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| 1 | Distribution of lipids in modern soils from various regions with continuous climate (moisture-heat) change in China and their climate significance显示文摘Total 26 modern soil samples were collected from various regions under different climate conditions from tropical to arid temperate in China and systematically analyzed for their organic matters by GC/MS in order to evaluate climatic impacts on soil organic components. Abundant lipids molecules were recognized, including n-alkanes, n-alkenones, and long-chain branched alkanes. We find the pre- dominance of main peaks of long-chain n-alkanes (nC29, nC31, nC33) and short-chain ones (nC16, nC17, nC18) records information of soil generation in warm-humid and cold-dry regions. The proportion of n-alkanes (nC16+nC17+nC18) to (nC29+nC31+nC33) varies in good agreement with moisture-heat conditions and thus probably can serve as a new index for climate change. The ratios of C21-/nC22+, nC17/nC31 and (nC15+nC17+nC19) / ( nC27+nC29 +nC31) of n-alkanes, indicating respectively input ratios of lower bacterial alga, aquatic organisms, and higher plants and terraneous organisms, co-vary well in different climate regions from forest to grassland and desert, suggesting that they have also reflected the difference of climates between monsoon region and inland one. The C21-/C22+ ratio of n-alkan-2-one records largely the discrepancy of temperature from north to south of China bordered by the Qinling Mountains, but less humidity. The C21-/C22+ ratio of n-alkan-3-ones changes well with climatic factors, such as tem- perature and humidity. The biogenic source of series A-D long-chain branched alkanes may be derived from some kinds of special epiphyte that most likely live in weak oxic-anoxic and moisture-heat envi- ronments, suggesting their distribution record as well some information on climatic change. All these researches demonstrate that the distributions of lipids molecules in modern soils in China record well signals of climates from quite different climatic regions, and can serve as important climatic proxies to reveal climatic change over China. | WANG YongLi FANG XiaoMin BAI Yan XI XiaoXia ZHANG XiZheng WANG YouXiao | 2007 | Science China Earth Sciences2007，50，4： | 11 |
| 2 | Dust storm in Asia continent and its bio-environmental effects in the North Pacific: A case study of the strongest dust event in April, 2001 in central Asia显示文摘Testing the effects of iron fertilization in booming metabolism of microbes in North Pacific Ocean has become an important hot topic in current global climate change study. The first supportive evidence with natural iron inputs to ocean was ob-tained by Bishop and his colleagues at the PAPA re-gion in North Pacific Ocean. They found a rapid in-crease of marine phytoplankton over North Pacific Ocean after a strong dust storm in April 2001. We demonstrate that the dust deposition flux during this dust storm period decreases exponentially with in-creasing distance from the dust source regions along the dust transport pathway, through integration of synoptic dynamics, changes of TOMS-AI (aerosol index) and surface PM10 values along the dust pathway and changes of particulate organic carbon and chlorophyll in surface oceans. This strong dust storm may result in deposition of about 3.1—5.8 μg/m3 eolian iron into the PAPA region in North Pa-cific Ocean, thus causing a rapid increase of marine phytoplankton productivity observed by Bishop and his colleagues. This work supplies more direct and detailed evidence, from continental dust process, to support the iron hypothesis with natural iron inputs to the surface oceans through dust storms. | HAN Yongxiang FANG Xiaomin XI Xiaoxia SONG Lianchun YANG Shengli | 2006 | Chinese Science Bulletin2006，51，6： | 8 |
| 3 | Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma显示文摘Background:Despite integrin being highlighted as a stiffness-sensor molecule in matrix stiffness-driven angiogenesis,other stiffness-sensor molecules and their mechanosensory pathways related to angiogenesis in hepatocellular carcinoma(HCC)remain obscure.Here,we explored the interplay between Piezo1 and integrinβ1 in the mechanosensory pathway and their effects on HCC angiogenesis to better understand matrix stiffness-induced angiogenesis.Methods:The role of Piezo1 in matrix stiffness-induced angiogenesis was investigated using orthotopic liver cancer SD rat models with high liver stiffness background,and its clinical significance was evaluated in human HCC tissues.Matrix stiffness-mediated Piezo1 upregulation and activation were assayed using an in vitro fibronectin(FN)-coated cell culture system with different stiffness,Western blotting and Ca^(2+)probe.The effects of shPiezo1-conditioned medium(CM)on angiogenesis were examined by tube formation assay,wound healing assay and angiogenesis array.The underlying mechanism by which Piezo1 participated in matrix stiffness-induced angiogenesis was analyzed by microRNA quantitative real-time polymerase chain reaction(qRT-PCR),matrix stiffness measurement,dual-luciferase reporter assay,ubiquitination assay and co-immunoprecipitation.Results:Increased matrix stiffness significantly upregulated Piezo1 expression at both cellular and tissue levels,and high expression of Piezo1 indicated an unfavorable prognosis.High matrix stiffness also noticeably enhanced the activation level of Piezo1,similar to its expression level.Piezo1 knockdown significantly suppressed tumor growth,angiogenesis,and lung metastasis of HCC rat models with high liver stiffness background.shPiezo1-CM from HCC cells attenuated tube formation and migration abilities of vascular endothelial cells remarkably,and analysis of differentially expressed pro-angiogenic factors revealed that Piezo1 promoted the expression and secretion of vascular endothelial growth factor(VEGF),CXC chemokine ligand 16(CXCL16)and insulin-like growth factor binding protein 2(IGFBP2).Matrix stiffness-caused Piezo1 upregulation/activation restrained hypoxia inducible factor-1α(HIF-1α)ubiquitination,subsequently enhanced the expression of downstream pro-angiogenic factors to accelerate HCC angiogenesis.Besides,collagen 1(COL1)-reinforced tissue stiffening resulted in more expression of Piezo1 via miR-625-5p.Conclusions:This study unravels a new mechanism by which the inte-grinβ1/Piezo1 activation/Ca2+influx/HIF-1αubiquitination/VEGF,CXCL16 and IGFBP2 pathway participates in matrix stiffness-driven HCC angiogenesis.Simultaneously,a positive feedback regulation loop as stiff matrix/integrinβ1/miR-625-5p/Piezo1 and COL1/stiffer matrix mediates matrix stiffness-caused Piezo1 upregulation. | Miao Li Xi Zhang Mimi Wang Yaohui Wang Jiali Qian Xiaoxia Xing Zhiming Wang Yang You Kun Guo Jie Chen Dongmei Gao Yan Zhao Lan Zhang Rongxin Chen Jiefeng Cui Zhenggang Ren | 2022 | Cancer Communications2022，42，11： | 3 |
| 4 | Lipids and membrane-associated proteins in autophagy显示文摘Autophagy is essential for the maintenance of cellular homeostasis and its dysfunction has been linked to various diseases.Autophagy is a membrane driven process and tightly regulated by membrane-associated proteins.Here,we summarized membrane lipid composition,and membrane-associated proteins relevant to autophagy from a spatiotemporal perspective.In particular,we focused on three important membrane remodeling processes in autophagy,lipid transfer for phagophore elongation,membrane scission for phago-phore closure,and autophagosome-lysosome membrane fusion.We discussed the significance of the discoveries in this field and possible avenues to follow for future studies.Finally,we summarized the membrane-associated biochemical techniques and assays used to study membrane properties,with a discussion of their applications in autophagy. | Linsen Li Mindan Tong Yuhui Fu Fang Chen Shen Zhang Hanmo Chen Xi Ma Defa Li Xiaoxia Liu Qing Zhong | 2021 | Protein & Cell2021，12，7： | 3 |
| 5 | Assessment of microbial community structure in human colostrum and mature milk based on geographical location and delivery mode显示文摘Breast milk is the most suitable food for the growth and development of infants because it fulfills all the nutritional requirements at this growth stage^([1]).In addition,the wide range of bioactive compounds in milk exerts numerous beneficial effects to infants,including immune system development,protection from infections and metabolism regulation^([2]). | Xiaoxia Xi Weiqiang Huang Qiangchuan Hou Lai-Yu Kwok Zhihong Sun Tiansong Sun | 2017 | Science Bulletin2017，62，11： | 2 |
| 6 | Assessment of strong earthquake risk in the Chinese mainland from 2021 to 2030显示文摘The long-term earthquake prediction from 2021 to 2030 is carried out by researching the active tectonic block boundary zones in the Chinese mainland.Based on the strong earthquake recurrence model,the cumulative probability of each target fault in the next 10 years is given by the recurrence period and elapsed time of each fault,which are adopted from relevant studies such as seismological geology,geodesy,and historical earthquake records.Based on the long-term predictions of large earthquakes throughout the world,this paper proposes a comprehensive judgment scheme based on the fault segments with the seismic gap,motion strongly locked,sparse small-moderate earthquakes,and apparent Coulomb stress increase.This paper presents a comprehensive analysis of the relative risk for strong earthquakes that may occur in the coming 10 years on the major faults in the active tectonic block boundary zones in the Chinese mainland.The present loading rate of each fault is first constrained by geodetic observations;the cumulative displacement of each fault is then estimated by the elapsed time since the most recent strong earthquake. | Zhigang Shao Yanqiang Wu Lingyun Ji Faqi Diao Fuqiang Shi Yujiang Li Feng Long Hui Zhang Wuxing Wang Wenxin Wei Peng Wang Xiaoxia Liu Qi Liu Zhengyang Pan Xiaofei Yin Yue Liu Wei Feng Zhenyu Zou Jia Cheng Renqi Lu Yueren Xu Xi Li | 2023 | Earthquake Research Advances2023，3，1： | 2 |
| 7 | Inefficiency of C3H/HeN Mice to Control Chlamydial Lung Infection Correlates with Downregulation of Neutrophil Activation during the Late Stage of Infection显示文摘我们以前报导在 C3H/HeN (C3H ) 老鼠的 neutrophils 的巨大的渗入不能高效地控制感染和力量贡献的 Chlamydia muridarum (厘米) 到肺感染的这些老鼠的高危险性。为了推进,在 chlamydial 感染期间在 C3H 鼠标定义嗜中性的回答的性质,分别地,我们检验与 neutrophils 渗入和激活有关的粘附分子和 CD11b 的表达式后面的 intranasal 厘米感染。结果证明 selectins (E-selectin, P-selectin 和 L-selectin ) 的表示,和在 C3H 老鼠的肺的细胞间的房间粘附 molecule-1 (ICAM-1 ) 比在 C57BL/6 (B6 ) 更显著地增加了老鼠,更抵抗的紧张。这些结果在 C3H 老鼠与巨大的 neutrophils 渗入相关很好。相反,外部血上的 CD11b 表示和在 C3H 鼠标的肺 neutrophils 在感染(白天 14 ) 的迟了的噬菌体期间与 B6 鼠标相比展出了重要减小。这些调查结果建议在 C3H 鼠标的粘附分子的高级表达式可以提高 neutrophils 招募到肺,但是 neutrophils 上的 CD11b 表示的衰落可以稀释嗜中性的功能。因此, neutrophils 上的 CD11b 下面规定可以贡献 C3H 老鼠的失败控制 chlamydial 肺感染。 | Xiaofei Tang Xiaokun Bu Naihong Zhang Xiaoxia Li Huanjun Huang Hong Bai Xi Yang | 2009 | Cellular & Molecular Immunology2009，6，4： | 2 |
| 8 | Mining intrinsic information of convalescent patients after suffering coronavirus disease 2019 in Wuhan显示文摘OBJECTIVE:To summarize the potential characteristics of convalescent patients with coronavirus disease 2019(COVID-19)in China based on emerging clinical tongue data and guide the treatment and recovery of COVID-19 patients from the perspective of Traditional Chinese Medicine tongue diagnosis.METHODS:In this study,we developed and validated radiomics-based and lab-based methods as a novel approach to provide individualized pretreatment evaluation by analyzing different features to mine the orderliness behind tongue data of convalescent patients.In addition,this study analyzed the tongue features of convalescent patients from clinical tongue qualitative values,including thick and thin,fur,peeling,fat and lean,tooth marks and cracked,and greasy and putrid fur.RESULTS:We included 2164 tongue images in total(34%from day 0,35.4%from day 14 and 30.6%from day 28)from convalescent patients.The significance results are shown as follows.Firstly,as the recovery time prolongs,the L average values of tongue and coat decrease from 60.21 to 57.18 and from 60.06 to 57.03 respectively.Secondly,the decrease of abnormality rate of tongue coat,included greasy tongue fur,putrid fur,teeth-mark,thick-thin fur,are of significant statistical difference(P<0.05).Thirdly,the average value of gray-level cooccurrence matrices increases from 0.173 to 0.194,the average value of entropy increases from 0.606 to 0.665,the average value of inverse difference normalized decrease from 0.981 to 0.979,and the average value of dissimilarity decrease from 0.1576 to 0.1828.The details of other radiomics features are describe in results section.CONCLUSIONS:Our experiment shows that patients in different recovery periods have a relationship with quantitative values of tongue images,including L color space of the tongue and coat radiomics features analysis.This relationship can help clinical doctors master the recovery and health of patients as soon as possible and improve their understanding of the potential mechanisms underlying the dynamic changes and mechanisms underlying COVID-19. | YAN Shixing LüYi LIU Ziqing REN Meng HE Haiyang XIAO Li GUO Feng PENG Miao LI Xiaoxia WANG Yong XU Xi YANG Tao SHAO Zuoyu HUANG Jingjing XIAO Mingzhong | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 1 |
| 9 | Analysis of Continuous Thunderstorm in One Week at Qingdao Airport Based on Sounding Data显示文摘Continuous thunderstorm occurring at Qingdao Airport in China from August 7 to 13,2022 was analyzed based on sounding data.The weather was divided into thunderstorm gale,thunderstorm and heavy precipitation,and some physical quantities and time variables which can effectively identify severe convective weather types were preliminarily obtained.The results show that CAPE was sensitive to different types of weather,but the uncertainty was relatively large.Convective temperature T_(CON),temperature difference between 500 and 850 hPa,and vertical wind shear can distinguish thunderstorm gale,thunderstorm and heavy precipitation weather obviously.Besides,K index,Showalter index,θ_(se) difference between 500 and 850 hPa were also important basis to distinguish thunderstorm and heavy precipitation weather.Thunderstorm gale can be distinguished by the 24-hour variations of K index,and the difference of dew point between 500 and 850 hPa.The 24-hour variations of(T-T_(d))_(500) and vertical wind shear can be used to distinguish between heavy precipitation and thunderstorm weather;the 24-hour variation of stratification stability Δθ_(se) can distinguish the three kinds of weather well.For the wind field,the existence of vertical wind shear was required for strong convective weather,and the 24-hour increment of thunderstorm gale and thunderstorm was larger than that of heavy precipitation. | Yuan LIU Xiaoxia HE Xi LIU Jinghua ZHAO | 2023 | Meteorological and Environmental Research2023，14，1： | 0 |
| 10 | TREM-2 Drives Development of Multiple Sclerosis by Promoting Pathogenic Th17 Polarization显示文摘Multiple sclerosis(MS)is a neuroinflammatory demyelinating disease,mediated by pathogenic T helper 17(Th17)cells.However,the therapeutic effect is accompa-nied by the fluctuation of the proportion and function of Th17 cells,which prompted us to find the key regulator of Th17 differentiation in MS.Here,we demonstrated that the triggering receptor expressed on myeloid cells 2(TREM-2),a modulator of pattern recognition receptors on innate immune cells,was highly expressed on pathogenic CD4-positive T lymphocyte(CD4^(+)T)cells in both patients with MS and experimental autoimmune encephalomyelitis(EAE)mouse models.Conditional knockout of Trem-2 in CD4^(+)T cells significantly alleviated the disease activity and reduced Th17 cell infiltration,activation,differentiation,and inflammatory cytokine production and secretion in EAE mice.Furthermore,with Trem-2 knockout in vivo experiments and in vitro inhibitor assays,the TREM-2/zeta-chain associated protein kinase 70(ZAP70)/signal transducer and activator of transcription 3(STAT3)signal axis was essential for Th17 activation and differentiation in EAE progression.In conclusion,TREM-2 is a key regulator of pathogenic Th17 in EAE mice,and this sheds new light on the potential of this therapeutic target for MS. | Siying Qu Shengfeng Hu Huiting Xu Yongjian Wu Siqi Ming Xiaoxia Zhan Cheng Wang Xi Huang | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 11 | Abnormal activity detection for surveillance video synopsis显示文摘Video synopsis is an effective and innovative way to produce short video abstraction for huge video archives,while keeping the dynamic characteristic of activities in the original video.Abnormal activity,as the critical event,is always the main concern in video surveillance context.However,in traditional video synopsis,all the normal and abnormal activities are condensed together equally,which can make the synopsis video confused and worthless.In addition,the traditional video synopsis methods always neglect redundancy in the content domain.To solve the above-mentioned issues,a novel video synopsis method is proposed based on abnormal activity detection and key observation selection.In the proposed algorithm,activities are classified into normal and abnormal ones based on the sparse reconstruction cost from an atomically learned activity dictionary.And key observation selection using the minimum description length principle is conducted for eliminating content redundancy in normal activity.Experiments conducted in publicly available datasets demonstrate that the proposed approach can effectively generate satisfying synopsis videos. | 祝晓斌 Wang Qian Li Haisheng Guo Xiaoxia Xi Yan Shen Yang | 2016 | High Technology Letters2016，22，2： | 0 |
| 12 | Cloning and Bioinformatics Analysis of FaPHYC Gene in Tall Fescue (Festuca arundinacea)显示文摘The cDNA of PHYC gene of tall fescue ( Festuca arundinacea ) was cloned by RT-PCR,named FaPHYC.The sequence was analyzed by bioinformatic software,and the results showed that the full-length cDNA(3816 bp) was obtained with an open reading frame predicated to be 3 411 bp,which encoded 1 136 amino acids.By BLASTP analysis,the N-terminal of FaPHYC was composed of GAF and pPhytochrome domains,and its C-terminal included two repeated PAS domains,one histidine kinase A domain and one histidine kinase-like ATPase domain.The phylogenetic analysis showed that FaPHYC was closely related to PHYCs from other Gramineae plants.The qRT-PCR results showed that FaPHYC expression was regulated by drought stress,heat stress,salt stress and nitrogen stress.The real-time quantitative PCR assay showed the expression of FaPHYC in tall fescue seedlings was continuously up-regulated during the light period and down-regulated in the dark.The results suggest that FaPHYC is photoperiod sensitive and plays a functional role in flowering regulation by photoperiod in tall fescue.The FaPHYC gene was cloned and reported from tall fescue for the first time,which lays a foundation for the investigation of the stress mechanism of FaPHYC in tall fescue plant. | Lu CAI Xiaoxia LIU Degang ZHAO Xiaoli WANG Xi CHEN | 2019 | Agricultural Biotechnology2019，8，5： | 0 |
| 13 | Dynamic changes of autophagy during hypertrophic scar formation and the role of autophagy intervention显示文摘Background:The role of autophagy in the formation of hypertrophic scars(HS)remains unclear.This study aimed to explore the role and potential mechanism of autophagy during the development of HS.Methods:RNA and protein expression levels of Beclin-1,p62,and LC3II in normal skin tissues and HS specimens from different patients were examined.Autophagy inducers and inhibitors were used to cure established HS in rabbit ears,and the expression of Beclin-1,p62,and LC3II at the RNA and protein level was determined.Lastly,the effects of autophagy inducers and inhibitors on HS development were analyzed.Results:Compared to normal skin tissues,the expression of LC3II and Beclin-1 was higher(P<0.05),while that of p62 was lower(P<0.05)in HS tissues.In addition,the LC3II/LC3I ratio was increased during HS formation,and the altered expression of the three proteins stabilized after one year.Administration of autophagy inducers enhanced the formation of HS as well as the expression levels of LC3II and Beclin-1 but decreased p62 expression.Meanwhile,administration of autophagy inhibitors increased the expression of LC3II,Beclin-1,and p62,along with reduced HS formation.Conclusion:Autophagic activity increased during HS initiation and subsequent stabilization.In addition,autophagy inhibitors were able to inhibit HS formation by suppressing autophagy,whereas autophagy inducers promoted scar hyperplasia by enhancing autophagy。 | Yu Liu Xiaoxia Chen Yuan Fang Yu Yan Bin He Junlin Liao Ke Cao Xi Zhang Siwei Qu Jianda Zhou | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，3： | 0 |
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