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| 1 | Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2显示文摘肝炎 B 病毒 X 蛋白质(HBx ) 在 hepatocellular 癌的发展起一个关键作用。这里,我们寻求了识别 HBx 由调停的机制肝房间增长。我们发现那 HBx upregulated cyclooxygenase-2 (COX-2 ) 的层次, 5-lipoxygenase (5 哈鱼) 和 phosphorylated 在肝房间的细胞外的调整信号的蛋白质 kinases 1/2 (p-ERK1/2 ) 。导致 HBx 的 p-ERK1/2 被 Gi/o 蛋白质,艇长或哈鱼的抑制废除。另外, HBx 增加了前列腺素 E2 (PGE2 ) 的数量,免除房间线的 leukotriene B4 (LTB4 ) 源于 hepatocytes。而且,这些释放 arachidonic 酸代谢物能激活 ERK1/2。有趣地,激活 ERK1/2 能 upregulate 以一种积极反馈方式的 COX-2 和 5 哈鱼的表示。在结论, HBx 经由包含 COX-2, 5 哈鱼,释放 arachidonic 酸代谢物, Gi/o 蛋白质和 p-ERK1/2 的一个积极反馈环提高并且维持肝房间增长。 | Changliang Shan Fuqing Xu Shuai Zhang Jiacong YOU Xiaona You Liyan Qiu Jie Zheng Lihong Ye Xiaodong Zhang | 2010 | Cell Research2010，20，5： | 15 |
| 2 | Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses显示文摘Hematopoietic stem cells(HSCs)in adults are believed to be born from hemogenic endothelial cells(HECs)in mid-gestational embryos.Due to the rare and transient nature,the HSC-competent HECs have never been stringently identified and accurately captured,let alone their genuine vascular precursors.Here,we first used high-precision single-cell transcriptomics to unbiasedly examine the relevant EC populations at continuous developmental stages with intervals of 0.5 days from embryonic day(E)9.5 to E11.0.As a consequence,we transcriptomically identified two molecularly different arterial EC populations and putative HSCprimed HECs,whose number peaked at El 0.0 and sharply decreased thereafter,in the dorsal aorta of the aorta-gonadmesonephros(AGM)region.Combining computational prediction and in vivo functional validation,we precisely captured HSCcompetent HECs by the newly constructed Neurl3-EGFP reporter mouse model,and realized the enrichment further by a combination of surface markers(Procr+Kit+CD44+,PK44).Surprisingly,the endothelial-hematopoietic dual potential was rarely but reliably witnessed in the cultures of single HECs.Noteworthy,primitive vascular ECs from E8.0 experienced two-step fate choices to become HSC-primed HECs,namely an Initial arterial fate choice followed by a hemogenic fate conversion.This finding resolves several previously observed contradictions.Taken together,comprehensive understanding of endothelial evolutions and molecular programs underlying HSC-primed HEC specification in vivo will facilitate future investigations directing HSC production in vitro. | Siyuan Hou Zongcheng Li Xiaona Zheng Yun Gao Ji Dong Yanli Ni Xiaobo Wang Yunqiao Li Xiaochen Ding Zhilin Chang Shuaili Li Yuqiong Hu Xiaoying Fan Yu Hou Lu Wen Bing Liu Fuchou Tang Yu Lan | 2020 | Cell Research2020，30，5： | 8 |
| 3 | DNA degradation within mouse brain and dental pulp cells 72 hours postmortem显示文摘In this study, we sought to elucidate the process of DNA degradation in brain and dental pulp cells of mice, within postmortem 0-72 hours, by using the single cell gel electrophoresis assay and professional comet image analysis and processing techniques. The frequency of comet-like cells, the percentage of tail DNA, tail length, tail moment, Olive moment and tail area increased in tandem with increasing postmortem interval. In contrast, the head radius, the percentage of head DNA and head area showed a decreasing trend. Linear regression analysis revealed a high correlation between these parameters and the postmortem interval. The findings suggest that the single cell gel electrophoresis assay is a quick and sensitive method to detect DNA degradation in brain and dental pulp cells, providing an objective and accurate new way to estimate postmortem interval. | Jilong Zheng Xiaona Li Di Shan Han Zhang Dawei Guan | 2012 | Neural Regeneration Research2012，7，4： | 5 |
| 4 | Highly sensitive phototransistors based on twodimensional GaTe nanosheets with direct bandgap显示文摘 | Pingan Hu Jia Zhang Mina Yoon Xiao-Fen Qiao Xin Zhang Wei Feng Pingheng Tan Wei Zheng Jingjing Liu Xiaona Wang Juan C. Idrobo David B. Geohegan Kai Xiao | 2014 | Nano Research2014，7，5： | 3 |
| 5 | Decision making in the newsvendor problem: A cross-national laboratory study显示文摘 | Tianjun Feng L. Robin Keller Xiaona Zheng | 2010 | Omega2010，，1： | 1 |
| 6 | Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol显示文摘 | Meifeng Yang Junye Miao Joshua Rizak Rongwei Zhai Zhengbo Wang Tanzeel Huma Ting Li Na Zheng Shihao Wu Yingwei Zheng Xiaona Fan Jianzhen Yang Jianhong Wang Shangchuan Yang Yuanye Ma Longbao Lü Rongqiao He Xintian Hu | 2014 | Journal of Alzheimer's Disease2014，，4： | 1 |
| 7 | Impact of Supplier's Lead Time and Forecast Demand Updating on Retailer's Order Quantity Variability in a Two-level Supply Chain显示文摘 | Zheng Xiaona | 2003 | Int J Production Economics2003，86，： | 1 |
| 8 | “Bricks-and-mortar” vs. “clicks-and-mortar”: An equilibrium analysis显示文摘 | Fernando Bernstein Jing-Sheng Song Xiaona Zheng | 2006 | European Journal of Operational Research2006，，3： | 1 |
| 9 | A culture-free method for detection of Vibrio vulnif icus from coastal seawater based on loop-mediated isothermal amplification targeting vcgC gene显示文摘Vibrio vulnificus is an opportunistic pathogen widely distributed in estuarine and coastal seawaters.In this study,a culture-free method was developed to rapid detection of V.vulnificus in all seasons,based on loop-mediated isothermal amplification(LAMP) targeting virulent-correlated gene(vcg).The new assay method allows differentiation between the virulent and non-virulent strain of V.vulnificus accurately.This method also allows effective detection of the pathogeny in winter when the bacterium lives in the viable but non-culturable(VBNC) state.A total of 30 costal seawater samples collected in all seasons were used for the evaluation of this method.The results show that the method is sensitive,accurate and convenient. | LI Yongjun ZHENG Zejun ZHAO Yulong WEI Xiaona ZHU Lin HUANG Xitai | 2010 | Acta Oceanologica Sinica2010，29，2： | 1 |
| 10 | Embryonic lineage tracing with Procr-CreER marks balanced hematopoietic stem cell fate during entire mouse lifespan显示文摘The functional heterogeneity of hematopoietic stem cells(HSCs) has been comprehensively investigated by single-cell transplantation assay.However,the heterogeneity regarding their physiological contribution remains an open question,especially for those with life-long hematopoietic fate of rigorous selfrenewing and balanced differentiation capacities.In this study,we revealed that Procr expression was detected principally in phenotypical vascular endothelium co-expressing DII4 and CD44 in the midgestation mouse embryos,and could enrich all the HSCs of the embryonic day 11.5(E11.5) aortagonad-mesonephros(AGM) region.We then used a temporally restricted genetic tracing strategy to irreversibly label the Procr-exp res sing cells at E9.5.Interestingly,most labeled mature HSCs in multiple sites(such as AGM) around E11.5 were functionally categorized as lymphomyeloid-balanced HSCs assessed by direct transplantation.Furthermore,the labeled cells contributed to an average of 7.8% of immunophenotypically defined HSCs in E14.5 fetal liver(FL) and 6.9% of leukocytes in peripheral blood(PB) during one-year follow-up.Surprisingly,in aged mice of 24 months,the embryonically tagged cells displayed constant contribution to leukocytes with no bias to myeloid or lymphoid lineages.Altogether,we demonstrated,for the first time,the existence of a subtype of physiologically long-lived balanced HSCs as hypothesized,whose precise embryonic origin and molecular identity await further characterization. | Xiaona Zheng Guangyu Zhang Yandong Gong Xiaowei Ning Zhijie Bai Jian He Fan Zhou Yanli Ni Yu Lan Bing Liu | 2019 | Journal of Genetics and Genomics2019，46，10： | 1 |
| 11 | Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin显示文摘 | Caiyun Li Dianrui Zhang Hejian Guo Leilei Hao Dandan Zheng Guangpu Liu Jingyi Shen Xiaona Tian Qiang Zhang | 2013 | International Journal of Pharmaceutics2013，，1： | 1 |
| 12 | Assessment of the allergenicity and antigenicity potential of enzymatically hydrolyzed cow milk显示文摘Cow milk allergy is a major cause of food hypersensitivity in infants and children.However,to the best of our knowledge,there has been minimal research on the antigenicity of cow milk(CM).As it is currently unknown if enzymatically hydrolyzed cow milk(HM)induces severe immunogenic responses,the potential allergenicity of HM was systematically evaluated in this work.HM effectively attenuated symptoms of weight loss and diarrhea,suppressed levels of mast cell tryptase,and relieved allergic inflammation of the intestine.Moreover,HM reduced the B220+cell count in mouse blood.In addition,in vitro studies demonstrated that gastrointestinal digestion of HM was not resistant to pepsin or trypsin.Thus,HM effectively alleviated allergic reactions and exhibited lower potential allergenicity.These results provide practical information for the future development of hypoallergenic CM products. | Xiaona Liang Hui Yang Xue Luo Na Chen Zhisong Ai Yu Xing Wei Huang Zongzhou Wang Yan Zheng Xiqing Yue | 2022 | Food Bioscience2022，45，1： | 0 |
| 13 | Single-cell transcriptomic profiling of non-hematopoietic circulating cells in mid-gestational mouse embryos显示文摘The circulatory system is indispensable for an animal’s normal physiology.In addition to well-characterized hematopoietic cells,several types of circulating non-hematopoietic cells have been identified in adult mice(Zhang and Huang,2012;Schreier and Triampo,2020). | Yanyan Li Yanjuan Chen Xiaona Zheng Yun Gao Yuxuan Zheng Zongcheng Li Han He Fuchou Tang Bing Liu Yu Lan | 2021 | Journal of Genetics and Genomics2021，48，6： | 0 |
| 14 | Multiple-order rogue wave solutions to a(2+1)-dimensional Boussinesq type equation显示文摘In this paper,based on the Hirota bilinear method and symbolic computation approach,multipleorder rogue waves of(2+1)-dimensional Boussinesq type equation are constructed.The reduced bilinear form of the equation is deduced by the transformation of variables.Three kinds of rogue wave solutions are derived by means of bilinear equation.The maximum and minimum values of the first-order rogue wave solution are given at a specific moment.Furthermore,the second-order and third-order rogue waves are explicitly derived.The dynamic characteristics of three kinds of rogue wave solutions are shown by three-dimensional plot. | Mengqi Zheng Xiaona Dong Caifeng Chen Maohua Li | 2022 | Communications in Theoretical Physics2022，74，8： | 0 |
| 15 | Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grown on Cd/Pb-contaminated farmland显示文摘Substitute planting with rapeseed offers promise for safely using large areas of Cd/Pb-contaminated farmland.Cd/Pb distributions during rapeseed oil production were investigated and health risks posed by the oil were assessed.Tests were performed using three cultivars(Brassica rapa SYH and ZS100 and Brassica napus QY-1)and four oil extraction techniques(mechanical and low-temperature pressing and n-hexane and subcritical low-temperature butane extraction).The amounts of Cd and Pb in oil were 0.73%-8.44%and 3.14%-11.76%,respectively,of the amounts in rapeseed and were strongly affected by the cultivar and oil extraction technique.The heavy metal(HM)concentrations were lower in solvent-extracted oil(particularly subcritical low-temperature butane extracted oil,in which HMs were not detected)than mechanically pressed oil.The Cd and Pb transfer indices were lower(meaning larger proportions of HMs were retained by the rapeseed meal)for B.rapa than B.napus.This was attributed to a high HM binding protein content of B.rapa seed.Health risks to humans were assessed using a probabilistic risk assessment model.The carcinogenic risk was mainly(97.1%-99.9%)caused by Cd and poses more concern than non-carcinogenic risk.Stronger health risks are posed by mechanically pressed than solvent-extracted oil,and higher carcinogenic risks are posed to people living in rural areas than urban areas.Substitute planting with B.rapa and extracting oil with organic solvent(preferably subcritical low-temperature butane)are optimal for safely utilizing Cd/Pb-contaminated soil.Attention should be paid to the health risks posed by Cd in oil to rural populations. | Junmei Guo Yuexing Wei Junxing Yang Tongbin Chen Guodi Zheng Tianwei Qian Xiaona Liu Xiaofei Meng Mengke He | 2023 | Frontiers of Environmental Science & Engineering2023，17，7： | 0 |
| 16 | Removal of ammonium and nitrate through Anammox and FeS-driven autotrophic denitrification显示文摘An autotrophic denitrifying bioreactor with iron sulfide(FeS)as the electron donor was operated to remove ammonium(NH_(4)^(+))and nitrate(NO_(3)^(-))synergistically from wastewater for more than 298 d.The concentration of FeS greatly affected the removal of NH_(4)^(+)/NO_(3)^(-).Additionally,a low hydraulic retention time worsened the removal efficiency of NH_(4)^(+)/NO_(3)^(-).When the hydraulic retention time was 12 h,the optimal removal was achieved with NH_(4)^(+)and NO_(3)^(-)removal percentages both above 88%,and the corresponding nitrogen removal loading rates of NH_(4)^(+)and NO_(3)^(-)were 49.1 and 44.0 mg/(L·d),respectively.The removal of NH_(4)^(+)mainly occurred in the bottom section of the bioreactor through sulfate/ferric reducing anaerobic ammonium oxidation(Sulfammox/Feammox),nitrification,and anaerobic ammonium oxidation(Anammox)by functional microbes such as Nitrospira,Nitrosomonas,and Candidatus Kuenenia.Meanwhile,NO_(3)^(-)was mainly removed in the middle and upper sections of the bioreactor through autotrophic denitrification by Ferritrophicum,Thiobacillus,Rhodanobacter,and Pseudomonas,which possessed complete denitrification-related genes with high relative abundances. | Yanfei Wang Xiaona Zheng Guangxue Wu Yuntao Guan | 2023 | Frontiers of Environmental Science & Engineering2023，17，6： | 0 |
| 17 | Conjugated Porous Networks Based on Cyclotriveratrylene Building Block for Hydrogen Adsorption显示文摘Macrocyclic CTV-Br3 经由联合生产僵硬多孔的材料 CTV-CMP-1 和 CTV-CMP-2 的反应的铃木和 Sonogashira-Hagihara 与线性 benzene-1,4-diboronic 酸和 1,4-diethynylbenzene 反应了。多孔的材料有好热、化学的稳定性。CTV-CMP-1 和 CTV-CMP-2 的 Brunauer-Emmet-Teller 特定的表面区域是 314 和 218 | Xiaona Han Lei Li Zhitang Huang Junmin Liu Qiyu Zheng | 2013 | Chinese Journal of Chemistry2013，31，5： | 0 |
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