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| 1 | A review on phospholipids and their main applications in drug delivery systems显示文摘Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity.These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of applications in drug delivery systems.The aim of this review is to summarize phospholipids and some of their related applications in drug delivery systems,and highlight the relationship between the properties and applications,and the effect of the species of phospholipids on the efficiency of drug delivery.We refer to some relevant literatures,starting from the structures,main sources and properties of phospholipids to introduce their applications in drug delivery systems.The present article focuses on introducing five types of carriers based on phospholipids,including liposomes,intravenous lipid emulsions,micelles,drug-phospholipids complexes and cochleates. | Jing Li Xuling Wang Ting Zhang Chunling Wang Zhenjun Huang Xiang Luo Yihui Deng | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 23 |
| 2 | Photodegradation of fluoroquinolone antibiotic gatifloxacin in aqueous solutions显示文摘Fluoroquinolone antibiotics (FQs) are frequently detected as emerging pollutants in aqueous environments.In this study,kinetics,influencing factors and mechanisms on the photodegradation of gatifloxacin,a representative FQ,were investigated.The photodegradation follows the pseudo-first-order kinetics.Gatifloxacin photodegrades with a quantum yield of (5.94 ± 0.95) × 10 3 in pure water and undergoes direct photolysis as well as self-sensitized photodegradation.The FQ photodegrades slower in freshwater and seawater than in pure water,which is attributed to the integrative effects of pH and the aqueous dissolved matter (e.g.,humic acids and NO 3-) on the photodegradation.A toxicity test using Vibrio fischeri revealed the formation of hazardous photoproducts. | GE LinKe CHEN JingWen ZHANG SiYu CAI XiYun WANG Zhuang WANG ChunLing | 2010 | Chinese Science Bulletin2010，55，15： | 17 |
| 3 | Marine Yeasts and Their Applications in Mariculture显示文摘The terrestrial yeasts have been receiving great attention in science and industry for over one hundred years because they can produce many kinds of bioactive substances. However, little is known about the bioactive substances of marine yeasts. In recent years, it has been found that marine yeasts have wide applications in mariculture and other fields. Therefore,marine yeasts, the bioactive substances from them and the applications of marine yeasts themselves and the bioactive substances they produced are reviewed in this paper. | CHI Zhenming LIU Zhiqiang GAO Lingmei GONG Fang MA Chunling WANG Xianghong LI Haifeng | 2006 | Journal of Ocean University of China2006，5，3： | 12 |
| 4 | Arab/c/opste N^(6)-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies显示文摘The biological functions of the epitranscriptomic modification N^(6)-methyladenosine(m^(6)A)in plants are not fully understood.CPSF30-L is a predominant isoform of the polyadenylation factor CPSF30 and consists of CPSF30-S and an m^(6)A-binding YTH domain.Little is known about the biological roles of CPSF30-L and the molecular mechanism underlying its m^(6)A-binding function in alternative polyadenylation.Here,we charac-terized CPSF30-L as an Arabidopsis m^(6)A reader whose m^(6)A-binding function is required for the floral tran-sition and abscisic acid(ABA)response.We found that the m^(6)A-binding activity of CPSF30-L enhances the formation of liquid-like nuclear bodies,where CPSF30-L mainly recognizes m*A-modified far-upstream elements to control polyadenylation site choice.Deficiency of CPSF30-L lengthens the 3'untranslated region of three phenotypes-related transcripts,thereby accelerating their mRNA degradation and leading to late flowering and ABA hypersensitivity.Collectively,this study uncovers a new molecular mechanism for m^(6)A-driven phase separation and polyadenylation in plants. | Peizhe Song Junbo Yang Chunling Wang Qiang Lu Linqing Shi Subiding Tayier Guifang Jia | 2021 | Molecular Plant2021，14，4： | 12 |
| 5 | An effective method for improving the accuracy of Argo objective analysis显示文摘基于南船座数据的最佳的插值目的分析,改进被做到广泛地在数据吸收和客观分析系统使用的一个背景错误协变性矩阵的实验公式。明确地,关联的一个评价可伸缩那能有效地改善南船座客观分析的精确性被开发了。这个方法能自动地适应一个变量的坡度变化并且被叫作坡度依赖者关联规模方法。它南船座客观分析上的效果与 Gaussian 脉搏和光谱分析理论上被验证。一个维的模拟实验的结果证明坡度依赖者关联规模能改进客观分析系统的适应性,为充分吸收在有更大的海洋学的坡度的区域的观察的短波信息的分析计划使它可能。新计划在太平洋被用于南船座数据目的分析系统。结果显然被改进。 | ZHANG Chunling XU Jianping BAO Xianwen WANG Zhenfeng | 2013 | Acta Oceanologica Sinica2013，32，7： | 11 |
| 6 | Origin and accumulation of high-maturity oil and gas in deep parts of the Baxian Depression, Bohai Bay Basin, China显示文摘Great quantities of light oil and gas are produced from deep buried hill reservoirs at depths of 5,641 m to 6,027 m and 190 °C to 201 °C in the Niudong-1 Well, representing the deepest and hottest commercial hydrocarbons discovered in the Bohai Bay Basin in eastern China. This discovery suggests favorable exploration prospects for the deep parts of the basin. However, the discovery raises questions regarding the genesis and accumulation of hydrocarbons in deep reservoirs. Based on the geochemical features of the hydrocarbons and characteristics of the source rocks as well as thermal simulation experiments of hydrocarbon generation, we conclude that the oil and gas were generated from the highly mature Sha-4 Member (Es4 ) source rocks instead of thermal cracking of crude oils in earlier accumulations. The source kitchen with abnormal pressures and karsted carbonate reservoirs control the formation of high-maturity hydrocarbon accumulations in the buried hills (i.e., Niudong-1) in conjunction with several structural-lithologic traps in the Es4 reservoirs since the deposition of the upper Minghuazhen Formation. This means the oil and gas exploration potential in the deep parts of the Baxian Depression is probably high. | Zhao Xianzheng Jin Qiang Jin Fengming Ma Peng Wang Quan Wang Jing Ren Chunling Xi Qiuling | 2013 | Petroleum Science2013，10，3： | 10 |
| 7 | Dongbeititan dongi,the First Sauropod Dinosaur from the Lower Cretaceous Jehol Group of Western Liaoning Province,China显示文摘我们此处描述一条 sauropod 恐龙的头部的骨骼在西方的辽宁省的 Beipiao 区域从更低的白垩纪 Jehol 组恢复了的一根部分柱子,东北中国。它拥有的特征的一间套房,包括骆驼它的 presacral 元素,在背面的肋骨的近似结束的 pneumatocoels 的存在,和特别腿节的中间地偏斜的近似部分的晚内部的结构,决定性地建立标本的 titanosauriform 亲密关系。它在有不同于另外的 titanosauriforms 一 craniocaudally 伸长有摆平的 cranioventral 极端和一张长、光滑、稍微凸的王牌的鸟喙骨耻骨的平坦的边。它代表新税在上, Dongbeititan 盾 i 情报。et sp。nov。比较研究建议 Dongbeititan 是基础 titanosauriform,比 Euhelopus 导出,但是少些比 Gobititan 和 Jiutaisaurus 发源的更多, Fusuisaurus,和 Huanghetitan。Dongbeititan 表示第一条 sauropod 恐龙从西方的辽宁省的更低的白垩纪 Jehol 组报导了。 | WANG Xuri YOU Hailu MENG Qingjin GAO Chunling CHENG Xiaodong LIU Jinyuan | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 9 |
| 8 | Vegetation Development and Water Level Changes in Shenjiadian Peatland in Sanjiang Plain,Northeast China显示文摘This paper documents a 7800-year proxy record from the Shenjiadian peatland on the Sanjiang Plain in Northeast China.High-resolution plant macrofossil and colorimetric humification methods were used to reconstruct the vegetation and hydrologic history from a 193 cm-long sedimentary profile.Detrended correspondence analysis(DCA) was applied to transform the raw plant macrofossil data into latent indices of peatland water level.The vegetation community transited from an Equisetum fluviatile community to a Carex lasiocarpa community at approximately 3800 cal yr BP and was followed by a Carex-shrub community at approximately 480 cal yr BP.Based on the plant macrofossil DCA axis 1 scores and humification values,we distinguished four hydrologic periods:a wet period from 7800 cal yr BP to 4500 cal yr BP,dry periods up to 1600 cal yr BP,drier periods until 300 cal yr BP,and the driest period from 300 cal yr BP until the present.Through a comparison with other climate records,we suggest that the East Asian summer monsoon(EAM) was the main driving force for vegetation and water level changes to the Shenjiadian peatland through its impacts on precipitation. | WANG Chunling ZHAO Hongyan WANG Guoping | 2015 | Chinese Geographical Science2015，25，4： | 8 |
| 9 | Guidance Control for Parallel Parking Tasks显示文摘Parking into small berths remains difficult for unskilled drivers. Researchers had proposed different automatic parking systems to solve this problem. The first kind of strategies(called parking trajectory planning) designs a detailed reference trajectory that links the start and ending points of a special parking task and let the vehicle track this reference trajectory so as to park into the berth. The second kind of strategies(called guidance control) just characterizes several regimes of driving actions as well as the important switching points in certain rule style and let the vehicle follows the pre-selected series of actions so as to park into the berth. Parking guidance control is simpler than parking trajectory planning. However, no studies thoroughly validated parking guidance control before. In this paper, a new automatic parking method is presented, which could characterize the desired control actions directly. Then the feasibility is examined carefully. Tests show that a simple parking guidance control strategy can work in most parallel parking tasks, if the available parking berth is not too small. This finding helps to build more concise automatic parking systems that can efficiently guide human drivers. | Jiyuan Tan Chunling Xu Li Li Fei-Yue Wang Dongpu Cao Lingxi Li | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 7 |
| 10 | New Species of Enantiornithes(Aves:Ornithothoraces) from the Qiaotou Formation in Northern Hebei,China显示文摘我们从北 Hebei 的更低的白垩纪 Qiaotou 形成在 enantiornithine 鸟的新种上报导,中国。新 taxon, Shenqiornis mengi 情报。et sp。nov,拥有几 enantiornithine synapomorphies,但是从另外的已知的种类是唯一的。标本有关于 enantiornithine 揭示新信息的一个保存得很好的颅骨头部的形态学。新 taxon 拥有一大与显示某 enantiornithines 可能有的一个长尖端细的颧骨的过程眼窝后部一充分 diapsid 颅骨,在 Confuciusornis。标本的牙齿形态学是唯一的并且多半在 Enantiornithes 以内代表以前未知的营养的专门化。 | WANG Xuri Jingmai K. O'CONNOR ZHAO Bo Luis M. CHIAPPE GAO Chunling CHENG Xiaodong | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 5 |
| 11 | An Energy-Saving Task Scheduling Strategy Based on Vacation Queuing Theory in Cloud Computing显示文摘High energy consumption is one of the key issues of cloud computing systems. Incoming jobs in cloud computing environments have the nature of randomness, and compute nodes have to be powered on all the time to await incoming tasks. This results in a great waste of energy. An energy-saving task scheduling algorithm based on the vacation queuing model for cloud computing systems is proposed in this paper. First, we use the vacation queuing model with exhaustive service to model the task schedule of a heterogeneous cloud computing system.Next, based on the busy period and busy cycle under steady state, we analyze the expectations of task sojourn time and energy consumption of compute nodes in the heterogeneous cloud computing system. Subsequently, we propose a task scheduling algorithm based on similar tasks to reduce the energy consumption. Simulation results show that the proposed algorithm can reduce the energy consumption of the cloud computing system effectively while meeting the task performance. | Chunling Cheng Jun Li Ying Wang | 2015 | Tsinghua Science and Technology2015，20，1： | 5 |
| 12 | Amylase Production by the Marine Yeast Aureobasidium pullulans N13d显示文摘The marine yeast strain N13d, producing an extracellular amylase, was isolated from the deep sea sediments of the Pa-cific Ocean. This strain was identified to be Aureobasidium pullulans by 18S rRNA gene sequence analysis and routine yeast identi-fication methods. The optimal sea water medium for amylase production by this yeast strain was 1.0% peptone and 1.0% soluble starch with pH 4.0. The optimal conditions for amylase production by this yeast strain were with temperature 28 ℃, aeration rate 6 Lmin-1 and agitation speed 250 rmin-1. Under these conditions, 58.5 units of amylase activity per mg protein were produced within 56 h of fermentation. | LI Haifeng, CHI Zhenming *, WANG Xiaohong, and MA Chunling UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Qingdao 266003, P. R. China | 2007 | Journal of Ocean University of China2007，6，1： | 5 |
| 13 | Corrosion behavior of Mg-Zn-Ca amorphous alloys with Nd addition in simulated body fluids显示文摘The effects of Nd addition on corrosion behavior of Mg66Zn30Ca4 amorphous alloys in simulated body f luids(SBF) were studied in this paper. Electrochemical properties of the samples before and after corrosion were determined. Surface morphologies of samples after immersion in SBF at 37℃ for different times were observed under scanning electron microscope(SEM). Results show that the corrosion resistance of Mg-based alloys in SBF is improved with the addition of Nd element. The electrochemical properties indicate that microalloying Nd element to the alloys leads to an ennoblement in the open circuit potentials of the alloys and a decrease in the anodic current density in SBF, especially for the Mg66-xZn30Ca4 Ndx alloys with Nd content of 1.0at.%-1.5at.%. It was observed that the surface morphologies of the alloys immersed in SBF change with the Nd addition. A f lakelike structure parallel to the alloy substrate formed on the surface of 1.0at.% Nd-containing alloy immersed in SBF for 7 days improves the corrosion resistance of the amorphous alloys by blocking the corrosion liquid from attacking the alloys. | Qin Chunling Xiao Tongna Li Yongyan Wang Zhifeng Liu Li Xiong Hanqing Zhao Weimin | 2014 | China Foundry2014，11，6： | 5 |
| 14 | Multi-objective optimization design of wheat centralized seed feeding device based on particle swarm optimization (PSO) algorithm显示文摘In order to solve the problem of interaction between multiple evaluation indexes of seed metering performance under multiple factors of centralized seed feeding device,a multi-objective optimization of structure based on particle swarm optimization(PSO)algorithm was proposed in this paper.The wheat centralized seed feeding device was taken as the research object,and the experimental factors were cone angle of type hole,working speed and seed filling gap.The working process of wheat centralized seed feeding device was simulated by discrete element method(DEM).The average seed number of type hole,the variation coefficient of the average seed number of type hole,and the maximum tangential force between seed and seed feeding mechanism were selected as the evaluation indexes.Through the variance analysis of the evaluation indexes by the experimental factors,the optimization objective function was constructed.Using PSO algorithm,the multi-objective optimization was carried out for the wheat centralized seed feeding device.The optimization results show that the best structural combination parameters of the wheat centralized seed feeding device are the hole cone angle of 31.6°and the seed filling gap of 4.6 mm.The validity of the method was verified by simulation and field test.The results show that the PSO algorithm multi-objective optimization method proposed in this paper can provide a reference for the structural improvement and optimal design of the centralized seed feeding device. | Qingqing Wang Zhaodong Li Weiwei Wang Chunling Zhang Liqing Chen Ling Wan | 2020 | International Journal of Agricultural and Biological Engineering2020，13，6： | 4 |
| 15 | An efficient catalytic system for the synthesis of glycerol carbonate by oxidative carbonylation of glycerol显示文摘Glycerol carbonate was synthesized by the oxidative carbonylation of glycerol catalyzed by the commercial Pd/C with the aid of NaI.High conversion of glycerol(82.2%),selectivity to glycerol carbonate(>99%),and TOF(900 h–1)were obtained under the conditions of 5 MPa(pCO:pO2=2:1),140 oC,2 h.The highly active palladium species were generated in situ by dissolution from the carbon support and stabilized by re-deposition onto the support surface after the reaction was finished.Palladium dissolution and re-deposition were crucial and inherent parts of the catalytic cycle,which involved heterogeneous reactions.This Pd/C catalyst could be recycled and efficiently reused for four times with a gradual decrease in activity.Moreover,the influences of various parameters,e.g.,types of catalysts,solvents,additives,reaction temperature,pressure,and time on the conversion of glycerol were investigated.A reaction mechanism was proposed for oxidative carbonylation of glycerol to glycerol carbonate. | WANG LiYan LIU Yan LIU ChunLing YANG RongZhen DONG WenSheng | 2013 | Science China Chemistry2013，56，10： | 4 |
| 16 | Asymptotic regulation of cascade systems with unknown control directions and nonlinear parameterization显示文摘A robust partial-state feedback asymptotic regulating control scheme is developed for a class of cascade systems with both nonlinear uncertainties and unknown control directions. A parameter separation technique is introduced to separate the time-varying uncertainty and the unmeasurable state from nonlinear functions. Then, the Nussbaum-type gain method together with the idea of changing supply functions is adopted in the design of a smooth partial-state regulator that can ensure all the signals of the closed-loop system are globally uniformly bounded. Especially, the system state asymptotically converges to zero. The design procedure is illustrated through an example and the simulation results show that the controller is feasible and effective. | Qiangde WANG Chunling WEI Yuqiang WU | 2009 | 控制理论与应用(英文版)2009，7，1： | 4 |
| 17 | A Positive Correlation between Elevated Altitude and Frequency of Mutant Alleles at the EPAS1 and HBB Loci in Chinese Indigenous Dogs显示文摘Hypoxia represents one of the most extreme environmental conditions for both human beings and animals living at high altitudes(Zhao et al.,2009).Over the past few years,great attention has been focused on the genetic bases of adaption to high-altitude environments(Bigham et al.,2010;Simonson et al.,2010).The domestic dog(Canis familiaris)is the first animal that | Ruoxi Fan Fei Liu Hong Wu Shifang Wu Chunling Zhu Yan Li Guodong Wang Yaping Zhang | 2015 | Journal of Genetics and Genomics2015，42，4： | 4 |
| 18 | Genome and transcriptome of Papaver somniferum Chinese landrace CHM indicates that massive genome expansion contributes to high benzylisoquinoline alkaloid biosynthesis显示文摘Opium poppy(Papaver somniferum)is a source of morphine,codeine,and semisynthetic derivatives,including oxycodone and naltrexone.Here,we report the de novo assembly and genomic analysis of P.somniferum traditional landrace‘Chinese Herbal Medicine’.Variations between the 2.62 Gb CHM genome and that of the previously sequenced high noscapine 1(HN1)variety were also explored.Among 79,668 protein-coding genes,we functionally annotated 88.9%,compared to 68.8%reported in the HN1 genome.Gene family and 4DTv comparative analyses with three other Papaveraceae species revealed that opium poppy underwent two whole-genome duplication(WGD)events.The first of these,in ancestral Ranunculales,expanded gene families related to characteristic secondary metabolite production and disease resistance.The more recent species-specific WGD mediated by transposable elements resulted in massive genome expansion.Genes carrying structural variations and large-effect variants associated with agronomically different phenotypes between CHM and HN1 that were identified through our transcriptomic comparison of multiple organs and developmental stages can enable the development of new varieties.These genomic and transcriptomic analyses will provide a valuable resource that informs future basic and agricultural studies of the opium poppy. | Li Pei Baishi Wang Jian Ye Xiaodi Hu Lihong Fu Kui Li Zhiyu Ni Zhenlong Wang Yujie Wei Luye Shi Ying Zhang Xue Bai Mengwan Jiang Shuhui Wang Chunling Ma Shujin Li Kaihui Liu Wanshui Li Bin Cong | 2021 | Horticulture Research2021，8，1： | 4 |
| 19 | Myocardin-related transcription factor A is up-regulated by 17β-estradiol and promotes migration of MCF-7 breast cancer cells via transactivation of MYL9 and CYR61显示文摘证据的许多线建议了雌激素不仅在乳癌的开始和增长,而且在癌症转移起重要作用。然而,后者事件的机械学的基础糟糕被理解。另外,最近的研究建议了那 myocardin 相关的抄写因素 A (MRTF -- 一) 可能与癌症有关转移。然而报告是矛盾的它的角色肯定尚待糊涂。在现在的学习,我们证明过多的 17-estradiol 能支持 MCF-7 乳癌房间和起来调整的迁居 MRTF 的表示 -- 一,肌浆球蛋白规章的轻链 9 (MYL9 ) ,并且充满半胱氨酸的 angiogenic inducer 61 (CYR61 ) 。MRTF 的 Overexpression -- A 显著地在 MYL9 和 CYR61 基因上通过它的 transactivation 效果支持了 MCF-7 房间的移植,当时 RNA 调停干扰 MRTF 击倒 -- A 强烈禁止了目标基因的抄写和表示并且减少了 MCF-7 房间的移植能力。这些结果提供了支持 MRTF 的支持转移的功能的新奇证据 -- 一,并且暗示了那 MRTF -- A 可能是一个开关让雌激素小径在乳癌把它的支持增长的角色变成刺激迁居的角色。 | Chunling Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 3 |
| 20 | Effects of Nutritional Factors on the Growth and Heterotrophic Eicosapentaenoic Acid Production of Diatom Nitzschia laevis显示文摘The effects of several nutritional factors on the growth and eicosapentaenoic acid(EPA) production of diatom Nitzschia laevis were studied. 4 LDM(quadrupled concentration of the nutrient salt) was the optimal concentration of nutrient salt for the growth and EPA production of N. laevis. The growth of N. laevis was inhibited when the glucose concentration was either lower than 10 gL-1 or higher than 15 gL-1. Both sodium nitrate and urea were good nitrogen sources for the growth and EPA production,while ammonium chloride seriously decreased the dry cell weight(DW) and the EPA content. Silicate seriously influenced the growth of N. laevis. The maximum DW of 2.34 gL-1 was obtained in the presence of 150 mgL-1 Na2SiO3· 9H2O. The EPA content remained almost the same when the silicate concentration was lower than 150 mgL-1;however,higher silicate concentrations resulted in a steady de-crease of EPA content. Low medium salinity(≤29) did not seem to influence the DW of N. laevis,and high salinity resulted in a decrease of DW. The highest EPA content(4.08%) and yield(110 mgL-1) were observed at the salinity of 36 and 29,respectively. | CAO Xiaohong LI Songyao WANG Chunling LU Meifang | 2008 | Journal of Ocean University of China2008，7，3： | 3 |
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