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| 1 | Performance of the Seasonal Forecasting of the Asian Summer Monsoon by BCC_CSM1.1(m)显示文摘This paper provides a comprehensive assessment of Asian summer monsoon prediction skill as a function of lead time and its relationship to sea surface temperature prediction using the seasonal hindcasts of the Beijing Climate Center Climate System Model, BCC CSM1.1(m). For the South and Southeast Asian summer monsoon, reasonable skill is found in the model's forecasting of certain aspects of monsoon climatology and spatiotemporal variability. Nevertheless, deficiencies such as significant forecast errors over the tropical western North Pacific and the eastern equatorial Indian Ocean are also found. In particular, overestimation of the connections of some dynamical monsoon indices with large-scale circulation and precipitation patterns exists in most ensemble mean forecasts, even for short lead-time forecasts.Variations of SST, measured by the first mode over the tropical Pacific and Indian oceans, as well as the spatiotemporal features over the Ni no3.4 region, are overall well predicted. However, this does not necessarily translate into successful forecasts of the Asian summer monsoon by the model. Diagnostics of the relationships between monsoon and SST show that difficulties in predicting the South Asian monsoon can be mainly attributed to the limited regional response of monsoon in observations but the extensive and exaggerated response in predictions due partially to the application of ensemble average forecasting methods. In contrast, in spite of a similar deficiency, the Southeast Asian monsoon can still be forecasted reasonably, probably because of its closer relationship with large-scale circulation patterns and El Nino–Southern Oscillation. | LIU Xiangwen WU Tongwen YANG Song JIE Weihua NIE Suping LI Qiaoping CHENG Yanjie LIANG Xiaoyun | 2015 | Advances in Atmospheric Sciences2015，32，8： | 25 |
| 2 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 3 | LPI radar signal detection based on radial integration of Choi-Williams time-frequency image显示文摘This paper mainly revolves the time-frequency image of low probability of intercept(LPI) radar signals and carries out research work on image features selection and extraction and recognition. Since Choi-Williams distribution(CWD) uses the exponential kernel of bilinear generalized class of time-frequency distribution, it has an excellent time-frequency aggregation. And it is suitable for detecting LPI radar signals in a low signal-to-noise ratio(SNR) condition. A radial integration method based on the integral rotating factor is proposed to detect LPI radar signals when the signals' time-frequency image is obtained. First, the digital image processing method is used to preprocess the LPI radar signals' time-frequency images after CWD transformation; then, the radial integration method based on the integral rotating factor is used to detect LPI radar signals in the binary images. The analytic results of real data show that the method has a good performance on detecting LPI radar signals in a low SNR condition. Additionally,the method is simple and takes less logic resources and has the potential of real-time detection of LPI radar signals. | Yongjian Liu Peng Xiao Hongchao Wu Weihua Xiao | 2015 | Journal of Systems Science & Complexity2015，28，5： | 18 |
| 4 | Metabolic changes in cancer: beyond the Warburg effect显示文摘改变的新陈代谢是癌症房间的特点之一。在癌症房间的最著名的新陈代谢的反常是 Warburg 效果,它甚至面对氧表明增加的 glycolysis。然而,肿瘤相关的新陈代谢的畸形没被限制到在葡萄糖发酵和氧化 phosphorylation 之间的改变的平衡。象 p53 和 c-myc 那样的关键肿瘤基因被发现是新陈代谢的主人管理者。象 succinate 脱氢酶, fumarate hydratase, pyruvate kinase,和 isocitrate 脱氢酶变化或表示水平改变那样的新陈代谢的酶都被连接到 tumorigenesis。在这评论,我们介绍一些联系癌症的新陈代谢的混乱和他们的分子的 tumorigenic 机制的当前的理解。 | Weihua Wu Shimin Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，1： | 15 |
| 5 | COVID-19 Super Spreading Event Amongst Elderly Individuals—Jilin Province,China,January 2021显示文摘Summary What is already known on this topic?Clusters of COVID-19 cases often happened in small settings(e.g.,families,offices,school,or workplaces)that facilitate person-to-person virus transmission,especially from a common exposure.What is added by this report?On January 10 and 11,2021,an individual gave three product promotional lectures in Tonghua City. | Laishun Yao Mingyu Luo Tiewu Jia Xingang Zhang Zhulin Hou Feng Gao Xin Wang Xiaogang Wu Weihua Cheng Guoqian Li Jing Lu Bing Zhao Tao Li Enfu Chen Dapeng Yin Biao Huang | 2021 | China CDC weekly2021，3，10： | 13 |
| 6 | Long-term trends of fine particulate matter and chemical composition in the Pearl River Delta Economic Zone (PRDEZ), China显示文摘在下午 2.5 层次理解趋势为提出是必要的干净空气计划。这份报纸在珀尔河三角洲经济地区(PRDEZ ) 为 2000 年从各种各样的出版来源分析下午 2.5 数据到 2010。在下午 2.5 团集中的长期的变化被分析。结果给那位首相看 2.5, 器官的碳(OC ) ,元素的碳(EC ) ,并且那么 42 显示出一个类似的趋势,在 2005 前增加然后稍微减少。年度普通下午 2.5 集中从 49.1 g ? | Xuemei WANG Weihua CHEN Duohong CHEN Zhiyong WU Qi Fan | 2016 | Frontiers of Environmental Science & Engineering2016，10，1： | 11 |
| 7 | Dynamic simulation of urban water metabolism under water environmental carrying capacity restrictions显示文摘为城市的水新陈代谢(UWM ) 的一个修订概念在这研究被介绍在关于 UWM 的当前的研究探讨机能不全,这些问题把新陈代谢的过程与传统的城市的水联系了。反馈环能被分析环境带增加水在传统的 UWMS 的上的新城市的水新陈代谢系统(UWMS ) 的能力(WECC ) 。UWMS 的反馈环的分析被用来构造系统动力学(SD ) 为在 WECC 限制下面的系统的模型。水新陈代谢的过程作为一个例子在北京用 Tongzhou 区域为不同情形被模仿。最新发达的 UWM 盒子的结果证明 Tongzhou 区域的水环境能支持 1.1926 | Weihua ZENG Bo WU Ying CHAI | 2016 | Frontiers of Environmental Science & Engineering2016，10，1： | 9 |
| 8 | Relationships between Interannual and Intraseasonal Variations of the Asian–Western Pacific Summer Monsoon Hindcasted by BCC CSM 1.1(m)显示文摘Using hindcasts of the Beijing Climate Center Climate System Model, the relationships between interannual variability(IAV) and intraseasonal variability(ISV) of the Asian–western Pacific summer monsoon are diagnosed. Predictions show reasonable skill with respect to some basic characteristics of the ISV and IAV of the western North Pacific summer monsoon(WNPSM) and the Indian summer monsoon(ISM). However, the links between the seasonally averaged ISV(SAISV) and seasonal mean of ISM are overestimated by the model. This deficiency may be partially attributable to the overestimated frequency of long breaks and underestimated frequency of long active spells of ISV in normal ISM years, although the model is capable of capturing the impact of ISV on the seasonal mean by its shift in the probability of phases.Furthermore, the interannual relationships of seasonal mean, SAISV, and seasonally averaged long-wave variability(SALWV; i.e., the part with periods longer than the intraseasonal scale) of the WNPSM and ISM with SST and low-level circulation are examined. The observed seasonal mean, SAISV, and SALWV show similar correlation patterns with SST and atmospheric circulation, but with different details. However, the model presents these correlation distributions with unrealistically small differences among different scales, and it somewhat overestimates the teleconnection between monsoon and tropical central-eastern Pacific SST for the ISM, but underestimates it for the WNPSM, the latter of which is partially related to the too-rapid decrease in the impact of El Nino–Southern Oscillation with forecast time in the model. | LIU Xiangwen WU Tongwen YANG Song LI Qiaoping CHENG Yanjie LIANG Xiaoyun FANG Yongjie JIE Weihua NIE Suping | 2014 | Advances in Atmospheric Sciences2014，31，5： | 9 |
| 9 | Chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and nonalcoholic steatohepatitis via angiogenesis rather than endoplasmic reticulum stress显示文摘In the present study,we aimed to investigate the role of endoplasmic reticulum stress(ERS)and its related inflammation and angiogenesis in liver fibrosis in a rat model of combined hypoxia and nonalcoholic steatohepatitis(NASH)and to confirm whether the intervention of hypoxia-inducible factor 1α(HIF1α)can improve fibrosis.Liver histological changes and biochemical indices,HIF1α,inflammatory factors,ERS-related parameters(GRP78,CHOP,caspase-3,and caspase-12),and angiogenesis indices(VEGFA,VEGFR2,and CD34)were evaluated.Compared with the control rats,the liver tissue of rats with hypoxia and NASH had obvious NASH characteristics and hepatic fibrosis was significantly aggravated,including bridging fibrosis in some rats.The mRNA expression levels of HIF1α,VEGFA,and VEGFR2 and total immunohistochemical staining scores of VEGFR2 and CD34 were significantly increased.In addition,HIF1α silencing significantly decreased HIF1α,biochemical indices(ALT,AST,and TG),inflammatory factors(TNFα,IL6,and IL1β),and angiogenesis indices(CD34 and VEGFR2),consequently,improved the hepatic fibrosis score in the rat model of combined hypoxia and NASH.Taken together,chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and NASH via angiogenesis rather than ERS and HIF1α intervention can improve liver fibrosis,angiogenesis,inflammatory factors,and biochemical indices.Therefore,HIF1α is a key regulatory factor of liver fibrosis in rats with combined hypoxia and NASH. | Wei Wu Weiping Li Jiaojiao Wei Chunsheng Wang Yunliang Yao Weihua Zhu Weimei He Weimei Zhou Jiang Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 8 |
| 10 | The point defect and electronic structure of K doped LaCo_(0.9)Fe_(0.1)O_(3)perovskite with enhanced microwave absorbing ability显示文摘ABO_(3)perovskites,owning unique properties,have great research prospect in electromagnetic wave absorption field.Normally,doping can significantly regulate the dielectric loss,whereas the magnetic loss can be ignored.In this work,the crystal structure and electromagnetic properties can be regulated systematically by the K,Fe co-doping for LaCoO_(3)perovskites(LKCFO)under the condition of fixed F content.In addition,the obtained samples show the obvious interfacial polarization effect on accounting to the small size effect,which is conducive to the effective microwave absorption.By analyzing the evolution of the positron annihilation lifetime and the first-principles calculation of the oxygen density of states for the series of LKCFO perovskites,it is found that the charge transport characteristics will be controlled by the point defect generated by allelic doping.The point defect content decreases and then increases as the doping level rises.The prepared perovskite exhibits the lowest defect density and the largest dielectric loss capability,which indicates that the lower point defects promote electron migration and thus enhance the dielectric loss;thus,the electromagnetic wave absorption bandwidth up to 6.2 GHz is reached.In contrast,both insufficient and excessive K doping are detrimental to the enhancement of microwave absorption.Especially,the practical application value was investigated using Computer Simulation Technology(CST)simulations.The LKCFO-2 exhibits the smallest RCS value(below-10 dBm^(2))at almost-90°-90°with a thickness of 2 mm,providing an effective method for study excellent microwave absorption and scattering property. | Fan Wang Weihua Gu Jiabin Chen Yue Wu Ming Zhou Shaolong Tang Xingzhong Cao Peng Zhang Guangbin Ji | 2022 | Nano Research2022，15，4： | 7 |
| 11 | A Sequential Converted Measurement Kalman Filter with Doppler Measurements in ECEF Coordinate System显示文摘When there is the correlation between Doppler and slant range, previous literatures have presented some sequential filter algorithms. However, they are only applied to simplified fixed radar' s local coordinate system. As a result, a Sequential converted measurement Kalman filter(SCMKF) with Doppler measurements based on the Earth centered earth fixed(ECEF) coordinate system applicable to a moving airborne platform which has time varying attitude is proposed. Firstly, the correlated Doppler and range are decorrelated using the Cholesky factorization, then the converted position measurements are obtained by a series of coordinate transformation with unchanged range component and other observations, such as azimuth and elevation angles; the corresponding error covariances are derived which are used to the Converted measurement Kalman filter(CMKF).Finally the sequential filter is implemented for changed pseudo-Doppler measurements. The proposed method is validated through Monte Carlo test compared with the performance of CMKF with just converted position measurements and traditional SCMKF with Doppler which ignores the correlation between Doppler and range noises,and the conclusion is obtained that utilizing Doppler information correctly can improve tracking performance, nevertheless, the improvement gain of filter accuracy is limited,which can provide some references for engineering application. | WU Weihua JIANG Jing FENG Xun QIN Xing | 2016 | Chinese Journal of Electronics2016，25，1： | 6 |
| 12 | Changes in nitrogen budget and potential risk to the environment over 20 years(1990–2010) in the agroecosystems of the Haihe Basin, China显示文摘The nitrogen balance can serve as an indicator of the risk to the environment of nitrogen loss from agricultural land. To investigate the temporal and spatial changes in agricultural nitrogen application and its potential threat to the environment of the Haihe Basin in China, we used a database of county-level agricultural statistics to calculate agricultural nitrogen input, output,surplus intensity, and use efficiency. Chemical fertilizer nitrogen input increased by 51.7% from1990 to 2000 and by 37.2% from 2000 to 2010, concomitant with increasing crop yields.Simultaneously, the nitrogen surplus intensity increased by 53.5% from 1990 to 2000 and by16.5% from 2000 to 2010, presenting a continuously increased environmental risk. Nitrogen use efficiency decreased from 0.46 in 1990 to 0.42 in 2000 and remained constant at 0.42 in 2010,partly due to fertilizer composition and type improvement. This level indicates that more than half of nitrogen inputs are lost in agroecosystems. Our results suggest that although the improvement in fertilizer composition and types has partially offset the decrease in nitrogen use efficiency, the environmental risk has still increased gradually over the past 20 years, along with the increase in crop yields and nitrogen application. It is important to achieve a better nitrogen balance through more effective management to significantly reduce the environmental risk,decrease nitrogen surplus intensity, and increase nitrogen use efficiency without sacrificing crop yields. | Mengmeng Zheng Hua Zheng Yingxia Wu Yi Xiao Yihua Du Weihua Xu Fei Lu Xiaoke Wang Zhiyun Ouyang | 2015 | Journal of Environmental Sciences2015，27，2： | 6 |
| 13 | The Role of Host Cytoskeleton in Flavivirus Infection显示文摘The family of flaviviruses is one of the most medically important groups of emerging arthropod-borne viruses. Host cell cytoskeletons have been reported to have close contact with flaviviruses during virus entry, intracellular transport, replication, and egress process, although many detailed mechanisms are still unclear. This article provides a brief overview of the function of the most prominent flaviviruses-induced or-hijacked cytoskeletal structures including actin, microtubules and intermediate filaments, mainly focus on infection by dengue virus, Zika virus and West Nile virus. We suggest that virus interaction with host cytoskeleton to be an interesting area of future research. | Yue Zhang Wei Gao Jian Li Weihua Wu Yaming Jiu | 2019 | Virologica Sinica2019，34，1： | 6 |
| 14 | A Facial Expression Emotion Recognition Based Human-robot Interaction System显示文摘A facial expression emotion recognition based human-robot interaction(FEER-HRI) system is proposed, for which a four-layer system framework is designed. The FEERHRI system enables the robots not only to recognize human emotions, but also to generate facial expression for adapting to human emotions. A facial emotion recognition method based on2D-Gabor, uniform local binary pattern(LBP) operator, and multiclass extreme learning machine(ELM) classifier is presented,which is applied to real-time facial expression recognition for robots. Facial expressions of robots are represented by simple cartoon symbols and displayed by a LED screen equipped in the robots, which can be easily understood by human. Four scenarios,i.e., guiding, entertainment, home service and scene simulation are performed in the human-robot interaction experiment, in which smooth communication is realized by facial expression recognition of humans and facial expression generation of robots within 2 seconds. As a few prospective applications, the FEERHRI system can be applied in home service, smart home, safe driving, and so on. | Zhentao Liu Min Wu Weihua Cao Luefeng Chen Jianping Xu Ri Zhang Mengtian Zhou Junwei Mao | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，4： | 5 |
| 15 | Photochemical indicators of ozone sensitivity: application in the Pearl River Delta, China显示文摘 | Lyumeng Ye Xuemei Wang Shaofeng Fan Weihua Chen Ming Chang Shengzhen Zhou Zhiyong Wu Qi Fan | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 5 |
| 16 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 17 | Au plasmon enhanced high performance β-Ga_2O_3 solar-blind photo-detector显示文摘Surface plasmon polariton(SPP) is electro-magnetic wave coupled to free electron oscillations near the surface of metal, and has been used to improve the photoelectric properties in many optoelectronic devices. In the present study, the Au nanoparticles(NPs)/β-Ga_2O_3 composite thin film was fabricated through depositing Au ultra-thin film on the β-Ga_2O_3 thin film followed by post-thermal treatment. Compared to bare β-Ga_2O_3 thin film, a significant absorption around 510 nm, which is attributed to SPP of Au NPs, was observed in the UV–vis spectrum of Au NPs/β-Ga_2O_3 composite thin film. The results showed that the photoresponse of Au NPs/Ga_2O_3 photodetector illuminated under 254 nm +532 nm light was much higher than that illuminated under 254 nm light, indicating an enhancement of photoelectric property for the solar-blind photodetector based on β-Ga_2O_3 thin film. | Yuehua An Xulong Chu Yuanqi Huang Yusong Zhi Daoyou Guo Peigang Li Zhenping Wu Weihua Tang | 2016 | Progress in Natural Science:Materials International2016，26，1： | 5 |
| 18 | Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression显示文摘Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic regimens.The aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA patients.However,the underpinning mechanism remains poorly understood.Deubiquitinase(DUB)is regarded as a main orchestrator in maintaining protein homeostasis.Here,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent manner.The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo.Further analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient samples.Collectively,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients. | Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin Wu Chenxi Zhao Jiao Wang Jiabin Lu Bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong Bo Yang Hong Zhu Qiaojun He | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 19 | A viral protein orchestrates rice ethylene signaling to coordinate viral infection and insect vector-mediated transmission显示文摘Arthropod-borne viruses cause serious threats to human health and global agriculture by rapidly spreading via insect vectors. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus that is frequently transmitted by planthoppers. However, the molecular mechanisms underlying its propagation in the host plants and epidemics in the field are largely unknown. Here, we showed that the SRBSDV-encoded P6 protein is a key effector that regulates rice ethylene signaling to coordinate viral infection and transmission. In early SRBSDV infection, P6 interacts with OsRTH2 in the cytoplasm to activate ethylene signaling and enhance SRBSDV proliferation;this also repels the insect vector to reduce infestation. In late infection, P6 enters the nucleus, where it interacts with OsEIL2, a key transcription factor of ethylene signaling. The P6-OsEIL2 interaction suppresses ethylene signaling by preventing the dimerization of OsEIL2, thereby facilitating viral transmission by attracting the insect vector. Collectively, these findings reveal a novel molecular mechanism by which an arbovirus modulates the host defense system to promote viral infection and transmission. | Yaling Zhao Xue Cao Weihua Zhong Shunkang Zhou Zhanbiao Li Hong An Xiahua Liu Ruifeng Wu Surakshya Bohora Yan Wu Zhenyi Liang Jiahao Chen Xin Yang Guohui Zhou Tong Zhang | 2022 | Molecular Plant2022，15，4： | 4 |
| 20 | Sr-Nd isotope stratification along water depth:An example from Datong hydrological station of Yangtze River显示文摘This study examines the effects of hydrologic sorting and mixing of sources on the Sr-Nd isotopic compositions of suspended sediments at different water depths. The samples were collected from three layers (surface, middle and bottom) at Datong hydrological station of Yangtze River during the flood season of 2010. Our results show that, 87 Sr/ 86 Sr values decrease from surface to bottom, ranging from 0.730332 to 0.720857. ε Nd (0) values range from 14.75 to 10.09, with surface sediments being the most negative. The isotope composition at the middle layer can best represent the mean isotopic composition of the total suspended sediments transported by a river. It is believed that the stratification of Sr-Nd isotope is attributable to mixing of sediments from different sources due to hydrological sorting. Sediments from the upper stream are found to be coarser, and tend to contribute more to the lower water column. Although Sr-Nd isotope is a well acknowledged tool to trace sediment provenance, the current study suggests that the grain size of the samples and the sampling locations should be taken into consideration when applying this method to provenance study. | LUO Chao ZHENG HongBo WU WeiHua WANG Ping CHEN YuLiang WEI XiaoChun | 2012 | Chinese Science Bulletin2012，57，34： | 4 |
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