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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Performance of RegCM4 over Major River Basins in China显示文摘A long-term simulation for the period 1990–2010 is conducted with the latest version of the International Centre for Theoretical Physics' Regional Climate Model(RegCM4), driven by ERA-Interim boundary conditions at a grid spacing of 25 km. The Community Land Model(CLM) is used to describe land surface processes, with updates in the surface parameters,including the land cover and surface emissivity. The simulation is compared against observations to evaluate the model performance in reproducing the present day climatology and interannual variability over the 10 main river basins in China,with focus on surface air temperature and precipitation. Temperature and precipitation from the ERA-Interim reanalysis are also considered in the model assessment. Results show that the model reproduces the present day climatology over China and its main river basins, with better performances in June–July–August compared to December–January–February(DJF).In DJF, we find a warm bias at high latitudes, underestimated precipitation in the south, and overestimated precipitation in the north. The model in general captures the observed interannual variability, with greater skill for temperature. We also find an underestimation of heavy precipitation events in eastern China, and an underestimation of consecutive dry days in northern China and the Tibetan Plateau. Similar biases for both mean climatology and extremes are found in the ERA-Interim reanalysis, indicating the difficulties for climate models in simulating extreme monsoon climate events over East Asia. | Xuejie GAO Ying SHI Zhenyu HAN Meili WANG Jia WU Dongfeng ZHANG Ying XU Filippo GIORGI | 2017 | Advances in Atmospheric Sciences2017，34，4： | 33 |
| 3 | Effects of Cr, Ni and Cu on the Corrosion Behavior of Low Carbon Microalloying Steel in a Cl^- Containing Environment显示文摘The effects of Cr, Ni and Cu on the corrosion behavior of low carbon microalloying steel in a Cl containing environment were investigated. The results revealed that the corrosion process could be divided into the initia stage in which the corrosion rate increased with accumulation of corrosion products and the later stage in which homogeneous and compact inner rust layers started to protect steel substrate out of corrosion mediums. The results of X-ray diffraction (XRD) indicated that the rust layers of the three-group steels (Cr Cr-Ni and Cr-Ni-Cu steels) were composed of α-FeOOH,β-FeOOH,γ-FeOOH, Fe3O4 and large amounts o amorphous compounds. The content of amorphous compounds of CreNieCu steel was about 2%-3% more than that of CreNi steel. The results of electron probe microanalysis (EPMA) showed that Cr concentrated mainly in the inner region of the rust of Cr-Ni-Cu steel, inner/outer interface especially, whereas Ni was uniformly distributed all over the rust and Cu was noticed rarely after 73 wet/dry cycles. The addition of C and Ni was beneficial to the formation of dense and compact inner rust layer, which was the most importan reason for the improvement of corrosion resistance of experimental steel. | Yanlei Zhou Jun Chen Yang Xu Zhenyu Liu | 2013 | Journal of Materials Science & Technology2013，29，2： | 29 |
| 4 | CMIP6 Evaluation and Projection of Temperature and Precipitation over China显示文摘This article evaluates the performance of 20 Coupled Model Intercomparison Project phase 6(CMIP6)models in simulating temperature and precipitation over China through comparisons with gridded observation data for the period of 1995–2014,with a focus on spatial patterns and interannual variability.The evaluations show that the CMIP6 models perform well in reproducing the climatological spatial distribution of temperature and precipitation,with better performance for temperature than for precipitation.Their interannual variability can also be reasonably captured by most models,however,poor performance is noted regarding the interannual variability of winter precipitation.Based on the comprehensive performance for the above two factors,the“highest-ranked”models are selected as an ensemble(BMME).The BMME outperforms the ensemble of all models(AMME)in simulating annual and winter temperature and precipitation,particularly for those subregions with complex terrain but it shows little improvement for summer temperature and precipitation.The AMME and BMME projections indicate annual increases for both temperature and precipitation across China by the end of the 21st century,with larger increases under the scenario of the Shared Socioeconomic Pathway 5/Representative Concentration Pathway 8.5(SSP585)than under scenario of the Shared Socioeconomic Pathway 2/Representative Concentration Pathway 4.5(SSP245).The greatest increases of annual temperature are projected for higher latitudes and higher elevations and the largest percentage-based increases in annual precipitation are projected to occur in northern and western China,especially under SSP585.However,the BMME,which generally performs better in these regions,projects lower changes in annual temperature and larger variations in annual precipitation when compared to the AMME projections. | Xiaoling YANG Botao ZHOU Ying XU Zhenyu HAN | 2021 | Advances in Atmospheric Sciences2021，38，5： | 21 |
| 5 | The Origin and Tectonic Significance of the Volcanic Rocks of the Yeba Formation in the Gangdese Magmatic Belt, South Tibet显示文摘Zircon U-Pb geochronology, Hf isotope and whole-rock geochemistry were performed on the tuffs of the Yeba Formation in the Gangdese magmatic belt, South Tibet. The results are used to detail the age, source nature and tectonic processes that led to the formation of the Gangdese belt. Dating results indicate that the rhyolitic-andesitic tuffs were formed at 174–170 Ma. Positive and variable zircon ε_(Hf)(t) values of the rhyolitic tuffs reveal that the source was dominated by juvenile material, however, experienced crustal contamination. The basaltic tuffs have low HREEs, high contents of compatible elements(V and Cr) and no Eu anomaly. In contrast, the rhyolitic-andesitic tuffs show low compatible trace elements, depletion in Eu but enrichment in incompatible elements(Rb, Zr and Hf). According to the discrimination diagrams of P_2O_5-SiO_2 and Th-Rb, the rhyolitic-andesitic tuffs show a close affinity to Ⅰ-type granitoids. Moreover, these tuffs are marked by significant depletion in Nb, Ta and Ti, plotted in calc-alkaline field, and with the andesitic-rhyolitic tuffs falling into an active continental margin setting. We suggest that these tuffs of the Yeba Formation were probably generated in an active continental margin above the northward subduction of the Neo-Tethyan oceanic lithosphere. | Xuxuan Ma Zhiqin Xu Xijie Chen Joseph G.Meert Zhenyu He Fenghua Liang Yuanku Meng Shiwei Ma | 2017 | Journal of Earth Science2017，28，2： | 20 |
| 6 | Effect of tannic acid on corrosion behavior of carbon steel in NaCl solution显示文摘Corrosion behavior of unrusted Q235 carbon steel was investigated in 3.5% NaCl solutions with 1–5 wt%tannic acid addition, using electrochemical methods including electrochemical impedance spectra(EIS),potentiodynamic polarization and scanning vibrating electrode technique(SVET) combined with surface analysis. Results show that the corrosion rate decreases with increasing tannic acid concentration. As compared with tannic acid-free solution, 1% tannic acid does not provide inhibition effect during the whole immersion, while inhibition effect is observed for 3% tannic acid after 8 h and for 5% tannic acid after 4 h. The inhibition efficiency by weight loss measurements(áw) for 1%, 3%, and 5% tannic is around-17.2%, 40.3%, and 51.5%, respectively. Corrosion of unrusted carbon steel in the presence of tannic acid is attributed to the joint effect of tannic acid adsorption and pH decrease. Formation of ferric-tannates is verified by X-ray photoelectron spectroscopy(XPS) and Raman spectra. The reaction mechanism between tannic acid and unrusted carbon steel is proposed. | Wenhua Xu En-Hou Han Zhenyu Wang | 2019 | Journal of Materials Science & Technology2019，35，1： | 16 |
| 7 | Geochronologic and petrochemical evidence for the genetic link between the Maomaogou nepheline syenites and the Emeishan large igneous province显示文摘The Maomaogou nepheline syenite is located at the inner zone of the Emeishan large igneous province and exhibits intrusive contact with the Emeishan basalts. SHRIMP U-Pb dating on zircons from this syenite yields an age of 261.6±4.4 Ma, in agreement with the age of the Panzhihua layered intrusion and the eruption age of the Emeishan basalts as constrained by stratigraphic data. Geochemical data fur-ther suggest that the Maomaogou syenite has a source analogue to the Emeishan basalt, and may have been formed by partial melting of gabbroic cumulates underplated in the lower crust. As s result, tem-poral and spatial relationships and petrogenetic constraints provide evidence for the genetic link be-tween basalts, mafic/ultramafic and intermediate/acidic intrusives in the Panxi area. | LUO ZhenYu XU YiGang HE Bin SHI YuRuo HUANG XiaoLong | 2007 | Chinese Science Bulletin2007，52，7： | 12 |
| 8 | Activation of northern margin of the North China Craton in Late Paleozoic:Evidence from U-Pb dating and Hf isotopes of detrital zircons from the Upper Carboniferous Taiyuan Formation in the Ningwu-Jingle basin显示文摘LA-MC-ICPMS U-Pb dating has been performed on detrital zircons from the Upper Carboniferous Tai-yuan Formation (N-8) in the Ningwu-Jingle Basin, west of the North China Craton (NCC). The ages of 72 detrital zircon grains are divided into three groups: 303―320 Ma (6 grains), 1631―2194 Ma (37 grains, peaked at 1850 Ma), 2318―2646 Ma (29 grains, peaked at 2500 Ma). Detrital zircons of Group 2 and Group 3 were likely derived from the basement of the NCC. Group 1 zircons exhibit 176Hf/177Hf ratios ranging from 0.281725 to 0.282239, with corresponding negative εHf(t) values of -12.4―-30.3 and old Hf model ages of 1.4―2.2 Ga. These characteristics show a strong resemblance to those of Carboniferous igneous zircons from the Inner Mongolia Paleo-uplift (IMPU) on the northern margin of the NCC, but differ significantly from those of the Xing-Meng Orogenic Belt, suggesting that the source of the Tai-yuan Formation partly came from the IMPU. All detrital zircons of Group 1 have relatively high Th/U ratios (> 0.67), indicating a magmatic origin. The mean age (304 ± 6 Ma) of the two youngest grains is close to the depositional age of the Taiyuan Formation, suggesting a strong tectonic uplift and magmatism in the IMPU during the Late Carboniferous. This paper provides important geological evidence for the activation of the northern margin of the NCC in the Late Paleozoic. | LI HongYan XU YiGang HUANG XiaoLong HE Bin LUO ZhenYu YAN Bin | 2009 | Chinese Science Bulletin2009，54，4： | 12 |
| 9 | Process mineralogy of Weishan rare earth ore by MLA显示文摘Mineral liberation analyser(MLA) was applied to quantitatively analyze the rare earth ore from Weishan in Shandong. Mineralogy parameters, such as mineral composition, occurrence states of rare earth elements(REEs) and valuable elements, mineral embedded grain size distribution, mineral association and liberation, are obtained. Results show that the contents of REEs and other valuable elements mainly contained in the ore were La 1.02 wt%, Ce 4.29 wt%, Pr 0.34 wt%, Nd 0.84 wt%, Sr 3.4 wt%and Ba 26.53 wt%, respectively. The REEs mainly occur in bastnaesite and carbocernaite in the form of independent mineral and the contents of bastnaesite and carbocernaite in the ore were 5.96 wt% and12.30 wt%, respectively. 67.34% of strontium occurs in carbocernaite and the rest occurs in celestobarite and strontianite mineral. 92.71% of barium occurs in barite. Liberation of main rare-earth minerals such as bastnaesite and carbocernaite is more than 80% when the grinding fineness is78.42% passing 74 μm. The research results could be employed to provide detailed basic theoretical data for further improvement of the beneficiation process flow and the processing index of rare earth ore, the recycling of other valuable minerals and the comprehensive utilization of tailings. | Caili Xu Chengbin Zhong Renliang Lyu Yaoyang Ruan Zhenyue Zhang Ru'an Chi | 2019 | Journal of Rare Earths2019，37，3： | 12 |
| 10 | Effects of dietary yeast nucleotides on growth, non-specific immunity intestine growth and intestinal microbiota of juvenile hybrid tilapia Oreochromis niloticus ♀ × Oreochromis aureus ♂显示文摘This study investigated the effect of dietary supplementation of yeast nucleotides on the growth, nonspecific immunity, intestine growth and intestinal microbiota of juvenile hybrid tilapia. Tilapia(initial average weight of 8.02 g) was fed test diets supplemented with a yeast-originated nucleotide mixture(0,0.15, 0.30, 0.60, and 1.20 g/100 g diet) for 8 weeks. Fish fed the diet with 0.60% nucleotide had significantly higher weight gain than the control group(P < 0.05). Feed efficiency was improved in the fish fed 0.60 and 1.20% nucleotide compared with that in the control group. The optimal doses of nucleotides supplementation for growth and feed efficiency of fish were determined as 0.63 and 0.81%, respectively.Intestinal growth was improved in the 0.30 and 0.60% groups, as indicated by significant increase in intestine length. The fish fed 0.60 and 1.20% nucleotide showed higher super oxide dismutase(SOD)activity and lower malondialdehyde(MDA) level in the liver than the control fish, indicating enhancement of the anti-oxidant status. Serum lysozyme activity was significantly increased in the 0.15 and 0.3%nucleotide supplementation groups, suggesting an enhancement effect on the non-specific immune response. Lastly, dietary nucleotides supplementation exerted moderate influence on the intestinal microbiota of hybrid tilapia. A reduction in the cumulative abundance of putative butyrate-producing species was observed in the intestinal microbiota of fish fed diets with 0.60% nucleotide compared with the control, implying an interaction between dietary nucleotides and butyrate production. Briefly, dietary supplementation with 0.60% nucleotide improve the growth performance, immune activity and intestine growth in tilapia. | Li Xu Chao Ran Suxu He Jianli Zhang Jun Hu Yalin Yang Zhenyu Du Yanou Yang Zhigang Zhou | 2015 | Animal Nutrition2015，，3： | 12 |
| 11 | Heterogeneous oxidation of cyclohexanone catalyzed by TS-1:Combined experimental and DFT studies显示文摘 | Changjiu Xia Long Ju Yi Zhao Hongyi Xu Bin Zhu Feifei Gao Min Lin Zhenyu Dai Xiaodong Zou Xingtian Shu | 2015 | 催化学报2015，36，6： | 11 |
| 12 | ABNORMAL FLOWER AND GRAIN 1 encodes OsMADS6 and determines palea identity and affects rice grain yield and quality显示文摘The palea and lemma are floral organ structures unique to grasses;these structures form the hull and directly affect grain size and quality. However, the molecular mechanisms controlling the development of the hull are not well understood. In this study, we characterized the rice(Oryza sativa) abnormal flower and grain1(afg1) mutant, a new allele of OsMADS6. Similar to previously characterized osmads6 alleles, in the afg1 floret, the palea lost its marginal region and acquired the lemma identity. However, in contrast to other osmads6 alleles, the afg1 mutant showed altered grain size and grain quality, with decreased total starch and amylose contents, and increased protein and soluble sugar contents. The analysis of transcriptional activity suggested that AFG1 is a transcriptional activator and may affect grain size by regulating the expression levels of several genes related to cell expansion and proliferation in the afg1 mutant. These results revealed that AFG1 plays an important role in determining palea identity and affecting grain yield and quality in rice. | Xiaoqi Yu Saisai Xia Qiankun Xu Yuanjiang Cui Ming Gong Dali Zeng Qiang Zhang Lan Shen Guiai Jiao Zhenyu Gao Jiang Hu Guangheng Zhang Li Zhu Longbiao Guo Deyong Ren Qian Qian | 2020 | Science China(Life Sciences)2020，63，2： | 10 |
| 13 | Enhancing mineral liberation of a Canadian rare earth are with microwave pretreatment显示文摘Liberation. as an attribute of mineralogy characteristic. whose impacts on finely disseminated Canadian rare earth ore was studied with microwave pretreatment. Samples of a light rare earth ore along with mostly ankerite and biotite as dominant gangue minerals as well as bastnaesite, strontianite and goethite as dominated minerals were exposed to further comminution by ball mill and microwave pretreatment fragmentation. Mineralogical characteristics were analyzed by using a mineral liberation analyzer(MLA).The results indicated that tight association mutually penetrates among dominated minerals in the range size of -300 + 212 μm and 212 + 150 μm and gangue minerals in the form of adjacent type. fine vein type. shell type and packing type. Temperature in the ore samples pre-treated by microwave can rapidly rise to 250 ℃ with microwave power of 0-1.5 kW and microwave time of 0-2 min. Applying the microwave pretreatment merely reduces the hardness of the ore causing the fracture of rare earth ore, but this does not transform or change the original mineralogy characteristics of the ore samples. On the basis of above study. the liberation value of bastnaesite, strontianite and goethite with microwave pretreatment is greater than with conventional comminution when the liberation class is above 75%. The distribution of particle size of rare earth ore samples is better with microwave pretreatment than with conventional comminution for particle size of 7.4 × 10^(-5) m. With microwave pretreatment, the theoretical grade-recovery of bastnaesite. strontianite and goethite in the rare earth ore attains better results than with conventional comminution at a given grade. | Chengbin Zhong Caili Xu Renliang Lyu Zhenyue Zhang Xiaoyan Wu Ru'an Chi | 2018 | Journal of Rare Earths2018，36，2： | 10 |
| 14 | Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer's disease显示文摘Accelerated forgetting has been identified as a feature of Alzheimer's disease(AD),but the therapeutic efficacy of the manipulation of biological mechanisms of forgetting has not been assessed in AD animal models.Ras-re-lated C3 botulinum toxin substrate 1(Rac1),a small GTPase,has been shown to regulate active forgetting in Drosophila and mice?Here,we showed that Rac1 activity is aberrantly elevated in the hippocampal tissues of AD patients and AD animal models.Moreover,amyloid-beta 42 could induce Rac1 activation in cultured cells.The elevation of Rac1 activity not only accelerated 6-hour spatial memory decay in 3-month-old APP/PS1 mice,but also significantly contributed to severe memory loss in aged APP/PS1 mice.A similar age-dependent Rac1 activity-based memory loss was also observed in an AD fly model.Moreover,inhibition of Rac1 activity could ameliorate cognitive defects and synaptic plasticity in AD animal models.Finally,two novel compounds,identified through behavioral screening of a randomly selected pool of brain permeable small molecules for their positive effect in rescuing memory loss in both fly and mouse models,were found to be capable of inhibiting Rac1 activity.Thus,multiple lines of evidence corroborate in supporting the idea that inhibition of Rac1 activity is effective for treating AD-related memory loss. | Wenjuan Wu Shuwen Du Wei Shi Yunlong Liu Ying Hu Zuolei Xie Xinsheng Yao Zhenyu Liu Weiwei Ma Lin Xu Chao Ma Yi Zhong | 2019 | Protein & Cell2019，10，10： | 10 |
| 15 | The Dabie Orogen as the early Jurassic sedimentary provenance: Constraints from the detrital zircon SHRIMP U-Pb dating显示文摘The SHRIMP U-Pb ages of detrital zircon from the oldest Mesozoic strata, the Fanghushan Fomation, in the Hefei Basin range from 200 Ma to ca. 2500 Ma, which indicates that the Dabie Orogen as the early Jurassic sedimentary provenance was complex. The composition of the Dabie Orogen includes: the Triassic high pressure-ultrahigh pressure metamorphic rocks, of which the detrital zircon ages are from 234 Ma to 200 Ma; the rocks possibly related to the Qinling and Erlangping Groups representing the southern margin of the Sino-Korean craton in the Qinling and Dabie area, of which the detrital zircon has an age of 481-378 Ma; the Neoproterozoic rocks originated from the Yangtze croton, of which the detrital zircon ages are 799-721 Ma old; and the rocks with the detrital zircon ages of ca. 2000 Ma and ca. 2500 Ma, which could be the old basement of the Yangtze craton. | LI Renwei, WAN Yusheng, CHENG Zhenyu, ZHOU Jianxiong, XU Yunhua, LI Zhong & JIANG Maosheng Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，2： | 9 |
| 16 | Carbon-coated mesoporous Co9S8 nanoparticles on reduced graphene oxide as a long-life and high-rate anode material for potassium-ion batteries显示文摘Carbon-coated mesoporous Co9S8 nanoparticles supported on reduced graphene oxide(rGO)are successfully synthesized by a simple process.This composite makes full use of the protection of the carbon layer on the surface,the good conductivity and three-dimensional(3D)structure of rGO,the mesoporous structure and nanoscale size of Co9S8,thereby presenting the excellent electrochemical performances in potassium-ion batteries,407.9 mAh·g^−1 after 100 cycles at 0.2 A·g^−1 and 215.1 mAh·g^−1 at 5 A·g^−1 in rate performances.After 1,200 cycles at 1.0 A·g^−1,this composite still remains a capacity of 210.8 mAh·g^−1.The redox reactions for potassium storage are revealed by ex-situ transmission electron microscope(TEM)/high-resolution TEM(HRTEM)images,selected area electron diffraction(SAED)patterns and X-ray photoelectron spectroscopy(XPS)spectra.The application of this composite as the host of sulfur for Li-S batteries is also explored.It sustains a capacity of 431.8 mAh·g^−1 after 800 cycles at 3 C,leading to a degradation of 0.052%per cycle.These results confirm the wide applications of this composite for electrochemical energy storage. | Guangyao Ma Xiao Xu Zhenyu Feng Chenjing Hu Yansong Zhu Xianfeng Yang Jian Yang Yitai Qian | 2020 | Nano Research2020，13，3： | 9 |
| 17 | Targeting BMI-1-mediated epitheliale-mesenchymal transition to inhibit colorectal cancer liver metastasis显示文摘Liver is the most common metastatic site for colorectal cancer(CRC),there is no satisfied approach to treat CRC liver metastasis(CRCLM).Here,we investigated the role of a polycomb protein BMI-1 in CRCLM.Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulated and associated with T4 stage,invasion depth and right-sided primary tumor.Knockdown BMI-1 in high metastatic HCT116 and LOVO cells repressed the migratory/invasive phenotype and reversed epithelialemesenchymal transition(EMT),while BMI-1 overexpression in low metastatic Ls174 T and DLD1 cells enhanced invasiveness and EMT.The effects of BMI-1 in CRC cells were related to upregulating snail via AKT/GSK-3βpathway.Furthermore,knockdown BMI-1 in HCT116 and LOVO cells reduced CRCLM using experimental liver metastasis mice model.Meanwhile,BMI-1 overexpression in Ls174 T and DLD1 significantly increased CRCLM.Moreover,sodium butyrate,a histone deacetylase and BMI-1 inhibitor,reduced HCT116 and LOVO liver metastasis in immunodeficient mice.Our results suggest that BMI-1 is a major regulator of CRCLM and provide a potent molecular target for CRCLM treatment. | Zhiyao Xu Zhuha Zhou Jing Zhang Feichao Xuan Mengjing Fan Difan Zhou Zhenyu Liuyang Ximei Ma Yiyang Hong Yihong Wang Sherven Sharma Qinghua Dong Guanyu Wang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 8 |
| 18 | Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19显示文摘The coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 was identified in December 2019.The symptoms include fever,cough,dyspnea,early symptom of sputum,and acute respiratory distress syndrome(ARDS).Mesenchymal stem cell(MSC)therapy is the immediate treatment used for patients with severe cases of COVID-19.Herein,we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19.MSC transplantation increases the immune indicators(including CD4 and lymphocytes)and decreases the inflammation indicators(interleukin-6 and C-reactive protein).High-flow nasal cannula can be used as an initial support strategy for patients with ARDS.With MSC transplantation,the fracrion of inspired O2(Fi02)of the two patients gradually decreased while the oxygen saturation(Sa02)and partial pressure of oxygen(P02)improved.Additionally,the patients9 chest computed tomography showed that bilateral lung exudate lesions were adsorbed after MSC infusion.Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19,particularly in patients with ARDS. | Lingling Tang Yingan Jiang Mengfei Zhu Lijun Chen Xiaoyang Zhou Chenliang Zhou Peng Ye Xiaobei Chen Baohong Wang Zhenyu Xu Qiang Zhang Xiaowei Xu Hainv Gao Xiaojun Wu Dong Li Wanli Jiang Jingjing Qu Charlie Xiang Lanjuan Li | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 19 | High-Efficiency Reduction of Rice Amylose Content via CRISPR/Cas9-Mediated Base Editing显示文摘Rice is a staple food for more than half of the human population.It has been estimated that by 2030,rice production must increase by 40%to meet the growing demand(Khush,2005).In addition,with the improvement of people's living standards,the demand for elite rice with better eating and cooking quality(ECQ)is increasing.ECQ is determined by several factors,including amylose content(AC),gel consistency(GC),gelatinization temperature(GT)and viscosity,where AC is the predominant factor(Juliano,1998). | Li He Li Xiufeng Xu Yang Liu Hualong He Mingliang Tian Xiaojie Wang Zhenyu Wu Xiuju Bu Qingyun Yang Jie | 2020 | Rice science2020，27，6： | 7 |
| 20 | Age and generation of Fogang granite batholith and Wushi diorite-hornblende gabbro body显示文摘Fogang granitic batholith, the largest Late Mesozoic batholith in the Nanling region, has an exposure area of ca. 6000 km2. Wushi diorite-hornblende gabbro body is situated at the northeast part of the ba- tholith. Both the granitic batholith main body and the diorite-hornblende gabbro body belong to high-K calc alkaline series. Compared with the granitic main body, the Wushi body has lower Si (49%―55%), higher Fe, Mg, Ca, lower REE, less depletion of Eu, Ba, P, Ti, and obvious depletion of Zr, Hf. Zircon LA-ICP-MS dating and the mineral-whole rock isochron dating reveal that Fogang granitic main body and Wushi body were generated simultaneously at ca. 160 Ma. The Fogang granitic main body has high (87Sr/86Sr)i ratios (0.70871―0.71570) and low εNd(t) values (?5.11―?8.93), suggesting the origins of the granitic rocks from crustal materials. Their Nd two-stage model ages range from 1.37―1.68 Ga. The Sr and Nd isotopic compositions and the Nd model ages of the granitic rocks may suggest that the giant Fogang granitic main body was generated from a heterogeneous source, with participation of mantle component. Wushi diorite-hornblende gabbro is an unusual intermediate-basic magmatic rock series, with high (87Sr/86Sr)i ratios (0.71256―0.71318) and low εNd(t) values (?7.32―?7.92), which was possibly formed through mixing between the mantle-derived juvenile basaltic magma and the magma produced by the dehydration melting of lower crustal basaltic rocks. | XU XiSheng LU WeiMin HE ZhenYu | 2007 | Science China Earth Sciences2007，50，2： | 7 |
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