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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020,5,1: | 42 |
| 2 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022,35,1: | 20 |
| 3 | UNIFORMLY-STABLE FINITE ELEMENT METHODS FOR DARCY-STOKES-BRINKMAN MODELS显示文摘在这篇论文,我们认为 2D 和 3D Darcy 司烧连接问题。这些方程与 Brinkman 模型有关震颤两个 Darcy 是法律并且司烧在 PDE,但是与强烈不连续的粘性系数和 zeroth 顺序的一种单个形式的方程称为系数。我们在场构造一致地稳定的有限元素近似的三个不同方法。开始的二个方法基于 Darcy-Stokes-Brinkman 方程的原来的弱明确的表达。在我们考虑存在的第一个方法司烧元素。我们证明一个马厩司烧如果并且仅当分离地没有分叉的速度暗示几乎到处没有分叉的,元素关于系数和 Darcy-Stokes-Brinkman 方程的 jumps 也是一致地稳定的。在第二个方法,我们由修改遵守元素的一些著名 H (div ) 构造一致地稳定的元素。我们以一个统一方法给一些新 2D 和 3D 元素。在最后方法,我们与一个稳定术语修改 Darcy-Stokes-Brinkman 方程的原来的弱明确的表达。我们证明所有传统的马厩司烧元素在这新明确的表达下面关于系数和他们的 jumps 是一致地稳定的。 | Xiaoping Xie Jinchao Xu Guangri Xue | 2008 | Journal of Computational Mathematics2008,26,3: | 19 |
| 4 | A BRIEF REVIEW AND PROSPECT OF EXPERIMENTAL SOLID MECHANICS IN CHINA显示文摘In this review,a critical look at the research progress of experimental solid mechanics in China for the past years is presented.Issues are discussed of the discovery and development of new fundamental methods and techniques versus performance benchmarking for many of their applications.Included herein are photoelasticity and various forms of modern photomechanics,acoustical techniques,image processing and videometrics,radial and spectrum techniques,and experimental mechanics on micro/nano scale.It is also noticed that both the ever developed instrumentation and specialized synthetical techniques have played important roles in advancing experimental mechanics in scientific researches and industrial applications.Finally,an attempt is made to look into the future of experimental solid mechanics with personal opinions offered on what the future trends will be for the researches in the field. | Xide Li Huimin Xie Yilan Kang Xiaoping Wu | 2010 | Acta Mechanica Solida Sinica2010,23,6: | 17 |
| 5 | Influence of different mining layouts on the mechanical properties of coal显示文摘Non-pillar mining,top-coal caving and protected coal seam mining are the most popular mining methods in coal exploitation,and the different mining layouts will change the stress state and failure mechanism of coal in front of the working face.In this paper,mining-induced mechanical behaviors under three mining layouts have been simulated in the laboratory to investigate the effects of mining layouts on the deformation and strength of coal.Furthermore,the coal failure mechanism under different mining layouts is analyzed microscopically.The experimental results indicate that the stage characteristics of the coal deformation are obvious.Under the serial action of non-pillar mining,top-coal caving and protected coal seam mining layouts,the values of radial deformation,volume strain and Poisson's ratio increase,while the peak strength and deformation modulus decrease at the same buried depth,and the peak strength under non-pillar mining,top-coal caving and protected coal seam mining is about 3.0,2.5 and 2.0 times of the initial confining pressure,respectively.The results also indicate that the trend of the coal deformation decreases with the increase of the buried depth under the same mining layout,while the strength and deformation modulus increase,and the failure mechanism under three mining layouts is dominated with shear/tensile failure. | Xie Heping Zhao Xiaoping Liu Jianfeng Zhang Ru Xue Dongjie | 2012 | International Journal of Mining Science and Technology2012,22,6: | 14 |
| 6 | Spiral Steel Wire Based Fiber-Shaped Stretchable and Tailorable Triboelectric Nanogenerator for Wearable Power Source and Active Gesture Sensor显示文摘Continuous deforming always leads to the performance degradation of a flexible triboelectric nanogenerator due to the Young’s modulus mismatch of different functional layers.In this work,we fabricated a fiber-shaped stretchable and tailorable triboelectric nanogenerator(FST-TENG)based on the geometric construction of a steel wire as electrode and ingenious selection of silicone rubber as triboelectric layer.Owing to the great robustness and continuous conductivity,the FST-TENGs demonstrate high stability,stretchability,and even tailorability.For a single device with ~6 cm in length and ~3 mm in diameter,the open-circuit voltage of ~59.7 V,transferred charge of ~23.7 nC,short-circuit current of ~2.67 μA and average power of ~2.13 μW can be obtained at 2.5 Hz.By knitting several FST-TENGs to be a fabric or a bracelet,it enables to harvest human motion energy and then to drive a wearable electronic device.Finally,it can also be woven on dorsum of glove to monitor the movements of gesture,which can recognize every single finger,different bending angle,and numbers of bent finger by analyzing voltage signals. | Lingjie Xie Xiaoping Chen Zhen Wen Yanqin Yang Jihong Shi Chen Chen Mingfa Peng Yina Liu Xuhui Sun | 2019 | Nano-Micro Letters2019,11,3: | 13 |
| 7 | ROBUST GLOBALLY DIVERGENCE-FREE WEAK GALERKIN METHODS FOR STOKES EQUATIONS显示文摘这份报纸建议并且分析柔韧的全球性没有分叉的弱 Galerkin (WG ) 的一个班有限元素方法为司烧方程。新方法使用 Pk/Pk-1 (k 1 ) 为在元素的内部的速度和压力的不连续的有限元素联合,和 piecewise Pl/Pk (l = k - 1, k ) 为内部元素的边界上的速度和压力的踪迹近似。我们的方法不仅产出全球性没有分叉的速度答案,而且关于雷纳兹数字有一致错误估计。数字实验被提供显示出建议方法的坚韧性。[从作者抽象] | Gang Chen Minfu Feng Xiaoping Xie | 2016 | Journal of Computational Mathematics2016,34,5: | 11 |
| 8 | Flexible self-charging power units for portable electronics based on folded carbon paper显示文摘对便携式的电子学的迫切要求支持了高效率、持续、甚至可拉长的自我控告的力量来源的发展。在这个工作,我们建议为从人的运动和力量便携式计算机电子学收获机械精力基于合拢的碳(FC ) 统一纸的灵活自我控告的力量。现在的单位主要由摩擦电 nanogenerator (FC-TENG ) 和 supercapacitor (FC-SC ) 组成,基于合拢的复写纸精力 harvester 和存储设备分别地。这个有利几何图案向高幼仔模量复写纸提供优秀 stretchability 并且使力量单位能甚至在严重变丑下面工作,扭动,并且滚动,例如弯曲。另外,张力的紧张能被调节合拢三角的复写纸的合拢的角度最大化。而且,包装设备的防水性质使它可洗,保护它免受人的汗的伤害,并且使它能在严厉环境工作。最后,同样准备的自我控告的力量单位被把它放在人的身体上从手拍,踩的脚,并且手臂接触成功地驱动一块电子手表收获机械精力测试。这个工作表明可拉长的自我控告的力量单位的出色的潜力,它将进一步为便携 / 便携式的电子学支持高幼仔模量材料的发展。 | Changjie Zhou Yanqin Yang Na Sun Zhen Wen Ping Cheng Xinkai Xie Huiyun Shao Qingqing Shen Xiaoping Chen Yina Liu Zhong Lin Wang Xuhui Sun | 2018 | Nano Research2018,11,8: | 9 |
| 9 | Triboelectric–Electromagnetic Hybrid Generator for Harvesting Blue Energy显示文摘Progress has been developed in harvesting lowfrequency and irregular blue energy using a triboelectric–electromagnetic hybrid generator in recent years. However,the design of the high-efficiency, mechanically durable hybrid structure is still challenging. In this study, we report a fully packaged triboelectric–electromagnetic hybrid generator(TEHG), in which magnets were utilized as the trigger to drive contact–separation-mode triboelectric nanogenerators(CS-TENGs) and coupled with copper coils to operate rotary freestanding-mode electromagnetic generators(RF-EMGs). The magnet pairs that produce attraction were used to transfer the external mechanical energy to the CS-TENGs, and packaging of the CS-TENGpart was achieved to protect it from the ambient environment. Under a rotatory speed of 100 rpm, the CS-TENGs enabled the TEHG to deliver an output voltage, current,and average power of 315.8 V, 44.6 μA, and ~ 90.7 μW,and the output of the RF-EMGs was 0.59 V, 1.78 m A, and 79.6 μW, respectively. The cylinder-like structure made the TEHG more easily driven by water flow and demonstrated to work as a practical power source to charge commercial capacitors. It can charge a 33μF capacitor from 0 to 2.1 V in 84 s, and the stored energy in the capacitor can drive an electronic thermometer and form a self-powered water-temperature sensing system. | Huiyun Shao Ping Cheng Ruixuan Chen Lingjie Xie Na Sun Qingqing Shen Xiaoping Chen Qianqian Zhu Yi Zhang Yina Liu Zhen Wen Xuhui Sun | 2018 | Nano-Micro Letters2018,10,3: | 9 |
| 10 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018,6,4: | 8 |
| 11 | Investigation of influence of coal properties on dense-phase pneumatic conveying at high pressure显示文摘Experiments of dense-phase pneumatic conveying of pulverized coal using nitrogen were carried out in a test facility at pressures of up to 3.7 MPa to study the effects of coal type, particle size and moisture content on flow characteristics. The Jenike shear test and scanning electron microscopy (SEM) were employed to provide a better understanding of effects of the material properties on flow characteristics. Two kinds of pulverized coals, Yanzhou and Datong, with similar particle size, moisture content and density, were used in the test. Pressure drop increases with increasing the particle size at similar solid-gas ratio, superficial velocity and pressure in the receiving hopper, and pressure drops through different test sections decrease firstly and then rise with increasing the conveying velocity for the same particle size, mass flow rate and pressure in the receiving hopper. The flowability of pulverized coal decreases with increasing the moisture content in the range from 3.24% to 8.18%. Unconfined yield strength (UYS) increases and flow function (FF) decreases with increasing the moisture content. Results of the shearing tests are consistent with the results of the conveying study. Pressure drops through different test sections are discussed and analyzed. | Cai Liang Xiaoxu Xie Pan Xu Xiaoping Chen Changsui Zhao Xin Wu | 2012 | Particuology2012,10,3: | 8 |
| 12 | LOW ORDER NONCONFORMING RECTANGULAR FINITE ELEMENT METHODS FOR DARCY-STOKES PROBLEMS显示文摘In this paper,we consider lower order rectangular finite element methods for the sin-gularly perturbed Stokes problem.The model problem reduces to a linear Stokes problemwhen the perturbation parameter is large and degenerates to a mixed formulation of Pois-son's equation as the perturbation parameter tends to zero.We propose two 2D andtwo 3D nonconforming rectangular finite elements,and derive robust discretization errorestimates.Numerical experiments are carried out to verify the theoretical results. | Shiquan Zhang Xiaoping Xie Yumei Chen | 2009 | Journal of Computational Mathematics2009,27,2: | 7 |
| 13 | Geochronological and geochemical constraints on the Cuonadong leucogranite, eastern Himalaya显示文摘First comprehensive investigations of the Cuonadong leucogranite exposed in North Himalayan gneiss dome of southern Tibet are presented in this study.The SIMS U–Pb ages of oscillatory zircon rims scatter in a wide range from 34.1 to 16.0 Ma, and the Cuonadong leucogranite probably emplaced at 16.0 Ma. High-precision ^(40)Ar/^(39)Ar dating on a muscovite sample yields an essentially flat age spectrum with consistent plateau and isochron ages, indicating that the Cuonadong leucogranite cooled below 450 °C at 14 Ma. Based on the youngest zircon U–Pb age and muscovite^(40)Ar/^(39)Ar age, the Cuonadong leucogranite experienced rapid cooling with a rate of 119 °C/Myr from 16 to 14 Ma. The geochronological data of this undeformed leucogranite also suggest that the ductile extension of the South Tibetan Detachment System in the eastern Himalaya ceased by ca. 14 Ma. Furthermore,the initial Sr–Nd isotopic compositions and Nd model ages demonstrate that the leucogranite was derived from metapelitic source within the Greater Himalayan Crystalline Complex. The distinct Ba depletion with high Rb/Sr ratios and negative Eu anomalies make it clear that the leucogranite melts were generated by breakdown of muscovite under fluid-absent conditions. | Jiajia Xie Huaning Qiu Xiujuan Bai Wanfeng Zhang Qiang Wang Xiaoping Xia | 2018 | Acta Geochimica2018,37,3: | 7 |
| 14 | Design of PANDA ring-core fiber with 10 polarization-maintaining modes显示文摘We present a polarization-maintaining PANDA ring-core fiber(PM-PRCF) characterized by the combination of a ring-core structure with two stress-applying rods. This special fiber design separates the adjacent modes and avoids the cutoff of the higher-order modes, which is a common problem in elliptical core polarization-maintaining few-mode fibers. Using a high-contrast index ring and stress-induced birefringence, the PM-PRCF features support for 10 vector modes, with effective refractive index separations from their adjacent modes >10^(-4).Broadband performance is investigated subsequently over a wide wavelength range from 1500 to 1630 nm.The proposed fiber is targeted at applications in space-division multiplexing while eliminating the complex multiple-input multiple-output signal processing. | Haozhe Yan Shangyuan Li Zhengyang Xie Xiaoping Zheng Hanyi Zhang Bingkun Zhou | 2017 | Photonics Research2017,5,1: | 7 |
| 15 | Cross-cultural adaption and psychometric properties of the Chinese version of the Diabetes Behavior Rating Scale: a pilot study显示文摘Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus(T1 DM). The Diabetes Behavior Rating Scale(DBRS) has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1 DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbach's α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability(r=0.81, P=0.001). Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores(r=.0.32, P=0.003) and hemoglobin A1 c(HbA1 c) levels(r=.0.36, P=0.002). Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T1 DM. | Jing Zhu Jingjing Xu Yang Chen Yong Gu Li Ji Yufeng Zhou Min Zhu Hsiang-Ting Hsu Xiaoping Huang Cuiping Yuan Yun Shi Dan Yan Lili Xie Shuang Chen Tao Yang Wei He | 2018 | Science China(Life Sciences)2018,61,3: | 6 |
| 16 | Trace Fossils from Lower Cambrian Wusongger Formation in Xiaoerbulake Outcrop,Kalpin Area,Xinjiang显示文摘Based on the analysis of trace fossils collected from the typical outcrop of the Lower Cambrian Wusongger Formation in the Kalpin area,ten ichnospecies of six ichnogenus were identified in the upper member of the Wusongger Formation,with most of them being found for the first time.The trace fossils are described seriatim.The ichnospecies are mainly represented by such common trace fossils as Ophiomorpha nodosa,Helminthopsis hieroglyphica,Helminthopsis ichnosp.,Planolites beverleyensis,Planolites vulgaris,Planolites montanus,Palaeophycus striatus,Palaeophycus curvatus?,Cochlichnus anguineus and Rituichnus elongatum.The trace fossils are of high diversity and low abundance,and can be diagnosed as the Cruziana ichnofacies.They can be interpreted as having formed in a shallow water environment. | BAI Zhongkai LU Xiuxiang LIU Xiaoping XIE Qilai LI Jianjiao WU Jianjun | 2012 | Acta Geologica Sinica(English Edition)2012,86,2: | 6 |
| 17 | An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China显示文摘 | Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg | 2014 | Chinese Medical Journal2014,,1: | 6 |
| 18 | Temporal-spatial distribution and ore-forming material source of gold,copper and silver polymetallic ore deposits in the Fuping mantle structure zone显示文摘This study was conducted following research on metallogenesis in the Zhangjiajie-Xuanhua and East Hebei mantle branch structure zones. The Fuping mantle branch structure zone is one where Au, Cu and Ag poly-metallic ore resources are concentrated in North Hebei. However, there has existed a long-standing controversy on the temporal-spatial distribution of ore resources and their ore-forming material sources. In terms of age dating and the comprehensive analysis of S, Pb, O, C and Si isotopes, it is considered that the temporal-spatial distribution of ore resources in this mantle branch structure zone is obviously controlled by the Fuping mantle branch structure. In space there is developed such a metallogenic pattern as to be Ag, Pb and Zn polymetallic ore deposits with gold appearing inside and copper appearing outside. Metallogenesis is dated mainly at Yanshanian, the ore-forming materials were derived predominantly from the deep interior of the Earth, and ore-forming fluids were derived largely from Yanshanian magmatism. | WANG Baode NIU Shuyin SUN Aiqun LIU Yaming XIE Yan JIANG Xiaoping ZHAO Yongli GAO Yincang ZHAO Fuwang | 2010 | Chinese Journal Of Geochemistry2010,29,3: | 6 |
| 19 | Characteristics of Late-Quaternary Activity and Seismic Risk of the Northeastern Section of the Longmenshan Fault Zone显示文摘Following the 2008 Wenchuan M8 earthquake,the seismic risk of the northeastern section of the Longmenshan fault zone and the adjacent Hanzhong basin has become an issue that receives much concern.It is facing,however,the problem of a lack of sufficient data because of little previous work in these regions.The northeastern section of the Longmenshan fault zone includes three major faults:the Qingchuan fault,Chaba-Lin’ansi fault,and Liangshan south margin fault,with the Hanzhong basin at the northern end.This paper presents investigations of the geometry,motion nature,and activity ages of these three faults,and reveals that they are strike slip with normal faulting,with latest activity in the Late Pleistocene.It implies that this section of the Longmenshan fault zone has been in an extensional setting,probably associated with the influence of the Hanzhong basin.Through analysis of the tectonic relationship between the Longmenshan fault zone and the Hanzhong basin,this work verifies that the Qingchuan fault played an important role in the evolution of the Hanzhong basin,and further studies the evolution model of this basin.Finally,with consideration of the tectonic setting of the Longmenshan fault zone and the Hanzhong basin as well as seismicity of surrounding areas,this work suggests that this region has no tectonic conditions for great earthquakes and only potential strong events in the future. | WANG Mingming ZHOU Bengang YANG Xiaoping XIE Chao GAO Xianglin | 2013 | Acta Geologica Sinica(English Edition)2013,87,6: | 6 |
| 20 | Mining geographic episode association patterns of abnormal events in global earth science data显示文摘Abnormal events in earth science have great influence on both the natural envi-ronment and the human society. Finding association patterns among these events has great significance. Because data in earth science has characteristics of mass,high dimension,spatial autocorrelation and time delay,existing mining technolo-gies cannot be directly used on it. We propose a RSNN (range-based searching nearest neighbors) spatial clustering algorithm to reduce the data size and auto-correlation. Based on the clustered data,we propose a GEAM (geographic episode association pattern mining) algorithm which can deal with events time lags and find interesting patterns with specific constraints,to mine the association patterns. We carried out experiments on global climate datasets and found many interesting association patterns. Some of the patterns are coincident with known knowledge in climate science,which indicates the correctness and feasibilities of our methods,and the others are unknown to us before,which will give new information to this research field. | WU TianShu,SONG GuoJie,MA XiuJun,XIE KunQing,GAO XiaoPing & JIN XingXing Key Laboratory of Machine Perception,Ministry of Education,and Department of Machine Intelligence,Peking University,Beijing 100871,China | 2008 | Science China(Technological Sciences)2008,51,S1: | 5 |