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| 1 | Observation of ocean current response to 1998 Hurricane Georges in the Gulf of Mexico显示文摘The ocean current response to a hurricane on the shelf-break is examined. The study area is the DeSoto Canyon in the northeast Gulf of Mexico, and the event is the passage of 1998 Hurricane Georges with a maximum wind speed of 49 m/s. The data sets used for analy- sis consist of the mooring data taken by the Field Program of the DeSoto Canyon Eddy Intrusion Study, and simultaneous winds ob- served by NOAA (National Oceanic and Atmospheric Administration) Moored Buoy 42040. Time-depth ocean current energy density images derived from the observed data show that the ocean currents respond almost immediately to the hurricane with important differ- ences on and off the shelf. On the shelf, in the shallow water of 100 m, the disturbance penetrates rapidly downward to the bottom and forms two energy peaks, the major peak is located in the mixed layer and the secondary one in the lower layer. The response dissipates quickly after external forcing disappears. Off the shelf, in the deep water, the major disturbance energy seems to be trapped in the mixed layer with a trailing oscillation; although the disturbance signals may still be observed at the depths of 500 and 1 290 m. Verti- cal dispersion analysis reveals that the near-initial wave packet generated off the shelf consists of two modes. One is a barotropic wave mode characterized by a fast decay rate of velocity amplitude of 0.020 s-1, and the other is baroclinic wave mode characterized by a slow decay rate of 0.006 9 s-1. The band-pass-filtering and empirical function techniques are employed to the frequency analysis. The results indicate that all frequencies shift above the local inertial frequency. On the shelf, the average frequency is 1.04f in the mixed layer, close to the diagnosed frequency of the first baroclinic mode, and the average frequency increases to 1.07f in the thermocline. Off the shelf, all frequencies are a little smaller than the diagnosed frequency of the first mode. The average frequency decreases from 1.035f in the mixed layer to 1.02f in the thermocline, implying a trend for the shift in frequency of the oscillations towards f with the depth. | ZHENG Quanan LAI Ronald J HUANG Nortlen E PAN Jiayi LIU W Timothy | 2006 | Acta Oceanologica Sinica2006，25，1： | 20 |
| 2 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 3 | Single-phase high-entropy intermetallic compounds(HEICs): bridging high-entropy alloys and ceramics显示文摘High-entropy intermetallic compounds(HEICs)were fabricated by mechanical alloying and spark plasma sintering to fill a knowledge gap between the traditional high-entropy alloys(HEAs)and emerging highentropy ceramics(HECs).Notably,several four-or five-component equimolar aluminides,such as the B2-phase(Fe1/5 Co1/5 Ni1/5 Mn1/5 Cu1/5)Al,have been made into single-phase HEICs for the first time.Thermodynamic modeling and a reversible,temperature-dependent,phase-stability experiment suggest that such B2-phase HEICs are entropy-stabilized phases.The structure of these HEICs resembles that of HECs with high-entropy mixing of fo ur or five elements of nearly equal fractions in one and only one sublattice,but with significant(10%)anti-site defects(differing from typical HECs).A new phase stability rule for forming single B2-phase HEICs is proposed.Five additional HEICs of predominantly D022 phases have also been made.This study broadens the families of equimola r,single-phase,high-entropy materials that have been successfully fabricated. | Naixie Zhou Sicong Jiang Timothy Huang Mingde Qin Tao Hu Jian Luo | 2019 | Science Bulletin2019，64，12： | 8 |
| 4 | Application of the modern ophiolite concept with special reference to Precambrian ophiolites显示文摘Much has been learned in the past 40 years about the great diversity of the internal structure and geochemical compositions of Phanerozoic ophiolites, indicating that these on-land fragments of ancient oceanic lithosphere formed in distinctly different tectonic settings during their igneous evolution. Recent studies in Archean and Proterozoic greenstone belts have shown that the Precambrian rock record may also include exposures of a diverse suite of ophiolite complexes as part of craton development in the early history of the Earth. We review the salient features of the Precambrian ophiolite record to highlight what has been learned about Precambrian oceanic spreading systems since the original Penrose definition of ophiolites in 1972. Some of the diagnostic, characteristic, typical, and rare aspects of ophiolites of all ages are presented in a table in order to help determine if tectonically deformed and metamophosed sequences in Precambrian shield areas may be considered as ophiolites. The results of this comparative study are important in that they enable researchers to more realistically characterize allochthonous mafic/ultramafic rock sequences as ophiolitic or non-ophiolitic. This approach is more deterministic in contrast to some other arbitrary classification schemes requiring three or four of the Penrose-style ophiolitic units to be present in the Precambrian record for a specific rock sequence to be considered ophiolitic. Once these tectonic fragments are recognized as remnants of ancient oceanic lithosphere, great progress shall be made in understanding early Earth history. We discuss the significance and implications of the Precambrian ophiolite record to constrain the mode and nature of the plate tectonics that operated in deep time. | Timothy M. KUSKY WANG Lu Yildirim DILEK Paul ROBINSON PENG SongBai HUANG XuYa | 2011 | Science China Earth Sciences2011，54，3： | 4 |
| 5 | 皮肤病患者预防新型冠状病毒肺炎个人防护专家共识(第一版)显示文摘2019年12月以来,湖北省武汉市陆续出现新型冠状病毒感染引起的以肺部病变为主的新发呼吸道传染病,即新型冠状病毒肺炎(COVID-19),之后呈现快速蔓延.该病具有发病迅速、传染性强、病程变化快等特点,因此采取甲类传染病的预防、控制措施.当前全国正处于新型冠状病毒肺炎防控工作的紧张阶段,皮肤病患者多存在皮肤屏障功能受损情况,会增加易感性.因此,皮肤病患者的个人防护工作亦极为迫切.针对上述问题,我们组织美国、英国、澳大利亚,中国香港、中国澳门、中国台湾及中国多省市著名专家、教授联合编写了皮肤病患者个人防护专家共识,内容较为翔实,以满足当前抗击新型冠状病毒肺炎疫情工作的需要,帮助皮肤病患者更好地做好个人防护. | 无 邓列华 孙乐栋 曾凡钦 赵华 王宏伟 姜群 林泽 | 2020 | 暨南大学学报(自然科学与医学版)2020，41，2： | 4 |
| 6 | HMGB1 in health and disease显示文摘 | Rui Kang Ruochan Chen Qiuhong Zhang Wen Hou Sha Wu Lizhi Cao Jin Huang Yan Yu Xue-gong Fan Zhengwen Yan Xiaofang Sun Haichao Wang Qingde Wang Allan Tsung Timothy R. Billiar Herbert J. Zeh Michael T. Lotze Daolin Tang | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 7 | Seasonal Variations of CH_4 Emissions in the Yangtze River Delta Region of China Are Driven by Agricultural Activities显示文摘Developed regions of the world represent a major atmospheric methane(CH_4) source,but these regional emissions remain poorly constrained.The Yangtze River Delta(YRD) region of China is densely populated(about 16% of China's total population) and consists of large anthropogenic and natural CH_4 sources.Here,atmospheric CH_4 concentrations measured at a 70-m tall tower in the YRD are combined with a scale factor Bayesian inverse(SFBI) modeling approach to constrain seasonal variations in CH_4 emissions.Results indicate that in 2018 agricultural soils(AGS,rice production) were the main driver of seasonal variability in atmospheric CH_4 concentration.There was an underestimation of emissions from AGS in the a priori inventories(EDGAR—Emissions Database for Global Atmospheric Research v432 or v50),especially during the growing seasons.Posteriori CH_4 emissions from AGS accounted for 39%(4.58 Tg,EDGAR v432) to 47%(5.21 Tg,EDGAR v50) of the total CH_4 emissions.The posteriori natural emissions(including wetlands and water bodies) were1.21 Tg and 1.06 Tg,accounting for 10.1%(EDGAR v432) and 9.5%(EDGAR v50) of total emissions in the YRD in2018.Results show that the dominant factor for seasonal variations in atmospheric concentration in the YRD was AGS,followed by natural sources.In summer,AGS contributed 42%(EDGAR v432) to 64%(EDGAR v50) of the CH_4 concentration enhancement while natural sources only contributed about 10%(EDGAR v50) to 15%(EDGAR v432).In addition,the newer version of the EDGAR product(EDGAR v50) provided more reasonable seasonal distribution of CH_4 emissions from rice cultivation than the old version(EDGAR v432). | Wenjing HUANG Timothy JGRIFFIS Cheng HU Wei XIAO Xuhui LEE | 2021 | Advances in Atmospheric Sciences2021，38，9： | 2 |
| 8 | Early diagnosis and therapeutic strategies for hepatocellular carcinoma:From bench to bedside显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-related deaths worldwide.The prognosis of patients with HCC remains poor largely due to the late diagnosis and lack of effective treatments.Despite being widely used,alpha-fetoprotein serology and ultrasonography have limited diagnostic performance for early-stage HCC.The emergence of omics strategies has contributed to significant advances in the development of non-invasive biomarkers for the early diagnosis of HCC including proteins,metabolites,circulating tumor deoxyribonucleic acid,and circulating non-coding ribonucleic acid.Early diagnosis is beneficial to patients as it increases the proportion who can be treated with curative treatment,thus prolonging survival outcomes.Currently,multiple clinical trials involving locoregional,systemic therapies,and combinations of these modalities are changing therapeutic strategies for different stage HCC.Success in several preclinical trials that involve immunotherapeutic innovations has created the potential to complement and enforce other treatment strategies in the future.This review summarizes the most recent advances in noninvasive early molecular detection,current therapy strategies,and potential immunotherapeutic innovations of HCC. | Ming-Cheng Guan Ming-Da Wang Si-Yu Liu Wei Ouyang Lei Liang Timothy M Pawlik Qiu-Ran Xu Dong-Sheng Huang Feng Shen Hong Zhu Tian Yang | 2021 | World Journal of Gastrointestinal Oncology2021，13，4： | 2 |
| 9 | TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c‐Kit<sup>+</sup> cardiac stem cells in ischemic heart disease显示文摘 | Rafia S. Al‐Lamki Wanhua Lu Jun Wang Jun Yang Timothy J. Sargeant Richard Wells Chenqu Suo Penny Wright Martin Goddard Qunhua Huang Amir H. Lebastchi George Tellides Yingqun Huang Wang Min Jordan S. Pober John R. Bradley | 2013 | Stem Cells2013，，9： | 1 |
| 10 | Osteopontin is a negative regulator of proliferation and differentiation in MC3T3-E1 pre-osteoblastic cells显示文摘 | Weibiao Huang Brian Carlsen George Rudkin Micah Berry Kenji Ishida Dean T Yamaguchi Timothy A Miller | 2004 | Bone2004，，5： | 1 |
| 11 | Nano Li4Ti5O12-LiMn2O4 batteries with high power capability and improved cycle-life显示文摘 | Pasquier A D Huang C C Timothy S | 2009 | Journal of Power Sources2009，186，2： | 1 |
| 12 | Binding properties of a peptide derived from β-lactamase inhibitory protein显示文摘 | Gary W Huang W Timothy P | 2001 | Antimicrob Agents Chemother2001，45，2： | 1 |
| 13 | Modelling of meander migration in an incised channel显示文摘为有切口的蜿蜒地流的河的一个更新的线性计算机模型被开发了。模型在一条切入的蜿蜒地流的隧道模仿床地形学,流动地,和河岸侵蚀率。在在上游的沉积负担减少的一种情形(例如水坝闭合或土壤保存) ,冲积的河经验十字节加深并且斜坡变平。隧道迁居率可能以二个方法被影响:减少的隧道斜坡和浸泡河岸高度。建议数字模型联合传统一个维(1D ) 在模仿隧道侵蚀的沉积运输模型和为隧道蜿蜒地流的线性模型。一个非平衡沉积运输模型被用来更新隧道床举起和阶段。一个线性蜿蜒地流模型被用来计算隧道排列和河岸侵蚀 / 生长,它被 1D 沉积运输模型接着使用。在 1D 沉积运输模型,隧道床举起和阶段在每隧道十字节被代表。在蜿蜒地流的模型,床举起和阶段被存储在二维(2D ) 代表隧道和地面性质(举起和阶段) 的房间。一个新方法被建议关于在 1D 河几何学和 2D 隧道和地面之间的床举起和床材料部分交换信息。模型的能力用隧道切口在发生在在上游的结束的 Friedkin 的实验室隧道迁居的模拟被表明。 | Jianchun HUANG Blair P. GREIMANN Timothy J. RANDLE | 2014 | International Journal of Sediment Research2014，29，4： | 1 |
| 14 | Yin Yang 1 Plays an Essential Role in Breast Cancer and Negatively Regulates p27显示文摘 | Meimei Wan Weiwei Huang Timothy E. Kute Lance D. Miller Qiang Zhang Heather Hatcher Jingxuan Wang Daniel B. Stovall Gregory B. Russell Paul D. Cao Zhiyong Deng Wei Wang Qingyuan Zhang Ming Lei Suzy V. Torti Steven A. Akman Guangchao Sui | 2012 | The American Journal of Pathology2012，，： | 1 |
| 15 | Cofilin phosphatases and regulation of actin dynamics显示文摘 | Timothy Y Huang Céline DerMardirossian Gary M Bokoch | 2005 | Current Opinion in Cell Biology2005，，1： | 1 |
| 16 | Archean podiform chromitites and mantle tectonites in ophiolitic melange, North China Craton: a record of early oceanic mantle processes显示文摘 | LI J H TIMOTHY M K HUANG X N | 2002 | GSA Today2002，12，7： | 1 |
| 17 | Fermented Camellia sinensis , Fu Zhuan Tea, regulates hyperlipidemia and transcription factors involved in lipid catabolism显示文摘 | Donghe Fu Elizabeth P. Ryan Jianan Huang Zhonghua Liu Tiffany L. Weir Randall L. Snook Timothy P. Ryan | 2011 | Food Research International2011，，9： | 1 |
| 18 | In Vitro Mineralization of Human Mesenchymal Stem Cells on Three-Dimensional Type I Collagen versus PLGA Scaffolds: A Comparative Analysis显示文摘 | Erwin A. Kruger Daniel D. Im David S. Bischoff Clifford T. Pereira Weibiao Huang George H. Rudkin Dean T. Yamaguchi Timothy A. Miller | 2011 | Plastic and Reconstructive Surgery2011，，6： | 1 |
| 19 | Fermented Camellia sinensis , Fu Zhuan Tea, regulates hyperlipidemia and transcription factors involved in lipid catabolism显示文摘 | Donghe Fu Elizabeth P. Ryan Jianan Huang Zhonghua Liu Tiffany L. Weir Randall L. Snook Timothy P. Ryan | 2011 | Food Research International2011，，9： | 1 |
| 20 | Osteopontin is a negative regulator of proliferation and differentiation in MC3T3-E1 pre-osteoblastic cells显示文摘 | Weibiao Huang Brian Carlsen George Rudkin Micah Berry Kenji Ishida Dean T Yamaguchi Timothy A Miller | 2004 | Bone2004，，5： | 1 |
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