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| 1 | Using acupoint-to-acupoint penetrative needling to treat poststroke spastic paralysis:a clinical progress review显示文摘OBJECTIVE: To determine the characteristics and advantages of acupoint-to-acupoint penetrative needling(AAPN) treatment for post-stroke spastic paralysis(PSSP) to improve the clinical outcomes of this disease in the future.METHODS: Randomized, controlled trials of PSSP patients receiving AAPN treatment were searched from MEDLINE, EMBASE, and China National Knowledge Infrastructure Database between January 2006 and June 2013. Key words included: clinic or clinical, acupuncture, needling, acupoint-to-acupoint, penetrative or penetration or penetrating,stroke or apoplexy or cerebral infarction or cerebral hemorrhage, spastic paralysis or spasticity or palsy,and hypermyotonia. Language was limited to English and Chinese. Case series reports, review articles, and animal studies were excluded.RESULTS: AAPN showed better clinical results on PSSP than other acupuncture treatments, especially when combined with adjunct therapies such as electroacupuncture, bloodletting, and rehabilitation. The greatest benefit was achieved with rehabilitation combined with penetration from Yang-channel acupoints to Yin-channel acupoints in the upper limbs, and from Yin-channel acupoints to Yang-channel acupoints in the lower limbs with a reinforcing maneuver.CONCLUSION: AAPN is an effective treatment for PSSP, and it can accelerate and enhance functional repair of PSSP patients. | Xiafei Liu Chunling Bao Guirong Dong | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 7 |
| 2 | CYBERCITY:CONCEPTION,TECHNICAL SUPPORTS AND TYPICAL APPLICATIONS显示文摘In this paper,the concepts about the CyberCity and the corresponding technique supports and typical applications are introduced.As the pilot projects,the applications of CCGIS software in CyberShenzhen and CyberShanghai are also presented.At last,some of key technologies such as the reconstruction of three dimensional city model,vast amount of data integration and its real time application of 3D animation are discussed. | li deren zhu qing li xiafei | 2000 | Geo-Spatial Information Science2000，3，4： | 3 |
| 3 | Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis显示文摘The plant aluminum(Al)-activated malate transporter ALMT1 mediates the efflux of malate to chelate the Al in acidic soils and underlies the plant Al resistance.Here we present cryo-electron microscopy(cryo-EM)structures of Arabidopsis thaliana ALMT1(AtALMT1)in the apo,malate-bound,and Al-bound states at neutral and/or acidic pH at up to 3.0Åresolution.The AtALMT1 dimer assembles an anion channel and each subunit contains six transmembrane helices(TMs)and six cytosolicα-helices.Two pairs of Arg residues are located in the center of the channel pore and contribute to malate recognition.Al binds at the extracellular side of AtALMT1 and induces conformational changes of the TM1-2 loop and the TM5-6 loop,resulting in the opening of the extracellular gate.These structures,along with electrophysiological measurements,molecular dynamic simulations,and mutagenesis study in Arabidopsis,elucidate the structural basis for Al-activated malate transport by ALMT1. | Jiangqin Wang Xiafei Yu Zhong Jie Ding Xiaokang Zhang Yanping Luo Ximing Xu Yuan Xie Xiaoxiao Li Tian Yuan Shao Jian Zheng Wei Yang Jiangtao Guo | 2022 | Cell Research2022，32，1： | 3 |
| 4 | Strontium isotopic signature of hydrothermal sedimenta- tion from Early Cambrian barite deposits in east Guizhou,China显示文摘The ore genesis model for barite deposits in east Guizhou Province has been in dispute and the major debate focuses on whether they are product of the submarine hydrothermal sedimentation. This note presents new stron- tium isotope data from 19 samples of Dahebian and Yuping barite deposits, and their 87Sr/86Sr ratios are significantly lower than that of the coeval seawater. The Sr/86Sr ratios of 87 17 samples out of 19 samples rang from 0.708310 to0.708967, indicating that theymight be related to the mantel admixture. Two isotopic ratios in this study are higher than those of coeval seawater (0.7090), collected from late-stage barite mineral vein of interpenetrative strata and a barite nodule bearing hypidiomorphic granular pyrite, which indicates that they might be related to the continental admixture. The study provides Sr isotopic evidence not only for the subma- rine hydrothermal exhalative genesis of Dahebian and Yup- ing barite deposits, but also for distinguishing the barite mineralization of late stage. | XIAFei MADongsheng PANJiayong SUNZhanxue CAOShuanglin NIEWenming WUKai | 2004 | Chinese Science Bulletin2004，49，24： | 3 |
| 5 | Evening exercise is associated with lower odds of visual field progression in Chinese patients with primary open angle glaucoma显示文摘Background:Exercise is widely known to lower intraocular pressure and increase ocular blood flow,which may be beneficial for glaucoma management.However,there are few studies that have reported on the relationship between exercise and glaucoma progression.The aim of our study was to investigate the exercise habits of those with primary open angle glaucoma(POAG)and its association with the progression of visual field(VF)loss.Methods:Daily physical activity(PA)was monitored by an accelerometer(ActiGraph wGT3x-BT)which patients wore for more than 10 h of being awake on their right wrists for 1 week.Results:Seventy-one non-progressive and 27 progressive patients were enrolled in the study.24-h moderate to vigorous physical activity(MVPA)exercise showed that POAG patients had similar variation trends consisting of 3 wave peaks and 2 wave hollows.Minutes spent in MVPA was 19.89±15.81 and 21.62±15.10 during 07:00–09:00 h(p=0.204),15.40±14.49 and 15.67±12.43 during 15:00–17:00 h(p=0.822)and 17.26±21.11 and 11.42±11.58 during 18:00–20:00 h(p=0.001)in the non-progressive and progressive group,respectively.Univariate analysis indicated that 10 min of MVPA(18:00–20:00 h)[odds ratio,OR(95%CI)=0.82(0.73,0.92)],average mean arterial pressure[OR(95%CI)=0.96(0.94,0.98)],age[OR(95%CI)=1.06(1.03,1.08)],male[OR(95%CI)=0.67(0.48,0.96)],spherical equivalent[OR(95%CI)=1.14(1.07,1.22)]and IOP-lowering medications[OR(95%CI)=1.54(1.16,2.05)]were significantly correlated with having progressive VF damage.Multivariable analysis showed that 10 min of MVPA(18:00–20:00 h)[OR(95%CI)=0.85(0.75,0.97)]was associated with progressive VF loss even after adjusting for other risk factors.Conclusions:Evening exercise may lower the odds of VF progression,suggesting that exercise habits possibly play an important role in glaucoma progression. | Xiafei Pan Kai Xu Xin Wang Guofu Chen Huanhuan Cheng Alice Jia Liu Laurence Tang Hou Lin Zhong Jie Chen Yuanbo Liang | 2020 | Eye and Vision2020，7，1： | 2 |
| 6 | Metagenomic insights into the effects of submerged plants on functional potential of microbial communities in wetland sediments显示文摘Submerged plants in wetlands play important roles as ecosystem engineers to improve self-purification and promote elemental cycling.However,their effects on the functional capacity of microbial communities in wetland sediments remain poorly understood.Here,we provide detailed metagenomic insights into the biogeochemical potential of microbial communities in wetland sediments with and without submerged plants(i.e.,Vallisneria natans).A large number of functional genes involved in carbon(C),nitrogen(N)and sulfur(S)cycling were detected in the wetland sediments.However,most functional genes showed higher abundance in sediments with submerged plants than in those without plants.Based on the comparison of annotated functional genes in the N and S cycling databases(i.e.,NCycDB and SCycDB),we found that genes involved in nitrogen fixation(e.g.,nifD/H/K/W),assimilatory nitrate reduction(e.g.,nasA and nirA),denitrification(e.g.,nirK/S and nosZ),assimilatory sulfate reduction(e.g.,cysD/H/J/N/Q and sir),and sulfur oxidation(e.g.,glpE,soeA,sqr and sseA)were significantly higher(correctedp<0.05)in vegetated vs.unvegetated sediments.This could be mainly driven by environmental factors including total phosphorus,total nitrogen,and C:N ratio.The binning of metagenomes further revealed that some archaeal taxa could have the potential of methane metabolism including hydrogenotrophic,acetoclastic,and methylotrophic methanogenesis,which are crucial to the wetland methane budget and carbon cycling.This study opens a new avenue for linking submerged plants with microbial functions,and has further implications for understanding global carbon,nitrogen and sulfur cycling in wetland ecosystems. | Binhao Wang Xiafei Zheng Hangjun Zhang Xiaoli Yu Yingli Lian Xueqin Yang Huang Yu Ruiwen Hu Zhili He Fanshu Xiao Qingyun Yan | 2021 | Marine Life Science & Technology2021，3，4： | 1 |
| 7 | Sedimentary Environments of the Cangfanggou Groupin Junggar Basin,Xinjiang,in Response to Climate and Tectonic Regime显示文摘Detailed studies of petrology, palaeocurrent direction, paiaeogeomorphology and palaeohydrody-namics have been conducted for the Permian-Triassic Cangfanggou Group in the foredeep of the Bogda Mountains in the southeastern Junggar Basin, Xinjiang. Sedimentary environments and fades of alluvial fans and pebbly braided rivers, sandy braided rivers, meandering rivers, low-sinuosity rivers, swamps and fresh-water lakes are recognized in the group. Climate and tectonics of source areas strongly controlled the evolution of the sedimentary environments and facies in the foredeep. The block faulting in the Bogda Mountains increased the ground slope, which led to a drastic increase in the grain size of the sediments. Humid climate, being beneficial to plant growth, would provide protection of channel banks and at the same time weaken chemical weathering in the source area, thus large amounts of clay materials are available for the formation of clay plugs. As a result, stable banks and meandering river belts | LOU Zhanghua ZHU Rong TANG Zhonghua LIU Zhigang ZHAO Xiafei CHEN Zhongcai | 2000 | Acta Geologica Sinica(English Edition)2000，74，4： | 1 |
| 8 | Lentivirus‐Mediated bcl‐2 Gene Therapy Improves Function and Structure of Chemotherapy‐Damaged Ovaries in Wistar Rats显示文摘 | Xuefeng Wang Yuanli He Mubiao Liu Xiafei Fu | 2013 | Am J Reprod Immunol2013，，5： | 1 |
| 9 | Bone marrow mesenchymal stem cells transplantation improves ovarian function and structure in vitro and in a rat model of chemotherapy - induced ovarian damage 显示文摘 | Fu Xiafei He Yuanli Xie Chuhai | 2008 | Cytotherapy2008，10，4： | 1 |
| 10 | Identification of Q-Markers from Hedan Tablet by employing “spiderweb”mode and taking compounds'hepatotoxicity into account显示文摘Objective Due to the complicated compounds and the synergistic effect of multi-compounds,the quality control and assessment of Chinese materia medica(CMM)encounters a great challenge about how to identify the key compounds,which are directly correlated with its efficacy and safety.On the guidance of study on quality marker(Q-Marker),identification of Q-Markers was performed from Hedan Tablet(HDT)by the aid of the“spider-web”mode and hepatotoxicity evaluation derived from our previous researches and literatures.Methods By the established ultra performance liquid chromatography with photodiode array detector(UPLC-PDA)method,online UPLC-DPPH·and offline antioxidant assay,21 candidate compounds of HDT were systematically investigated and comprehensively evaluated by the“spider-web”mode for them properties of Q-Marker based on“content-stability-activity”.In addition,the Q-Markers related with hepatotoxicity based on our previous researches and literatures were identified.Results Salvianolic acid B(SaB),quercetin-3-O-glucuronide(Qug),isoquercitrin(IQ)and hyperoside(Hyp)were adopted as the preferable Q-Markers of HDT according to the shaded area(A)of tested compounds in“spider-web”mode.Psoralen(Ps),isopsoralen(IP),psoralenoside(PO)and isopsoralenoside(IPO)were also strongly recommended as Q-Markers closely related with safety by considering hepatotoxicity of the accumulated Ps and IP and conversion between glycoside(PO and IPO)and aglycone(Ps and IP).Conclusion This study provided scientific evidence for quality control and assessment of HDT,and also provided a meaningful reference for application of Q-Markers in CMM. | Danni Wang Jiamin Ding Xiafei Feng Xin Chai Jing Yang Chunlei Liu Yingzi Zeng Wanhui Zhou Yuefei Wang | 2022 | Chinese Herbal Medicines2022，14，4： | 1 |
| 11 | The valuation of China’s environmental degradation from 2004 to 2017显示文摘This paper aims to evaluate the cost of environmental degradation by adopting the conventional environmental economic methodology in China from 2004 to 2017 and summarize the change in both the causes and costs of China’s environmental degradation.Results from this study revealed the following:i.The environmental degradation cost in China increased from 511 billion yuan to 1,892 billion yuan from 2004 to 2017,and its share in the GDP decreased from 3.05% to 2.23%;ii.The environmental degradation cost growth rate was lower than the GDP growth rate.The environmental degradation cost growth rate decreased sharply,by dropping from 10% in 2014 to 2% in 2017.The environmental benefits of industrial transformation have emerged;iii.The provinces of Shandong,Hebei,Jiangsu,Henan,and Guangdong had the highest environmental degradation costs.The annual average growth rate of the environmental degradation costs in Jiangsu,Guangdong,and Zhejiang were lower than their growth rate of the GDP respectively;iv.Consideration of environmental degradation cost in decision-making could contribute to the high-quality development of China. | Guoxia Ma Fei Peng Weishan Yang Gang Yan Shuting Gao Xiafei Zhou Ji Qi Dong Cao Yue Zhao Wen Pan Hongqiang Jiang Hong Jing Guangxia Dong Minxue Gao Jingbo Zhou Fang Yu Jinnan Wang | 2020 | Environmental Science and Ecotechnology2020，，1： | 1 |
| 12 | Special ROV- Underwater Tunnel Inspector (UNTI)显示文摘1. Introduction Remotely operated vchicles (ROV) are advanced technical underwater operating equip-ment. They are whidely used in underwater engineering, underwater rescue and sea oil activities.General ROVs can work in deep water. But the horizontal working distance is limited. Atmaximal working depth they can usually move around the mother ship inside a circle with a di- | Ren Ping , Xie Changjiang, Ma Xiafei and Zhen Quankun Senior Engineer, Chinese Underwater Technology Institute (CUTI), 1500 Longwu Road, Shanghai 200231 Engineer, Chinese Underwater Technology Institute (CUTI), 1500 Longwu Road, Shanghai 200231 | 1993 | China Ocean Engineering1993，8，4： | 0 |
| 13 | Clinical evidence of an interferon-glucocorticoid therapeutic synergy in COVID-19显示文摘Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system.In contrast,interferons are a crucial component of host antiviral immunity and can be directly suppressed by glucocorticoids.To investigate whether therapeutic interferons can compensate glucocorticoids-induced loss of antiviral immunity,we retrospectively analyzed a cohort of 387 PCR-confirmed COVID-19 patients with quasi-random exposure to interferons and conditional exposure to glucocorticoids.Among patients receiving glucocorticoids,early interferon therapy was associated with earlier hospital discharge(adjusted HR 1.68,95%Cl 1.19-2.37)and symptom relief(adjusted HR 1.48;95%Cl 1.06-2.08),while these associations were insignificant among glucocorticoids nonusers.Early interferon therapy was also associated with lower prevalence of prolonged viral shedding(adjusted OR 0.24,95%Cl 0.10-0.57)only among glucocorticoids users.Additionally,these associations were glucocorticoid cumulative dose-and timing-dependent.These findings reveal potential therapeutic synergy between interferons and glucocorticoids in COVID-19 that warrants further investigation. | Yingying Lu Feng Liu Gangling Tong Feng Qiu Pinhong Song Xiaolin Wang Xiafei Zou Deyun Wan Miao Cui Yunsheng Xu Zhihua Zheng Peng Hong | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
| 14 | 1.5-m flat imaging system aligned and phased in real time显示文摘Flat optics has been considered promising for constructions of spaceborne imaging systems with apertures in excess of 10 m.Despite recent advances,there are long-existing challenges to perform in-phase stitching of multiple flat optical elements.Phasing the segmented planar instrument has remained at the proof of concept.Here,we achieve autonomous system-level cophasing of a 1.5-m stitching flat device,bridging the gap between the concept and engineering implementation.To do so,we propose a flat element stitching scheme,by manipulating the point spread function,which enables our demonstration of automatically bringing seven flat segments'tip/tilt and piston errors within the tolerance.With phasing done,the 1.5-m system has become the largest phased planar instrument ever built in the world,to our knowledge.The first demonstration of phasing the large practical flat imaging system marks a significant step towards fielding a 10-m class one in space,also paving the way for ultrathin flat imaging in various remote applications. | ZONGLIANG XIE KAIYUAN YANG YANG LIU TIANRONG XU BOTAO CHEN XIAFEI MA YONG RUAN HAOTONG MA JUNFENG DU JIANG BIAN DUN LIU LIHUA WANG TAO TANG JIAWEI YUAN GE REN BO QI HU YANG | 2023 | Photonics Research2023，11，7： | 0 |
| 15 | Strategies to improve the fluorescent signal of the tripartite sfGFP system显示文摘Bimolecular fluoresce nee compleme ntati on(BiFC)is a popular method used to detect proteinprotein interactions.For a BiFC assay,a fluorescent protein is usually split into two parts,and the fluoresce nee is recovered upon the in teracti on between the fused proteins of interest.As an elega nt extensi on of BiFC,a tripartite superfold green fluoresce nt protein(sfGFP)system that has the advantages of low background fluorescence and small fusion tag size has been developed.However,the tripartite system exhibits a low fluorescence signal in some cases.To address this problem,we proposed to in crease the affinity betwee n the two parts,G1-9 and G11,of the tripartite system by adding affinity pairs.Among the three affinity pairs tested,LgBiT-HiBiT improved both the signal and sign a I-to-noise(S/N)ratio to the greatest exte nt.More strikingly,the direct covalent fusion of G11 to G1-9,which converted the tripartite system into a new bipartite system,enhanced the S/N ratio from 20 to 146,which is superior to the bipartite sfGFP system split at 157/158 or 173/174.Our results implied that the 10th p-strand of sfGFP has a low affinity and a good recovery efficiency to construct a robust BiFC system,and this concept might be applied to other fluorescent proteins with similar structure to construct new BiFC systems. | Jing Shen Wenlu Zhang Chunyang Gan Xiafei Wei Jie Li Yuxue Sun Yi Yuan Xuefei Cai Quanxin Long Jing Cui Haitao Guo Ailong Huang Jieli Hu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 0 |
| 16 | Effect of Pyrophyllite Addition on Properties of Lightweight Insulation Refractory Materials显示文摘To solve the problem of over-high density of lightweight insulation refractory bricks prepared with fly ash,new lightweight insulation refractory materials with density < 0. 89 g·cm^(-3) were synthesized using pyrophyllite,fly ash,and Suzhou clay as the main starting materials and saw dust as the pore forming substance,and controlling the addition of the pyrophyllite( 20%,30%,and 40% by mass) and the treating temperature( 1 250,1 300,1 350,and 1 400 ℃). The synthesized materials were characterized by the XRD,SEM and the thermal conductivity measuring instrument. The results show at pyrophyllite addition of 30% and treat temperature of 1 400 ℃,the material can achieve linear shrinkage of 6. 6%,apparent porosity of 57%,bulk density of 0. 75 g·cm^(-3),compressive strength of 2. 7 MPa,and thermal conductivity at 350 ℃ of 0. 152-0. 216 W·( m·K)^(-1). This indicates that the pyrophyllite decomposition at high temperatures forms mullite and amorphous quartz introducing volume expansion,which counteracts some shrinkage at high temperatures.So it is feasible to use pyrophyllite,fly ash waste and clay to prepare lightweight insulation refractory materials. | CHEN Ruoyu LI Yuanbing XIANG Ruofei LI Shujing FAN Xiafei LI Yawei SANG Shaobai | 2017 | China's Refractories2017，26，3： | 0 |
| 17 | A correction technique for false topographic perception of remote-sensing images based on an inverse topographic correction techniqu显示文摘The false topographic perception phenomenon(FTPP)refers to the visual misperception in remote-sensing images that certain types of terrains are visually interpreted as other types in rugged lands,for example,valleys as ridges and troughs as peaks.For this reason,the FTPP can influence the visualization and interpretation of images to a great extent.To scrutinize this problem,the paper firstly reviews and tests the existing FTPP-correction techniques and identifies the inverse slope-matching technique as an effective approach to visually enhance remote-sensing images and retain the colour information.The paper then proposes an improved FTPP-correction procedure that incorporates other image-processing techniques(e.g.linear stretch,histogram matching,and flat-area replacement)to enhance the performance of this technique.A further evaluation of the proposed technique is conducted by applying the technique to various study areas and using different types of remote-sensing images.The result indicates the method is relatively robust and will be a significant extension to geovisual analytics in digital earth research. | Donghai Zhang Wenquan Zhu Xiang Chen Zhoutao Zheng Xiafei Zhou Tao Jiang | 2016 | International Journal of Digital Earth2016，9，10： | 0 |
| 18 | Evaluation of different primers of the 18S rRNA gene to profile amoeba communities in environmental samples显示文摘Amoeboid protists,an assemblage of organisms belonging to different phylogenetic lineages,have drawn increasing attention due to their crucial ecological roles in various environments and their potential health risks.Currently,18S rRNA gene sequencing is widely applied for the detection of amoebae.However,it is not clear which is the best primer pair for 18S rRNA gene amplification in amoebae.This study compared the four most commonly used primer pairs for revealing the diversity,composition,core species,and community assembly processes of amoebae in water and sediments.We found that the choice of primers artificially influences the detection of community composition of amoebae.We also found that short-read fragments may lead to mismatches in taxonomy and were not suitable for phylogenetic analyses.In contrast,full-length primers could detect the highest number of amoeba lineages and annotate 80%of reads belonging to amoebae to known species.However,full-length primers did not detect as many amoeba species as V4 primers.Moreover,we showed that beta diversity and community assembly determination were largely unaffected by primer choice,but different primers could influence our interpretations of the ecological process underlying stochasticity and determinism.This study indicates that full-length read sequencing and V4 region Illumina sequencing are suitable for profiling amoeba diversity in the environment. | Xiafei Zheng Zhili He Cheng Wang Qingyun Yan Longfei Shu | 2022 | Water Biology and Security2022，1，3： | 0 |
| 19 | Deciphering microeukaryotic–bacterial co-occurrence networks in coastal aquaculture ponds显示文摘Microeukaryotes and bacteria are key drivers of primary productivity and nutrient cycling in aquaculture ecosystems.Although their diversity and composition have been widely investigated in aquaculture systems,the co-occurrence bipartite network between microeukaryotes and bacteria remains poorly understood.This study used the bipartite network analysis of high-throughput sequencing datasets to detect the co-occurrence relationships between microeukaryotes and bacteria in water and sediment from coastal aquaculture ponds.Chlorophyta and fungi were dominant phyla in the microeukaryotic–bacterial bipartite networks in water and sediment,respectively.Chlorophyta also had overrepresented links with bacteria in water.Most microeukaryotes and bacteria were classified as generalists,and tended to have symmetric positive and negative links with bacteria in both water and sediment.However,some microeukaryotes with high density of links showed asymmetric links with bacteria in water.Modularity detection in the bipartite network indicated that four microeukaryotes and twelve uncultured bacteria might be potential keystone taxa among the module connections.Moreover,the microeukaryotic–bacterial bipartite network in sediment harbored significantly more nestedness than that in water.The loss of microeukaryotes and generalists will more likely lead to the collapse of positive co-occurrence relationships between microeukaryotes and bacteria in both water and sediment.This study unveils the topology,dominant taxa,keystone species,and robustness in the microeukaryotic–bacterial bipartite networks in coastal aquaculture ecosystems.These species herein can be applied for further management of ecological services,and such knowledge may also be very useful for the regulation of other eutrophic ecosystems. | Xiafei Zheng Kui Xu Jonathan Naoum Yingli Lian Bo Wu Zhili He Qingyun Yan | 2023 | Marine Life Science & Technology2023，5，1： | 0 |
| 20 | Identification of prototype compounds and their metabolites in rats’ serum from Xuefu Zhuyu Decoction by UPLC-Q-TOF/MS显示文摘Objective: As a classic prescription in traditional Chinese medicine, Xuefu Zhuyu Decoction(XFZYD) has been widely used in the clinical treatment of cardiovascular and cerebrovascular diseases. In order to unveil the potentially effective compounds, a rapid ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS) method was established to identify prototype compounds and their metabolites from XFZYD in rats’ serum.Methods: The serum from rats after intragastric administration of XFZYD aqueous extract was analyzed by UPLC-Q-TOF/MS method. The prototype compounds and their metabolites were identified by comparison with the reference standards and tentatively characterized by comprehensively analyzing the retention time, MS data, characteristic MS fragmentation pattern and retrieving literatures.Results: A total of 175 compounds(24 prototype compounds and 151 metabolites) were identified and tentatively characterized. The metabolic pathways of prototype compounds in vivo were also summarized, including glucuronidation, hydrolyzation, sulfation, demethylation, and hydroxylation, and so on.Conclusion: In this study, a UPLC-Q-TOF/MS technique was developed to analyze prototype compounds and their metabolites from XFZYD in serum, which would provide the evidence for further studying the effective compounds of XFZYD. | Xiaoyu Zhang Zhenzuo Jiang Lei Zhang Cheng Xue Xiafei Feng Xin Chai Yuefei Wang | 2023 | Chinese Herbal Medicines2023，15，1： | 0 |
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