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| 1 | Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis显示文摘Necroptosis 和 pyroptosis 是有血浆膜破裂的一个普通特征的规划房间死亡的二种形式。这里,我们与 necroptosis 比较学习了 pyroptosis 的形态学和机制。与 necroptosis 不同, pyroptosis 经历膜 blebbing 并且生产 apoptotic 在血浆膜以前的像身体的房间伸出(称为的 pyroptotic 身体) 破裂。在 necroptosis 的破裂是像爆炸的,而在 pyroptosis 它导致房间变平。necroptosis 的实行被混合的系 kinase 调停,这被知道像域(MLKL ) 在血浆膜的 oligomers,而 gasdermin-D (GSDMD ) 调停在它由 caspase-1 或 caspase-11 的劈开以后的 pyroptosis。我们显示出那 N 终端碎片 caspase 劈开产生的 GSDMD (GSDMD-N ) 也形成 oligomer 并且移居到血浆膜杀死房间。MLKL 和 GSDMD-N 是脂性的,两蛋白质的 N 终端序列为他们的 oligomerization 和血浆膜 translocation 是重要的。不同于在血浆膜上形成隧道的 MLKL,那导致渗透地胀大的选择离子的流入冲破的房间, GSDMD-N 形成非选择的毛孔并且不依靠增加的 osmolarity 破坏房间。我们的学习表明 GSDMD 的形成毛孔的活动和 MLKL 的形成隧道的活动在 pyroptosis 和 necroptosis 决定血浆膜破裂的不同方法。 | Xin Chen Wan-ting He Lichen Hu Jingxian Li Yuan Fang Xin Wang Xiaozheng Xu Zhuo Wang Kai Huang Jiahuai Han | 2016 | Cell Research2016，26，9： | 110 |
| 2 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 3 | Effects of Tai Ji Quan training on gait kinematics in older Chinese women with knee osteoarthritis: A randomized controlled trial显示文摘Background: Although Tai Ji Quan has been shown to relieve pain and improve functional mobility in people with knee osteoarthritis(OA), little is known about its potential benefits on gait characteristics among older Chinese women who have a high prevalence of both radiographic and symptomatic knee OA. This study aims to assess the efficacy of a tailored Tai Ji Quan intervention on gait kinematics for older Chinese women with knee OA.Methods: A randomized controlled trial involving 46 older women in Shanghai, China, with clinically diagnosed knee OA. Randomized(1:1)participants received either a 60 min Tai Ji Quan session(n = 23) 3 times weekly or a 60 min bi-weekly educational session(n = 23) for 24 weeks.Primary outcomes were changes in gait kinematic measures from baseline to 24 weeks. Secondary outcomes included changes in scores on the Western Ontario and Mc Master University Osteoarthritis Index(WOMAC) and Short Physical Performance Battery(SPPB).Results: After 24 weeks the Tai Ji Quan group demonstrated better performance in gait velocity(mean difference, 8.40 cm/s, p = 0.01), step length(mean difference, 3.52 cm, p = 0.004), initial contact angle(mean difference, 2.19°, p = 0.01), and maximal angle(mean difference, 2.61°,p = 0.003) of flexed knees during stance phase compared to the control group. In addition, the Tai Ji Quan group showed significant improvement in WOMAC scores(p < 0.01)(mean difference,-4.22 points in pain, p = 0.002;-2.41 points in stiffness, p < 0.001;-11.04 points in physical function, p = 0.006) and SPPB scores(mean difference, 1.22 points, p < 0.001).Conclusion: Among older Chinese women with knee OA, a tailored Tai Ji Quan intervention improved gait outcomes. The intervention also improved overall function as indexed by the WOMAC and SPPB. These results support the use of Tai Ji Quan for older Chinese adults with knee OA to both improve their functional mobility and reduce pain symptomatology. | Qingguang Zhu Lingyan Huang Xie Wu Lin Wang Yunya Zhang Min Fang Yu Liu JingXian Li | 2016 | Journal of Sport and Health Science2016，5，3： | 14 |
| 4 | Total pollution effect of urban surface runoff显示文摘For pollution research with regard to urban surface runoff,most sampling strategies to date have focused on differences in land usage. With single land-use sampling,total surface runoffpollution effect cannot be evaluated unless every land usage spot is monitored. Through a new sampling strategy known as mixed stormwater sampling for a street community at discharge outlet adjacent to river,this study assessed the total urban surface runoffpollution effect caused by a variety of land uses and the pollutants washed off from the rain pipe system in the Futian River watershed in Shenzhen City of China.The water quality monitoring indices were COD(chemical oxygen demand),TSS(total suspend solid),TP(total phosphorus),TN(total nitrogen)and BOD(biochemical oxygen demand).The sums of total pollution loads discharged into the river for the four indices of COD,TSS,TN,and TP over all seven rainfall events were very different.The mathematical model for simulating total pollution loads was established from discharge outlet mixed stormwater sampling of total pollution loads on the basis of four parameters:rainfall intensity,total land area,impervious land area,and pervious land area.In order to treat surface runoffpollution,the values of MFF30(mass first flush ratio)and FF30(first 30%of runoffvolume) can be considered as split-flow control criteria to obtain more effective and economical design of structural BMPs(best management practices)facilities. | LUO Hongbing LUO Lin HUANG Gu LIU Ping LI Jingxian HU Sheng WANG Fuxiang XU Rui HUANG Xiaoxue | 2009 | Journal of Environmental Sciences2009，21，9： | 13 |
| 5 | Ultrasonic-assisted Oxidation Leaching of Nickel Sulfide Concentrate显示文摘The feasibility of oxidation leaching process of nickel from nickel sulfide ore and the form of different components in the lixivium has been studied at first. The method of leaching nickel sulfide concentration directly by oxidants with existence of ultrasonic has been advanced. The process of leaching nickel from nickel sulfide concentration by using the system of persulfate and silver has been determined. The influence of different factors on the leaching rates of nickel,such as with and without ultrasonic,the concentration of Na2S2O8,liquid-solid ratio and the concentration of AgNO3 have been explored. The results show that:(1) in the oxidative leaching system,nickel can be leached completely as Ni2+ or NiSO4(aq.) from nickel sulfide concentration in theory;(2) the nicopyrite can not exist steadily in the persulfate acid leaching system,but Ni2+can. Meanwhile,sulfur may be existed steadily in the leaching process;(3) nicopyrite with much lower electrostatic potential may be leached earlier than chalcopyrite and sideropyrite;and(4) the overall reaction rate of the leaching process can be enhanced with ultrasonic radiation,but it does not change the mechanism of leaching. The more oxidant concentration or higher liquid-solid ratio is,the higher leaching percentage of nickel. The leaching percentage of nickel can be increased significantly by adding a small amount of AgNO3 during the leaching processes. Under the same conditions,the higher concentration of AgNO3 is,the higher leaching yields of nickel will be obtained. | XUE Juanqin LU Xi DU Yewei MAO Weibo WANG Yujie LI Jingxian | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 12 |
| 6 | Experimental investigation on drag reduction in turbulent boundary layer over superhydrophobic surface by TRPIV显示文摘This study aims at the mechanism of drag reduction in turbulent boundary layer(TBL) with superhydrophobic surface.Comparing the time-resolved particle image velocimetry(TRPIV) measurement results with that of hydrophilic surface,the drag reduction rate over a superhydrophobic surface is approximately10%.To investigate the characteristics of coherent structure in a drag-reduced TBL with superhydrophobic surface,a modified multi-scale spatial locally-averaged structure function is proposed for detecting coherent structure.The conditional sampling and spatial phase-lock average methods are employed to obtain the topology of physical quantities like the velocity fluctuation,spanwise vorticity,and Reynolds stress during eject and sweep process.The results indicate that the suppression of coherent structure burst in the near-wall region is the key mechanism in reducing the skin friction drag for TBL over superhydrophobic surface. | Haiping Tian Jingxian Zhang Erdan Wang Zhaohui Yao Nan Jiang | 2015 | Theoretical & Applied Mechanics Letters2015，5，1： | 7 |
| 7 | Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization显示文摘甾醇规章的元素绑定蛋白质(SREBP ) 抄写因素是在哺乳动物和在真菌的 hypoxic 改编的氧应答的管理者的细胞的类脂化合物动态平衡的主人管理者。SREBP C 终点绑在 SREBP 激活劈开的蛋白质(SCAP ) 的 WD40 领域,它由在 Golgi 控制到激活的朊酶的 SREBP-SCAP 建筑群和存取的 ER-to-Golgi 运输授与甾醇规定。这里,我们生物化学地并且在结构上表演 Sre1 和 Scp1,分裂酵母 SREBP 和 SCAP 的 carboxyl 终端域(CTD ) ,形成功能的 4:4 oligomer 和 Sre1-CTD 形式一 dimers 更暗淡。在 3.5 Å 的 Sre1-CTD 的水晶结构;并且在 5.4 Å 的建筑群的 cryo 他们结构;和在 vitro 生物化学的证据阐明在为 Scp1 绑定, Sre1-CTD dimerization 和 tetrameric 要求的 Sre1-CTD 的三个不同区域形成。最后,这些在结构上鉴别领域在细胞的上下文被验证,证明合适的 4:4 oligomeric 建筑群形成为 Sre1 激活被要求。 | Xin Gong Hongwu Qian Wei Shao Jingxian Li Jianping Wu Jun-Jie Liu Wenqi Li Hong-Wei Wang Peter Espenshade Nieng Yan | 2016 | Cell Research2016，26，11： | 6 |
| 8 | Laboratory evaluation of cement treated aggregate containing crushed clay brick显示文摘The waste clay bricks fromdebris of buildings were evaluated through lab tests as environmental friendly materials for pavement sub-base in the research. Five sets of coarse aggregates which contained 0,25%,50%,75% and 100% crushed bricks,respectively,were blended with sand and treated by 5% cement. The test results indicated that cement treated aggregate which contains crushed clay brick aggregate had a lower maximumdry density( M DD) and a higher optimummoisture content( OMC). Moreover,the unconfined compressive strength( UCS),resilience modulus,splitting strength,and frost resistance performance of the specimens decreased with increase of the amount of crushed clay brick aggregate. On the other hand,it can be observed that the use of crushed clay brick in the mixture decreased the dry shrinkage strain of the specimens. Compared with the asphalt pavement design specifications of China,the results imply that the substitution rate of natural aggregate with crushed clay brick aggregate in the cement treated aggregate sub-base material should be less than 50%( 5% cement content in the mixture). Furthermore,it needs to be noted that the cement treated aggregate which contains crushed clay bricks should be cautiously used in the cold region due to its insufficient frost resistance performance. | Liqun Hu Jingxian Hao Linbing Wang | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，5： | 6 |
| 9 | Large-area high quality PtSe2 thin film with versatile polarity显示文摘Two-dimensional(2D)materials have attracted increasing attention for their outstanding structural and electrical properties.However,for mass-production of field effect transistors(FETs)and potential applications in integrated circuits,large-area and uniform 2D thin films with high mobility,large on-off ratio,and desired polarity are needed to synthesize firstly.Here,a transfer-free growth method for platinum diselenide(PtSe2)films has been developed.The PtSe2 films have been synthesized with various thicknesses in centimeter-sized scale.Typical FET made from a few layer PtSe2 show p-type unipolar,with a high field-effect hole mobility of 6.2 cm^(2) V^(−1) s^(−1) and an on-off ratio of 5×10^(3).The versatile semimetal-unipolar-ambipolar transition in synthesized PtSe2 films is also firstly observed as the thickness thinning.This work realizes the large-scale preparation of PtSe2 with prominent electrical properties and provides a new strategy for polarity's modulation. | Wei Jiang Xudong Wang Yan Chen Guangjian Wu Kun Ba Ningning Xuan Yangye Sun Peng Gong Jingxian Bao Hong Shen Tie Lin Xiangjian Meng Jianlu Wang Zhengzong Sun | 2019 | InfoMat2019，1，2： | 5 |
| 10 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 11 | Nanotechnologies for enhancing cancer immunotherapy显示文摘Immunotherapy,a burgeoning field differs from traditional cancer treatments,is revolutionizing oncologic therapeutics.It aims to stimulate the innate and adaptive immune system of a patient to fight against tumor cells.However,low response rate and immune-related adverse effects(irAEs)remain problems during its management.A novel technology using nanomaterials may bring a solution.Various nanoparticles have been investigated as delivery systems to augment cancer therapeutic efficacy in the lab and clinic.In this review,we briefly summarize the connotation of immunotherapy,the application of nanotechnology in cancer,especially focusing on the synergistic effect of nanoplatform-based technology combined with cancer immunotherapy,hoping to make readers a deep insight into this interdisciplinary field. | Jingxian Yang Chunhui Wang Shuo Shi Chunyan Dong | 2020 | Nano Research2020，13，10： | 4 |
| 12 | Monitoring paddy rice phenology using time series MODIS data over Jiangxi Province,China显示文摘Paddy rice is one of the most important crops in the world.Accurate estimation and monitoring of paddy rice phenology is necessary for management and yield prediction.Remotely sensed time-series data are essential for estimation of crop phenology stages across large areas.Here,the paddy rice phenological stages(i.e.,transplanting,tillering,heading,and harvesting)were detected in Jiangxi Province,China.A comparison study was conducted using ground observation data from 10 agricultural meteorological stations,collected between 2006 and 2008.The phenological stages were detected using Moderate Resolution Imaging Spectroradiometer(MODIS)time-series enhanced vegetation index(EVI)data.Savitzky-Golay filter and wavelet transform were used to reduce the noise in the time-series EVI data and reconstruct the smoothed EVI time-series profile.Key phenological stages of double-cropping rice were detected using the characteristics of the smoothed EVI profile.The root mean square errors(RMSEs)for each stage were ±10 days around the ground observation data.The results suggest that Savitzky-Golay filter and wavelet transform are promising approaches for reconstructing high-quality EVI time-series data.Moreover,the phenological stages of double-cropping rice could be detected using time-series MODIS EVI data smoothed by Savitzky-Golay filter and wavelet transform. | Li Shihua Xiao Jiangtao Ni Ping Zhang Jing Wang Hongshu Wang Jingxian | 2014 | International Journal of Agricultural and Biological Engineering2014，7，6： | 3 |
| 13 | Presence of estrogenic activity from emission of fossil fuel combustion as detected by a recombinant yeast bioassay 显示文摘 | Wang Jingxian Wu Wenzhong | 2003 | Atmospheric Environment2003，37，： | 1 |
| 14 | Effect of laser remelting on corrosion behavior of plasma-sprayed Ni-coated WC coatings显示文摘 | Xie Guozhi Zhang Jingxian Lu Yijun Wang Keyu Mo Xiangyin Lin Pinghua | 2007 | Materials Science & Engineering A2007，，： | 1 |
| 15 | Rapid and complete dechlorination of PCP in aqueous solution using Ni-Fe nanoparticles under assistance of ultrasound,Chemosphere显示文摘 | Zhang Weihua Quan Xie Wang Jingxian | 2006 | 65(1):58-642006，65，1： | 1 |
| 16 | A1 and/or Ni-doped nanomanganese dioxide with anisotropic expan- sion and their electrochemical characterisation in primary Li-MnO2 batteries 显示文摘 | Zeng Jian Wang Shengping Yu Jingxian | 2014 | Journal of Solid State Electro- chemistry2014，18，6： | 1 |
| 17 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 18 | Removal of airborne nanoparlides by membrane coated filters显示文摘 | Jingxian Liu David Y H Pui Jing Wang | 2011 | Science of the To- tal Environment2011，409，22： | 1 |
| 19 | Presence of estrogenic activity from emission of fossil fuel combustion as detected by a recombinant yeast bioassay显示文摘 | Wang Jingxian Wu Wenzhong Berhard Henkelmann | 2003 | Atmospheric Environment2003，，37： | 1 |
| 20 | De- temination of PAH, PCB, and OCP in water from the Three Gorges Reservoir accumulated by semipermeable membrane devices ( SPMD ) 显示文摘 | WANG Jingxian BI Yonghong PFISTER G | 2009 | Chemosphere2009，75，8： | 1 |
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