequencing, real-time quantitative PCR(RT-q PCR) and luciferase reporter assay. Moreover, augmentation of Wnt activity via lithium chloride(Li Cl) treatment remarkably enhanced β-catenin signaling and cell proliferation of HRECs. Additionally, Li Cl partially reversed the angiogenesis defects in Emc3-c KO mice. Our data reveal that Emc3 plays essential roles in angiogenesis through direct control of FZD4 expression and Norrin/β-catenin signaling. | Mu Yang Shujin Li Wenjing Liu† Xiao Li Yunqi He Yeming Yang Kuanxiang Sun Lin Zhang Wanli Tian Lixin Duan Huafu Chen Dezhong Yao Zhenglin Yang Xianjun Zhu | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 12 | Tetraphenylethylene-Based Emissive Supramolecular Metallacages Assembled by Terpyridine Ligands显示文摘We report the preparation and emission properties of tetraphenylethylene(TPE)-based metallacages with aggregation-induced emission(AIE)activities through coordination-driven self-assembly.Two supramolecular cages,[Zn6LA3]and[Zn6LB3],were assembled via TPE-decorated terpyridine(tpy)ligands,LA and LB,respectively,with Zn(II)ions.We performed a subtle change by introducing extra alkyne connectivity into LB to increase the degree of conjugation and geometric constraint,compared with LA.As a result,we obtained a highly emissive cage,[Zn6LB3],even in a dilute solution. | Meng Li Shan Jiang Zhe Zhang Xin-Qi Hao Xin Jiang Hao Yu Pingshan Wang Bin Xu Ming Wang Wenjing Tian | 2020 | CCS Chemistry2020，2，4： | 2 |
| 13 | Promising electroplating solution for facile fabrication of Cu quantum point contacts显示文摘在这篇文章,我们在制造和一个新奇、电气化学地帮助的机械地可控制的裂缝连接(EC-MCBJ ) 准备的 Cu 量点接触的运输大小上报导方法。由采用影印石版术和湿蚀刻的过程,推迟了电极对在 Si 微芯片上成功地有图案、制作。而非采用一个酸 Cu electroplating 答案,一个新奇碱的 electroplating 答案被开发并且利用了建立在电极对之间的 Cu nanocontacts。典型地,同样制作的 Cu nanocontacts 的宽度被发现比 18 nm 小。很多 Cu 量点接触然后被造家的 MCBJ 安装生产并且描绘。除了常规直方图,在山峰趋于与增加传导力在振幅减少的地方,传导力直方图的一种异常类型,展出不同山峰振幅,被观察。通过最大值的统计分析 Si 微芯片,和理论计算的许可的弯曲,我们证明我们的碱的 Cu electroplating 答案负担得起与随后的 MCBJ 操作兼容的 Cu nanocontacts,它为 Cu 量点接触的制造是必要的。当复杂电子横梁平版印刷术没被要求, EC-MCBJ 方法快、简单、划算。而且,它是可能的对从他们的各自的 electroplating 答案的各种各样的金属的量点接触的制造和描述合适。 | Yang Yang Junyang Liu Jueting Zheng Miao Lu Jia Shi Wenjing Hong Fangzu Yang Zhongqun Tian | 2017 | Nano Research2017，10，10： | 2 |
| 14 | Hyperactive PI3Kδ predisposes naive T cells to activation via aerobic glycolysis programs显示文摘Activated phosphoinositide 3-kinaseδsyndrome(APDS)is an autosomal-dominant combined immunodeficiency disorder resulting from pathogenic gain-of-function(GOF)mutations in the PIK3CD gene.Patients with APDS display abnormal T cell homeostasis.However,the mechanisms by which PIK3CD GOF contributes to this feature remain unknown.Here,with a cohort of children with PIK3CD GOF mutations from multiple regions of China and a corresponding CRISPR/Cas9 gene-edited mouse model,we reported that hyperactive PI3Kδdisrupted TNaive cell homeostasis in the periphery by intrinsically promoting the growth,proliferation,and activation of TNaive cells.Our results showed that PIK3CD GOF resulted in loss of the quiescence-associated gene expression profile in naive T cells and promoted naive T cells to overgrow,hyperproliferate and acquire an activated functional status.Naive PIK3CD GOF T cells exhibited an enhanced glycolytic capacity and reduced mitochondrial respiration in the resting or activated state.Blocking glycolysis abrogated the abnormal splenic T cell pool and reversed the overactivated phenotype induced by PIK3CD GOF in vivo and in vitro.These results suggest that enhanced aerobic glycolysis is required for PIK3CD GOF-induced overactivation of naive T cells and provide a potential therapeutic approach for targeting glycolysis to treat patients with APDS as well as other immune disorders. | Yanjun Jia Qiuyun Yang Yanping Wang Wenyan Li Xuemei Chen Tao Xu Zhirui Tian Minxuan Feng Liang Zhang Wenjing Tang Na Tian Lina Zhou Wenxia Song Xiaodong Zhao | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 15 | Recent advances on interface engineering of perovskite solar cells显示文摘Lead halide perovskite solar cells(PSCs)have been rapidly developed in the past decade.Owing to its excellent power conversion efficiency with robust and low-cost fabrication,perovskite quickly becomes one of the most promising candidates for the next-generation photovoltaic technology.With the development of PSCs,the interface engineering has witnessed its increasingly critical role in maximizing the device performance as well as the long-term stability,because the interfaces in PSCs are closely correlated with the defect management,carrier dynamics and surface passivation.This review focuses on interfacial modification between the perovskite active layer and the charge transport layer,as well as the recent advances on high-efficiency and stable PSCs driven by interface engineering strategies.The contributing roles of interface engineering in terms of defect passivation,inhibiting ion migration,optimization of energy band alignment and morphological control are discussed.Finally,based on the latest progress and advances,strategies and opportunities for the future research on interface engineering for PSCs are proposed to promote the development of perovskite photovoltaic technology. | Wenjing Yu Xiaoran Sun Mu Xiao Tian Hou Xu Liu Bolin Zheng Hua Yu Meng Zhang Yuelong Huang Xiaojing Hao | 2022 | Nano Research2022，15，1： | 2 |
| 16 | Vertically coupled ZnO nanorods on MoS2 monolayers with enhanced Raman and photoluminescence emission显示文摘由分层的材料组成的混合结构由于他们的非凡的悦耳的光、电子、催化的性质收到了许多注意。这里,我们为在瞬间上联合垂直 ZnO nanorods 描述热水的策略 < 潜水艇 class= “ a-plus-plus ” > 没有催化剂的 2 单层。这些 vapor-solid-grown 瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 单层帮助经由取向附生种垂直 ZnO nanorods。提高的拉曼和光致发光排出物从瞬间被观察 < 潜水艇 class= “ a-plus-plus ” > 在在这些的 ZnO nanorods 下面的 2 单层联合了结构,它被归因于 ZnO nanorods 的轻天线效果。这些为分层的材料的混血儿和加入协议将为与导致迷人的基本现象和先进设备的可调节的分层的结构支持异质接面的构造提供新观点和机会。 | Kenan Zhang Yun Zhang Tianning Zhang Wenjing Dong Tiaoxing Wei Yan Sun Xin Chen Guozhen Shen Ning Dai | 2015 | Nano Research2015，8，3： | 2 |
| 17 | Organic Fluorescent Molecule with High Solid State Lumines- cent Efficiency and Protonation Stimuli-response显示文摘有高稳固的州的光效率的新奇器官的 fluorophor 基于 1,4 二度(2,2-di (pyridin-2-yl ) 乙烯基) ,苯(BDP2VB ) 被设计并且综合。它在答案微弱地射出,但是处于总数状态成为强壮的 emitter,证明它的聚集导致了排放(AIE ) 性质。根据水晶结构分析, J 类型聚集在分子的收拾行李的模式被形成,它被表明有益增加高荧光灯处于稳固的状态的量效率。另外, BDP2VB 的排放颜色能由 protonation 刺激处于稳固的状态以及在答案戏剧性地变化。 | Suqian Ma Jibo Zhang Jinlong Chen Lijuan Wang Bin Xu Wenjing Tian | 2013 | Chinese Journal of Chemistry2013，31，11： | 1 |
| 18 | Electronic structures and optical properties of two anthracene derivatives显示文摘The electronic structures and the optical properties of two anthracene derivatives, DBMA and DAA, are investigated by both experimental tech- niques and quantum chemical calculations. The cy- clic voltammetry and differential pulse polarograph measurement revealed that the introduction of ben- zol-imidazol and pyrrolo-pyridine group on the an- thracene block can affect the electrochemical be- havior of DBMA and DAA. Both UV/visible absorption and emission spectra of DBMA and DAA are red-shifted in contrast to the unsubstituted anthra- cene, so that the anthracene derivatives emit at blue-green region and the luminescence yields are remarkably elevated (over 90%). The B3LYP/6-31G theoretical calculations explored that the electronic structures of the anthracene derivatives are per- turbed by the side substitutes on the anthracene block, and the slight variation of the electronic struc- tures results in the enhanced electron accepting abil- ity and the decrease of the HOMO-LUMO energy gap, which is the origin of the emission to be shifted to blue-green region. The non-planar geometry struc- tures of DBMA and DAA are responsible for the ex- cellent luminescence yields. | ZHANG Peng XIA Baohui SUN Yinghui YANG Bing TIAN Wenjing WANG Yue ZHANG Guo | 2006 | Chinese Science Bulletin2006，51，20： | 1 |
| 19 | Toxicity of zinc oxide nanoparticles to zebrafish embryo:a physicoehemical study of toxicity mechanism 显示文摘 | Bai Wei Zhang Zhiyong Tian Wenjing | 2010 | Journal of Nanoparticle Research2010，12，： | 1 |
| 20 | Coupling remote sensing retrieval with numerical simulation for SPM study—Taking Bohai Sea in China as a case显示文摘 | Xiaoling Chen Jianzhong Lu Tingwei Cui Wensheng Jiang Liqiao Tian Liqiong Chen Wenjing Zhao | 2009 | International Journal of Applied Earth Observations and Geoinformation2009，，： | 1 |
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