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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | High-dimensional orbital angular momentum multiplexing nonlinear holography显示文摘Nonlinear holography has been identified as a vital platform for optical multiplexing holography because of the appearance of new optical frequencies.However,due to nonlinear wave coupling in nonlinear optical processes,the nonlinear harmonic field is coupled with the input field,laying a fundamental barrier to independent control of the interacting fields for holography.We propose and experimentally demonstrate high-dimensional orbital angular momentum(OAM)multiplexing nonlinear holography to overcome this problem.By dividing the wavefront of the fundamental wave into different orthogonal OAM channels,multiple OAM and polarization-dependent holographic images in both the fundamental wave and second-harmonic wave have been reconstructed independently in the spatial frequency domain through a type-II second harmonic generation process.Moreover,this method can be easily extended to cascadedχ2 nonlinear optical processes for multiplexing in more wavelength channels,leading to potential applications in multicasting in optical communications,multiwavelength display,multidimensional optical storage,anticounterfeiting,and optical encryption. | Xinyuan Fang Haocheng Yang Wenzhe Yao Tianxin Wang Yong Zhang Min Gu Min Xiaoa | 2021 | Advanced Photonics2021，3，1： | 8 |
| 3 | Enhanced antibacterial behavior of a novel Cu-bearing high-entropy alloy显示文摘Contact infection of bacteria and viruses has been a critical threat to human health. The worldwideoutbreak of COVID-19 put forward urgent requirements for the research and development of the selfantibacterial materials, especially the antibacterial alloys. Based on the concept of high-entropy alloys, thepresent work designed and prepared a novel Co_(0.4)FeCr_(0.9)Cu_(0.3) antibacterial high-entropy alloy with superior antibacterial properties without intricate or rigorous annealing processes, which outperform the antibacterial stainless steels. The antibacterial tests presented a 99.97% antibacterial rate against Escherichiacoli and a 99.96% antibacterial rate against Staphylococcus aureus after 24 h. In contrast, the classic antibacterial copper-bearing stainless steel only performed the 71.50% and 80.84% antibacterial rate, respectively. The results of the reactive oxygen species analysis indicated that the copper ion release and theimmediate contact with copper-rich phase had a synergistic effect in enhancing antibacterial properties.Moreover, this alloy exhibited excellent corrosion resistance when compared with the classic antibacterialstainless steels, and the compression test indicated the yield strength of the alloy was 1015 MPa. Thesefindings generate fresh insights into guiding the designs of structure-function-integrated antibacterial alloys. | Guangyu Ren Lili Huang Kunling Hu Tianxin Li Yiping Lu Dongxu Qiao Haitao Zhang Dake Xu Tongmin Wang Tingju Li Peter K.Liaw | 2022 | Journal of Materials Science & Technology2022，，22： | 6 |
| 4 | Quasi-phase-matching-division multiplexing holography in a three-dimensional nonlinear photonic crystal显示文摘Nonlinear holography has recently emerged as a novel tool to reconstruct the encoded information at a new wavelength,which has important applications in optical display and optical encryption.However,this scheme still struggles with low conversion efficiency and ineffective multiplexing.In this work,we demonstrate a quasi-phasematching(QPM)-division multiplexing holography in a three-dimensional(3D)nonlinear photonic crystal(NPC).3D NPC works as a nonlinear hologram,in which multiple images are distributed into different Ewald spheres in reciprocal space.The reciprocal vectors locating in a given Ewald sphere are capable of fulfilling the complete QPM conditions for the high-efficiency reconstruction of the target image at the second-harmonic(SH)wave.One can easily switch the reconstructed SH images by changing the QPM condition.The multiplexing capacity is scalable with the period number of 3D NPC.Our work provides a promising strategy to achieve highly efficient nonlinear multiplexing holography for high-security and high-density storage of optical information. | Pengcheng Chen Chaowei Wang Dunzhao Wei Yanlei Hu Xiaoyi Xu Jiawen Li Dong Wu Jianan Ma Shengyun Ji Leran Zhang Liqun Xu Tianxin Wang Chuan Xu Jiaru Chu Shining Zhu Min Xiao Yong Zhang | 2021 | Light(Science & Applications)2021，10，8： | 5 |
| 5 | Ductile and ultrahigh-strength eutectic high-entropy alloys by large-volume 3D printing显示文摘1.Introduction Additive manufacturing or 3D printing outweighs conventional casting methods in the aspect of complex parts fabrication,which can realize one-step formation without the need of complicated cast dies.3D printing significantly promotes industrial production for making near-net shaped components.However,this promising technique is not always ideally applicable for metals and alloys.For example,titanium alloys prepared by 3D printing often suf-fer from poor plasticity,and usually require further complex heat treatment or hot isostatic pressing treatment,in order to remove internal stress and regulate plasticity and strength[1,2],which de-feats the original intention of employing additive manufacturing.One of the fundamental causes for such issues is the low fluidity of the alloys upon melting,leading to great chemical heterogeneity,high porosity content and residual stresses.This limitation hinders further design and fabrication of high-performance printable alloys from large scale production and application. | Yiping Lu Xiaoxiang Wu Zhenghong Fu Qiankun Yang Yong Zhang Qiming Liu Tianxin Li Yanzhong Tian Hua Tan Zhiming Li Tongmin Wang Tingju Li | 2022 | Journal of Materials Science & Technology2022，，31： | 4 |
| 6 | Pristine PN junction toward atomic layer devices显示文摘In semiconductor manufacturing,PN junction is formed by introducing dopants to activate neighboring electron and hole conductance.To avoid structural distortion and failure,it generally requires the foreign dopants localize in the designated micro-areas.This,however,is challenging due to an inevitable interdiffusion process.Here we report a brand-new junction architecture,called'layer PN junction',that might break through such limit and help redefine the semiconductor device architecture.Different from all existing semiconductors,we find that a variety of van der Waals materials are doping themselves from n-to p-type conductance with an increasing/decreasing layer-number.It means the capability of constructing homogeneous PN junctions in monolayers'dimension/precision,with record high rectification-ratio(>10^(5))and low cut-off current(<1 pA).More importantly,it spawns intriguing functionalities,like gate-switchable-rectification and noise-signal decoupled avalanching.Findings disclosed here might open up a path to develop novel nanodevice applications,where the geometrical size becomes the only critical factor in tuning charge-carrier distribution and thus functionality. | Hui Xia Man Luo Wenjing Wang Hailu Wang Tianxin Li Zhen Wang Hangyu Xu Yue Chen Yong Zhou Fang Wang Runzhang Xie Peng Wang Weida Hu Wei Lu | 2022 | Light(Science & Applications)2022，11，7： | 4 |
| 7 | Periodically poled LiNbO3 crystals from 1D and 2D to 3D显示文摘A periodically-poled LiNbO3(PPLN) crystal features space-dependent second-order nonlinear coefficients, which is one of the most important materials to effectively control nonlinear optical interactions through quasi-phase matching(QPM). By using electric-field poling method, 1D and 2D PPLN crystals have been successfully fabricated for laser frequency conversion, quantum light sources, nonlinear beam shaping and nonlinear optical imaging. Recently, femtosecond laser engineering technique is utilized to prepare 3D domain structures inside LiNbO3 crystal, which provides a promising platform to control nonlinear interacting waves in 3D configuration. After 40 years of developments, PPLN crystals still have exciting prospects in fundamental researches and practical applications for integrated photonic chip, quantum information processing,and so on. | WANG TianXin CHEN PengCheng XU Chuan ZHANG Yong WEI DunZhao HU XiaoPeng ZHAO Gang XIAO Min ZHU ShiNing | 2020 | Science China(Technological Sciences)2020，63，7： | 3 |
| 8 | Molecularly Imprinted Polymer Thin Film Based Surface Plasmon Resonance Sensor to Detect Hemoglobin显示文摘 | WANG Yang ZHANG Qingwen REN Yamin JING Lijing WEI Tianxin | 2014 | Chemical Research in Chinese Universities2014，30，1： | 2 |
| 9 | A novel as-cast precipitation-strengthened Al_(0.5)V_(0.1)FeCrMnNi_(0.9) high-entropy alloy with high strength and plasticity显示文摘A novel Al_(0.5)V_(0.1)FeCrMnNi_(0.9) high-entropy alloy was designed to achieve enhanced strength and plasticity. The as-cast Al_(0.5)V_(0.1)FeCrMnNi_(0.9) alloy shows a typical dendritic microstructure consisting of a body-centered cubic-structured matrix phase and a B2-structured nanoprecipitate phase. Nanoprecipitates are homogeneous and dispersed in the matrix. The as-cast Al_(0.5)V_(0.1)FeCrMnNi_(0.9) alloy exhibits a compressive yield strength of 1.104 GPa, a fracture strength of 2.926 GPa, and a fracture strain of 45.7%. The product of strength and plasticity of this alloy is 133.72 GPa%, which is superior to that of most of the reported high-entropy alloys. The strengthening mechanisms were evaluated in detail, which indicates that the coherent precipitation enhancement contributes to the unusually high strength and plasticity. | LI ChunHui WANG MingLiang ZHANG HuanZhi ZHANG GuoJia LI TianXin LU YiPing LI TingJu | 2021 | Science China(Technological Sciences)2021，64，9： | 2 |
| 10 | Lithospheric structures across the Qiman Tagh and western Qaidam Basin revealed by magnetotelluric data collected using a self-developed SEP system显示文摘Geophysics offers an important means to investigate the physical processes occurring inside the earth.In particular,since the 1960s,electromagnetic(EM)methods have played important roles in mineral exploration and engineering investigation.Such investigation requires extensive data acquisition and experimental analysis based on geophysical techniques.However,high-performance geophysical equipment,particularly EM exploration equipment,has been dominated by large geophysical companies from the United States,Canada,Germany,and other European countries for decades.This has limited the development of deep exploration technology in China.Recently,we have developed a high-resolution acquisition system with a wireless control unit and a high-power transmitting system for surface EM prospecting(SEP).The new system has been tested in the high-intensity,noisy environment in Jian-sanjiang area,Heilongjiang Province.We then conducted a field survey on the western edge of Qaidam Basin,Qinghai Province.A highly conductive anomaly was found in the upper mantle below the Qinmantage Mountains,which indicates a possible northward fluid channel that runs from below the Qinmantage Mountains to the bottom of the western crust of the Qaidam Basin.Identification of this significant feature was made possible by the new SEP for its better resolution than the previous systems.Also,geophysical analysis confirmed that the thick Cenozoic sediments of the Qaidam Basin are underlain by rigid Precambrian basement rocks and are characterized by a series of folds.The resistivity profile indicates that the Qaidam Basin was formed due to the folding structures in the northern part of the Qinghai-Tibet Plateau which provided an additional evidence for the uplifting of the Qinghai-Tibet Plateau. | Qingyun DI Guoqiang XUE Zhongxing WANG Lanfang HE Renzhong PEI Tianxin ZHANG Guangyou FANG | 2021 | Science China Earth Sciences2021，64，10： | 2 |
| 11 | Prostate specific membrane antigen knockdown impairs the tumorigenicity of LNCaP prostate cancer cells by inhibiting the phosphatidylinositol 3-kinase/Akt signaling pathway显示文摘 | Guo Zhenghui Lai Yiming Du Tao Zhang Yiming Chen Jieqing Bi Liangkuan Lin Tianxin Liu Hao Wang Wei Xu Kewei Jiang Chun Han Jinli Zhang Caixia Dong Wen Huang Jian Huang Hai | 2014 | Chinese Medical Journal2014，，5： | 2 |
| 12 | Cryptococcus neoformans,a global threat to human health显示文摘Background Emerging fungal pathogens pose important threats to global public health. The World Health Organization has responded to the rising threat of traditionally neglected fungal infections by developing a Fungal Priority Pathogens List (FPPL). Taking the highest-ranked fungal pathogen in the FPPL,Cryptococcus neoformans, as a paradigm, we review progress made over the past two decades on its global burden, its clinical manifestation and management of cryptococcal infection, and its antifungal resistance. The purpose of this review is to drive research efforts to improve future diagnoses, therapies, and interventions associated with fungal infections.Methods We first reviewed trends in the global burden of HIV-associated cryptococcal infection, mainly based on a series of systematic studies. We next conducted scoping reviews in accordance with the guidelines described in the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews using PubMed and ScienceDirect with the keywordCryptococcus neoformans to identify case reports of cryptococcal infections published since 2000. We then reviewed recent updates on the diagnosis and antifungal treatment of cryptococcal infections. Finally, we summarized knowledge regarding the resistance and tolerance ofC. neoformans to approved antifungal drugs.Results There has been a general reduction in the estimated global burden of HIV-associated cryptococcal meningitis since 2009, probably due to improvements in highly active antiretroviral therapies. However, cryptococcal meningitis still accounts for 19% of AIDS-related deaths annually. The incidences of CM in Europe and North America and the Latin America region have increased by approximately two-fold since 2009, while other regions showed either reduced or stable numbers of cases. Unfortunately, diagnostic and treatment options for cryptococcal infections are limited, and emerging antifungal resistance exacerbates the public health burden.Conclusions The rising threat ofC. neoformans is compounded by accumulating evidence for its ability to infect immunocompetent individuals and the emergence of antifungal-resistant variants. Emphasis should be placed on further understanding the mechanisms of pathogenicity and of antifungal resistance and tolerance. The development of novel management strategies through the identification of new drug targets and the discovery and optimization of new and existing diagnostics and therapeutics are key to reducing the health burden. | Youbao Zhao Leixin Ye Fujie Zhao Lanyue Zhang Zhenguo Lu Tianxin Chu Siyu Wang Zhanxiang Liu Yukai Sun Min Chen Guojian Liao Chen Ding Yingchun Xu Wanqing Liao Linqi Wang | 2023 | Infectious Diseases of Poverty2023，12，2： | 2 |
| 13 | Fluorescent probe gold nanodots to quick detect Cr(VI) via oxidoreduction quenching process显示文摘A method is described here for the quickly(<30 s) accurate determination of Cr(VI)(Cr_2O_7^(2-)), based on fluorescent probes gold nanodots(AuNDs, excitation/emission peaks at 395/604 nm) coated with glutathione(GSH). The fluorescence of the AuNDs responses linearly to Cr(VI) concentrations, ranging widely from 1 nM to 10 m M with detection limit as low as 0.35 nM. At the same time, the AuNDs is demonstrated highly selective for Cr(VI) detection over other acid group ions and metal ions without any masking reagent. These make probability for practical use. The quenching mechanism is investigated deeply via fluorescent lifetime, XPS and TEM analysis. Different from most reported quenching explanation of aggregation derived from charge attraction, these results verify the redox reaction between Cr_2O_7^(2-)and sulfhydryl(–S) of GSH. The Au(I)–S bonds of AuNDs broke, accompanies with the oxidation of –S to form S–S bonds. As a result, AuNDs cross linked to each other. In the end, the fluorescence quenched. Attractively, the present study provides a new strategy for pollutant detection, such as from harmful Cr(VI) of Cr_2O_7^(2-)to nontoxic Cr(III). | Yueqi Zhao Yuanqing Sun Yingnan Jiang Shanliang Song Tianxin Zhao Yue Zhao Xinyu Wang Baoquan Li Bai Yang Quan Lin | 2019 | Science China Chemistry2019，62，1： | 1 |
| 14 | The downregulation of ErbB3 binding protein 1 (EBP1) is associated with poor prognosis and enhanced cell proliferation in hepatocellular carcinoma显示文摘 | Baoying Hu Yicheng Xiong Runzhou Ni Lixian Wei Dawei Jiang Gang Wang Di Wu Tianxin Xu Fengbo Zhao Mingyan Zhu Chunhua Wan | 2014 | 2014 (1-2)2014，，1： | 1 |
| 15 | Purification and crystallization of xylitol from fermentation broth of corncob hydrolysates显示文摘Xylitol,a five-carbon sugar alcohol,is a valuable sugar substitute,and widely used in the pharmaceutical,odontological and food industry due to its interesting properties.In the past decades,the xylitol industry has grown rapidly and more attention has been focused on xylitol purification,which possesses an important proportion of the whole industry.In our paper,the purification and crystallization of xylitol fermentation broth by biotechnology using corncob hydrolysates as substance were studied.An initial xylitol fermentation broth was decolored with activated carbon(1%M-1,60℃,165 rpm),desalted with a combination of two ionexchange resins(732 and D301),and residual sugars were separated with UBK-555(Ca^(2+)).Then the solution was vacuum-concentrated up to supersaturation(750 g/L xylitol).After adding 1%xylitol crystal seeds,the supersaturated solution was cooled to-20℃for 48 h.The crystalline xylitol of a regular tetrahedral shape with purity 95%and crystallization yield 60.2%was obtained from the clarified xylitol fermentation broth.An intact,economical and environmental-friendly route of purification and crystallization of xylitol from fermentation of corncob hydrolysates was obtained,and its experimental procedure and data provided a sound basis for large-scale industrial production. | Jinchao WEI Qipeng YUAN Tianxin WANG Le WANG | 2010 | Frontiers of Chemical Science and Engineering2010，4，1： | 1 |
| 16 | PD-L1^(+)exosomes from bone marrow-derived cells of tumor-bearing mice inhibit antitumor immunity显示文摘Tumors escape immune attack by upregulating the surface expression of PD-L1,which interacts with PD-1 on T cells to activate immune inhibitory signaling.Anti-PD-1 treatments can effectively block this inhibitory signaling and activate antitumor immune responses.However,anti-PD-1 treatment also has a tumor suppressive effect in patients whose tumor cells do not express PD-L1.The underlying mechanisms are poorly defined.Here,we report that exosomes from bone marrow-derived cells(BMDCs)in tumor-bearing mice,but not in healthy mice,carry PD-L1.PD-L1 on these exosomes is biofunctional and can inhibit CD8^(+)T cell proliferation and activation in vitro and in vivo.The transfer of exogenous exosomes from BMDCs and the inhibition of the production of endogenous exosomes by BMDCs promote and suppress tumor growth,respectively.PD-L1^(+)exosomes from BMDCs can be found in tumor tissues.In addition,exosomes from BMDCs promote tumor metastasis in a PD-L1-dependent manner.Therefore,our results indicate that exosomes from BMDCs play important roles in tumor immunosuppression via PD-L1. | Yan Sun Jufeng Guo Lei Yu Tianxin Guo Jiaoli Wang Xian Wang Yinghu Chen | 2021 | Cellular & Molecular Immunology2021，18，10： | 1 |
| 17 | Polycation-functionalized gold nanodots with tunable near-infrared fluorescence for simultaneous gene delivery and cell imaging显示文摘 | Yuanqing Sun Dandan Wang Yueqi Zhao Tianxin Zhao Hongchen Sun Xiangwei Li Chuanxi Wang Bai Yang Quan Lin | 2018 | Nano Research2018，11，5： | 1 |
| 18 | Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches显示文摘Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS. | Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang | 2020 | Asian Journal of Urology2020，7，3： | 1 |
| 19 | The antimicrobial peptide PFR induces necroptosis mediated by ER stress and elevated cytoplasmic calcium and mitochondrial ROS levels: cooperation with Ara-C to act against acute myeloid leukemia显示文摘Dear Editor,Antimicrobial peptides(AMPs)are an ancient class of short polypeptides present in a large number of species in nature with a variety of functions.1 PFR(PFWRIRIRR-NH 2)is one kind of AMP identified among the derivatives of lactoferrin.2 Our previous results showed that PFR inhibited the proliferation of human acute myeloid leukemia(AML)HL60 cells potentially without toxicity against normal cells.In addition,PFR induced necrosis by membrane disruption detected using scanning electron micro-scopy.3 However,the underlying mechanisms of these effects are not clearly understood. | Yudie Lv Gang Shao Qiyu Zhang Xi Wang Yueming Meng Lingfei Wang Feiyan Huang Tianxin Yang Yuanting Jin Caiyun Fu | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 1 |
| 20 | Scanning capacitance microscopy investigation on InGaAs/ InP avalanche photodiode structures:Light-induced polarity reversal显示文摘 | Hao Yin Tianxin Li Wenjuan Wang | | 0，，： | 1 |
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