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| 1 | A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings显示文摘In recent years,the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage,owing to their weak hemostatic function,inferior wet tissue adhesion,and low mechanical properties.Herein,a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property(308.47±29.20 kPa)and excellent hemostatic efficiency(96.5%±2.1%)was constructed as a hemostatic sealant.Typically,we combined chitosan(CS)with silk fibroin(SF)by cross-linking them through tannic acid(TA)to maintain the structural stability of the hydrogel,especially for wet tissue adhesion ability(shear adhesive strength=29.66±0.36 kPa).Compared with other materials reported previously,the obtained CS/TA/SF hydrogel yielded a lower amount of blood loss and shorter time to hemostasis in various arterial and visceral bleeding models,which could be ascribed to the synergistic effect of wound closure under wet state as well as intrinsic hemostatic activity of CS.As a superior hemostatic sealant,the unique hydrogel proposed in this work can be exploited to offer significant advantages in the acute wound and massive hemorrhage with the restrictive access of therapeutic moieties. | Ziwen Qiao Xueli Lv Shaohua He Shumeng Bai Xiaochen Liu Linxi Hou Jingjing He Dongmei Tong Renjie Ruan Jin Zhang Jianxun Ding Huanghao Yang | 2021 | Bioactive Materials2021，6，9： | 14 |
| 2 | Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses显示文摘Hematopoietic stem cells(HSCs)in adults are believed to be born from hemogenic endothelial cells(HECs)in mid-gestational embryos.Due to the rare and transient nature,the HSC-competent HECs have never been stringently identified and accurately captured,let alone their genuine vascular precursors.Here,we first used high-precision single-cell transcriptomics to unbiasedly examine the relevant EC populations at continuous developmental stages with intervals of 0.5 days from embryonic day(E)9.5 to E11.0.As a consequence,we transcriptomically identified two molecularly different arterial EC populations and putative HSCprimed HECs,whose number peaked at El 0.0 and sharply decreased thereafter,in the dorsal aorta of the aorta-gonadmesonephros(AGM)region.Combining computational prediction and in vivo functional validation,we precisely captured HSCcompetent HECs by the newly constructed Neurl3-EGFP reporter mouse model,and realized the enrichment further by a combination of surface markers(Procr+Kit+CD44+,PK44).Surprisingly,the endothelial-hematopoietic dual potential was rarely but reliably witnessed in the cultures of single HECs.Noteworthy,primitive vascular ECs from E8.0 experienced two-step fate choices to become HSC-primed HECs,namely an Initial arterial fate choice followed by a hemogenic fate conversion.This finding resolves several previously observed contradictions.Taken together,comprehensive understanding of endothelial evolutions and molecular programs underlying HSC-primed HEC specification in vivo will facilitate future investigations directing HSC production in vitro. | Siyuan Hou Zongcheng Li Xiaona Zheng Yun Gao Ji Dong Yanli Ni Xiaobo Wang Yunqiao Li Xiaochen Ding Zhilin Chang Shuaili Li Yuqiong Hu Xiaoying Fan Yu Hou Lu Wen Bing Liu Fuchou Tang Yu Lan | 2020 | Cell Research2020，30，5： | 8 |
| 3 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 4 | Comprehensive analysis of miRNA-gene regulatory network with clinical significance in human cancers显示文摘microRNAs(miRNAs),particularly the exosomal miRNAs have been widely used as biomarkers and promising therapeutic targets in cancer.However,a comprehensive analysis of miRNA-gene regulatory network with clinical significance remains scarce.The emergence of high-throughput multi-omics data over large,well-characterized patient cohorts provides an unprecedented opportunity to address this problem.Herein,we performed a clinic-centered analysis to identify cancer-associated miRNAs,miRNA-target axis.We first calculated the correlation among miRNA,mRNA and 75 unique clinico-pathological characteristics(CPCs)in 26 cancer types,and established an online resource(4CR).Interestingly,we found that the high expression of several DNA methylation-related enzymes was associated with adverse outcomes of cancer patients,and these genes were regulated by a cluster of miRNAs.Furthermore,by integrating exosomal miRNA and m RNA databases,we identified exosomal miRNA biomarkers for non-invasive cancer surveillance and therapy monitoring.Finally,we explored the role of CPC-related miRNAs for therapeutic effect prediction of drugs based on their shared targets.Our analysis pipeline illustrated the significance of clinic-centered analysis in miRNA-gene pair identification and provided helpful clues for future cancer studies. | Xiuliang Cui Yang Liu Wen Sun Jin Ding Xiaochen Bo Hongyang Wang | 2020 | Science China(Life Sciences)2020，63，8： | 2 |
| 5 | Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals显示文摘Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients.Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis.However,during early embryonic angiogenesis,the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals.Here,we constructed the single-cell transcriptomic Iandscape of vascular endothelial cells(VECs)during the time window for the occurrenee of key vasculogenic and angiogenic events in both mouse and human embryos.We uncovered two distinct arterial VEC types,the major artery VECs and arterial plexus VECs,and un expectedly diverge nt arteriove nous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically.Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2^(CrexER) | Siyuan Hou Zongcheng Li Ji Dong Yun Gao Zhilin Chang Xiaochen Ding Shuaili Li Yunqiao Li Yang Zeng Qian Xin Baihan Wang Yanli Ni Xiaowei Ning Yuqiong Hu Xiaoying Fan Yu Hou Xianlong Li Lu Wen Bin Zhou Bing Liu Fuchou Tang Yu Lan | 2022 | Cell Research2022，32，4： | 2 |
| 6 | Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense显示文摘Eukaryotic aquaporins share the characteristic of functional multiplicity in transporting distinct substrates and regulating various processes,but the underlying molecular basis for this is largely unknown.Here,we report that the wheat(Triticum aestivum)aquaporin TaPIP2;10 undergoes phosphorylation to promote photosynthesis and productivity and to confer innate immunity against pathogens and a generalist aphid pest.In response to elevated atmospheric CO_(2)concentrations,TaPIP2;10 is phosphorylated at the serine residue S280 and thereafter transports CO_(2)into wheat cells,resulting in enhanced photosynthesis and increased grain yield.In response to apoplastic H_(2)O_(2) induced by pathogen or insect attacks,TaPIP2;10 is phosphorylated at S121 and this phosphorylated form transports H_(2)O_(2) into the cytoplasm,where H_(2)O_(2)intensifies host defenses,restricting further attacks.Wheat resistance and grain yield could be simultaneously increased by TaPIP2;10 overexpression or by expressing a TaPIP2;10 phosphomimic with aspartic acid substitutions at S121 and S280,thereby improving both crop productivity and immunity. | Kai Lu Xiaochen Chen Xiaohui Yao Yuyan An Xuan Wang Lina Qin Xiaoxu Li Zuodong Wang Shuo Liu Zhimao Sun Liyuan Zhang Lei Chen Baoyan Li Baoyou Liu Weiyang Wang Xinhua Ding Yonghua Yang Meixiang Zhang Shenshen Zou Hansong Dong | 2022 | Molecular Plant2022，15，11： | 2 |
| 7 | Tracing the Methane Events by Stable Carbon Isotopes of Benthic Foraminifera at Glacial Periods in the Andaman Sea显示文摘Stable isotopes of carbon and oxygen variations in foraminiferal shells have been widely used in paleo-environment studies.However,studies about the shells of benthic foraminifera in methanehydrate-bearing sediments as reliable geochemical proxies to reconstruct the potential methane release events in the geologic past are rare.In this study,we present the stable carbon and oxygen isotopes of fossil benthic foraminifera including one epifaunal species(Cibicidoides wuellerstorfi)and two infaunal species(Bulimina mexicana and Uvigerina peregrina)from the Site U1447 of IODP 353 Expedition to trace methane events in the Andaman Sea,where one of the thickest and deepest gas hydrate stability zones was discovered.Theδ^(13)C values of benthic foraminifera show that there are eight distinct intervals with negative values in the last~10 Myr,interpreted as a record of long-term fluctuations in methane emission.Six of these methane events occurred during the glacial sea-level lowstands in the last~1.1 Myr.We,therefore,infer that the trigger mechanism for these events might be the hydrate destabilization caused by sea level fall.The methane events that occurred at~2.11 and~5.93 Ma are more likely related to the sudden changes in sedimentation,either slide events or marked variations in sedimentation rate. | Yue Cen Jiasheng Wang Xuan Ding Dorrik Stow Zhou Wang Can Chen Xiaochen Ma | 2022 | Journal of Earth Science2022，33，6： | 1 |
| 8 | Ternary phase interfacial polymerization of polypyrrole/MWCNT nanocomposites with core–shell structure显示文摘 | Yongqin Han Mingxia Shen Xiaochen Lin Bing Ding Luojiang Zhang Hao Tong Xiaogang Zhang | 2012 | Synthetic Metals . 2012 (9-10)2012，，9： | 1 |
| 9 | A review on basic data-driven approaches for industrial process monitoring显示文摘 | YIN Shen DINGS X XIE Xiaochen | 2014 | IEEE Transactions on Industrial Electronics2014，61，11： | 1 |
| 10 | Osteogenic and anti-tumor Cu and Mn-doped borosilicate nanoparticles for syncretic bone repair and chemodynamic therapy in bone tumor treatment显示文摘Critical bone defects caused by extensive excision of malignant bone tumor and the probability of tumor recurrence due to residual tumor cells make malignant bone tumor treatment a major clinical challenge.The present therapeutic strategy concentrates on implanting bone substitutes for defect filling but suffers from failures in both enhancing bone regeneration and inhibiting the growth of tumor cells.Herein,Cu and Mn-doped borosilicate nanoparticles(BSNs)were developed for syncretic bone repairing and anti-tumor treatment,which can enhance bone regeneration through the osteogenic effects of Cu^(2+) and Mn^(3+) ions and meanwhile induce tumor cells apoptosis through the hydroxyl radicals produced by the Fenton-like reactions of Cu^(2+) and Mn^(3+) ions.In vitro study showed that both osteogenic differentiation of BMSCs and angiogenesis of endothelial cells were promoted by BSNs,and consistently the critical bone defects of rats were efficiently repaired by BSNs through in vivo evaluation.Meanwhile,BSNs could generate hydroxyl radicals through Fenton-like reactions in the simulated tumor microenvironment,promote the generation of intracellular reactive oxygen species,and eventually induce tumor cell apoptosis.Besides,subcutaneous tumors of mice were effectively inhibited by BSNs without causing toxic side effects to normal tissues and organs.Altogether,Cu and Mn-doped BSNs developed in this work performed dual functions of enhancing osteogenesis and angiogenesis for bone regeneration,and inhibiting tumor growth for chemodynamic therapy,thus holding a great potential for syncretic bone repairing and anti-tumor therapy. | Libin Pang Renliang Zhao Jing Chen Jingxin Ding Xiaochen Chen Wenwen Chai Xu Cui Xiaolin Li Deping Wang Haobo Pan | 2022 | Bioactive Materials2022，7，6： | 1 |
| 11 | Dynamic grouping of heterogeneous agents for exploration and strike missions显示文摘The ever-changing environment and complex combat missions create new demands for the formation of mission groups of unmanned combat agents.This study aims to address the problem of dynamic construction of mission groups under new requirements.Agents are heterogeneous,and a group formation method must dynamically form new groups in circumstances where missions are constantly being explored.In our method,a group formation strategy that combines heuristic rules and response threshold models is proposed to dynamically adjust the members of the mission group and adapt to the needs of new missions.The degree of matching between the mission requirements and the group’s capabilities,and the communication cost of group formation are used as indicators to evaluate the quality of the group.The response threshold method and the ant colony algorithm are selected as the comparison algorithms in the simulations.The results show that the grouping scheme obtained by the proposed method is superior to those of the comparison methods. | Chen CHEN Xiaochen WU Jie CHEN Panos M.PARDALOS Shuxin DING | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，1： | 1 |
| 12 | Dynamics of a multiplex neural network with delayed couplings显示文摘Multiplex networks have drawn much attention since they have been observed in many systems,e.g.,brain,transport,and social relationships.In this paper,the nonlinear dynamics of a multiplex network with three neural groups and delayed interactions is studied.The stability and bifurcation of the network equilibrium are discussed,and interesting neural activities of the network are explored.Based on the neuron circuit,transfer function circuit,and time delay circuit,a circuit platform of the network is constructed.It is shown that delayed couplings play crucial roles in the network dynamics,e.g.,the enhancement and suppression of the stability,the patterns of the synchronization between networks,and the generation of complicated attractors and multi-stability coexistence. | Xiaochen MAO Xingyong LI Weijie DING Song WANG Xiangyu ZHOU Lei QIAO | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，3： | 1 |
| 13 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studiesonpattern formation in coculturecell systemscan provide insights intomany physiological and pathologicalprocesses Here,we investigate how theextracellular matrix(ECM)may influence the patterning in coculture systems.Themodel coculture system we use is composed of highly motile invasivebreast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“cllective pulling”effect resultingfrom ECM-mediated transmssion of active contractile forces generated bythe polarized migration of the invasive cells along the vertical direction.Themechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangu Ye Yang Jiao Liyu Liu | 2022 | Research2022，，2： | 0 |
| 14 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studies on pattern formation in coculture cell systems can provide insights into many physiological and pathological processes.Here,we investigate how the extracellular matrix(ECM)may influence the patterning in coculture systems.The model coculture system we use is composed of highly motile invasive breast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“collective pulling”effect resulting from ECM-mediated transmission of active contractile forces generated by the polarized migration of the invasive cells along the vertical direction.The mechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangfu Ye Yang Jiao Liyu Liu | 2021 | Research2021，，1： | 0 |
| 15 | Clinical significance of serum IgM and IgG levels in COVID-19 patients in Hubei Province,China显示文摘Background:There have been many studies about coronavirus disease 2019(COVID-19),but the clinical signifi-cance of quantitative serum severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)-specific IgM and IgG levels of COVID-19 patients have not been exhaustively analyzed.We aimed to investigate the time profiles of these IgM/IgG levels in COVID-19 patients and their correlations with clinical features.Methods:A multicenter clinical study was conducted from February 20 to March 52020.It involved 179 COVID-19 patients(108 males and 71 females)from five hospitals in Huangshi in Hubei Province,China.To detect SARS-CoV-2-specific IgM/IgG,quantitative antibody assays(two-step indirect immunoassays with direct chemilu-minescence technology)based on the nucleocapsid protein(NP)and spike protein 1(S1)were used.For normally distributed data,means were compared using the t-test,��2-test,or exact probability method.For categorical data,medians were compared using Mann-Whitney U test.Results:The median age was 57(44-69)years(58[38-69]for males and 57[49-68]for females).The median duration of positive nucleic acid test was 22.32(17.34-27.43)days.The mortality rate was relatively low(3/179,1.68%).Serum SARS-CoV-2-specific IgG was detected around week 1 after illness onset,gradually increased until peaking in weeks 4 and 5,and then declined.Serum IgM peaked in weeks 2 and 3,then gradually declined and returned to its normal range by week 7 in all patients.Notably,children had milder respiratory symptoms with lower SARS-CoV-2-specific IgM/IgG levels.The duration of positive nucleic acid test in the chronic obstructive pulmonary disease(COPD)group was 30.36(18.99-34.76)days,which was significantly longer than that in the non-COPD group(21.52[16.75-26.51]days;P=0.025).The peak serum SARS-CoV-2-specific IgG was sig-nificantly positively correlated with the duration of positive nucleic acid test.The incidence rate of severe and critical cases in the IgM hi group(using the median IgM level of 29.95 AU/mL as the cutofffor grouping)was about 38.0%(19/50),which was twice as much as that in the IgM lo group(18.4%;9/49).The patients with positive chest imaging and lymphocytopenia(<1×10^(9)/L)had a higher SARS-CoV-2-specific IgM level.Conclusions: Quantitative SARS-CoV-2-specific IgM and IgG levels are helpful for the diagnosis, severity classifi- cation, and management of COVID-19 patients, and they should be monitored in each stage of this disease. | Zhenjiang Bai Qing Li Qinghui Chen Changming Niu Yu Wei Hanpeng Huang Wei Zhao Nian Chen Xin Yao Qiang Zhang Chuanyong Mu Jian Feng Chuanlong Zhu Zhuo Li Ming Ding Binhui Feng Chaochao Jin Xiang Lu Yi Yang Shuiyan Wu Xiaochen Shu Haibo Qiu YingZi Huang | 2022 | Journal of Intensive Medicine2022，2，1： | 0 |
| 16 | INCloud:integrated neuroimaging cloud for data collection,management,analysis and clinical translations显示文摘Background Neuroimaging techniques provide rich and accurate measures of brain structure and function,and have become one of the most popular methods in mental health and neuroscience research.Rapidly growing neuroimaging research generates massive amounts of data,bringing new challenges in data collection,large-scale data management,efficient computing requirements and data mining and analyses.Aims To tackle the challenges and promote the application of neuroimaging technology in clinical practice,we developed an integrated neuroimaging cloud(INCloud).INCloud provides a full-stack solution for the entire process of large-scale neuroimaging data collection,management,analysis and clinical applications.Methods INCloud consists of data acquisition systems,a data warehouse,automatic multimodal image quality check and processing systems,a brain feature library,a high-performance computing cluster and computer-aided diagnosis systems(CADS)for mental disorders.A unique design of INCloud is the brain feature library that converts the unit of data management from image to image features such as hippocampal volume.Connecting the CADS to the scientific database,INCloud allows the accumulation of scientific data to continuously improve the accuracy of objective diagnosis of mental disorders.Results Users can manage and analyze neuroimaging data on INCloud,without the need to download them to the local device.INCloud users can query,manage,analyze and share image features based on customized criteria.Several examples of'mega-analyses'based on the brain feature library are shown.Conclusions Compared with traditional neuroimaging acquisition and analysis workflow,INCloud features safe and convenient data management and sharing,reduced technical requirements for researchers,high-efficiency computing and data mining,and straightforward translations to clinical service.The design and implementation of the system are also applicable to imaging research platforms in other fields. | Qingfeng Li Lijuan Jiang Kaini Qiao Yang Hu Bing Chen Xiaochen Zhang Yue Ding Zhi Yang Chunbo Li | 2021 | General Psychiatry2021，34，6： | 0 |
| 17 | A simple structure copolymer donor based on carboxylated benzodithiophene for polymer solar cells显示文摘The design and development of low-cost and efficient photovoltaic materials remain a major challenge for the research and application of polymer solar cells(PSCs).Therefore,developing efficient photovoltaic polymers with simple structure and easy preparation has become an important research topic.Here we report a facilely synthesized electron-donating polymer X1 with a simple chemical structure,which is composed of carboxylated benzo[1,2-b:4,5-b′]dithiophene(BDT)and thiophene unit.The carboxylate substituents on the BDT unit endowed the polymer with appropriate solubility,low-lying highest occupied molecular orbital(HOMO)energy level,and superior absorption.The PSCs based on X1 as the donor showed a high power conversion efficiency of 16.6%,with a remarkable short-circuit current density of 27.07 m A cm^(-2).These results demonstrated that X1 is a highly promising candidate for low-cost and efficient PSCs.Furthermore,this study revealed the potential of carboxylated BDT as an effective building block in the research and development of high-performance photovoltaic materials. | Xiaochen Wang Rui Zhao Zicheng Ding Shengzhong(Frank)Liu Yongfang Li | 2022 | Science China Chemistry2022，65，9： | 0 |
| 18 | Wellbore stability model in shale formation under the synergistic effect of stress unloading-hydration显示文摘According to the transversely isotropic theory and weak plane criterion, and considering the mechanical damages due to stress unloading and hydration during drilling, a shale wellbore stability model with the influence of stress unloading and hydration was established using triaxial test and shear test. Then, factors influencing the wellbore stability in shale were analyzed. The results indicate that stress unloading occurs during drilling in shale. The larger the confining pressure and axial stress, the more remarkable weakening of shale strength caused by stress unloading. The stress unloading range is positively correlated with the weakening degree of shale strength. Shale with a higher development degree of bedding is more prone to damage along bedding. In this case, during stress unloading, the synergistic effect of weak structural plane and stress unloading happens, leading to a higher weakening degree of shale strength and poorer mechanical stability, which brings a higher risk of wellbore instability. Fluid tends to invade shale through bedding, promoting the shale hydration. Hydration also can weaken shale mechanical stability, causing the decline of wellbore stability. Influence of stress unloading on collapse pressure of shale mainly occurs at the early stage of drilling, while the influence of hydration on wellbore stability mainly happens at the late stage of drilling. Bedding, stress unloading and hydration jointly affect the wellbore stability in shale. The presented shale wellbore stability model with the influence of stress unloading and hydration considers the influences of the three factors. Field application demonstrates that the prediction results of the model agree with the actual drilling results, verifying the reliability of the model. | DING Yi LIU Xiangjun LIANG Lixi XIONG Jian LI Wei WEI Xiaochen DUAN Xi HOU Lianlang | 2023 | Petroleum Exploration and Development2023，50，6： | 0 |
| 19 | High-efficiency organic solar cells processed from a halogen-free solvent system显示文摘The use of non-halogenated solvents for the green manufacture of high-efficiency organic solar cells(OSCs)is important for their future application.However,the power conversion efficiency(PCE)of the non-halogenated solvent processed OSCs is generally lower than their halogenated counterpart due to the poor film microstructure caused by the solubility issue.Herein,we propose a halogen-free solvent system to optimize film microstructure of the photovoltaic blend based on the polymer donor D18and small-molecule acceptor(SMA)L8-BO towards high-efficiency OSCs.The solvent system is consisted of a main solvent carbon disulfide and an additive paraxylene,where the former ensures the good solution-processability and promotes the solution aggregation of L8-BO,and the latter can finely control the phase-separation process by selectively dissolving the SMA.This solvent combination robustly produces a high-quality active layer,i.e.,the bicontinuous networks of donor and acceptor with nano-sized phase-separation and strongπ-πstacking.With the effective charge generation,transport and collection,the resulting device from the non-halogenated solvent system shows a high PCE of 17.50%,which is comparable to that of the device prepared from the halogenated solvent chloroform(ca.17.11%).This article proposes a new strategy for the green fabrication of high-efficiency OSCs to accelerate their industrialization. | Yueling Su Zicheng Ding Rui Zhang Weibing Tang Wenliang Huang Zhichao Wang Kui Zhao Xiaochen Wang Shengzhong(Frank)Liu Yongfang Li | 2023 | Science China Chemistry2023，66，8： | 0 |
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