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| 1 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 2 | Impact of China’s Air Pollution Prevention and Control Action Plan on PM2.5 chemical composition over eastern China显示文摘China promulgated the Air Pollution Prevention and Control Action Plan(the Action Plan)in 2013 and developed stringent control measures to mitigate fine particulate matter(PM2.5) pollution.Here,we investigated the PM2.5 chemical composition changes over eastern China associated with the Action Plan during 2013-2017 using satellite-based PM2.5 chemical composition data derived using CMAQ simulations and satellite inputs.The PM2.5 concentrations decreased considerably during this time as a result of the reductions in all chemical species in PM2.5.The population-weighted mean concentrations over eastern China decreased from 11.1 to 6.7μgm-3 for SO42-,13.8-13.1μgm-3 for NO3-,7.4-5.8μgm-3 for NH4+,9.9-8.4μgm-3 for OM,4.6-3.8μg m-3 for BC and 12.9-9.6μg m-3 for other species in PM2.5.SO42-had the largest reduction of 40%,while NO3-had the lowest reduction of 5%,resulting in a greater fraction of NO3-and a smaller fraction of SO42-in PM2.5.Among the three key regions,Beijing-Tianjin-Hebei had the largest reduction in PM2.5 and its chemical compositions.The decrease in SO42-concentrations was in line with the reduction of SO2 emissions,and the major driver of the SO2 emission reductions was the industrial sector.The decrease in NO3 concentrations was limited because the decrease in SO2 emissions and the stable NH3 emissions facilitated the formation of NO3-from HNO3,which partially offset the reduction in NOx emissions driven by the power sector.To mitigate PM2.5 pollution more effectively,future efforts are needed to reduce NH3 emissions. | Guannan GENG Qingyang XIAO Yixuan ZHENG Dan TONG Yuxuan ZHANG Xiaoye ZHANG Qiang ZHANG Kebin HE Yang LIU | 2019 | Science China Earth Sciences2019，62，12： | 16 |
| 3 | Attribution of PM_(2.5) exposure in Beijing-Tianjin-Hebei region to emissions:implication to control strategies显示文摘The Beijing-Tianjin-Hebei(BTH) region is one of the most heavily polluted regions in China,with both high PM_(2.5) concentrations and a high population density.A quantitative source-receptor relationship can provide valuable insights that can inform effective emission control strategies.Both source apportionment(SA) and source sensitivity(SS) can provide such information from different perspectives.In this study,both methods are applied in northern China to identify the most significant emission categories and source regions for PM_(2.5) exposure in BTH in 2013.Despite their differences,both models show similar distribution patterns for population and simulated PM_(2.5) concentrations,resulting in overall high PM_(2.5) exposure values(approximately 110 μg/m~) and particularly high exposure values during the winter(approximately 200 μ/m~).Both methods show that local emissions play a dominant role(70%),with some contribution from surrounding provinces(e.g.,Shandong) via regional transport.The two methods also agree on the priority of local emission controls:both identify industrial,residential,and agricultural emissions as the top three categories that should be controlled locally.In addition,the effect of controlling agricultural ammonia emissions is approximately doubled when the co-benefits of reducing nitrate are considered.The synthesis of SA and SS for addressing specific categories of emissions provides a quantitative basis for the development of emission control strategies and policies for controlling PM_(2.5)in China. | Xin Li Qiang Zhang Yang Zhang Lin Zhang Yuxuan Wang Qianqian Zhang Meng Li Yixuan Zheng Guannan Geng Timothy J.Wallington Weijian Han Wei Shen Kebin He | 2017 | Science Bulletin2017，62，13： | 15 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | Design and baseline data of a populationbased metabonomics study of eye diseases in eastern China: the Yueqing Ocular Diseases Investigation显示文摘Background:China is undergoing a massive transition toward an urban and industrial economy.These changes will restructure the demographics and economy which will eventually influence the future patterns of disease.The risk factors of vision-impairing eye diseases remain ambiguous and poorly understood.Metabolomics is an ideal tool to understand and shed light on the ocular disease mechanisms for earlier treatment.This article aims to describe the design,methodology and baseline data of the Yueqing Ocular Diseases Investigation(YODI),a developed county population-based study to determine the prevalence and primary causes of visual impairment;also with metabonomics analysis we aimed to identify,predict and suggest some preventive biomarkers that cause blindness.Methods:A population-based,cross-sectional study.Randomized clustering sampling was used to identify adults aged 50 years and older in Xiangyang Town,Yueqing county-level City.The interviews covered demographic,behavioral,ocular risk factors and mental health state.The ocular examination included visual acuity,autorefraction,intraocular pressure,anterior and posterior segment examinations,fundus photography,retinal tomography and angiography,and visual field testing.Anthropometric measurements included height and weight,waist and hip circumference,blood pressure,pulse rate,electrocardiogram,and abdominal ultrasound scan.A venous blood sample was collected for laboratory tests and metabonomics studies.Results:Of the 5319 individuals recruited for the YODI,4769(89.7%)subjects were enrolled for analyses.The median age was 62.0 years,and 45.6%were male.The educational level of illiteracy or semi-illiteracy,primary,middle and high school or above was 29.8%,45.5%,20.1%,and 3.3%,respectively.Majority of the participants were female,younger,and less educated when compared with nonparticipants.The average body mass index and waist-hip ratios were 24.4±3.4 kg/m^(2) and 0.9±0.1 respectively.Blood sample collection reached a sample size of 1909(479 from subjects with selfreported diabetes and 1430 from one-third of the 4290 subjects without self-reported diabetes).Conclusions:The YODI provides population-based data with a high response rate(89.7%)on the prevalence and primary causes of major vision-impairing eye diseases in developed county areas in eastern China.Metabonomics analysis from YODI will provide further association of metabolic characteristics with the visual impairment eye diseases.The risk prediction model could be created and has the potential to be generalized to developed eastern areas in China for prevention. | Yuxuan Deng Yuanbo Liang Sigeng Lin Liang Wen Jin Li Yue Zhou Meixiao Shen Jingwei Zheng Kemi Feng Yanting Sun Kwapong Willaim Robert Jia Qu Fan Lu | 2020 | Eye and Vision2020，7，1： | 4 |
| 6 | Deciphering primate retinal aging at single-cell resolution显示文摘Dear Editor, The retina is a light-sensitive highly-organized tissue,which is vulnerable to aging and age-related retinal diseases.Specifically,progressive retinal degeneration leads to visual function deterioration and vision impairment in the elderly(Lin et al.,2016).In diseases such as age-related macular degeneration(AMD),retinitis pigmentosa(RP)and diabetic retinopathy(DR),pathological process lacking effective treatments profoundly and negatively impact on the quality of life in the elderly(Lin et al.,2016;Chen et al.,2019).Thus,an in-depth molecular assessment of the mechanisms driv-ing retinal aging is of urgent scientific and medical importance. | Si Wang Yuxuan Zheng Qingqing Li Xiaojuan He Ruotong Ren Weiqi Zhang Moshi Song Huifang Hu Feifei Liu Guoqiang Sun Shuhui Sun Zunpeng Liu Yang Yu Piu Chan Guo-Guang Zhao Qi Zhou Guang-Hui Liu Fuchou Tang Jing Qu | 2021 | Protein & Cell2021，12，11： | 4 |
| 7 | Catalytic alkane dehydrogenations显示文摘Olefins find widespread applications in the synthesis of polyolefins and fine chemicals. With an increasing demand for olefins, the technologies for alkane dehydrogenation have drawn much attention. Several types of heterogeneous catalysts have found applications in industry for the dehydrogenation of light alkanes, mainly ethane, propane, and butane. In the past three decades, a number of transition-metal complexes,particularly pincer-ligated iridium complexes, have been developed as the homogeneous catalysts for alkane dehydrogenations. The homogeneous catalyst systems operate under much milder conditions compared with the heterogeneous systems, and some systems exhibit good activity and high regioselectivity in dehydrogenation of alkanes longer than butane. | Yuxuan Zhang Wubing Yao Huaquan Fang Aiguo Hu Zheng Huang | 2015 | Science Bulletin2015，60，15： | 4 |
| 8 | A single-cell transcriptomic atlas of primate pancreatic islet aging显示文摘Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine cells age heterogeneously,complicating the efforts to unravel the molecular drivers underlying endocrine aging.To overcome these obstacles,we undertook single-cell RNA sequencing of pancreatic islet cells obtained from young and aged non-diabetic cynomolgus monkeys.Despite sex differences and increased transcriptional variations,agedβ-cells showed increased unfolded protein response(UPR)along with the accumulation of protein aggregates.We observed transcriptomic dysregulation of UPR components linked to canonical ATF6 and IRE1 signaling pathways,comprising adaptive UPR during pancreatic aging.Notably,we found aging-relatedβ-cell-specific upregulation of HSP90 B1,an endoplasmic reticulum-located chaperone,impeded high glucose-induced insulin secretion.Our work decodes aging-associated transcriptomic changes that underlie pancreatic islet functional decay at single-cell resolution and indicates that targeting UPR components may prevent loss of proteostasis,suggesting an avenue to delayingβ-cell aging and preventing aging-related diabetes. | Jingyi Li Yuxuan Zheng Pengze Yan Moshi Song Si Wang Liang Sun Zunpeng Liu Shuai Ma Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Weiqi Zhang Guang-Hui Liu Fuchou Tang Jing Qu | 2021 | National Science Review2021，8，2： | 3 |
| 9 | In vitro expansion of human sperm through nuclear transfer显示文摘Dear Editor,Mammalian haploid embryonic stem cells(haESCs)represent an ideal tool for genetic analysis due to the presence of only one set of genetic materials.HaESCs fall into two readily distinguishable groups based on their genome origins:parthenogenetic haESCs(PG-haESCs)that are derived from oocyte-originated parthenogenetic embryos and androgenetic haESCs(AG-haESCs)that are produced through sperm nuclear transfer.Both PG-and AGhaESCs are feasible for delineating genome function at cellular level in vitro.Importantly,AG-haESCs can be used as a sperm replacement and applied to deciphering gene function at organismal level when combined with CRISPR-Cas9 technology.1 However,while PG-haESCs have been generated from both rodent and primates,2-5 AG-haESCs can only be obtained in rodent to date. | Xiaoyu Merlin Zhang Keliang Wu Yuxuan Zheng Han Zhao Junpeng Gao Zhenzhen Hou Meiling Zhang Jiaoyang Liao Jingye Zhang Yuan Gao Yuanyuan Li Lin Li Fuchou Tang Zi-Jiang Chen Jinsong Li | 2020 | Cell Research2020，30，4： | 3 |
| 10 | Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks显示文摘Meiotic recombination is initiated by the formation of double-strand breaks(DSBs),which are repaired as either crossovers(COs)or noncrossovers(NCOs).In most mammals,PRDM9-mediated H3K4me3 controls the nonrandom distribution of DSBs;however,both the timing and mechanism of DSB fate control remain largely undetermined.Here,we generated comprehensive epigenomic profiles of synchronized mouse spermatogenic cells during meiotic prophase I,revealing spatiotemporal and functional relationships between epigenetic factors and meiotic recombination.We find that PRDM9-mediated H3K4me3 at DSB hotspots,coinciding with H3K27ac and H3K36me3,is intimately connected with the fate of the DSB.Our data suggest that the fate decision is likely made at the time of DSB formation:earlier formed DSBs occupy more open chromatins and are much more competent to proceed to a CO fate.Our work highlights an intrinsic connection between PRDM9-mediated H3K4me3 and the fate decision of DSBs,and provides new insight into the control of CO homeostasis. | Yao Chen Ruitu Lyu Bowen Rong Yuxuan Zheng Zhen Lin Ruofei Dai Xi Zhang Nannan Xie Siqing Wang Fuchou Tang Fei Lan Ming-Han Tong | 2020 | Cell Research2020，30，3： | 3 |
| 11 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 12 | Facile synthesized Cu-SnO2 anode materials with three-dimensional metal cluster conducting architecture for high performance lithium-ion batteries显示文摘Metal oxide anode material is one of promising candidates for the next-generation LIBs, due to its high theoretical capacity and low cost. The poor conductivity and huge volume change during charge/discharge, however, restrict the commercialization of metal oxide anode material. In this work, we design a novel Cu-SnO_2 composite derived from Cu_6 Sn_5 alloy with three dimensional(3 D) metal cluster conducting architecture. The novel Cu structure penetrates in the composite particles inducing high conductivity and space-confined SnO_2,which restrict the pulverization of SnO_2 during lithiation/delithiation process. The optimized Cu-SnO_2 composite anode delivers an initial discharge capacity of 933.7 mA h/g and retains a capacity of 536.1 mA h/g after 200 cycles, at 25℃ and a rate of 100 mA/g. Even at the high rate of 300 mA/g, the anode still exhibits a capacity of more than 29% of that tested at 50 mA/g.Combining with the phase and morphology analysis, the novel Cu-SnO_2 composite not only has good electrical conductivity, but also possesses high theoretical capacity(995 mAh/g), which may pave a new way for the design and construction of next-generation metal oxide anode materials with high power and cycling stability. | Zhijia Zhang Yuxuan Hou Shaofei Zhang Guoliang Zhang Ming Li Huanming Lu Yong Li Xuerong Zheng Zhijun Qiao Zhenyang Yu Qin Huang Jianli Kang | 2018 | Chinese Chemical Letters2018，29，11： | 2 |
| 13 | Revealing the correlation between structure evolution and electrochemical performance of high-voltage lithium cobalt oxide显示文摘Lithium cobalt oxide(LCO)is the dominating cathode materials for lithium-ion batteries(LIBs)deployed in consumer electronic devices for its superior volumetric energy density and electrochemical performances.The constantly increasing demands of higher energy density urge to develop high-voltage LCO via a variety of strategies.However,the corresponding modification mechanism,especially the influence of the long-and short-range structural transitions at high-voltage on electrochemical performance,is still not well understood and needs further exploration.Based on ss-NMR,in-situ X-ray diffraction,and electrochemical performance results,it is revealed that the H3 to H1-3 phase transition dictates the structural reversibility and stability of LCO,thereby determining the electrochemical performance.The introduction of La and Al ions could postpone the appearance of H1-3 phase and induce various types of local environments to alleviate the volume variation at the atomic level,leading to better reversibility of the H1-3 phase and smaller lattice strain,and significantly improved cycle performance.Such a comprehensive long-range,local,and electronic structure characterization enables an in-depth understanding of the structural evolution of LCO,providing a guiding principle for developing high-voltage LCO for high energy density LIBs. | Jiajia Wan Jianping Zhu Yuxuan Xiang Guiming Zhong Xiangsi Liu Yixiao Li Kelvin H.L.Zhang Chaoyu Hong Jianming Zheng Kai Wang Yong Yang | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 14 | Effects of Al^3+ on the microstructure and bioflocculation of anoxic sludge显示文摘The aluminum ions generated from mining aluminum,electrolytic aluminum and the industrial production of aluminum-based coagulants(such as AlCl3 and Al2(SO4)3)enter sewage treatment plants and interact with activated sludges.An anaerobic/anoxic/oxic(A2^O)process was used to reveal the effects of Al^3+on the pollutant removal efficiencies,bioflocculation and the micro structure of sludge.The results showed that a low concentration of Al^3+improved the pollutant removal efficiencies and increased the sludge particle size.However,a high concentration of Al^3+hindered microbial flocculation and reduced the pollutant removal efficiencies.With a 10 mg/L Al^3+addition,the chemical oxygen demand(COD),total nitrogen(TN)and NH4+-N increased by 3%,16%and 27%,and reached as high as 68%,60%and 87%,respectively.At the same time,the dehydrogenase activity,flocculation ability(FA)and contact angle of the sludge reached their maximum levels at 41.3 mg/L/hr,45%and 79.63°,respectively.The specific surface area of the sludge decreased to 7.084 m2/g and the sludge pore size distribution shifted to concentrate in the me soporous range.Most of Al^3+was adsorbed on the surface of sludge,changing the physicochemical properties and physical structure of the sludge. | Lanhe Zhang Jing Zheng Shulei Tian Haifeng Zhang Xiaohui Guan Suiyi Zhu Xiaoyu Zhang Yuxuan Bai Ping Xu Jian Zhang Zheng Li | 2020 | Journal of Environmental Sciences2020，32，5： | 1 |
| 15 | Recent evolution of Jiuduansha Shoal in Yangtze Estuary and its eorresponding to engineering projects 显示文摘 | Zheng Jinhai Peng Yuxuan Zhang Chi | 2013 | Journal of Coastal Research2013，65，1： | 1 |
| 16 | Rapid evaluation of heterologous chimeric RBD-dimer mRNA vaccine for currently-epidemic Omicron sub-variants as booster shot after inactivated vaccine显示文摘With continuous mutations of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the severe immune escape of Omicron sub-variants urges the development of next-generation broad-spectrum vaccines,especially as booster jabs after high-level vaccination coverage of inactivated vaccines in China and many other countries.Previously,we developed a coronavirus disease 2019(COVID-19)protein subunit vaccine ZF2001?based on the tandem homo-prototype receptor-binding domain(RBD)-dimer of the SARS-CoV-2 spike protein.We upgraded the antigen into a hetero-chimeric prototype(PT)-Beta or Delta-BA.1 RBD-dimer to broaden the cross-protection efficacy and prove its efficiency with protein subunit and mRNA vaccine platforms.Herein,we further explored the hetero-chimeric RBD-dimer mRNA vaccines and evaluated their broad-spectrum activities as booster jabs following two doses of inactivated vaccine(Ⅳ)in mice.Our data demonstrated that the chi-meric vaccines significantly boosted neutralizing antibody levels and specific T-cell responses against the vari-ants,and PT-Beta was superior to Delta-BA.1 RBD as a booster in mice,shedding light on the antigen design for the next-generation COVID-19 vaccines. | Qian Chen Pei Du Yuxuan Han Xuehui Ma Rong Zhang Xiaoyu Rong Xu Zhao Renyi Ma Huiting Yang Anqi Zheng Qingrui Huang Jinghua Yan Hui Wang Xin Zhao Lianpan Dai George F.Gao Qihui Wang | 2023 | Biosafety and Health2023，5，2： | 1 |
| 17 | Present-day movement characteristics of the Qinghai Nanshan fault and its surrounding area from GPS observation显示文摘The Qinghai Nanshan fault is a larger fault in the Northeastern Xizang Plateau.In previous studies,its movement characteristics are mainly investigated with geological and seismic observations,and the tectonic transformation role of the fault on its east is not yet clear.This study uses data fusion to obtain denser GPS observations near the Qinghai Nanshan fault.Based on tectonic characteristics,we establish a block model to investigate the fault slip rate,locking degree,and slip deficit.The results show that the Qinghai Nanshan fault slip rate is characterized by sinistral and convergent movement.Both the sinistral and convergent rates display a decreasing trend from west to east.The locking degree and slip deficit are higher in the western segment(with an average of about 0.74 and 1.1 mm/a)and lower in the eastern segment.Then,we construct a strain rate field using GPS observations to analyze the regional strain characteristics.The results indicate that along the fault,the western segment shows a larger shear strain rate and negative dilation rate.Regional earthquake records show that the frequency of earthquakes is lower near the fault.The joint results suggest that the western segment may have a higher earthquake risk.In addition,the insignificant fault slip rate in the eastern segment may indicate that it does not participate in the tectonic transformation among the Riyueshan,Lajishan,and West Qinling faults. | Yang Liu Yuxuan Qiu Jialiang Liu Luyun Xiong Caijun Xu Jianghui Geng Gang Zheng Tianchen Sheng | 2024 | Geodesy and Geodynamics2024，15，2： | 0 |
| 18 | Motion analysis of passive dynamic walking with a rigorously constraint model: A necessary condition for maintaining period-1 gait显示文摘The friction force is an important environmental factor that influences dynamic walking.While most of the related works simply assume static friction or Coulomb friction,we use the LuGre friction,which accounts for both static and dynamic effects,to model the horizontal ground reaction force of passive dynamic walking.We present a detailed mathematical modeling method and perform numerical simulations using it.Furthermore,we analyze the ground surface cases of the Coulomb friction condition and static friction condition to verify the model’s generalization.We discover the required condition for the existence of the period-1 gait through investigation.Our mathematical model and theoretical analysis add to our understanding of passive dynamic walking,which helps to positively utilize the natural dynamics of the legged locomotion system in control design. | Yanqiu Zheng Longchuan Li Yuxuan Xiang Yuetong He Cong Yan Fumihiko Asano | 2022 | Biomimetic Intelligence & Robotics2022，2，2： | 0 |
| 19 | Research Article In situ reconstruction induced oxygen-deficient multiphase Cu based species hybridized with Ni single atoms as tandem platform for CO_(2) electroreduction显示文摘Tandem catalysis,capable of decoupling individual steps,provides a feasible way to build a high-efficiency CO_(2) electro-conversion system for multicarbons(C_(2+)).The construction of electrocatalytic materials is one of focusing issues.Herein,we fabricated a single atom involved multivalent oxide-derived Cu composite material and found it inclined to reconstruct into oxygen-deficient multiphase Cu based species hybridized with monatomic Ni on N doped C matrix.In this prototype,rapid CO generation and C-C coupling are successively achieved on NiN4 sites and surface amorphized Cu species with defects,resembling a micro-production line.In this way,the in situ formed tandem catalyst exhibited a high Faradaic efficiency(FE)of~78%for C_(2+)products along with satisfactory durability over 50 h.Particularly,the reconstruction-induced amorphous layer with abundant asymmetric sites should be favorable to improve the ethanol selectivity(FE:63%),which is about 10 times higher than that of the non-tandem Cu-based contrast material.This work offers a new approach for manipulating tandem catalyst systems towards enhancing C_(2+)products. | Juzhe Liu Yuheng Wang Pengpeng Mo Feng Yang Kaiqi Jiang Zhixiang Cheng Yuxuan Liu Zhiyi Sun Zheng Liu Yimei Zhang Wenxing Chen | 2024 | Nano Research2024，17，5： | 0 |
| 20 | Asymmetrically coordinated single atom Cu catalyst with unsaturated C-Cu-N structure for CO_(2) reduction to CO显示文摘Single atom catalysts(SACs)play a crucial role in energy catalysis due to their distinct coordination environment and high atomic utilization efficiency.This study focuses on the synthesis of a monatomic Cu catalyst with Cu-N1C1 coordination anchored to N-doped Ti_(3)C_(2)T_(x) MXene(Cu SA@N-Ti_(3)C_(2)T_(x))to achieve efficient reduction of CO_(2) to CO.Detailed characterization,including morphology and multispectral analysis,confirmed the uniform distribution of asymmetrically coordinated Cu atoms in unsaturated C-Cu-N bridge fragments on Ti_(3)C_(2)T_(x).The Cu SA@N-Ti_(3)C_(2)T_(x) catalyst exhibited an excellent CO selectivity with Faraday efficiency of 97.4%at-0.58 V vs.reversible hydrogen electrode(RHE)and satisfactory durability.The in situ X-ray absorption fine structure(XAFS)results confirmed that the carbon dioxide reduction reaction(CO_(2)RR)product distribution is mainly affected by potential-dependent valence change of Cu species.These findings highlight the extensive potential of tuning coordination structure of MXene-based single-atom catalysts for CO_(2) reduction reactions. | Zheng Liu Yuxuan Liu Jingqiao Zhang Ting Cao Zhiyi Sun Juzhe Liu Huishan Shang | 2024 | Nano Research2024，17，5： | 0 |
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