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72篇 您的检索式:作者名="Wenhuan"
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1Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC显示文摘Epithelial–mesenchymal transition(EMT)is involved in both physiological and pathological processes.EMT plays an essential role in the invasion,migration and metastasis of tumours.Autophagy has been shown to regulate EMT in a variety of cancers but not in head and neck squamous cell carcinoma(HNSCC).Herein,we investigated whether autophagy also regulates EMT in HNSCC.Analyses of clinical data from three public databases revealed that higher expression of fibronectin-1(FN1)correlated with poorer prognosis and higher tumour pathological grade in HNSCC.Data from SCC-25 cells demonstrated that rapamycin and Earle’s balanced salt solution(EBSS)promoted autophagy,leading to increased FN1 degradation,while 3-methyladenine(3-MA),bafilomycin A1(Baf A1)and chloroquine(CQ)inhibited autophagy,leading to decreased FN1 degradation.On the other hand,autophagic flux was blocked in BECN1 mutant HNSCC Cal-27 cells,and rapamycin did not promote autophagy in Cal-27 cells;also in addition,FN1 degradation was inhibited.Further,we identified FN1 degradation through the lysosome-dependent degradation pathway using the proteasome inhibitor MG132.Data from immunoprecipitation assays also showed that p62/SQSTM1 participated as an autophagy adapter in the autophagy–lysosome pathway of FN1 degradation.Finally,data from immunoprecipitation assays demonstrated that the interaction between p62 and FN1 was abolished in p62 mutant MCF-7 and A2780 cell lines.These results indicate that autophagy significantly promotes the degradation of FN1.Collectively,our findings clearly suggest that FN1,as a marker of EMT,has adverse effects on HNSCC and elucidate the autophagy–lysosome degradation mechanism of FN1.Xinchen Liu Lin Meng Xing Li Daowei Li Qilin Liu Yumeng Chen Xiangwei Li Wenhuan Bu Hongchen Sun 2020International Journal of Oral Science2020,12,4:7
2Effects of dietary leucine supplementation on the gene expression of mammalian target of rapamycin signaling pathway and intestinal development of broilers显示文摘This experiment was to investigate the effects of dietary leucine supplementation on the gene expression of mammalian target of rapamycin(mTOR) signaling pathway and intestinal development of broilers. A total of 384 one-day-old broilers were randomly assigned into 4 treatments with 6 replicates(16 broilers per replicate). Broilers in these treatment groups were offered the following diets with 1.37,1.77,2.17 and2.57% of leucine. These diet treatments were named 1.37 TM, 1.77 TM, 2.17 TM, and 2.57 TM. The experiment lasted 21 days and all birds had free access to feed and water. Results indicated that there was no significant difference in body weight, average daily gain and average feed intake among all treatments(P > 0.05). The broiler duodenal villus height in 2.57 TM was the lowest, but the highest occurred in1.37 TM on d 7 and 14(P < 0.05). The villus height in the jejunum and ileum increased along with leucine level from 1.37 to 2.17%. The villus height of jejunum was significantly higher in 2.17 TM than in 1.37 TM on d 7 and 14, and the ratio of villus height to crypt depth(V:C) in the duodenum, jejunum and ileum increased significantly(P < 0.05) on d 21. The gene expression level of mTOR in the duodenum decreased with increasing leucine level and was higher in 1.37 TM than in 2.57 TM on d 7 and 14(P < 0.05). On d 14 and 21 of the trial, the expression of S6 K1 in the duodenum was higher in 1.37 TM than in 2.57 TM(P < 0.05), and the expression of mTOR, S6 K1 in the jejunum and ileum increased with increasing leucine level form 1.37 to 2.17%, whereas a significant difference occurred between 1.37 TM and 2.17 TM(P< 0.05).In conclusion, the addition of leucine fails to enhance the growth performance of broilers. However,leucine can improve intestinal development by enhancing villus height and V:C ratio in the jejunum and ileum. Moreover, the expression of mTOR, S6 K1 increased as the level of dietary leucine was elevated from 1.37 to 2.17%.Yinlian Chang Huiyi Cai Guohua Liu Wenhuan Chang Aijuan Zheng Shu Zhang Ruibo Liao Wei Liu Yang Li Jia Tian 2015Animal Nutrition2015,,4:6
3MII:A Novel Text Classification Model Combining Deep Active Learning with BERT显示文摘Active learning has been widely utilized to reduce the labeling cost of supervised learning.By selecting specific instances to train the model,the performance of the model was improved within limited steps.However,rare work paid attention to the effectiveness of active learning on it.In this paper,we proposed a deep active learning model with bidirectional encoder representations from transformers(BERT)for text classification.BERT takes advantage of the self-attention mechanism to integrate contextual information,which is beneficial to accelerate the convergence of training.As for the process of active learning,we design an instance selection strategy based on posterior probabilities Margin,Intra-correlation and Inter-correlation(MII).Selected instances are characterized by small margin,low intra-cohesion and high inter-cohesion.We conduct extensive experiments and analytics with our methods.The effect of learner is compared while the effect of sampling strategy and text classification is assessed from three real datasets.The results show that our method outperforms the baselines in terms of accuracy.Anman Zhang Bohan Li Wenhuan Wang Shuo Wan Weitong Chen 2020Computers, Materials & Continua2020,,6:4
4Molecular mechanisms of growth depression in broiler chickens(Gallus Gallus domesticus)mediated by immune stress:a hepatic proteome study显示文摘Background:Immunological stress decreases feed intake,suppresses growth and induces economic losses.However,the underlying molecular mechanism remains unclear.Label-free liquid chromatography and mass spectrometry(LC-MS)proteomics techniques were employed to investigate effects of immune stress on the hepatic proteome changes of Arbor Acres broilers(Gallus Gallus domesticus)challenged with Escherichia coli lipopolysaccharide(LPS).Results:Proteomic analysis indicated that 111 proteins were differentially expressed in the liver of broiler chickens from the immune stress group.Of these,28 proteins were down-regulated,and 83 proteins were up-regulated in the immune stress group.Enrichment analysis showed that immune stress upregulated the expression of hepatic proteins involved in defense function,amino acid catabolism,ion transport,wound healing,and hormone secretion.Furthermore,immune stress increased valine,leucine and isoleucine degradation pathways.Conclusion:The data suggests that growth depression of broiler chickens induced by immune stress is triggered by hepatic proteome alterations,and provides a new insight into the mechanism by which immune challenge impairs poultry production.Aijuan Zheng Anrong Zhang Zhimin Chen Shoaib Ahmed Pirzado Wenhuan Chang Huiyi Cai Wayne L.Bryden Guohua Liu 2021Journal of Animal Science and Biotechnology2021,12,4:4
5Large-area and highly uniform carbon nanotube film for nigh-performance thin film transistors显示文摘Guodong Dong Jie Zhao Lijun Shen Jiye Xia Hu Meng Wenhuan Yu Qi Huang Hua Han Xuelei Liang Lianmao Peng 2018Nano Research2018,11,8:3
6The production of iron oxide during peridotite serpentinization:Influence of pyroxene显示文摘Serpentinization produces molecular hydrogen(H2)that can support communities of microorganisms in hydrothermal fields;H2 results from the oxidation of ferrous iron in olivine and pyroxene into ferric iron,and consequently iron oxide(magnetite or hematite)forms.However,the mechanisms that control H2 and iron oxide formation are poorly constrained.In this study,we performed serpentinization experiments at 311℃ and 3.0 kbar on olivine(with <5% pyroxene),orthopyroxene,and peridotite.The results show that serpentine and iron oxide formed when olivine and orthopyroxene individually reacted with a saline starting solution.Olivine-derived serpentine had a significantly lower FeO content(6.57±1.30 wt.%)than primary olivine(9.86 wt.%),whereas orthopyroxene-derived serpentine had a comparable FeO content(6.26±0.58 wt.%)to that of primary orthopyroxene(6.24 wt.%).In experiments on peridotite,olivine was replaced by serpentine and iron oxide.However,pyroxene transformed solely to serpentine.After 20 days,olivine-derived serpentine had a FeO content of 8.18±1.56 wt.%,which was significantly higher than that of serpentine produced in olivine-only experiments.By contrast,serpentine after orthopyroxene had a slightly higher FeO content(6.53±1.01 wt.%)than primary orthopyroxene.Clinopyroxene-derived serpentine contained a significantly higher FeO content than its parent mineral.After 120 days,the FeO content of olivine-derived serpentine decreased significantly(5.71±0.35 wt.%),whereas the FeO content of orthopyroxene-derived serpentine increased(6.85±0.63 wt.%)over the same period.This suggests that iron oxide preferentially formed after olivine serpentinization.Pyroxene in peridotite gained some Fe from olivine during the serpentinization process,which may have led to a decrease in iron oxide production.The correlation between FeO content and SiO_2 or AI_2 O_3 content in olivine-and orthopyroxene-derived serpentine indicates that aluminum and silica greatly control the production of iron oxide.Based on our results and data from natural serpentinites reported by other workers,we propose that aluminum may be more influential at the early stages of peridotite serpentinization when the production of iron oxide is very low,whereas silica may have a greater control on iron oxide production during the late stages instead.Ruifang Huang Chiou-Ting Lin Weidong Sun Xing Ding Wenhuan Zhan Jihao Zhu 2017Geoscience Frontiers2017,8,6:3
7Numerical Simulation for Shallow Strata Stability of Coral Reef in the Southwest of Yongshu Reef(South China Sea)显示文摘In recent years, infrastructure construction on coral reefs has been increasingly developed. Therefore, the shallow strata stability of coral reefs in the South China Sea should be evaluated. This study aims to investigate the profiles for the shallow strata of coral reefs in the southwest of the Yongshu Reef, particularly in the hydrodynamic marine environment, and to establish a geological model for numerical simulation using Geo-Studio. The shallow strata of the coral reefs include mass gravel, sand gravel, mid-coarse sand, silty sand, fine sand, and reef limestone. The shallow reef slope near the lagoon is similar to a ‘layer cake', in which the side close to the sea is analogous to a ‘block cake'. The simulation results showed that coral reef stability depends on wave loads and earthquake strength and on the physical properties of coral reefs. The factor of safety for the outer reef is greater than 10.0 under static, wave, and seismic conditions; this indicated that the outer reefs were less affected by waves and earthquakes. However, the factor of safety next to the lagoon varied from 0.1 to 5.3. The variation was primarily caused by the thick strata of coral reefs close to the sea(reef limestone, typically with the thickness > 10 m and equivalent to a block). The soil and rock layers in the coral reef strata with thicknesses < 10 m showed weak engineering geological characteristics. Our findings can provide useful information to future construction projects on coral reefs.TANG Qinqin ZHANG Jinchang FENG Yingci LI Jian YAO Yantao SUN Jie ZHAN Wenhuan 2018Journal of Ocean University of China2018,17,4:3
8Low temperature catalytic oxidation of NO over different-shaped CeO2显示文摘To investigate the effect of CeO_2 nanomaterial morphology on its performance for NO catalytic oxidation.Three kinds of CeO_2 nanomaterials including CeO_2 nanorods,nanospheres and nanoparticles were prepared by hydrothermal method and used for catalytic oxidation of NO at low temperature. The experimental results show that CeO_2 nanorods are of the best catalytic performance. Characterization techniques including TEM, XRD, H_2-TPR, NO-TPD and XPS were used to determine the relationship between the morphology of CeO_2 nanomaterial and its catalytic performance. TEM images show that CeO_2 nanorods predominantly exposed(110) and(10 0) planes, while CeO_2 nanospheres and CeO_2 nanoparticles predominantly exposed(111) plane. The excellent catalytic performance of CeO_2 nanorods could be ascribed to the low crystallinity, high reducibility, strong NO adsorption ability and the presence of more surface chemisorbed oxygen.Wenhuan Wang Ruitang Guo Weiguo Pan Guoxin Hu 2018Journal of Rare Earths2018,36,6:3
9An Analysis of Operational Efficiency of Agricultural Insurance Agency:Based on Three-Stage DEA Model显示文摘From the perspective of agricultural insurance agency,this paper focuses on the study of operational efficiency of agricultural insurance agency,and analyzes the operational efficiency of agricultural insurance agency and its influencing factors,in order to improve the operational efficiency of agricultural insurance agency,better supply agricultural insurance and achieve the policy effect of agricultural insurance.The results of this paper are as follows:( i) Either comprehensive operational efficiency or scale efficiency of Chinese-funded agency is higher than that of foreign-funded agency,but its pure technical efficiency is lower than that of foreign-funded agency,indicating that the managerial decision ability of Chinese-funded agency is weaker than that of foreign-funded agency,and needs to be improved;( ii) The operational efficiency of professional agricultural insurance agency is higher than that of comprehensive agricultural insurance agency,and the agricultural insurance agency is greatly affected by environmental factors;( iii) The operating time of agricultural insurance agency is proportional to its operational efficiency;( iv) The quality of employees is positively correlated with the capital and cost input difference,but negatively correlated with the difference in the number of employees. Therefore,it is necessary to pay attention to the improvement of employees' working efficiency while laying emphasis on employees' quality.Xuan CHEN Wenhuan WEI 2016Asian Agricultural Research2016,8,12:2
10Moderate papain addition improves the physicochemical,microbiological,flavor and sensorial properties of Chouguiyu,traditional Chinese fermented fish显示文摘The objective of this study was to investigate the effect of papain on the physicochemical and microbiological properties,volatile compound profiles,and sensorial attributes of Chouguiyu.Papain was applied at a dose of 10,50,200,400 U/g fish.Results showed that papain addition improved the release of free amino acids,essential amino acids,eicosapentaenoi acid(EPA,C20:5n3),and docosapentenoic acid(DPA,C22:5n6),respectively.Lower biogenic amines content,higher the volatile compound concentrations and relative abundance of Lactobacillales were also observed.Further results showed that the papain dose group decreased the fermentation time from 10 to 7 days while good organoleptic quality was remained,especially in the 200 U/g dose group.The redundancy analysis(RDA)showed a high correlation between Lactobacillus and the key volatile compounds in the 200 U/g and 400 U/g groups,which indicated that Lactobacillus could contribute to the fatty flavor.In summary,proper papain addition(i.e.200 U/g or 400 U/g)could reduce biogenic amines contents and maintain acceptable sensorial properties of Chouguiyu in a shorter fermentation time.Wenhuan Xu Cuicui Jiang Aoxue Liu Ruiqi Bao Wenqing Wang Zuoli Zhang Chaofan Ji Huipeng Liang Sufang Zhang Xinping Lin 2022Food Bioscience2022,46,2:2
11Analyses of active faults, seismic activities and sea floor unstable factors of the Zhujiang River Mouth Basin and its adjacent areas显示文摘-On the basis of the data of geophysics and seismic activities, the analyses of the active faults, seismic activities and the sea floor unstable factors of the Zhujiang River Mouth Basin have been made so as to study the characteristics of the compressional subactive continental margin of Cathaysian system, arc littoral strongly active fracture zone, the division of seismic subzone and seismic zone of the continental margin of northern South China Sea, the potential focal area, and to analyze the regional stability. We consider that the Zhujiang River Mouth Basin belongs to a stable or a moderately stable region.Liu Yixuan, Zhang Yixiang, Zhou Jialun , Xie Yixuan, Lu Chengbing, Zhong Jianqiang and Zhan Wenhuan South China Sea Institute of Oceanology, Academia Sinica, Guangzhou, China 1990Acta Oceanologica Sinica1990,9,3:2
12The oral microbiome of pregnant women facilitates gestational diabetes discrimination显示文摘The oral microbiota plays an important role in the development of various diseases,whereas its association with gestational diabetes mellitus (GDM) remains largely unclear.The aim of this study is to identify biomarkers from the oral microbiota of GDM patients by analyzing the microbiome of the saliva and dental plaque samples of 111 pregnant women.We find that the microbiota of both types of oral samples in GDM patients exhibits differences and significantly varies from that of patients with periodontitis or dental caries.Using bacterial biomarkers from the oral microbiota,GDM classification models based on support vector machine and random forest algorithms are constructed.The area under curve (AUC) value of the classification model constructed by combination of Lautropia and Neisseria in dental plaque and Streptococcus in saliva reaches 0.83,and the value achieves a maximum value of 0.89 by adding clinical features.These findings suggest that certain bacteria in either saliva or dental plaque can effectively distinguish women with GDM from healthy pregnant women,which provides evidence of oral microbiome as an informative source for developing noninvasive biomarkers of GDM.Xiaoqing Li Jiayong Zheng Xiuling Ma Bing Zhang Jinyang Zhang Wenhuan Wang Congcong Sun Yeping Wang Jianqiong Zheng Haiying Chen Jiejing Tao Hai Wang Fengyi Zhang Jinfeng Wang Hongping Zhang 2021Journal of Genetics and Genomics2021,48,1:2
13Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated with herpes zoster: a case report显示文摘Hang Xiang Xiaomei Zhang Chao Yang Wenhuan Xu Xin Ge Rong Zhang Ya Qiu Wanjun Sun Fan Li Tianyuan Xiang Haixu Chen Zheng Wang Qiang Zeng 2016Frontiers of Medicine2016,10,4:2
14Fullerene-Intercalated Graphitic Carbon Nitride as a HighPerformance Anode Material for Sodium-Ion Batteries显示文摘Two-dimensional(2D)graphitic carbon nitride(g-CN)is a promising anode material for sodium-ion batteries(SIBs),but its insufficient interlayer spacing and poor electronic conductivity impede its sodium storage capacity and cycling stability.Herein,we report the fabrication of a fullerene(C_(60))-modified graphitic carbon nitride(C_(60)@CN)material which as an anode material for SIBs shows a high-reversible capacity(430.5 mA h g^(−1) at 0.05 A g^(−1),about 3 times higher than that of pristine g-CN),excellent rate capability(226.6 mA h g^(−1) at 1 A g^(−1))and ultra-long cycle life(101.2 mA h g^(−1) after 5000 cycles at 5 A g^(−1)).Even at a high-active mass loading of 3.7 mg cm^(−2),a reversible capacity of 316.3 mA h g^(−1) can be obtained after 100 cycles.Such outstanding performance of C_(60)@CN is attributed to the C_(60) molecules distributed in the g-CN nanosheets,which enhance the electronic conductivity and prevent g-CN sheets from restacking,thus resulting in enlarged interlayer spacing and exposed edge N defects(pyridinic N and pyrrolic N)for sodium-ion storage.Furthermore,a sodium-ion full cell combining C60@CN anode and NVPF@rGO cathode provides high-coulombic efficiency(>96.5%),exceptionally high-energy density(359.8 W h kganode−1 at power density of 105.1 W kganode−1)and excellent cycling stability(89.2%capacity retention over 500 cycles at 1Aganode−1).This work brings new insights into the field of carbon-based anode materials for SIBs.Pengju Li Yanglin Shen Ximing Li Wenhuan Huang Xing Lu 2022Energy & Environmental Materials2022,5,2:2
15Emerged fossil corals on the coast of northwestern Hainan Island, China: Implications for mid-Holocene sea level change and tectonic uplift显示文摘Fossil corals are widespread on the coast of northwestern Hainan Island, China. Most of these corals are exposed during low tide levels, indicating that a higher sea level may have existed during their life time. The radiocarbon data introduced by this paper in combination with those from other sources show that the corals were alive mainly during the midto late-Holocene. Mid-Holocene sea levels 1-3 m higher than the present level were confirmed for adjacent coasts; however, the emerged corals on the investigated coast are not necessarily indicators of a higher eustatic sea level. They do predict relative sea levels of 1.5-3.4 m when using 1 m below the tidal datum as the upper limit of coral growth. However, using the Mean Lower Low Water as the coral's upper growth limit, the relative sea level on the non-volcanic coast was almost as high as the present level, whereas that on the volcanic coast was 0.4-2.0 m higher than present. Therefore, the exposure of these dead coral heads and their discrepancy in elevation may be the result of tectonic uplift caused by volcanic activities. From these results, the highest sea level of upward coral growth must be defined first when using fossil corals to reconstruct past sea levels. Meanwhile, vertical tectonics have to be taken into account as a significant factor when conducting high-resolution sea level reconstruction, although the South China coast is located in a 'tectonically stable' region.YAO YanTao ZHAN WenHuan SUN JinLong SUN Jie 2013Chinese Science Bulletin2013,58,23:2
16Enhanced ionic diffusion interface in hierarchical metal-organic framework@layered double hydroxide for high-performance hybrid supercapacitors显示文摘Layered double hydroxides(LDHs)with abundant accessible active sites are promising electrode materials for hybrid supercapacitor(HSC)due to their ultrahigh theoretical capacitances.However,the structural agglomeration of LDH leads to poor rate capability and durability.Herein,we construct a diffusion-controlled interface in hierarchical architecture of metal-organic framework(MOF)HKUST-1@cobalt-nickel LDH(denoted as HKUST-1@CoNiLDH)through an in situ etching/electro-deposition strategy.The rapid charge transfer and ionic diffusion in HKUST-1@CoNiLDH deliver a remarkable specific capacity of 297.23 mAh·g^(−1) at 1 A·g^(−1),superior to mostly reported LDH-based electrodes.More importantly,the as-prepared HKUST-1@CoNiLDH//activated carbon HSC exhibit a high energy density of 39.8 Wh·kg^(−1) at a power density of 799.9 W·kg^(−1) with an outstanding capacitance retention of 90%after 5,000 charge–discharge cycles.The in-depth understanding of the ionic diffusion among the MOF/LDH interfaces will greatly promote the further development of designing and synthesizing high performance energy conversion and storage devices.Yanan Zhang Junlei Chen Chenyang Su Keyao Chen Huabin Zhang Yuhao Yang Wenhuan Huang 2022Nano Research2022,15,10:2
17Effects of aflatoxins on growth performance and skeletal muscle of Cherry Valley meat male ducks显示文摘This study aims to evaluate the effects of aflatoxins on growth performance and skeletal muscle of Cherry Valley meat male ducks as they grow and develop. One-day-old healthy meat male ducks(n = 180) were randomly divided into 2 groups; there were 6 replicates in each group and 15 ducks in each replicate. The control group was fed a basic diet, and the experimental group was fed a mold-exposed cottonseed meal diet containing aflatoxins instead of normal cottonseed meal. The experimental period was 35 days, and divided into two stages of 1 to 14 days(early stage) and 15 to 35 days(late stage). During the experimental period, live weight, breast muscle weight and thigh muscle weight of meat male ducks were measured weekly. Results showed as follows: 1) aflatoxins contained in the mold-exposed diet significantly reduced daily weight gain and feed intake, and increased feed-to-gain ratio of meat male ducks at different ages(P < 0.05); 2) the Gompertz equation(W_t = W_m exp {-exp [-B(t-t~*)]}) could successfully fit the growth curve and growth and developmental patterns of skeletal muscles of Cherry Valley meat male ducks(R^2≥0.97); 3) the relationship between chest muscle and live weight was the best described by a power regression and polynomial regression(R^2 = 0.99); the relationship between live weight and thigh muscle weight was the best described by linear regression, polynomial regression, and power regression(R^2 = 0.99); 4) aflatoxins in the mold-exposed diet significantly reduced live weight, breast muscle weight and thigh muscle weight of Cherry Valley meat male ducks at various ages; and 5) aflatoxins delayed the age at peak in growth of meat male ducks, and reduced weights at the peak for breast muscle, thigh muscle and whole body as well as the maximal daily weight gain. In summary,aflatoxins delayed growth of Cherry Valley meat male ducks and development of skeletal muscle.Wenhuan Chang Qing Xie Aijuan Zheng Shu Zhang Zhimin Chen Jinquan Wang Guohuo Liu Huiyi Cai 2016Animal Nutrition2016,,3:2
18Research on the Impact of Distributed Generation on Relay Protection and Its Standards显示文摘Distributed generation(DG) will change characteristics of power flow and faults of traditional distribution network as well as the network operation mode, especially the operation of relay protection and automatic circuit breaker re-closing. In this paper, the characteristics and influences of several types of distributed generation and connection pattern, relay protection and automatic circuit breaker re-closing are analyzed. Standards of relay protection when distributed generation access to distribution network are discussed as well.Yang Guosheng Zhou Zexin Li Wei Liu Yu Liu Yadong Wang Xiaoyang Wang Wenhuan 2014Electricity2014,25,5:2
19Novel vector quantiser design using reinforced learning as a pre-process显示文摘Wenhuan Xu A K Nandi Jihong Zhang 2005Signal Processing2005,85,7:1
20The Influence of Ligand Configuration, Solvent Size and Solvent Polarity on the Porous Shape and Void Volume in a Series of Isomeric or Isomorphic Porous MOFs显示文摘HUANG Wenhuan LUAN Xinjun ZHOU Xiang 2013Cryst Eng Cornm2013,15,10:1
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