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| 1 | Association of H.pylori infection with gastric carcinoma:a Meta analysis显示文摘AIM: To follow the principles of evidence based medicine to reach the integrated results of these studies.METHODS: Twenty-one papers of case-control studies were selected, including 11 on gastric cancer, 7 on precancerous lesion of stomach and 3 on lymphoma of stomach: Meta analysis was used to sum up the odds ratios (OR) of these studies.RESULTS: H. Pylori vsgastric cancer (intestinal and diffuse type): the odds ratio from the fixed effect model is 3.0016(95% Cl 2.4197-3.7234, P < 0.001 ). H. Pylori vs precancerous lesion of stomach: a random effect model was used to calculate the summary odds ratio and its value is 2.5635 (95% Cl: 1.8477-3.5566, P < 0.01). H. Pylori vs lymphoma of stomach: though the quantity of literature is too small to make Meta analysis, the data of these 3 studies show that lymphoma of stomach is highly associated with H. Pylori infections.CONCLUSION: Since it had been revealed that H. Pylori infection pre-exists in gastric carcinoma and precancerous lesions, the results of Meta analysis present a strong evidence to support the conclusion that H. Pylori infection is a risk factor for gastric carcinoma. | Fu-Bo Xue~1 Yong-Yong Xu~1 Yi Wan~1 Bo-Rong Pan~2 Jun Ren~2 Dai-Ming Fan~3 1 Department of Health Statistics,Department of2 Oncology3 Gastroenterology of XiJing Hospital,the Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2001 | World Journal of Gastroenterology2001，7，6： | 66 |
| 2 | DIAGNOSIS AND TREATMENT OF CESAREAN SCAR PREGNANCY显示文摘Objective To investigate the early diagnosis and treatment of cesarean scar pregnancy(CSP).Methods Clinical data of 28 patients with CSP in Peking Union Medical College Hospital from January 1994 to April 2007,including age,interval from the last cesarean delivery to diagnosis,clinical presentation,location of the lesion,process of diagnosis and treatment,outcome,and follow-up,were retrospectively analyzed.Results CSP constituted 1.05% of all ectopic pregnancies,and the ratio of CSP to pregnancy was 1∶1221.The mean age of the group was 31.4 years.Twenty-six women had only one prior cesarean delivery.The interval from the last cesarean delivery to diagnosis ranged from 4 months to 15 years.The most common presenting symptoms of CSP were amenorrhoea and vaginal bleeding.Seventeen cases were misdiagnosed as early intrauterine pregnancies and 2 were misdiagnosed as gestational trophoblastic tumor.The other 9 were diagnosed definitely before treatment.The diagnosis was made based on cesarean delivery history,gynecologic examination,ultrasound,and magnetic resonance imaging(MRI).The treatment of CSP included systemic or local methotrexate administration,conservative surgery,and hysterectomy.The conservative treatment was successful in 24 cases.All of the 28 women were cured through individual therapies.Conclusions CSP is rare and usually misdiagnosed as other diseases.Ultrasound is valuable for diagnosing CSP,and MRI can be used as an adjunct to ultrasound scan.Early diagnosis offers the options of conservative treatment and greatly improves the outcome of patients.Individual therapy is strongly recommended. | Lan-zhou Jiao Jun Zhao Xi-run Wan Xin-yan Liu Feng-zhi Feng Tong Ren Yang Xiang | 2008 | Chinese Medical Sciences Journal2008，23，1： | 65 |
| 3 | The age of the base of the Paleoproterozoic Hutuo Group in the Wutai Mountains area, North China Craton: SHRIMP zircon U-Pb dating of basaltic andesite显示文摘Basalt and basaltic andesite metamorphosed at greenschist facies occurs with conglomerate layers at the bottom of the Paleoproterozoic Hutuo Group in the Wutai Mountains area, North China Craton. Detailed geological surveying confirms that these volcanic rocks are conformable within the neighboring sedimentary rocks. The SHRIMP results on basaltic andesite are divided into two groups. In one group the 207Pb/206Pb ages are from 2433 to 2558 Ma, which is consistent with the basement crustal age in Fuping and Wutai areas. In the other group, 13 grains yielded a weighted mean 207Pb/206Pb age of 2140±14 Ma. The latter is interpreted as the eruption age of the basaltic andesite, and gives the age of the base of the Hutuo Group. This result further suggests that the Hutuo Group formed in the middle Paleoproterozoic, not the early Palaeoproterozoic or late Archaean, as thought before, and is related to a 2.2-2.1 Ga rifting event in the Central North China Craton. | DU LiLin YANG ChongHui GUO JingHui WANG Wei REN LiuDong WAN YuSheng GENG YuanSheng | 2010 | Chinese Science Bulletin2010，55，17： | 43 |
| 4 | Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage显示文摘Intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity. However, we have few options for ICH therapy and limited knowledge about post-ICH neuronal death and related mechanisms. In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. Indeed, iron chelation therapy has shown efficacy in preclinical ICH studies. Recently, an iron-dependent form of non-apoptotic cell death known as ferroptosis was identified. It is characterised by an accumulation of iron-induced lipid ROS, which leads to intracellular oxidative stress. The ROS cause damage to nucleic acids, proteins and lipid membranes, and eventually cell death. Recently, we and others discovered that ferroptosis does occur after haemorrhagic stroke in vitro and in vivo and contributes to neuronal death. Inhibition of ferroptosis is beneficial in several in vivo and in vitro ICH conditions. This minireview summarises current research on iron toxicity, lipid peroxidation and ferroptosis in the pathomechanisms of ICH, the underlying molecular mechanisms of ferroptosis and the potential for combined therapeutic strategies. Understanding the role of ferroptosis after ICH will provide a vital foundation for cell death-based ICH treatment and prevention. | Jieru Wan Honglei Ren Jian Wang | 2019 | Stroke & Vascular Neurology2019，4，2： | 32 |
| 5 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 6 | Optimization of stratification scheme for a fishery-independent survey with multiple objectives显示文摘Fishery-independent surveys are often used for collecting high quality biological and ecological data to support fisheries management. A careful optimization of fishery-independent survey design is necessary to improve the precision of survey estimates with cost-effective sampling efforts. We developed a simulation approach to evaluate and optimize the stratification scheme for a fishery-independent survey with multiple goals including estimation of abundance indices of individual species and species diversity indices. We compared the performances of the sampling designs with different stratification schemes for different goals over different months. Gains in precision of survey estimates from the stratification schemes were acquired compared to simple random sampling design for most indices. The stratification scheme with five strata performed the best. This study showed that the loss of precision of survey estimates due to the reduction of sampling efforts could be compensated by improved stratification schemes, which would reduce the cost and negative impacts of survey trawling on those species with low abundance in the fishery-independent survey. This study also suggests that optimization of a survey design differed with different survey objectives. A post-survey analysis can improve the stratification scheme of fishery-independent survey designs. | XU Binduo REN Yiping CHEN Yong XUE Ying ZHANG Chongliang WAN Rong | 2015 | Acta Oceanologica Sinica2015，34，12： | 21 |
| 7 | Degradation of pyrene by immobilized microorganisms in saline-alkaline soil显示文摘Biodegradation of polycyclic aromatic hydrocarbons(PAHs) is very difficult in saline-alkaline soil due to the inhibition of microbial growth under saline-alkaline stress.The microorganisms that can most effectively degrade PAHs were screened by introducing microorganisms immobilized on farm byproducts and assessing the validity of the immobilizing technique for PAHs degradation in pyrene-contaminated saline-alkaline soil.Among the microorganisms examined,it was found that Mycobacterium sp.B2 is the best,and can degrade 82.2% and 83.2% of pyrene for free and immobilized cells after 30 days of incubation.The immobilization technique could increase the degradation of pyrene significantly,especially for fungi.The degradation of pyrene by the immobilized microorganisms Mucor sp.F2,fungal consortium MF and co-cultures of MB+MF was increased by 161.7%(P < 0.05),60.1%(P < 0.05) and 59.6%(P < 0.05) after 30 days,respectively,when compared with free F2,MF and MB+MF.Scanning electron micrographs of the immobilized microstructure proved the positive effects of the immobilized microbial technique on pyrene remediation in salinealkaline soil,as the interspace of the carrier material structure was relatively large,providing enough space for cell growth.Co-cultures of different bacterial and fungal species showed different abilities to degrade PAHs.The present study suggests that Mycobacterium sp.B2 can be employed for in situ bioremediation of PAHs in saline-alkaline soil,and immobilization of fungi on farm byproducts and nutrients as carriers will enhance fungus PAH-degradation ability in saline-alkaline soil. | Shanxian Wang Xiaojun Li Wan Liu Peijun Li Lingxue Kong Wenjie Ren Haiyan Wu Ying Tu | 2012 | Journal of Environmental Sciences2012，24，9： | 19 |
| 8 | Humoral and cellular immunogenecity of DNA vaccine based on hepatitis B core gene in rhesus monkeys显示文摘INTRODUCTIONHepatitis B virus (HBV) is the most commonetiologic agent for infectious liver diseases. It isestimated that there are more than 250 millionchronic HBV carriersin the world today and thereis a significant association among persistentinfection, liver cirrhosis and hepatocellularcarcinoma[1-3]. | Zu Hu Huang1 Hui Zhuang2 Shan Lu3 Ren Hua Guo1 Guo Min Xu2 Jie Cai1 Wan Fu Zhu2 1Department of Infectious Diseases. The First Affiliated Hospital of Nanjing Medical University, Nenjing 210029, Jiangsu Province. China2Faculty of Microbiology, Beijing University, Beijing 100000, China3University of Massachusetts Medical Center | 2001 | World Journal of Gastroenterology2001，7，1： | 19 |
| 9 | OsVPS9A Functions Cooperatively with OsRAB5A to Regulate Post-Golgi Dense Vesicle-Mediated Storage Protein Trafficking to the Protein Storage Vacuole in Rice Endosperm Cells显示文摘在米饭内乳房间, glutelins 作为 proglutelins 在不平的 endoplasmic 蜂窝胃上被综合并且被排序到称为蛋白质身体 II (PBII ) 的 theprotein 存储液泡(PSV ) ,在他们被变换成成熟形式的地方。稠密的泡(DV ) 调停了在大米种子的 proglutelins 的 trafficking 被建议了,但是这个过程的 post-Golgi 控制是 largelyunknown。DV 是否能与 PSV 直接熔化,是争论的另一件事。在这研究,我们建议规章的 mechanismunderlying 调停 DV, post-Golgi proglutelin trafficking 到 PBII (PSV ) 。gpa2, OsVPS9A 的 loss-of-function 异种,编码 OsRAB5A 的 GEF,积累了 uncleaved proglutelins。Proglutelins 对到沿着在 DV 形式的房间墙的 apoplast 的 paramural bodiesand 指向 mis,它在 PBII 尺寸导致了伴随物减小。Previouslyreported gpa1,在 OsRab5a 变异,有类似的显型,当时两倍异种加重了的 gpa1gpa2 条件。另外, OsVPS9A 在 vitro 并且在 vivo 与 OsRAB5A 交往了。我们断定 OsVPS9A 和 OsRAB5A 可以一起工作并且在调停 DV 的 post-Golgi proglutelintrafficking 起一个规章的作用到 PBII (PSV ) 。DV 可能直接熔化到 PBII (PSV ) 交付货物的证据也是 presented.Key 词: | Feng Liu Yulong Ren Yihua Wang Cheng Peng Kunneng Zhou Jia Lv Xiuping Guo Xin Zhang Jianmin wan Yiqun Bao | 2013 | Molecular Plant2013，6，6： | 16 |
| 10 | Identification Standard for ENSO Events and Its Application to Climate Monitoring and Prediction in China显示文摘The El Ni?o–Southern Oscillation(ENSO)reflects anomalous variations in the sea surface temperature(SST)and atmospheric circulation over the tropical central–eastern Pacific.It remarkably impacts on weather and climate worldwide,so monitoring and prediction of ENSO draw intensive research.However,there is not yet a unique standard internationally for identifying the timing,intensity,and type of ENSO events.The National Climate Center of China Meteorological Administration(NCC/CMA)has led the effort to establish a national identification standard of ENSO events,which was officially endorsed by the National Standardization Administration of China and implemented operationally in NCC/CMA in 2017.In this paper,two key aspects of this standard are introduced.First,the Ni?o3.4 SST anomaly index,which is well-recognized in the international ENSO research community and used operationally in the US,has replaced the previous Ni?o Z index and been used to identify the start,end,and peak times,and intensity of ENSO events.Second,two new indices—the eastern Pacific ENSO(EP)index and the central Pacific ENSO(CP)index,based on the SST conditions in Ni?o3 and Ni?o4 region respectively,are calculated to first determine the ENSO type before monitoring and assessing the impacts of ENSO on China’s climate.With this standard,all historical ENSO events since 1950 are consistently re-identified;their distinct properties are diagnosed and presented;and the impacts of ENSO events under different types on China’s climate are re-assessed.This standard is also employed to validate the intensity,grade,and type of the ENSO events predicted by the NCC/CMA operational ENSO prediction system.The new standard and the thus derived unified set of re-analyzed historical ENSO events and associated information provide a good reference for better monitoring and prediction of future ENSO events. | Hong-Li REN Bo LU Jianghua WAN Ben TIAN Peiqun ZHANG | 2018 | Journal of Meteorological Research2018，32，6： | 16 |
| 11 | Coping as a Mechanism Linking Stressful Life Events and Mental Health Problems in Adolescents显示文摘Objective Although stressful life events represent an etiologic factor of mental health problems in adolescents,few studies have been conducted to address mechanisms linking the stress‐psychopathology relation.The present study was designed to examine coping as a mediate factor on the relationship between stressful life events and symptoms of anxiety and depression.Methods The participants were 13 512 students from eight cities of China,who participated in a school‐based survey.Data were collected by a questionnaire comprising coping,stressful life events,anxiety,and depressive symptoms.As a model,a series of regression equations were used to examine whether coping mediated the association between stressful life events and symptoms of anxiety and depression.Results Each dimension of stressful life events showed significant correlation with anxiety,depression and coping (all P<0.001).In the model to analyze mediate effects,all standardized coefficients (β) were significant (all P<0.01),indicating marked mediator effects.Furthermore,negative coping might account for more mediate effects than positive coping on this relationship.Conclusion Coping partially mediated the relationship between stressful life events and mental health during adolescence.This study highlighted an important public health priority for preventive interventions targeting stress‐related psychopathology,and for further promoting adolescents'mental health. | MENG Xiu Hong TAO Fang Biao WAN Yu Hui HU Yan WANG Ren Xi | 2011 | Biomedical and Environmental Sciences2011，24，6： | 16 |
| 12 | The China Multi-Model Ensemble Prediction System and Its Application to Flood-Season Prediction in 2018显示文摘Multi-model ensemble prediction is an effective approach for improving the prediction skill short-term climate prediction and evaluating related uncertainties. Based on a combination of localized operation outputs of Chinese climate models and imported forecast data of some international operational models, the National Climate Center of the China Meteorological Administration has established the China multi-model ensemble prediction system version 1.0 (CMMEv1.0) for monthly-seasonal prediction of primary climate variability modes and climate elements. We verified the real-time forecasts of CMMEv1.0 for the 2018 flood season (June-August) starting from March 2018 and evaluated the 1991-2016 hindcasts of CMMEv1.0. The results show that CMMEv1.0 has a significantly high prediction skill for global sea surface temperature (SST) anomalies, especially for the El Nino-Southern Oscillation (ENSO) in the tropical central-eastern Pacific. Additionally, its prediction skill for the North Atlantic SST triple (NAST) mode is high, but is relatively low for the Indian Ocean Dipole (IOD) mode. Moreover, CMMEv1.0 has high skills in predicting the western Pacific subtropical high (WPSH) and East Asian summer monsoon (EASM) in the June-July-August (JJA) season. The JJA air temperature in the CMMEv1.0 is predicted with a fairly high skill in most regions of China, while the JJA precipitation exhibits some skills only in northwestern and eastern China. For real-time forecasts in March-August 2018, CMMEv1.0 has accurately predicted the ENSO phase transition from cold to neutral in the tropical central-eastern Pacific and captures evolutions of the NAST and IOD indices in general. The system has also captured the main features of the summer WPSH and EASM indices in 2018, except that the predicted EASM is slightly weaker than the observed. Furthermore, CMMEv1.0 has also successfully predicted warmer air temperatures in northern China and captured the primary rainbelt over northern China, except that it predicted much more precipitation in the middle and lower reaches of the Yangtze River than observation. | Hong-Li REN Yujie WU Qing BAO Jiehua MA Changzheng LIU Jianghua WAN Qiaoping LI Xiaofei WU Ying LIU Ben TIAN Joshua-Xiouhua FU Jianqi SUN | 2019 | Journal of Meteorological Research2019，33，3： | 16 |
| 13 | A Novel Chloroplast-Localized Pentatricopeptide Repeat Protein Involved in Splicing Affects Chloroplast Development and Abiotic Stress Response in Rice显示文摘Pentatricopeptide 重复(PPR ) 蛋白质在更高的植物包括一个大家庭并且在 organellar RNA 新陈代谢的各种各样的方面调制 organellar 基因表示 byparticipating。在米饭,家庭包含他们的功能仍然是的 477 个成员,和 majorityof 不清楚。在这研究,我们孤立并且描绘米饭变异的、白条纹叶(wsl ) ,它在开发早的显示萎黄病有条纹或刻痕之状态。基于地图的克隆表明 WSL 编码指向叶绿体的最新识别的米饭 PPR 蛋白质。在 wsl 异种,锐气依赖者质体基因表示是显著地下面调整的,并且质体 rRNAs 和翻译 productsaccumulate 到很底层。一致地与观察, wsl 在叶绿体抄本 rpl2 拼接显示出一个强壮的缺点,在异种导致异常抄本累积和它的产品减小。wsl 显示出提高的敏感到骆驼毛的织物,咸度,和糖,并且它积累更多的 H 2 O 2 比野类型。这些结果建议减少的翻译效率可以影响异种的反应到 abioticstress.Key 词: | Junjie Tan Zhenhua Tan Fuqing Wu Peike Sheng Yueqin Heng Xinhua Wang Yulong Ren Jiulin Wang Xiuping Guo Xin Zhang Zhijun Cheng Ling Jiang Xuanming Liu Haiyang Wang Jianmin Wan | 2014 | Molecular Plant2014，7，8： | 15 |
| 14 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 15 | Modeling the global ionospheric total electron content with empirical orthogonal function analysis显示文摘In the present work we model the global ionospheric total electron content (TEC) with the analysis of empirical orthogonal functions (EOF). The obtained statistical eigen modes, which makeup the modeled TEC, consist of two factors: the eigen vectors mapping TEC patterns at latitude and longitude (or local time LT), and the corresponding coefficients displaying the TEC variations in different time scales, i.e., the solar cycle, the yearly (annual and semiannual) and the diurnal universal time variations. It is found that the EOF analysis can separate the TEC variations into chief processes and the first two modes illustrate the most of the ionospheric climate properties. The first mode contains both the semiannual component which shows the semiannual ionospheric anomaly and the annual component which shows the annual or non-seasonal ionospheric anomaly. The second mode contains mainly the annual component and shows the normal seasonal ionospheric variation at most latitudes and local time sectors. The annual component in the second mode also manifests seasonal anomaly of the ionosphere at higher mid-latitudes around noontime. It is concluded that the EOF analysis, as a statistical eigen mode method, is resultful in analyzing the ionospheric climatology hence can be used to construct the empirical model for the ionospheric climatology. | WAN WeiXing DING Feng REN ZhiPeng ZHANG ManLian LIU LiBo NING BaiQi | 2012 | Science China(Technological Sciences)2012，55，5： | 15 |
| 16 | The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1 (RNMTL1) gene, a newly discovered 17p13.3 gene显示文摘The human RNA methyltransferase like i gene (RNMTL1) is one of thirteen newly discovered geneswithin a 116 Kb segment of the chromosome 17p13.3 that suffers from a high frequent loss of heterozygosityin human hepatocellular carcinoma in China[1-5]. To understand the molecular mechanisms underlyingtranscription control of the RNMTL1 gene in human cancers, we decline using of the conventional approachwhere the cis-elements bound by the known transcription factors are primary targets, and carried out thesystematic analyses to dissect the promoter structure and identify/characterize the key cis-elements thatare responsible for its strong expression in cell. The molecular approaches applied included 1, the primerextension for mapping of the transcription starts; 2, the transient transfection/reporter assays on a largenumber of deletion and site-specific mutants of the promoter segment for defining the minimal promoterand the crucial elements within; and 3, the electrophoresis mobility shift assay with specific antibodies forreconfirming the nature of the transcription factors and their cognate cis-elements. We have shown that theinteraction of an ATF/CREB element (-38 to -31) and its cognate transcription factors play a predominantrole in the promoter activity of the RNMTL1 gene. The secondary DNA structures of the ATF/CREBelement play a more vital role in the protein-DNA interaction. Finally, we reported a novel mechanismunderlying the YY1 mediated transcription repression, namely, the ATF/CREB dependent transcription-repression by YY1 is executed in absence of its own sequence-specific binding. | JIAN XU JING DE ZHU MIN NI DA FANG WAN JIAN REN GU | 2002 | Cell Research2002，12，4： | 14 |
| 17 | Diversity characterization and association analysis of agronomic traits in a Chinese peanut (Arachis hypogaea L.) mini-core collection显示文摘Association mapping is a powerful approach for exploring the molecular basis of phenotypic variations in plants.A peanut(Arachis hypogaea L.)mini-core collection in China comprising 298 accessions was genotyped using 109 simple sequence repeat(SSR)markers,which identified 554 SSR alleles and phenotyped for 15 agronomic traits in three different environments,exhibiting abundant genetic and phenotypic diversity within the panel.A model-based structure analysis assigned all accessions to three groups.Most of the accessions had the relative kinship of less than 0.05,indicating that there were no or weak relationships between accessions of the mini-core collection.For 15 agronomic traits in the peanut panel,generally the Q t K model exhibited the best performance to eliminate the false associated positives compared to the Q model and the general linear model-simple model.In total,89SSR alleles were identified to be associated with 15 agronomic traits of three environments by the Q t K model-based association analysis.Of these,eight alleles were repeatedly detected in two or three environments,and 15 alleles were commonly detected to be associated with multiple agronomic traits.Simple sequence repeat allelic effects confirmed significant differences between different genotypes of these repeatedly detected markers.Our results demonstrate the great potential of integrating the association analysis and marker-assisted breeding by utilizing the peanut mini-core collection. | Huifang Jiang Li Huang Xiaoping Ren Yuning Chen Xiaojing Zhou Youlin Xia Jiaquan Huang Yong Lei Liying Yan Liyun Wan Boshou Liao | 2014 | Journal of Integrative Plant Biology2014，56，2： | 14 |
| 18 | Grazing effects on herbage nutritive values depend on precipitation and growing season in Inner Mongolian grassland显示文摘Aims Grasslands are widely used for production of livestock,which depend on the nutritive value of herbage species.However,there are still large uncertainties as to how grazing,precipitation and growing season interactively affect herbage nutritive value.Methods Here,based on a grazing experiment with seven grazing intensities in an Inner Mongolian grassland since the year 2005,we analysed nutritive value of four dominant grass species from June to September in both a relatively wetter year(2008)and a drier year(2010).Herbage with high nutritive value is characterized by high concentration of crude protein,high concentration of cellulase digestible organic matter and low concentration of neutral detergent fibre.Important Findings We found that(i)grazing significantly increased the nutritive value of Leymus chinensis,Agropyron michnoi and Cleistogenes squarrosa but had minor effects on the nutritive value of Stipa grandis.(ii)For all species,nutritive values were greater in the wetter year than in the drier year and were greatest in the early growing season(June)and lowest at the end of the growing season(September).Inter-annual and inter-seasonal variations in nutritive value were much greater for L.chinensis and A.michnoi than for C.squarrosa and S.grandis,suggesting higher water use efficiency for the latter two species.(iii)Grazing significantly decreased the drought resistance of three species,but not of S.grandis.(iv)Grazing significantly increased inter-month variation in nutritive value for L.chinensis and A.michnoi but had relatively minor or no effects on that of C.squarrosa and S.grandis.Therefore,grazing effects on species nutritive values showed strong inter-annual and seasonal patterns,and species-specific responses might be related to species traits(i.e.water use efficiency,digestibility).Our results have important implications for ecosystem management of arid and semiarid grasslands under intense grazing and global climatic change. | Haiyan Ren Guodong Han Zhichun Lan Hongwei Wan Philipp Schönbach Martin Gierus Friedhelm Taube | 2016 | Journal of Plant Ecology2016，9，6： | 14 |
| 19 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 20 | Prediction of Primary Climate Variability Modes at the Beijing Climate Center显示文摘Climate variability modes, usually known as primary climate phenomena, are well recognized as the most important predictability sources in subseasonal–interannual climate prediction. This paper begins by reviewing the research and development carried out, and the recent progress made, at the Beijing Climate Center(BCC) in predicting some primary climate variability modes. These include the El Ni?o–Southern Oscillation(ENSO), Madden–Julian Oscillation(MJO), and Arctic Oscillation(AO), on global scales, as well as the sea surface temperature(SST) modes in the Indian Ocean and North Atlantic, western Pacific subtropical high(WPSH), and the East Asian winter and summer monsoons(EAWM and EASM, respectively), on regional scales. Based on its latest climate and statistical models, the BCC has established a climate phenomenon prediction system(CPPS) and completed a hindcast experiment for the period 1991–2014. The performance of the CPPS in predicting such climate variability modes is systematically evaluated. The results show that skillful predictions have been made for ENSO, MJO, the Indian Ocean basin mode, the WPSH, and partly for the EASM, whereas less skillful predictions were made for the Indian Ocean Dipole(IOD) and North Atlantic SST Tripole, and no clear skill at all for the AO, subtropical IOD, and EAWM. Improvements in the prediction of these climate variability modes with low skill need to be achieved by improving the BCC's climate models, developing physically based statistical models as well as correction methods for model predictions.Some of the monitoring/prediction products of the BCC-CPPS are also introduced in this paper. | Hong-Li REN Fei-Fei JIN Lianchun SONG Bo LU Ben TIAN Jinqing ZUO Ying LIU Jie WU Chongbo ZHAO Yu NIE Peiqun ZHANG Jin BA Yujie WU Jianghua WAN Yuping YAN Fang ZHOU | 2017 | Journal of Meteorological Research2017，31，1： | 13 |
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