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| 1 | Developing superior alleles of yield genes in rice by artificial mutagenesis using the CRISPR/Cas9 system显示文摘Rice yield is an important and complex agronomic trait controlled by multiple genes.In recent decades,dozens of yield-associated genes in rice have been cloned,many of which can increase production in the form of loss or degeneration of function.However,mutations occurring randomly under natural conditions have provided very limited genetic resources for yield increases.In this study,potentially yield-increasing alleles of two genes closely associated with yield were edited artificially.The recently developed CRISPR/Cas9system was used to edit two yield genes:Grain number 1a(Gn1a)and DENSE AND ERECT PANICLE1(DEP1).Several mutants were identified by a target sequence analysis.Phenotypic analysis confirmed one mutant allele of Gn1a and three of DEP1 conferring yield superior to that conferred by other natural high-yield alleles.Our results demonstrate that favorable alleles of the Gnla and DEP1 genes,which are considered key factors in rice yield increases,could be developed by artificial mutagenesis using genome editing technology. | Liyu Huang Ru Zhang Guangfu Huang Yanxia Li Getachew Melaku Shilai Zhang Haitao Chen Yanjuan Zhao Jing Zhang Yesheng Zhang Fengyi Hu | 2018 | The Crop Journal2018，6，5： | 8 |
| 2 | Inhibition of the toxic byproduct during photocatalytic NO oxidation via La doping in ZnO显示文摘It is of a great challenge to develop semiconductor photocatalysts with potential possibilities to simultaneously enhance photocatalytic efficiency and inhibit generation of toxic intermediates.In this study,we developed a facile method to induce the La doping and cationic vacancie(V(Zn))on ZnO for the highly efficient complete NO oxidation.The photocatalytic NO removal efficiency increases from 36.2%to 53,6%.Most importantly,a significant suppressed NO2 production also has been realized.According to the DFT calculations,ESR spectra and in situ FTIR spectra,the introduction of La^3+induce the redistribution of charge carriers in La-ZnO,which promote the production of·O2^- and lead to the formation of V(Zn)for the formation of·OH,contributing to the complete oxidation of NO to nitrate.Besides,the conversion pathway of photocatalytic NO oxidation has been elaborated,This work paves a new way to simultaneously realize the photocatalytic pollutants removal and the inhibition of toxic intermediates generation for efficient and safe air purification. | Chaowei Yuan Wen Cui Yanjuan Sun Jiadong Wang Ruimin Chen Jin Zhang Yuxin Zhang Fan Dong | 2020 | Chinese Chemical Letters2020，31，3： | 3 |
| 3 | Light-Induced Dynamic Stability of Oxygen Vacancies in BiSbO_(4) for Efficient Photocatalytic Formaldehyde Degradation显示文摘Defect engineering has been regarded as a versatile strategy to maneuver the photocatalytic activity.However,there are a few studies concerning how to maintain the stability of defects,which is important to ensure sustainable photocatalytic performance.Here,a novel strategy to modulate the structural properties of BiSbO_(4)using light-induced dynamic oxygen vacancies is reported by us for efficient and stable photocatalytic oxidation of formaldehyde.Interestingly,the continuous consumption and replenishment of vacancies(namely dynamic vacancies)ensure the dynamic stability of oxygen vacancies,thus guaranteeing the excellent photocatalytic stability.The oxygen vacancies could also accelerate the electron migration,inhibit the photogenerated electron/hole recombination,widen the light absorption spectra,and thus improve the photocatalytic formaldehyde removal performance.Combined with the results of in situ DRIFTS,the reaction mechanism for each step of formaldehyde oxidation is revealed.As supported by DFT calculation of Gibbs free energy,the introduction of oxygen vacancies into BiSbO_(4)can promote spontaneous process of formaldehyde oxidation.Our work highlights a promising approach for stabilizing the defects and proposes the photocatalytic reaction mechanism in combination with the thermodynamic functions. | Maoxi Ran Wen Cui Kanglu Li Lvcun Chen Yuxin Zhang Fan Dong Yanjuan Sun | 2022 | Energy & Environmental Materials2022，5，1： | 1 |
| 4 | pH-activatable oxidative stress amplifying dissolving microneedles for combined chemo-photodynamic therapy of melanoma显示文摘Photodynamic therapy(PDT)-mediated oxidation treatment is extremely attractive for skin melanoma ablation,but the strong hydrophobicity and poor tumor selectivity of photosensitizers,as well as the oxygen-consuming properties of PDT,leading to unsatisfactory therapeutic outcomes.Herein,a tumor acidic microenvironment activatable dissolving microneedle(DHA@HPFe-MN)was developed to realize controlled drug release and excellent chemo-photodynamic therapy of melanoma via oxidative stress amplification.The versatile DHA@HPFe-MN was fabricated by crosslinking a self-synthesized protoporphyrin(PpIX)-ADH-hyaluronic acid(HA)conjugate HA-ADH-PpIX with“iron reservoir”PA-Fe 3+complex in the needle tip via acylhydrazone bond formation,and dihydroartemisinin(DHA)was concurrently loaded in the hydrogel network.HA-ADH-PpIX with improved water solubility averted undesired aggregation of PpIX to ensure enhanced PDT effect.DHA@HPFe-MN with sharp needle tip,efficient drug loading and excellent mechanical strength could efficiently inserted into skin and reach the melanoma sites,where the acidic pH triggered the degradation of microneedles,enabling Fe-activated and DHA-mediated oxidation treatment,as evidenced by abundant reactive oxygen species(ROS)generation.Moreover,under light irradiation,a combined chemo-photodynamic therapeutic effect was achieved with amplified ROS generation.Importantly,the Fe-catalyzed ROS production of DHA was oxygen-independent,which work in synergy with the oxygen-dependent PDT to effectively destroy tumor cells.This versatile microneedles with excellent biosafety and biodegradability can be customized as a promising localized drug delivery system for combined chemo-photodynamic therapy of melanoma. | Yanjuan Huang Hualu Lai Jingwen Jiang Xiaoyu Xu Zishan Zeng Lingling Ren Qiuxing Liu Meixu Chen Tao Zhang Xin Ding Chunshun Zhao Shengmiao Cui | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，5： | 1 |
| 5 | Seeing Is Believing显示文摘Senior Chinese Tibetologist invites Americans to see the real Tibet for themselves Slavery,a bitter period in American history,ended more than a centu- ry ago in the United States,while for many Americans,its legacy is still felt today like a wound that | WANG YANJUAN & CHEN WEN | 2008 | Beijing Review2008，51，31： | 1 |
| 6 | Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability,easy preparation,and tunable catalytic properties,especially in the field of cancer therapy.However,the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their applications.Herein,we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots(BPQDs)nanozymes that simultaneously exhibited an exceptional near-infrared(NIR)photothermal property and dramatically photothermal-enhanced glucose oxidase(GOx)-like activity in the acidic tumor microenvironment.We demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9%that could rapidly heat the tumor up to 50℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously injection.Meanwhile,the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular glucose.By combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity,the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in vivo.We believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2022 | Nano Research2022，15，2： | 1 |
| 7 | Promoted reactants activation and charge separation leading to efficient photocatalytic activity on phosphate/potassium co-functionalized carbon nitride显示文摘Photocatalytic technology has been widely adopted to address the issue of air pollution. The separation of photogenerated carriers and the activation of reactants on catalyst surface are the main factors that affect the photocatalytic efficiency. Here, the phosphate/potassium(PO_4/K) cofunctionalized carbon nitride(labeled as PO_4-CN-K) was synthesized via a one-step in situ copyrolysis of thiourea and potassium phosphate. The unique electronic structure of PO_4-CN-K could significantly improve the performance of photocatalytic NO purification. The enhanced activity of PO_4-CN-K can be attributed to the promoted activation capacity for O_2, NO and H_2O on the catalyst surface,the decreased of carriers recombination, benefiting from the co-functionalization of phosphate groups on the surface of CN and the construction of K channels between CN layers. The photocatalytic NO conversion pathway is disclosed through time-dependent in situ FT-IR, indicating that PO_4-CN-K can efficiently convert NO molecules into harmless nitrate via the NO→NO+→nitrate/nitrite routes. The research provides a novel strategy to impel the development of photocatalytic technology for efficient air purification. | Maoxi Ran Peng Chen Jiarui Li Wen Cui Jieyuan Li Ye He Jianping Sheng Yanjuan Sun Fan Dong | 2019 | Chinese Chemical Letters2019，30，4： | 1 |
| 8 | Erratum to:Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Erratum to Nano Research 2022,15(2):1554–1563 https://doi.org/10.1007/s12274-021-3701-8 Figure 3(d)in the original paper contained duplicated micrographs(BPQDs+NIR)for different xenografts(B16 vs.CNE-2).This error did not affect any of the conclusions from the published paper. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2023 | Nano Research2023，16，1： | 0 |
| 9 | GLOBAL TRADE CONUNDRUM显示文摘Washington's recent actions against China over trade disputes and Beijing's strong reactions to those measures have heightened fears that mounting friction over bilateral trade will intensify.It is now'urgent'to get the China-U.S.trade relationship correct,said Stephen Roach,newly appointed Chairman of Morgan Stanley Asia.Roach,who for the past 16 years served as Morgan Stanley's chief economist,predicts a more broad-based consumer led growth in China in the next five years.He is also convinced that serious initiatives to be undertaken by the U.S.Government to penalize Chinese products as they are sold in the United States will be a big mistake.Beijing Review spoke to him about these and other aspects of Sino-U.S.trade and China's new economic growth model. | Wang Yanjuan and Chen Wen | 2007 | Beijing Review2007，50，20： | 0 |
| 10 | COMPETITION BUILDS STRENGTH IN FINANCIAL MARKETS显示文摘Transitioning from a“planned”economy to a“market”economy may be a long and arduous task for China,but opening its financial markets to foreign competition will help build stability and strength for the Chinese economy, says U.S.Ambassador Alan Holmer.Holmer,who was recently named as Special Envoy for China and for the Strategic Economic Dialogue,answered written questions by Beijing Review on his views of the economic relationship between China and the United States and the reforms he sees as vital to a good bilateral relationship. | Wang Yanjuan and Chen Wen | 2007 | Beijing Review2007，50，20： | 0 |
| 11 | Earth-Abundant CaCO_(3)-Based Photocatalyst for Enhanced ROS Production,Toxic By-Product Suppression,and Efficient NO Removal显示文摘Photoinduced reactive oxygen species(ROS)-based pollutant removal is one of the ideal solutions to achieve the conversion of solar energy into chemical energy and thus to address environmental pollution.Here,earthabundant CaCO_(3)-decorated g-C_(3)N_(4)(g-C_(3)N_(4)labeled as CN,CaCO_(3)-decorated g-C_(3)N_(4)sample labeled as CN-CCO)has been constructed by a facile thermal polymerization method for safe and efficient photocatalytic NO removal.The decorated CaCO_(3)as“transit hub”extends theπbonds of CN to deviate from the planes and steers the random charge carriers,which thus provides extra active sites and expedites spatial charge separation to facilitate adsorption/activation of reactants and promote formation of ROS participating in the removal of pollutant.Furthermore,boosted generation of ROS regulates the photocatalytic NO oxidation pathway and thus increases the selectivity of products.NO prefers to be directly oxidized into final product(nitrate)rather than toxic intermediates(NO_(2)),which is well demonstrated by theoretically simulated ROS-based reaction pathways and experimental characterization.The present work promotes the degradation of pollutant and simultaneously suppresses the formation of toxic by-product,which paves the way for ROS-based pollutant removal. | Wen Cui Wenjia Yang Peng Chen Lvcun Chen Jieyuan Li Yanjuan Sun Ying Zhou Fan Dong | 2022 | Energy & Environmental Materials2022，5，3： | 0 |
| 12 | A Serious Atmosphere显示文摘As the six-party talks got underway, Alan D. Romberg, Senior Associate and Director of the East Asia Program at the Henry L. Stimson Center, a Washington, D.C.-based international research institute, discussed the expectations for the talks with Beijing Review’s New York | Wang Yanjuan and Chen Wen | 2006 | Beijing Review2006，49，52： | 0 |
| 13 | Single-cell transcriptomic profiling of non-hematopoietic circulating cells in mid-gestational mouse embryos显示文摘The circulatory system is indispensable for an animal’s normal physiology.In addition to well-characterized hematopoietic cells,several types of circulating non-hematopoietic cells have been identified in adult mice(Zhang and Huang,2012;Schreier and Triampo,2020). | Yanyan Li Yanjuan Chen Xiaona Zheng Yun Gao Yuxuan Zheng Zongcheng Li Han He Fuchou Tang Bing Liu Yu Lan | 2021 | Journal of Genetics and Genomics2021，48，6： | 0 |
| 14 | Political Fallout in Japan显示文摘Japanese Defense Minister Fumio Kyuma resigned in early July after making controversial remarks about the U.S. atomic bombings during World War II. While speaking at a Chiba Prefecture university on June 30, Kyuma said that those bombings ended the war, and that “it could not be helped.” His remarks drew criticism from the Japanese, especially those who survived the two atomic bomb attacks on Hiroshima and Nagasaki. After Kyuma resigned, Japanese Prime Minister Shinzo Abe’s administration appointed Yuriko Koike, the country’s national security adviser, as Japan’s first female defense minister. Beijing Review talked with foreign affairs experts in China and the United States about whether Kyuma’s remarks will put a damper on U.S.-Japanese relations. | Wang Yanjuan and Chen Wen | 2007 | Beijing Review2007，50，30： | 0 |
| 15 | HANDLING HISTORY显示文摘Disputes over historical issues have been a factor affecting China-Japan relations for quite some time. If mishandled, they could remain an obstacle to the further improvement of bilateral ties, some American scholars believe.Richard C. Bush, senior fellow and Director of the Center for Northeast Asian Policy Studies at the Brookings Institution; Richard J. Samuels,Director of the Center for International Studies at the Massachusetts Institute of Technology (MIT) and Founding Director of the MIT Japan Program; and Ezra F. Vogel, a renowned U.S. scholar who specialized in East Asian studies an now is emeritus Henry Ford II Professor of the Social Sciences at Harvard University, shared their views on this issue with Beijing Review. | Wang Yanjuan and Chen Wen | 2007 | Beijing Review2007，50，15： | 0 |
| 16 | An Automatic Solid Phase Extraction and Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry for Determination of Seven Microcystins at Ultra-Trace Levels in Surface Water显示文摘A method was developed for the detection of seven microcystins(microcystin-LR, RR, YR, LA, LY, LW and LF) in surface water using automatic solid-phase extraction(A-SPE) coupled with ultra-performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS). The automated solid-phase extraction system was used to extract microcystins(MCs) from water samples. UPLC-MS/MS was used to determine MCs concentrations in just 5 min. Method detection limits were from 0.3 to 0.9 ng/L, microcystin recoveries ranged from 83.8% to 114%, and the relative standard deviation(RSD) varied from 5.6% to 12.5%. This analytical approach was found to be simple, highly sensitive, accurate, which required little manual operation. Additionally, to validate this analytical method, A-SPE+UPLC-MS/MS was applied to characterize the concentration of MCs in Taihu Lake, Wuxi, China. | SHEN Fei XU Yanjuan WANG Ye CHEN Jing | 2019 | Wuhan University Journal of Natural Sciences2019，24，1： | 0 |
| 17 | Taipingite-(Ce),(Ce73+,Ca2)∑9Mg(SiO4)3[SiO3(OH)]4F3,a new mineral from the Taipingzhen REE deposit,North Qinling Orogen,central China显示文摘A new cerite group mineral species,taipingite-(Ce),ideally(Ce7^3+,Ca2)∑9Mg(SiO4)3[SiO3(OH)]4 F3,has been found in the Taipingzhen rare earth element(REE)deposit in the North Qinling Orogen(NQO),Central China.It forms subhedral grains(up to approximately 100 μm×200 μm)commonly intergrown with the REE mineral assemblages and is closely associated with allanite-(Ce),gatelite-(Ce),tornebohmite-(Ce),fluocerite-(Ce),fluocerite-(La),fluorite,bastnasite-(Ce),parisite-(Ce)and calcite.Taipingite-(Ce)is light red to pinkish brown under a binocular microscope and pale brown to colorless in thin section,and it is translucent to transparent with a grayish-white streak and vitreous luster.This mineral is brittle with conchoidal fracture;has a Mohs hardness value of approximately 51/2 and exhibits no cleavage twinning or parting.The calculated density is 4.900(5)g/cm3.Optically,taipingite-(Ce)is uniaxial(+),withω=1.808(5),ε=1.812(7),c=ε,and a=b=ω.Furthermore,this mineral is insoluble in HCl,HNO3 and H2 SO4.Electron microprobe analysis demonstrated that the sample was relatively pure,yielding the empirical formula(with calculated H2 O):(Ce4.02La1.64Nd1.49Pr0.41Sm0.10Gd0.02Ho0.02Tm0.01Lu0.02Y0.03Ca0.66Mg0.05Th(0.01-0.51∑9(Mg0.75Fe0.253+)∑1(SiO4)3{[SiO3(OH)]3.98[PO3(OH)]0.02}∑4(F1.81OH1.17Cl0.02∑3.Taipingite-(Ce)is trigonal and exhibits space group symmetry R3 c with unit cell parameters a=10.7246(3)Å,c=37.9528(14)Å,V=3780.39(20)Å3 and Z=6.The strongest eight lines in the X-ray diffraction pattern are[d in A(I)(hkl)]:4.518(50)(202),3.455(95)(122),3.297(85)(214),3.098(35)(300),2.941(100)(02,10),2.683(65)(220),1.945(40)(238)and 1.754(40)(30,18).The crystal structure has been refined to a R1 factor of 0.025,calculated for the 2312 unique observed reflections(Fo≥4σ).The mineral is named after its discovery locality and is characterized as the F-dominant analogue of cerite-(Ce). | Kai Qu Xianzhang Sima Guang Fan Guowu Li Ganfu Shen Huakai Chen Xing Liu Qingqing Yin Ting Li Yanjuan Wang | 2020 | Geoscience Frontiers2020，11，6： | 0 |
| 18 | Rational Design of LDH/Zn_(2)SnO_(4) Heterostructures for Efficient Mineralization of Toluene Through Boosted Interfacial Charge Separation显示文摘It is crucial to efficiently separate and transport photo-induced charge carriers for the effective implementation of photocatalysis toward environmental remediation.A rational design strategy is proposed to validate such proposition through the construction of an interfacial structure in the form of LDH/Zn_(2)SnO_(4) heterostructures in this research.The interfacial charge transfer on LDH/Zn_(2)SnO_(4) is greatly promoted via the unique charge transfer pathway,as characterized by transient photocurrent responses,X-ray photoelectron spectroscopy,electron paramagnetic resonance spectrum,and photoluminescence analysis.As such,it contributes to the generation of reactive oxygen species(ROS)and the activation of reactants for the mineralization of toluene.According to the in situ DRIFTS spectra analysis,the accumulation of benzoic acid takes place possibly through the partial oxidation of the methyl group on toluene at the interface of the LDH/Zn 2 SnO 4 heterostructure.This process can greatly promote the photocatalytic oxidation of toluene with the enhanced ring-opening efficiency.The LDH/Zn 2 SnO 4 is thus demonstrated as superior photocatalyst against toluene(removal efficiency of 89.5%;mineralization of 83.1%;and quantum efficiency of 4.55×10^(−6) molecules/photon).As such,the performance of this composite far exceeds that of their individual components(e.g.,P25,pure Mg-Al LDH,or Zn_(2)SnO_(4)).This study is expected to offer a new path to the interfacial charge transfer mechanism based on the design of highly efficient photocatalysts for air purification. | Ben Lei Wen Cui Peng Chen Ruimin Chen Yanjuan Sun Ki-Hyun Kim Fan Dong | 2023 | Energy & Environmental Materials2023，6，1： | 0 |
| 19 | Playing With the Artistry of Language显示文摘Contemporary artist Xu Bing returns to Beijing to become vice president of the Central Academy of Fine | WANG YANJUAN & CHEN WEN | 2008 | Beijing Review2008，51，3： | 0 |
| 20 | “NIR-triggered ROS storage”photodynamic intraocular implant for high-efficient and safe posterior capsular opacification prevention显示文摘Posterior capsular opacification(PCO)is the leading cause of vision loss after cataract,mainly caused by the adhesion,proliferation and trans-differentiation of post-operative residual lens epithelial cells(LECs).Effective PCO prevention remains a huge challenge to ophthalmologists and researches for decades.Herein,we developed a“NIR-triggered ROS storage”intraocular implant(CTR-Py-Pp IX)based on capsular tension ring(CTR),which is concurrently linked with photosensitizer protophorphyrin IX(Pp IX)and energy storage2-pyridone derivative(Py),to guarantee instantaneous and sustainable ROS generation for LECs killing,aiming to achieve more efficient and safer photodynamic therapy(PDT)to effectively prevent PCO.The silylated Pp IX-Si and Py-Si were covalently conjugated to the plasma activated CTR surface to obtain CTR-Py-Pp IX.Results demonstrated that CTR-Py-Pp IX had dual functions of PDT and battery,in which Pp IX could generate ROS extracellularly under irradiation,with one part directly inhibiting LECs by lipid peroxidation(LPO)induction of cell membranes.Meanwhile,the excess ROS stored in Py could be continuously released to amplify LPO levels after the irradiation was removed.Ultimately,the proliferation of LECs in capsular bag was completely inhibited under mild irradiation conditions,achieving a sustainable and controlled PDT effect for effective PCO prevention with good biocompatibility.This NIR-triggered ROS storage intraocular implant would provide a more efficient and safer approach for long-term PCO prevention. | Yanjuan Huang Tao Zhang Qin Wei Zishan Zeng Yujun Gong Xiaoyu Xu Meixu Chen Chunshun Zhao | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，6： | 0 |
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