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| 1 | L-3-n-butylphthalide protects against vascular dementia via activation of the Akt kinase pathway显示文摘As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute ischemic stroke. The activated Akt kinase pathway can prevent the death of nerve cells and exhibit neuroprotective effects in the brain after stroke. This study provides the hypothesis that l-3-n-butylphthalide has a certain therapeutic effect on vascular dementia, and its mechanism depends on the activation of the Akt kinase pathway. A vascular dementia mouse model was established by cerebral repetitive ischemia/reperfusion, and intragastrically administered l-3-n-butylphthalide daily for 28 consecutive days after ischemia/reperfusion, or 7 consecutive days before ischemia/reperfusion. The Morris water maze test showed significant impairment of spatial learning and memory at 4 weeks after operation, but intragastric administration of l-3-n-butylphthalide, especially pretreatment with l-3-n-butylphthalide, significantly reversed these changes. Thionine staining and western blot analylsis showed that preventive and therapeutic application of l-3-n-butylphthalide can reduce loss of pyramidal neurons in the hippocampal CA1 region and alleviate nerve damage in mice with vascular demen-tia. In addition, phosphorylated Akt expression in hippocampal tissue increased significantly after l-3-n-butylphthalide treatment. Experimental findings demonstrate that l-3-n-butylphthalide has preventive and therapeutic effects on vascular dementia, and its mechanism may be mediated by upregulation of phosphorylated Akt in the hippocampus. | Yaping Huai Yanhong Dong Jing Xu Nan Meng Chunfeng Song Wenbin Li Peiyuan Lv | 2013 | Neural Regeneration Research2013，8，19： | 17 |
| 2 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 3 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 4 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 5 | Review-material degradation assessed by digital image processing:Fundamentals,progresses,and challenges显示文摘Material degradation is accompanied by the changes in surface structure,morphology,and composition.These changes can be recorded by a variety of image acquisition devices that export digital images in grayscale or true color to a detector.Information regarding corrosion type and extent can be extracted with image processing methods.This paper provides a comprehensive review of material degradation assessed by digital image processing.Digital image processing systems used to assess material degradation are briefly reviewed,and the algorithms developed to process metallic materials degradation images are described.Physical and electrochemical methods that can be used to support digital image processing results are summarized,and future work that will augment the present methods of evaluating material degradation are discussed. | Da-Hai Xia Shizhe Song Lei Tao Zhenbo Qin Zhong Wu Zhiming Gao Jihui Wang Wenbin Hu Yashar Behnamian Jing-Li Luo | 2020 | Journal of Materials Science & Technology2020，52，18： | 8 |
| 6 | The Assessment of Global Surface Temperature Change from 1850s:The C-LSAT2.0 Ensemble and the CMST-Interim Datasets显示文摘Based on C-LSAT2.0,using high-and low-frequency components reconstruction methods,combined with observation constraint masking,a reconstructed C-LSAT2.0 with 756 ensemble members from the 1850s to 2018 has been developed.These ensemble versions have been merged with the ERSSTv5 ensemble dataset,and an upgraded version of the CMSTInterim dataset with 5°×5°resolution has been developed.The CMST-Interim dataset has significantly improved the coverage rate of global surface temperature data.After reconstruction,the data coverage before 1950 increased from 78%−81%of the original CMST to 81%−89%.The total coverage after 1955 reached about 93%,including more than 98%in the Northern Hemisphere and 81%−89%in the Southern Hemisphere.Through the reconstruction ensemble experiments with different parameters,a good basis is provided for more systematic uncertainty assessment of C-LSAT2.0 and CMSTInterim.In comparison with the original CMST,the global mean surface temperatures are estimated to be cooler in the second half of 19th century and warmer during the 21st century,which shows that the global warming trend is further amplified.The global warming trends are updated from 0.085±0.004℃(10 yr)^(–1)and 0.128±0.006℃(10 yr)^(–1)to 0.089±0.004℃(10 yr)^(–1)and 0.137±0.007℃(10 yr)^(–1),respectively,since the start and the second half of 20th century. | Wenbin SUN Qingxiang LI Boyin HUANG Jiayi CHENG Zhaoyang SONG Haiyan LI Wenjie DONG Panmao ZHAI Phil JONES | 2021 | Advances in Atmospheric Sciences2021，38，5： | 8 |
| 7 | Electrochemical measurements used for assessment of corrosion and protection of metallic materials in the field:A critical review显示文摘Corrosion degradation is detrimental to metal structures as it shortens their lifetime and leads to huge economic losses and unexpected disasters.Therefore,the detection and monitoring of corrosion degradation is of great importance.Herein,we briefly review the state-of-the-art electrochemical methods,instrumentation(based on virtual instrumentation),and advanced sensor/probes that are used in the field for the assessment of corrosion damage.Typical corrosion monitoring results,some of which have been obtained at Tianjin University in the past 30 years,for metallic materials and organic coating/metal systems in atmospheric,marine,and soil conditions in the field are presented.Detection methods,data analysis,and theoretical and mathematical models regarding each corrosion system are discussed,and the challenges,problems and possible solutions for each case are suggested.Lastly,future developments,such as wireless,intelligent,and automatic electrochemical measurement,that will augment the present electrochemical methods of evaluating corrosion degradation are summarized. | Da-Hai Xia Cheng-Man Deng Digby Macdonald Sina Jamali Douglas Mills Jing-Li Luo Michael G.Strebl Mehdi Amiri Weixian Jin Shizhe Song Wenbin Hu | 2022 | Journal of Materials Science & Technology2022，，17： | 8 |
| 8 | Influence of plastic film mulching and planting density on yield,leaf anatomy,and root characteristics of maize on the Loess Plateau显示文摘In rainfed areas of northwestern China,maize production is constrained mainly by low temperature during early growth and water limitation during the entire growth period.Plastic film mulching is commonly used to increase maize yield in this area,because it increases topsoil temperature and moisture content as well as water use efficiency.However,the physiological and anatomical bases of maize yield improvement with plastic film mulching are not well understood.The effects of plastic film mulching and planting density on maize yield,photosynthetic characteristics,respiration,leaf anatomy,and root growth were studied in a two-year field experiment conducted on the Loess Plateau of China in 2017 and 2018.The experiment used a split-split plot design with two mulching treatments(plastic film mulching and no mulching),two planting densities(7.5×104 and10.5×104 plants ha-1),and two maize cultivars,Zhengdan 958 and Xianyu 335.Compared with no mulching,plastic film mulching increased maize yields by 31.1%–46.4%in 2017 and3.6%–34.7%in 2018.Compared with low planting density,high planting density significantly increased and slightly reduced yields of both cultivars in the dry year 2017 and the rainy year 2018,respectively.Plastic film mulching increased photosynthesis and respiration as well as leaf stomatal density and aperture.Photosynthetic rate,dark respiration,and stomatal conductance and aperture were lower at high planting than at low planting density.Maize yield was positively correlated with photosynthesis,dark respiration,and stomatal aperture.Mulching increased root dry weight and length in the 0–20 cm soil layer and root activity at maturity.Overall,the changes in root growth and leaf anatomy resulted in increased photosynthesis and dark respiration,and the increased photosynthesis contributed to the increase in grain yield and biomass production under plastic film mulching conditions.Our results increase understanding of the physiological mechanisms by which plastic film mulching increases maize yield in water-and temperature-limited areas. | Li Niu Yanyan Yan Peng Hou Wenbo Bai Rulang Zhao Yonghong Wang Shaokun Li Taisheng Du Ming Zhao Jiqing Song Wenbin Zhou | 2020 | The Crop Journal2020，8，4： | 6 |
| 9 | An asynchronous and parallel time-marching method: Application to three-dimensional MHD simulation of solar wind显示文摘An asynchronous and parallel time-marching method for three-dimensional (3D) time-dependent magnetohydrodynamic (MHD) simulation is used for large-scale solar wind simulation. It uses different local time steps in the corona and the heliosphere according to the local Courant-Friedrichs-Levy (CFL) conditions. The solar wind background with observed solar photospheric magnetic field as input is first presented. The simulation time for the background solar wind by using the asynchronous method is <1/6 of that by using the normal synchronous time-marching method with the same computation precision. Then, we choose the coronal mass ejection (CME) event of 13 November, 2003 as a test case. The time-dependent variations of the pressure and the velocity configured from a CME model at the inner boundary are applied to generate transient structures in order to study the dynamical interaction of a CME with the background solar wind flow between 1 and 230 Rs. This time-marching method is very effective in terms of computation time for large-scale 3D time-dependent numerical MHD problem. In this validation study, we find that this 3D MHD model, with the asynchronous and parallel time-marching method, provides a relatively satisfactory comparison with the ACE spacecraft obser- vations at L1 point. | SHEN Fang FENG XueShang SONG WenBin | 2009 | Science China(Technological Sciences)2009，52，10： | 6 |
| 10 | Foraging behavior of the Greater White-fronted Goose(Anser albifrons) wintering at Shengjin Lake: diet shifts and habitat use显示文摘Background: The habitat use and foraging behaviors of waterbirds are closely related to the distribution and abundance of their food resources. Reductions in food supply can cause waterbirds to shift their habitats and adjust their foraging behaviors to meet their nutritional requirements and increase fitness. Seasonal withdraw of the water levels in the river-connected lakes in the middle and lower Yangtze River floodplain provides abundant food resources for the wintering Greater White-fronted Goose(Anser albifrons). Sedge(Carex) meadows are critical foraging habitats for herbivorous waterbirds in the hydro-fluctuation belt, which changes with hydrological conditions and climate. This study aimed to examine the behavioral responses of the Greater White-fronted Goose to temporal-spatial changes of food availability in the Sedge meadows.Methods: Fields surveys were carried out at Shengjin Lake from November 2017 to April 2018. According to the phenology of Shengjin Lake, we divided the wintering season into three periods. The food density, minimum temperature, food items, grass height, and number of foraging geese were surveyed, and samples of the foraging behavior were collected. We analyzed the relationship of the foraging behavior and habitat use relative to the food resources, using correlation and linear regression analyses.Results: Along with the temporal-spatial variation and exploitation of food resources, the food abundance and items varied widely among the foraging sites. Over the whole wintering period, the foraging habitat with the highest utilization rate was the meadows, followed by the paddy fields, and then mudflats. Furthermore, the utilization of the meadows showed a bimodal distribution trend, while the paddy fields showed a unimodal trend, and a decreasing trend was seen in the mudflats over the whole wintering period. The results of the generalized linear model showed that the foraging rate was related to the food density and grass height, with a linearly increasing trend during the winter.Conclusions: With the change of food resources in the three habitats, the habitats used by the Greater White-fronted Geese shifted from meadows in the hydro-fluctuation belt to the paddy fields, and then back to the meadows. The time budget for foraging activities increased correspondingly, and there was an increase in the foraging rate to compensate for food shortages. | Yanguang Fan Lizhi Zhou Lei Cheng Yunwei Song Wenbin Xu | 2020 | Avian Research2020，11，1： | 5 |
| 11 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 12 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 13 | Analysis of direct operating cost of wide-body passenger aircraft: A parametric study based on Hong Kong显示文摘Analysis of the Direct Operating Cost(DOC) of aircraft is an important step towards achieving financially sustainable aviation operations. However, the value of the DOC for different aircraft types and flight scenarios is not widely available. In this study, we perform a systematic analysis of the DOC of every wide-body passenger aircraft currently in production, using the method of the Association of European Airlines(AEA). The elements of the DOC, e.g. financial costs, maintenance costs, and flight costs, are evaluated individually. Several realistic flight scenarios are considered, each with differences in route distance, fuel price, passenger number, and seating arrangement. For each flight scenario, the most cost-efficient aircraft type is identified and evaluated in the context of operations from Hong Kong International Airport. The information provided in this study could be useful to airline operators and policy makers. | Minwoo LEE Larry K.B.LI Wenbin SONG | 2019 | Chinese Journal of Aeronautics2019，32，5： | 4 |
| 14 | Live cell imaging and proteomic profiling of endogenous NEAT1 lncRNA by CRISPR/ Cas9-mediated knock-in显示文摘In mammalian cells,long noncoding RNAs(lncRNAs)form complexes with proteins to execute various biological functions such as gene transcription,RNA processing and other signaling activities.However,methods to track endogenous lncRNA dynamics in live cells and screen for lncRNA interacting proteins are limited.Here,we report the development of CERTIS(CRISPR-mediated Endogenous lncRNA Tracking and Immunoprecipitation System)to visualize and isolate endogenous lncRNA,by precisely inserting a 24-repeat MS2 tag into the distal end of lncRNA locus through the CRISPR7Cas9 technology.In this study,we show that CERTIS effectively labeled the paraspeckle lncRNA NEAT1 without disturbing its physiological properties and could monitor the endogenous expression variation of NEAT1.In addition,CERTIS displayed superior performance on both short-and long-term tracking of NEAT1 dynamics in live cells.We found that NEAT1 and paraspeckles were sensitive to topoisomerase I specific inhibitors.Moreover,RNA Immunoprecipitation(RIP)of the MS2-tagged NEAT1 lncRNA successfully revealed several new protein components of paraspeckle.Our results support CERTIS as a tool suitable to track both spatial and temporal lncRNA regulation in live cells as well as study the lncRNA-protein interactomes. | Bohong Chen Shengcheng Deng Tianyu Ge Miaoman Ye Jianping Yu Song Lin Wenbin Ma Zhou Songyang | 2020 | Protein & Cell2020，11，9： | 4 |
| 15 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 16 | Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 是世界范围的致命的肝恶意。在这研究,我们报导了那个蛋白质磷酸酶镁依赖者(PPM1D ) 1 高度在 HCC 案例(约 59%) 的多数被表示并且显著地把水平与高浆液 -fetoprotein (法新社) 联系了(P = 0.044 ) 。Kaplan- Meier 和考克斯回归数据显示 PPM1D overexpression 是 HCCspecific 全面幸存的一个独立预言者(HR, 2.799;95% CI, 1.346-5.818, P = 0.006 ) 。, Overexpressing PPM1D 支持了房间生存能力和侵略 RNA 调停干扰 PPM1D 击倒有教养的 HCC 房间的禁止的增长,侵略,和移植。另外,由小介入 RNA 的 PPM1D 抑制减少了在 vivo 的 HCC 房间的 tumorigenicity。总的来说,结果建议 PPM1D 为 HCC 是一个潜在的预示的标记和治疗学的目标。 | Zhi Xu Chunxiang Cao Haiyan Xia Shujing Shi Lingzhi Hong Xiaowei Wei Dongying Gu Jianmin Bian Zijun Liu Wenbin Huang Yixin Zhang Song He Nikki Pui-Yue Lee Jinfei Chen | 2016 | Frontiers of Medicine2016，10，1： | 3 |
| 17 | The role of personality,social economic and prevention strategy effects on health-related quality of life among people living with HIV/AIDS显示文摘Background::HIV/AIDS has transformed into a chronic controllable but not yet curable infectious disease as other chronic diseases to some extent.The additional of so called fourth 90%that included the improved health-related quality of life(HRQoL)for people living with HIV(PLWHIV)required solutions beyond antiretroviral therapy and viral load suppression.This study will explore the role of personality,social economic and prevention strategy effection on HRQoL among people living with HIV/AIDS.Methods::A cross-sectional study was conducted among PLWHIV aged more than 16 years old in the 10 municipalities in Yunnan Province,China from October 2019 to May 2020,enrolling total 1997 participants.Individual-level HRQoL data were measured by 12-item Short Form Health Survey(SF-12)and EuroQol Five Dimensions Questionnaire(EQ-5D-5L).We assembled municipal-level data about social economic from Yunnan Statistical Yearbook in 2020 and strategy practice information from the self-evaluation system.We used the principal component analysis to build the social economic and strategy effect on each area respectively and one-way ANOVA was used to perform univariate analysis to identify the predictors with significant differences.Finally we used multi-level model(MLM)to explore the personality,social economic and strategy effects in health-related quality of life among PLWHIV.Results::The global score for quality of life measured using EQ-5D-5L had an estimated mean score(standard deviation,SD)of 0.901±0.146.The HRQoL score measured using PCS-12 had an estimated mean score(SD)of 46.62±8.55.The mean MCS-12 score(SD)was estimated to be 47.80±9.71.The area-level predictors explained a proportion of 13.6-17.2%for the between-area variation of the HRQoL scores,regardless of the total HRQoL,physical component and mental component.The impacts of stigma(P<0.01),social support(P<0.001),anxiety(P<0.001),depression(P<0.05)and social economic status(P<0.05)on HRQoL at the individual-level were significantly different.The plots visualized the impact of individual-level factors on a respondent’s HRQoL was modified by the area-level characteristics.Conclusions::The study identified the possible strategy determinant of individual HRQoL of PLWHIV and also the area effect on HRQoL.Stigma,social support,anxiety,depression and social economic status were the individual-level determinants on HRQoL.These could be a valuable resource for evaluating the overall health of the areas and help improve local decision making. | Xiaowen Wang Hongbing Luo Enlong Yao RenhaiTang Wenbin Dong Fuyong Liu Jun Liang Huilan Li Minyang Xiao Zuyang Zhang Jin Niu Lijun Song Liru Fu Xuehua Li Shicong Qian Qing Guo Zhizhong Song | 2021 | Infectious Diseases of Poverty2021，10，4： | 3 |
| 18 | Profiles of and variations in aluminum species in PAC-MC used for the removal of blooming microalgae显示文摘Polyaluminum chloride modified clay(PAC-MC)is a safe and efficient red tide control agent that has been studied and applied worldwide.Although it is well known that the distribution of hydrolytic aluminum species in PAC affects its flocculation,little is known about the influence of particulars aluminum species on the microalgae removal efficiency of PAC-MC;this lack of knowledge creates a bottleneck in the development of more efficient MCs based on aluminum salts.The ferron method was used in this study to quantitatively analyze the distributions of and variations in different hydrolytic aluminum species during the process of microalgae removal by PAC-MC.The results showed that Ala,which made up 5%–20%of the total aluminum,and Alp,which made up 15%–55%of the total aluminum,significantly affected microalgae removal,with Pearson’s correlation coefficients of 0.83 and 0.89,respectively.Most of the aluminum in the PAC-MC sank rapidly into the sediments,but the rate and velocity of settlement were affected by the dose of modified clay.The optimal dose of PAC-MC for precipitating microalgae was determined based on its aluminum profile.These results provide guidance for the precise application of PAC-MC in the control of harmful algal blooms. | Xueyi Dong Xihua Cao Wenbin Jiang Xiuxian Song Zhiming Yu Shitao Yu | 2021 | Journal of Environmental Sciences2021，33，8： | 2 |
| 19 | Optical visualization and polarized light absorption of the single-wall carbon nanotube to verify intrinsic thermal applications显示文摘The predicted extraordinary properties of carbon nanotubes(CNTs)from theoretical calculations have great potential for many applications.However,reliable experimental determination of intrinsic properties at the single-tube level is currently a matter of concern,and many challenges remain because of the unhandled and nanoscale size of individual nanotubes.Here,we demonstrated a prototype to detect the intrinsic thermal conductivity of the single-wall carbon nanotube(SWCNT)and verify the significant non-resonant optical absorption behavior on tiny nanotubes by integrating the nanotube and ice into a new core-shell design.In particular,a reversible optical visualization method based on the individual suspended ultra-long SWCNT was first developed by wrapping a nanotube with ice in the cryogenic air environment.The light-induced thermal effect on the hybrid core-shell structure was used tomelt the ice shell,which subsequently acted as a temperature sensor to verify the intrinsic thermal conductivity of the core-like nanotube.More interestingly,we successfully determined for the first time the thermal response phenomenon of the tiny absorption cross section in SWCNT in the vertical-polarization configuration and the significant non-resonant absorption behavior in the parallel-polarization configuration.These investigations will provide a better understanding for the unique optical behaviors of CNT and enable the detection of intrinsic properties of various one-dimensional nanostructures such as nanotubes,nanowires,and nanoribbons. | Xiao Zhang Li Song Le Cai Xuezeng Tian Qiang Zhang Xiaoying Qi Wenbin Zhou Nan Zhang Feng Yang Qingxia Fan Yanchun Wang Huaping Liu Xuedong Bai Weiya Zhou Sishen Xie | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 20 | Enhancing the Stability of Passive Film on 304 SS by Chemical Modification in Alkaline Phosphate–Molybdate Solutions显示文摘The purpose of this work was to enhance the corrosion resistance of the passive fi lm on 304 stainless steel(SS)by chemical modifi cation in alkaline phosphate–molybdate solutions.The 304 SS was passivated in both phosphate and phosphate–molybdate mixed solutions to investigate the eff ect of molybdate on its corrosion resistance.The experimental results indicated that the passive fi lm showed better corrosion resistance in Cl?-containing solutions after modifi cation in phosphate–molybdate solutions than in phosphate-only solutions.Energy-dispersive spectroscopy analyses revealed that the passive fi lm formed in phosphate–molybdate solutions contained Mo and P after modifi cation,which is the reason for the enhanced corrosion resistance. | Chengcheng Pan Yang Song Weixian Jin Zhenbo Qin Shizhe Song Wenbin Hu Da-Hai Xia | 2020 | Transactions of Tianjin University2020，26，2： | 2 |
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