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| 1 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 2 | Efficacy of Rebixiao Chinese herbal tablets and Chinese formula granules in acute gout arthritis patients:a randomized,multicenter,double-blind,controlled trial显示文摘OBJECTIVE:To evaluate the clinical efficacy and safety of Rebixiao(RBX)Chinese herbal tablets(CHT)and Chinese formula granules(CFG)in the treatment of acute gout arthritis(AGA).METHODS:This randomized,multicenter,double-blind,controlled trial included 165 AGA patients with the damp-heat symptom pattern who were randomly divided into an RBX CHT group and an RBX CFG group and treated for 7 d at three centers.The total effective rates of the joint symptom score,Traditional Chinese Medicine(TCM)symptoms score,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)were used to evaluate the clinical efficacy.Safety assessments were also performed.RESULTS:Of the 165 enrolled patients,147 completed the clinical observation.There was no difference in baseline between the two groups.The total effective rates of the joint symptom score were 94.36%and 97.36%,and the total effective rates of the TCM symptoms score were 95.77%and 97.36%in the CFG group and CHT group,respectively.No statistical difference was found between the two groups(P>0.05).Additionally,ESR and CRP were similar in both groups(P>0.05).Furthermore,treatment efficacy regarding TCM and joint symptoms,the ESR,and CRP were consistent within each center and among the different centers(P>0.05).In addition,the incidence of adverse events was 4.22%and 2.63%in the CFG group and CHT group,respectively,and no difference was observed between the two groups(P>0.05).CONCLUSION:RBX CFG and CHT have significant and similar efficacy in the treatment of AGA,and CFG did not increase adverse side effects. | Wang Shasha Zhang Ying Dai Min Yang Min Leng Wenfei Peng Xiufeng Li Guojun Yang Jinbing Gan Jianping Zhu Fenglin Li Yanping Wu Bin | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 3 | Epidemiological and Genetic Characteristics of the H3 Subtype Avian Influenza Viruses in China显示文摘Avian influenza viruses(AIVs)are naturally preserved in waterfowls and sometimes spill over to infect humans and mammalian animals.The H3 subtype is one of the most prevalent influenza virus subtypes in waterfowls.Since 2000,H3 subtype AIVs have been continuously isolated from poultry and wild birds in the mainland of China,which implied a dynamic spread in large-scale geography and multiple species.Combinations of H3 with N1–N8 subtypes were reported,among which H3N2 and H3N8 subtypes predominated. | Jiaying Yang Lei Yang Wenfei Zhu Dayan Wang Yuelong Shu | 2021 | China CDC weekly2021，3，44： | 2 |
| 4 | Extremal length decomposition and domain constants for finitely connected domains 显示文摘 | Cheng Tao Yang Shanshuang Zhou Wenfei | 2014 | Comput Methods Funct Theory2014，14，： | 1 |
| 5 | A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet(Setaria italica)显示文摘 | Guanqing Jia Xuehui Huang Hui Zhi Yan Zhao QiangZhao Wenjun Li Yang Chai Lifang Yang Kunyan Liu Hengyun Lu Chuanrang Zhu Yiqi Lu Congcong Zhou Danlin Fan Qijun Weng Yunli Guo Tao Huang LeiZhang Tingting Lu Qi Feng Hangfei Hao HongkuanLiu Ping Lu Ning Zhang Yuhui Li Erhu Guo ShujunWang Suying Wang Jinrong Liu Wenfei Zhang GuoqiuChen Baojin Zhang Wei Li Yongfang Wang HaiquanLi Baohua Zhao Jiayang Li Xianmin Diao Bin HanJia | 2013 | Nature Genetics2013，45，8： | 1 |
| 6 | The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice显示文摘Human influenza viruses preferentially bind to sialic acid-α2,6-galactose (SAα2,6Gal) receptors, which are predominant in human upper respiratory epithelia, whereas avian influenza viruses preferentially bind to SAα2,3Gal receptors. However, variants with amino acid substitutions around the receptor-binding sites of the hemagglutinin (HA) protein can be selected after several passages of human influenza viruses from patients’ respiratory samples in the allantoic cavities of embryonated chicken eggs. In this study, we detected an egg-adapted HA S190R mutation in the pandemic H1N1 virus 2009 (pdmH1N1), and evaluated the effects of this mutation on receptor binding affinity and pathogenicity in mice. Our results revealed that residue 190 is located within the pocket structure of the receptor binding site. The single mutation to arginine at position 190 slightly increased the binding affinity of the virus to the avian receptor and decreased its binding to the long human α2,6-linked sialic acid receptor. Our study demonstrated that the S190R mutation resulted in earlier death and higher weight loss in mice compared with the wild-type virus. Higher viral titers at 1 dpi (days post infection) and diffuse damage at 4 dpi were observed in the lung tissues of mice infected with the mutant virus. | Yongkun Chen Tian Bai Wenfei Zhu Rongbao Gao Zhihong Deng Yi Shi Shumei Zou Yiwei Huang Xiyan Li Fangcai Li Zhaomin Feng Tao Chen Jing Yang Dayan Wang Lidong Gao Yuelong Shu | 2018 | Science China(Life Sciences)2018，61，7： | 1 |
| 7 | MDP25 mediates the fine-tuning of microtubule organization in response to salt stress显示文摘Microtubules are dynamic cytoskeleton structures playing fundamental roles in plant responses to salt stress.The precise mechanisms by which microtubule organization is regulated under salt stress are largely unknown.Here,we report that Arabidopsis thaliana MICROTUBULE-DESTABILIZING PROTEIN 25(MDP25;also known as PLASMA MEMBRANEASSOCIATED CATION-BINDING PROTEIN 1(PCaP1))helps regulate microtubule organization.Under salt treatment,elevated cytosolic Ca^(2+) concentration caused MDP25 to partially dissociate from the plasma membrane,promoting microtubule depolymerization.When Ca^(2+) signaling was blocked by BAPTA-AM or LaCl_(3),microtubule depolymerization in wild-type and MDP25-overexpressing cells was slower,while there was no obvious change in mdp25 cells.Knockout of MDP25 improved microtubule reassembly and was conducive to microtubule integrity under long-term salt treatment and microtubule recovery after salt stress.Moreover,mdp25 seedlings exhibited a higher survival rate under salt stress.The presence microtubule-disrupting reagent oryzalin or microtubule-stabilizing reagent paclitaxel differentially affected the survival rates of different genotypes under salt stress.MDP25 promoted microtubule instability by affecting the catastrophe and rescue frequencies,shrinkage rate and time in pause phase at the microtubule plus-end and the depolymerization rate at the microtubule minus-end.These findings reveal a role for MDP25 in regulating microtubule organization under salt treatment by affecting microtubule dynamics. | Peizhi Yang Jingwei Jin Jingru Zhang Dan Wang Xuechun Bai Wenfei Xie Tianming Hu Xuan Zhao Tonglin Mao Tao Qin | 2022 | Journal of Integrative Plant Biology2022，64，6： | 1 |
| 8 | NLFM Interference Suppressing Based on Time-Varying AR Modeling and Adaptive IIR Notch Filter显示文摘 | FENG Jining YANG Xiaobo DIAO Zhejun GONG Wenfei WU Siliang | 2011 | Chinese Journal of Electronics2011，20，4： | 1 |
| 9 | Mutations associated with egg adaptation of influenza A(H1N1)pdm09 virus in laboratory based surveillance in China, 2009–2016显示文摘Mutations of influenza virus associated with adaptation occurring during passage in embryonated chicken eggs could result in antigenic change or reduced vaccine effectiveness.In this study,we investigated the mutations of influenza A(H1N1)pdm09 egg isolates from the Chinese National Influenza Surveillance Network between 2009 and 2016.Thirteen mutations were identified in the hemagglutinin(HA)protein from viruses passaged in eggs,in comparing to those in cells.After scanning public database,four mutations,D127E,L191I,D222G/N and Q223R in HA1,which may alter the receptor-binding specificity,were observed frequently.Although the A(H1N1)pdm09 virus has evolved in human for nearly ten years,most egg-cultured viruses acquired one or more further mutations.Using the egg isolates for influenza surveillance requires extra caution because of these selected mutations,and their impacts on antigenicity and receptor-binding property need further evaluation.Currently,most of the influenza vaccines are produced using egg isolates,particularly in China.Thus,there is an urge to promote the establishment of an alternative influenza vaccine production platform. | Lei Yang Yanhui Cheng Xiang Zhao Hejiang Wei Minju Tan Xiyan Li Wenfei Zhu Weijuan Huang Wenbing Chen Jia Liu Zi Li Yuelong Shu Dayan Wang | 2019 | Biosafety and Health2019，1，1： | 1 |
| 10 | CONTROLLABILITY OF QUASI-LINEAR IMPULSIVE FUNCTIONAL BOUNDARY VALUE PROBLEMS显示文摘By employing the Schauder fixed-point theorem, we establish new sufficient conditions for the controllability of impulsive functional boundary value problems. | Shujie Yang Bao Shi Xiaolei Liu Wenfei Zhao | 2017 | Annals of Applied Mathematics2017，33，1： | 1 |
| 11 | Bandgap engineering of tetragonal phase CuFeS_(2)quantum dots via mixed-valence single-atomic Ag decoration for synergistic Cr(VI)reduction and RhB degradation显示文摘Bandgap engineering through single-atom site binding on semiconducting photocatalyst can boost the intrinsic activity,selectivity,carrier separation,and electron transport.Here,we report a mixed-valence Ag(0)and Ag(I)single atoms co-decorated semiconducting chalcopyrite quantum dots(Ag/CuFeS_(2)QDs)photocatalyst.It demonstrates efficient photocatalytic performances for specific organic dye(rhodamine B,denoted as RhB)as well as inorganic dye(Cr(VI))removal in water under natural sunlight irradiation.The RhB degradation and Cr(VI)removal efficiencies by Ag/CuFeS_(2)QDs were 3.55 and 6.75 times higher than those of the naked CuFeS_(2)QDs at their optimal pH conditions,respectively.Besides,in a mixture of RhB and Cr(VI)solution under neutral condition,the removal ratio has been elevated from 30.2%to 79.4%for Cr(VI),and from 95.2%to 97.3%for RhB degradation by using Ag/CuFeS_(2)QDs after 2 h sunlight illumination.The intrinsic mechanism for the photocatalytic performance improvement is attributed to the narrow bandgap of the single-atomic Ag(I)anchored CuFeS_(2)QDs,which engineers the electronic structure as well as expands the optical light response range.Significantly,the highly active Ag(0)/CuFeS_(2)and Ag(I)/CuFeS_(2)effectively improve the separation efficiency of the carriers,thus enhancing the photocatalytic performances.This work presents a highly efficient single atom/QDs photocatalyst,constructed through bandgap engineering via mixed-valence single noble metal atoms binding on semiconducting QDs.It paves the way for developing high-efficiency single-atom photocatalysts for complex pollutions removal in dyeing wastewater environment. | Yangzi Shangguan Yuanhao Zhou Renji Zheng Xuezhen Feng Qiuyue Ge Ranhao Wang Dazhong Yang Wenfei Wei Xiaoyong Wu Jia Lin Hong Chen | 2021 | Chinese Chemical Letters2021，32，11： | 1 |
| 12 | One-step synthesis of carbon-coated monocrystal molybdenum oxides nanocomposite as high-capacity anode materials for lithiumion batteries显示文摘Benefitting from higher specific capacities,acceptable cost,nontoxicity and unique crystal structures,the molybdenum oxides have been studied as the anode materials for lithium ion batteries(LIBs).Herein,a direct current(DC)arc-discharge plasma technique has been developed to in-situ synthesize carboncoated monocrystal molybdenum oxides((MoO3NRs/MoO2NPs)@C)nanocomposites,using coarse MoO_(3) bulk as the raw material and methane(CH4)gas as the carbon source.It is indicated that crystallographic traits of MoO_(3) and MoO2 nuclei give rise to an anisotropic growth of monocrystal MoO3 nanorods(NRs)along<100>direction and an isotropic growth of monocrystal MoO_(2) nanoparticles(NPs).The carbon shells on MoO3/MoO2 nanostructures are generated from the absorption of carbon atoms in surrounding atmosphere or the release of supersaturated carbon atoms in MoeOeC solid solution.Unique constitution and pseudo-capacitive behavior of(MoO3NRs/MoO2NPs)@C bring merits to excellent cycling performance and rate capability,i.e.a remarkable specific capacity of 840 mAh·g^(-1) after 100 cycles at a current density of 0.1 Ag^(-1) and a retained capacity of 210 mAh·g^(-1) at 6.4 A g^(-1).This work has offered a simple and efficient approach to fabricate the carbon-coated molybdenum oxides nanostructures for promising anode materials of LIBs。 | Zhiguo Rong Canfeng Fang Zhongyuan Zhang Wenfang Miao Xiyang Li Jingshuang Liang Wenfei Yang Yinong Wang Xiane Guo Youngguan Jung Xinglong Dong | 2021 | Journal of Materiomics2021，7，3： | 1 |
| 13 | En- hanced efficiency of polymer solar cells by incorporated Ag SiO2 core shell nanopartieles in the active layer 显示文摘 | Shen Wenfei Tang Jianguo Yang Renqiang | 2014 | RSC Advances2014，4，9： | 1 |
| 14 | Landslide hazard susceptibility evaluation based on SBAS-InSAR technology and SSA-BP neural network algorithm:A case study of Baihetan Reservoir Area显示文摘Landslide hazard susceptibility evaluation takes on critical significance in early warning and disaster prevention and reduction.In order to solve the problems of poor effectiveness of landslide data and complex calculation of weights for multiple evaluation factors in the existing landslide susceptibility evaluation models,in this study,a method of landslide hazard susceptibility evaluation is proposed by combining SBAS-InSAR(Small Baseline Subsets-Interferometric Synthetic Aperture Radar)and SSA-BP(Sparrow Search Algorithm-Back Propagation)neural network algorithm.The SBAS-InSAR technology is adopted to identify potential landslide hazards in the study area,update the cataloging data of landslide hazards,and 11 evaluation factors are chosen for constructing the SSA-BP model for training and validation.Baihetan Reservoir area is selected as a case study for validation.As indicated by the results,the application of SBAS-InSAR technology,combined with both ascending and descending orbit data,effectively addresses the incomplete identification of landslide hazards caused by geometric distortion of single orbit SAR data(e.g.,shadow,overlay,and perspective contraction)in deep canyon areas,thereby enabling the acquisition of up-to-date landslide hazard data.Moreover,in comparison to the conventional BP(Back Propagation)algorithm,the accuracy of the model constructed by the SSA-BP algorithm exhibits a significant increase,with mean squared error and mean absolute error reduced by 0.0142 and 0.0607,respectively.Additionally,during the process of susceptibility evaluation,the SSA-BP model effectively circumvents the issue of considerable manual interventions in calculating the weight of evaluation factors.The area under the curve of this model reaches 0.909,surpassing BP(0.835),random forest(0.792),and the information value method(0.699).The risk of landslide occurrence in the Baihetan Reservoir area is positively correlated with slope,surface temperature,and deformation rate,while it is negatively correlated with fault distance and normalized difference vegetation index.Geological lithology exerts minimal influence on the occurrence of landslides,with the risk being low in forest land and high in grassland.The method proposed in this study provides a useful reference for disaster prevention and mitigation departments to perform landslide hazard susceptibility evaluations in deep canyon areas under complex geological conditions. | GUO Junqi XI Wenfei YANG Zhiquan SHI Zhengtao HUANG Guangcai YANG Zhengrong YANG Dongqing | 2024 | Journal of Mountain Science2024，21，3： | 0 |
| 15 | Identification of a Novel Universal Potential Epitope on the Cytoplasmic Tail of H7N9 Virus Hemagglutinin显示文摘Dear Editor,H7N9 is a recently identified subtype of influenza A virus that caused a major outbreak in humans in China in 2013.According to the latest data provided by the Chinese Center for Disease Control and Prevention(http://www.moh.gov.cn/zwgk/yqbb3/ejlist.shtml,updated on October 31,2018),the mortality rate of H7N9 infections in China amounts to 39.7%(611/1536).Thus,H7N9 poses a serious public health threat. | Xi Liu Li Ding Jing Yuan Jian Liao Lian Duan Wenfei Wang Weiguo Tan Weiye Yu Boping Zhou Xinchun Chen Zheng Yang | 2019 | Virologica Sinica2019，34，3： | 0 |
| 16 | Preliminary Results of the Seismicity Monitoring Experiment around the 2019 Mw5.4 Earthquake Epicenter in the Central South China Sea Basin显示文摘On September 5,2019,a moderate earthquake of Mw5.4 unexpectedly occurred in the apparently quiescent central basin of the South China Sea.We immediately carried out a seismicity monitoring experiment around the epicenter by using broadband ocean bottom seismometers(OBS)for the following three scientific targets.The first is knowing the earthquake seismogenic mechanism,fault structure and further development.The second is finding the role of the residual spreading ridge playing in earthquake processes and further revealing the deep structures of the ridge directional turning area.The third is confirming the existence and significance of the so called“Zhongnan fault”.This paper reports the preliminary results of the first phase experiment.Five OBSs were deployed for seismicity monitoring with a duration of 288 days,but only three were recovered.Micro-earthquakes were firstly detected by an automatic seismic phase picking algorithm and then were verified by analyzing their seismic phases and time-frequency characteristics in detail.A total of 21,68 and 89 microearthquakes were picked out from the three OBSs respectively within the distance of 30 km.The dominant frequency of these micro-earthquakes is 12-15 Hz,indicating tectonic fracturing.During the first two months after the mainshock the seismicity was relatively stronger,and micro-earthquakes were still occurring occasionally till the end of observation,indicating the epicenter area is active.We used Match&Locate method to locate 57 micro-earthquakes preliminarily.Their spatial distribution shows that the seismicity is developed mainly along the NE direction roughly parallel to the residual ridge with depth variations between 10-20 km. | Wenfei Gong Aiguo Ruan Xiongwei Niu Zhenjie Wang Pingchuan Tan Xiaodong Wei Wei Wang Zhengyi Tong Liqun Cheng Fansheng Kong Shaoping Lu Jianke Fan Weiwei Ding Jinyao Gao Chunguo Yang Jiabiao Li | 2024 | Journal of Earth Science2024，35，1： | 0 |
| 17 | Observatory science with eXTP显示文摘In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s. | Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig Alessandro Riggio Jerome Rodriguez Pablo Rodríguez-Gil Patrizia Romano Agata Rózańska Takanori Sakamoto Tuomo Salmi Ruben Salvaterra andrea Sanna andrea Santangelo Tuomas Savolainen Stéphane Schanne Hendrik Schatz LiJing Shao andy Shearer Steven N.Shore Ben W.Stappers Tod E.Strohmayer Valery F.Suleimanov Jirí Svoboda F.-K.Thielemann Francesco Tombesi Diego F.Torres Eleonora Torresi Sara Turriziani andrea Vacchi Stefano Vercellone Jacco Vink Jian-Min Wang JunFeng Wang Anna L.Watts ShanShan Weng Nevin N.Weinberg Peter J.Wheatley Rudy Wijnands Tyrone E.Woods Stan E.Woosley ShaoLin Xiong YuPeng Xu Zhen Yan George Younes WenFei Yu Feng Yuan Luca Zampieri Silvia Zane andrzej A.Zdziarski Shuang-Nan Zhang Shu Zhang Shuo Zhang Xiao Zhang Michael Zingale | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 0 |
| 18 | Correlation between single nucleotide polymorphisms of 17β-HSD-1 and endometrial adenocarcinoma显示文摘Objective: To investigate the correlation between 17-beta-hydroxysteroid dehydrogenase type1(17β-HSD-1) gene polymorphisms and risk of endometrial adenocarcino-ma.Methods: Forty-one patients with endometrial adenocarcinoma were selected as experimen-tal group and twenty-seven healthy women were selected as control group.The three common single nucleotide polymorphism of 17β-HSD-1 gene at sites + 1004,+ 1322 and + 1954 were detected by allele-specific PCR(ASA-PCR).The allele frequencies were analyzed by SPSS13.0 software between endometrial cancer cases and controls.Results: We observed no significant difference in various frequency distribution between experimental group and control group.P1004= 0.994,P1322 = 0.974,and P1954 = 0.981.Conclusion: We found that three common SNPs with the 17β-HSD-1 gene were not associated with endometrial adenocarcinoma.We suggest that more research for 17β-HSD needs to explore. | Qian Shao Zhang Hong Han Wenfei Jian Yan Fu Weijiang Yang Xingsheng | 2011 | 现代妇产科进展2011，20，8： | 0 |
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