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| 1 | Molecular immune pathogenesis and diagnosis of COVID-19显示文摘Coronavirus disease 2019(COVID-19)is a kind of viral pneumonia which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The emergence of SARS-CoV-2 has been marked as the third introduction of a highly pathogenic coronavirus into the human population after the severe acute respiratory syndrome coronavirus(SARS-CoV)and the Middle East respiratory syndrome coro-navirus(MERS-CoV)in the twenty-first century.In this minireview,we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis,diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections,which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection. | Xiaowei Li Manman Geng Yizhao Peng Liesu Meng Shemin Lu | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 31 |
| 2 | Quasi-real-time simulation of rotating drum using discrete element method with parallel GPU computing显示文摘Real-time simulation of industrial equipment is a huge challenge nowadays. The high performance and fine-grained parallel computing provided by graphics processing units (GPUs) bring us closer to our goals. In this article, an industrial-scale rotating drum is simulated using simplified discrete element method (DEM) without consideration of the tangential components of contact force and particle rotation. A single GPU is used first to simulate a small model system with about 8000 particles in realtime, and the simulation is then scaled up to industrial scale using more than 200 GPUs in a 1D domain-decomposition parallelization mode. The overall speed is about 1/11 of the real-time. Optimization of the communication part of the parallel GPU codes can speed up the simulation further, indicating that such real-time simulations have not only methodological but also industrial implications in the near future. | Ji Xu Huabiao Oi Xiaojian Fang Liqiang Lu Wei Ge Xiaowei Wang Ming xu Feiguo Chen xianfeng He Jinghai Li | 2011 | Particuology2011，9，4： | 16 |
| 3 | Anchor Self-Localization Algorithm Based on UWB Ranging and Inertial Measurements显示文摘Localization systems utilizing Ultra-WideBand(UWB) have been widely used in dense urban and indoor environments. A moving UWB tag can be located by ranging to fixed UWB anchors whose positions are surveyed in advance. However, manually surveying the anchors is typically a dull and time-consuming process and prone to artificial errors. In this paper, we present an accurate and easy-to-use method for UWB anchor self-localization,using the UWB ranging measurements and readings from a low-cost Inertial Measurement Unit(IMU). The locations of the anchors are automatically estimated by freely moving the tag in the environment. The method is inspired by the Simultaneous Localization And Mapping(SLAM) technique used by the robotics community. A tightly-coupled Error-State Kalman Filter(ESKF) is utilized to fuse UWB and inertial measurements, producing UWB anchor position estimates and six Degrees of Freedom(6 DoF) tag pose estimates. Simulated experiments demonstrate that our proposed method enables accurate self-localization for UWB anchors and smooth tracking of the tag. | Qin Shi Sihao Zhao Xiaowei Cui Mingquan Lu Mengdi Jia | 2019 | Tsinghua Science and Technology2019，24，6： | 11 |
| 4 | A Domestication-Associated Gene GmPRR3b Regulates the Circadian Clock and Flowering Time in Soybean显示文摘Improved soybean cultivars have been adapted to grow at a wide range of latitudes,enabling expansion of cultivation worldwide.However,the genetic basis of this broad adaptation is still not clear.Here,we report the identification of GmPRR3b as a major flowering time regulatory gene that has been selected during domestication and genetic improvement for geographic expansion.Through a genome-wide association study of a diverse soybean landrace panel consisting of 279 accessions,we identified 16 candidate quantitative loci associated with flowering time and maturity time.The strongest signal resides in the known flowering gene E2,verifying the effectiveness of our approach.We detected strong signals associated with both flowering and maturity time in a genomic region containing GmPRR3b.Haplotype analysis revealed that GmPRR3bH6 is the major form of GmPRR3b that has been utilized during recent breeding of modern cultivars.mRNA profiling analysis showed that GmPRR3bH6 displays rhythmic and photoperiod-dependent expression and is preferentially induced under long-day conditions.Overexpression of GmPRR3bH6 increased main stem node number and yield,while knockout of GmPRR3bH6 using CRISPR/Cas9 technology delayed growth and the floral transition.GmPRR3bH6 appears to act as a transcriptional repressor of multiple predicted circadian clock genes,including GmCCAIa,which directly upregulates J/GmELF3a to modulate flowering time.The causal SNP(Chr12:5520945)likely endows GmPRR3bH6 a moderate but appropriate level of activity,leading to early flowering and vigorous growth traits preferentially selected during broad adaptation of landraces and improvement of cultivars. | Cong Li Ying-hui Li Yanfei Li Hongfeng Lu Huilong Hong Yu Tian Hongyu Li Tao Zhao Xiaowei Zhou Jun Liu Xinan Zhou Scott A.Jackson Bin Liu Li-juan Qiu | 2020 | Molecular Plant2020，13，5： | 11 |
| 5 | Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrowderived macrophage显示文摘Macrophages play critical roles in renal fibrosis.However,macrophages exhibit ontogenic and functional heterogeneities,and which population of macrophages contributes to renal fibrosis and the underlying mechanisms remain unclear.In this study,we genetically targeted Notch signaling by disrupting the transcription factor recombination signal binding protein-JK(RBP-J),to reveal its role in regulation of macrophages during the unilateral ureteral obstruction(UUO)-induced murine renal fibrosis.Myeloid-specific disruption of RBP-J attenuated renal fibrosis with reduced extracellular matrix deposition and myofibroblast activation,as well as attenuated epithelial-mesenchymal transition,likely owing to the reduced expression of TGF-β.Mean while,RBP-J deletion significantly hampered macrophage infiltration and activation in fibrotic kidney,although their proliferation appeared unaltered.By using macrophage clearance experiment,we found that kidney resident macrophages made negligible contribution,but bone marrow(BM)-derived macrophages played a major role in renal fibrogenesis.Further mechanistic analyses showed that Notch blockade reduced monocyte emigration from BM by down-regulating CCR2 expression.Finally,we found that myeloid-specific Notch activation aggravated renal fibrosis,which was mediated by CCR2^+macrophages infiltration.In summary,our data have unveiled that myeloid-specific targeting of Notch could ameliorate renal fibrosis by regulating BM-derived macrophages recruitment and activation,providing a novel strategy for intervention of this disease. | Yali Jiang Yuanyuan Wang Pengfei Ma Dongjie An Junlong Zhao Shiqian Liang Yuchen Ye Yingying Lu Peng Zhang Xiaowei Liu Hua Han Hongyan Qin | 2019 | Protein & Cell2019，10，3： | 10 |
| 6 | Why Was the Strengthening of Rainfall in Summer over the Yangtze River Valley in 2016 Less Pronounced than that in 1998 under Similar Preceding El Nino Events?Role of Midlatitude Circulation in August显示文摘It is widely recognized that rainfall over the Yangtze River valley(YRV) strengthens considerably during the decaying summer of El Ni ?no,as demonstrated by the catastrophic flooding suffered in the summer of 1998.Nevertheless,the rainfall over the YRV in the summer of 2016 was much weaker than that in 1998,despite the intensity of the 2016 El Nio having been as strong as that in 1998.A thorough comparison of the YRV summer rainfall anomaly between 2016 and 1998 suggests that the difference was caused by the sub-seasonal variation in the YRV rainfall anomaly between these two years,principally in August.The precipitation anomaly was negative in August 2016—different to the positive anomaly of 1998.Further analysis suggests that the weaker YRV rainfall in August 2016 could be attributable to the distinct circulation anomalies over the midlatitudes.The intensified 'Silk Road Pattern' and upper-tropospheric geopotential height over the Urals region,both at their strongest since 1980,resulted in an anticyclonic circulation anomaly over midlatitude East Asia with anomalous easterly flow over the middle-to-lower reaches of the YRV in the lower troposphere.This easterly flow reduced the climatological wind,weakened the water vapor transport,and induced the weaker YRV rainfall in August 2016,as compared to that in 1998.Given the unique sub-seasonal variation of the YRV rainfall in summer 2016,more attention should be paid to midlatitude circulation—besides the signal in the tropics—to further our understanding of the predictability and variation of YRV summer rainfall. | chaofan li wei chen xiaowei hong riyu lu | 2017 | Advances in Atmospheric Sciences2017，34，11： | 10 |
| 7 | An improved ground motion intensity measure for super high-rise buildings显示文摘Ground motion intensity measure (IM) is an important part in performance-based seismic design. A reasonable and efficient IM can make the prediction of the structural seismic responses more accurate. Therefore, a more reasonable IM for super high-rise buildings is proposed in this paper. This IM takes into account the significant characteristic that higher-order vibration modes play important roles in the seismic response of super high-rise buildings, as well as the advantages of some existing IMs. The key parameter of the proposed IM is calibrated using a series of time-history analyses. The collapse simulations of two super high-rise buildings are used to discuss the suitability of the proposed IM and some other existing IMs. The results indicate that the proposed IM yields a smaller coefficient of variation for the critical collapse status than other existing IMs and performs well in reflecting the contribution of higher-order vibration modes to the structural response. Hence, the proposed IM is more applicable to seismic design for super high-rise buildings than other IMs. | LU Xiao YE LiePing LU XinZheng LI MengKe MA XiaoWei | 2013 | Science China(Technological Sciences)2013，56，6： | 9 |
| 8 | Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure.Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy.However,there is a lack of effective specific treatments available for diabetic cardiomyopathy.In the present study,we aim to explore the effects of Liraglutide,a GLP-1 analogue,on diabetic cardiomyopathy in STZ-induced diabetic rats fed with high-fat diet.A total of 60 male Wistar rats were randomly assigned to three groups,i.e.normal group,model group,and Liraglutide group,with 20 rats in each group.Serum levels of TC,TG,LDL-C,NEFA,and hydroxyproline were measured using commercial kits.Cardiac function was evaluated by QRS waves,LVEDd,LVESd,and LVEF.Myocardial fibrosis was measured by immunohistochemistry.Our results demonstrated that chronic administration of Liraglutide decreased the level of blood glucose and significantly alleviated lipid metabolic disturbance compared with the model group.Furthermore,Liraglutide was found to improve the damaged cardiac function.In line with this,we also found that the alleviation of cardiac dysfunction was associated with the decreased fibrosis in diabetic myocardial tissues,which was reflected by the decreased expressions of P4hα-1,COL-1,COL-3,MMP-1,and MMP-9.Our results thus suggest that Liraglutide might have a myocardial protective effect by inhibiting P4hα-1-mediated myocardial fibrosis. | Tong Zhao Huiqiang Chen Fei Xu Juan Wang Yusheng Liu Xiaowei Xing Linlin Guo Mingxiang Zhang Qinghua Lu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 9 |
| 9 | Low-complexity method for DOA estimation based on ESPRIT显示文摘A low-complexity method for direction of arrival(DOA) estimation based on estimation signal parameters via rotational invariance technique(ESPRIT) is proposed.Instead of using the cross-correlation vectors in multistage Wiener filter(MSWF),the orthogonal residual vectors obtained in conjugate gradient(CG) method span the signal subspace used by ESPRIT.The computational complexity of the proposed method is significantly reduced,since the signal subspace estimation mainly needs two matrixvector complex multiplications at the iteration of data level.Furthermore,the prior training data are not needed in the proposed method.To overcome performance degradation at low signal to noise ratio(SNR),the expanded signal subspace spanned by more basis vectors is used and simultaneously renders ESPRIT yield redundant DOAs,which can be excluded by performing ESPRIT once more using the unexpanded signal subspace.Compared with the traditional ESPRIT methods by MSWF and eigenvalue decomposition(EVD),numerical results demonstrate the satisfactory performance of the proposed method. | Xuebin Zhuang Xiaowei Cui Mingquan Lu Zhenming Feng | 2010 | Journal of Systems Engineering and Electronics2010，21，5： | 6 |
| 10 | Variation in Summer Surface Air Temperature over Northeast Asia and Its Associated Circulation Anomalies显示文摘This study investigates the interannual variation of summer surface air temperature over Northeast Asia(NEA) and its associated circulation anomalies.Two leading modes for the temperature variability over NEA are obtained by EOF analysis.The first EOF mode is characterized by a homogeneous temperature anomaly over NEA and therefore is called the NEA mode.This anomaly extends from southeast of Lake Baikal to Japan,with a central area in Northeast China.The second EOF mode is characterized by a seesaw pattern,showing a contrasting distribution between East Asia(specifically including the Changbai Mountains in Northeast China,Korea,and Japan) and north of this region.This mode is named the East Asia(EA) mode.Both modes contribute equivalently to the temperature variability in EA.The two leading modes are associated with different circulation anomalies.A warm NEA mode is associated with a positive geopotential height anomaly over NEA and thus a weakened upper-tropospheric westerly jet.On the other hand,a warm EA mode is related to a positive height anomaly over EA and a northward displaced jet.In addition,the NEA mode tends to be related to the Eurasian teleconnection pattern,while the EA mode is associated with the East Asia-Pacific/PacificJapan pattern. | Wei CHEN Xiaowei HONG Riyu LU Aifen JIN Shizhu JIN Jae-Cheol NAM Jin-Ho SHIN Tae-Young GOO Baek-Jo KIM | 2016 | Advances in Atmospheric Sciences2016，33，1： | 6 |
| 11 | Asymmetric Relationship between the Meridional Displacement of the Asian Westerly Jet and the Silk Road Pattern显示文摘In previous work, a significant relationship was identified between the meridional displacement of the Asian westerly jet(JMD) and the Silk Road Pattern(SRP) in summer. The present study reveals that this relationship is robust in northward JMD years but absent in southward JMD years. In other words, the amplitude of the SRP increases with northward displacement of the jet but shows little change with southward displacement. Further analysis indicates that, in northward JMD years, the Rossby wave source(RWS) anomalies, which are primarily contributed by the planetary vortex stretching, are significantly stronger around the entrance of the Asian jet, i.e., the Mediterranean Sea–Caspian Sea area, with the spatial distribution being consistent with that related to the SRP. By contrast, in southward JMD years, the RWS anomalies are much weaker.Therefore, this study suggests that the RWS plays a crucial role in inducing the asymmetry of the JMD–SRP relationship.The results imply that climate anomalies may be stronger in strongly northward-displaced JMD years due to the concurrence of the JMD and SRP, and thus more attention should be paid to these years. | Xiaowei HONG Riyu LU Shuanglin LI | 2018 | Advances in Atmospheric Sciences2018，35，4： | 6 |
| 12 | Composition optimized trimetallic PtNiRu dendritic nanostructures as I versatile and active electrocatalysts for alcohol oxidation显示文摘Platinum-based nano crystals are the most effective electrocatalysts for accelerati ng the chemical tran sformatio ns on the anode in direct alcohol fuel cells. To facilitate practical applications and overcome the drawbacks of diverse alcohols, it is significant to develop electrocatalysts with high activities and a wide fuel flexibility. Here, we demonstrate a practicable solution method for fabricating composition tun able trimetallic PtNiRu den dritic nano structures (DNSs) which can serve as versatile and active catalysts for electrooxidatio n of a variety of liquid alcohols. A series of trimetallic DNSs with tun able Pt/Ni/Ru atomic ratios were successfully syn thesized by simply adjusti ng the feeding of precursors. Detailed electrochemical test indicates that, among other compositions, the Pt66Ni27Ru7 DNSs present much superior electroactivity in catalyzing electrooxidation of liquid alcohols in acidic mediums. Specifically, the mass activity and specific activity on the Pt66Ni27Ru7 DNSs, for electrooxidation of methanol, ethanol, and ethylene glycol, are 4.57 and 4.34 times, 3.55 and 3.42 times, and 2.37 and 2.28 times that of the commercial Pt black, respectively. X-ray photoelectron spectroscopy and CO stripping studies reveal the adsorption of CO on these PtNiRu DNSs is much weaker than on pure Pt. Meanwhile, the surface Ru sites can provide neighbouring -OH groups to facilitate the oxidati on and removal of the adsorbed in termediates (-CO) on the surface Pt sites, effectively improvi ng the CO tolera nee of the catalysts. The PtNiRu DNSs also show effectively boosted capacity for breaking the C-C bond in C2-alcohols, showing great potential for fuel-flexible fuel cell applications. | Yan Lu Wei Wang Xiaowei Chen Yuhui Zhang Yanchen Han Yong Cheng Xue-Jiao Chen Kai Liu Yuanyuan Wang Qiaobao Zhang Shuifen Xie | 2019 | Nano Research2019，12，3： | 6 |
| 13 | A Robust Graph Optimization Realization of Tightly Coupled GNSS/INS Integrated Navigation System for Urban Vehicles显示文摘This paper describes a robust integrated positioning method to provide ground vehicles in urban environments with accurate and reliable localization results. The localization problem is formulated as a maximum a posteriori probability estimation and solved using graph optimization instead of Bayesian filter. Graph optimization exploits the inherent sparsity of the observation process to satisfy the real-time requirement and only updates the incremental portion of the variables with each new incoming measurement. Unlike the Extended Kalman Filter(EKF) in a typical tightly coupled Global Navigation Satellite System/Inertial Navigation System(GNSS/INS)integrated system, optimization iterates the solution for the entire trajectory. Thus, previous INS measurements may provide redundant motion constraints for satellite fault detection. With the help of data redundancy, we add a new variable that presents reliability of GNSS measurement to the original state vector for adjusting the weight of corresponding pseudorange residual and exclude faulty measurements. The proposed method is demonstrated on datasets with artificial noise, simulating a moving vehicle equipped with GNSS receiver and inertial measurement unit. Compared with the solutions obtained by the EKF with innovation filtering, the new reliability factor can indicate the satellite faults effectively and provide successful positioning despite contaminated observations. | Wei Li Xiaowei Cui Mingquan Lu | 2018 | Tsinghua Science and Technology2018，23，6： | 5 |
| 14 | Microstructure Evolution and Mechanical Properties of a SMATed Mg Alloy under In Situ SEM Tensile Testing显示文摘Surface mechanical attrition treatment(SMAT) has been recently applied to bulk polycrystalline magnesium(Mg) alloys with gradient grain size distribution from the impact surface to inside matrix, hence effectively improving the alloys' mechanical performances. However, in-depth understanding of their mechanical property enhancement and grain size-dependent fracture mechanism remains unclear. Here,we demonstrated the use of in situ micro-tensile testing inside a high resolution scanning electron microscope(SEM) to characterize the microstructure evolution, in real time, of SMATed Mg alloy AZ31 samples with different grain sizes of ~10 μm('coarse-grain sample') and ~5 μm('fine-grain sample'), respectively, and compared the results with those of a raw Mg alloy AZ31. The quantitative tensile tests with in situ SEM imaging clearly showed that fracture of ‘fine-grain sample' was dominated by intergranular cracks,while both trans-granular and intergranular cracks led to the final failure of the ‘coarse-grain samples'.It is expected that this in situ SEM characterization technique, coupled with quantitative tensile testing method, could be applicable for studying other grain-refined metals/alloys, allowing to optimize their mechanical performances by controlling the grain sizes and their gradient distribution. | Xiaowei Liu Yong Liu Bin Jin Yang Lu Jian Lu | 2017 | Journal of Materials Science & Technology2017，33，3： | 5 |
| 15 | Increasing the efficiency of CRISPR/Cas9-based gene editing by suppressing RNAi in plants显示文摘Dear Editor,CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated)-based genome editing is a powerful and widely adopted technology for introducing specific mutations in animal and plant systems. | Xiaoyan Wang Jiayun Lu Kangwen Lao Suikang Wang Xiaowei Mo Xintong Xu Xuemei Chen Beixin Mo | 2019 | Science China(Life Sciences)2019，62，7： | 4 |
| 16 | Numerically stable method of signal subspace estimation based on multistage Wiener filter显示文摘In this paper,a numerically stable method of signal subspace estimation based on Householder multistage Wiener filter(HMSWF) is proposed.Numerical stability of the method lies on the fact that the Householder matrix in HMSWF ensures the unitary blocking operation and significantly strengthens the orthogonality of basis vectors,especially in the finite-precision implementation.In the following,we analyze the numerical stability of HMSWF and MSWF based on the correlation subtractive structure(CSS-MSWF) by establishing the equivalence between the forward recursion of MSWF and the Arnoldi algorithm in numerical linear algebra.Besides,the equivalence between HMSWF and the Householder QR decomposition(QRD) on the Krylov matrix underlying in MSWF is directly established.Based on the relationship,two theoretical upper bounds of the orthogonality error of basis vectors in signal subspace are obtained and it is demonstrated that the orthogonality of basis vectors based on HMSWF is perfectly preserved by the numerically well-behaved Householder matrix,and the corresponding signal subspace estimation is much more numerically stable than that based on CSS-MSWF.Simulations show the numerical stability of the proposed method of signal subspace estimation by HMSWF. | ZHUANG XueBin CUI XiaoWei LU MingQuan FENG ZhenMing | 2010 | Science China(Information Sciences)2010，53，12： | 4 |
| 17 | Nanoscale control of silks for regular hydroxyapatite formation | Xingliang He Xiaowei Huang Qiang Lu Shuling Bai Hesun Zhu | 2012 | Progress in Natural Science:Materials International2012，22，2： | 4 |
| 18 | HTDet:A Clustering Method Using Information Entropy for Hardware Trojan Detection显示文摘Hardware Trojans(HTs)have drawn increasing attention in both academia and industry because of their significant potential threat.In this paper,we propose HTDet,a novel HT detection method using information entropybased clustering.To maintain high concealment,HTs are usually inserted in the regions with low controllability and low observability,which will result in that Trojan logics have extremely low transitions during the simulation.This implies that the regions with the low transitions will provide much more abundant and more important information for HT detection.The HTDet applies information theory technology and a density-based clustering algorithm called Density-Based Spatial Clustering of Applications with Noise(DBSCAN)to detect all suspicious Trojan logics in the circuit under detection.The DBSCAN is an unsupervised learning algorithm,that can improve the applicability of HTDet.In addition,we develop a heuristic test pattern generation method using mutual information to increase the transitions of suspicious Trojan logics.Experiments on circuit benchmarks demonstrate the effectiveness of HTDet. | Renjie Lu Haihua Shen Zhihua Feng Huawei Li Wei Zhao Xiaowei Li | 2021 | Tsinghua Science and Technology2021，26，1： | 4 |
| 19 | Study on docetaxel-loaded nanoparticles with high antitumor efficacy against malignant melanoma显示文摘Docetaxel (文档) 对许多稳固的肿瘤举办非凡的活动。然而,文档的临床的功效由于它的差的溶解度被限制,低选择分发,在 vivo 的快消除,等等。在现在的学习,文档被合并到基于我们的以前的工作准备的 nanoparticles 的核心壳结构。获得的装载 docetaxel 的 nanoparticles (DOCNP ) 与各种各样的生物物理的方法论被描绘,并且它对恶意的黑瘤的 antitumor 功效在 vitro 并且在 vivo 被评估。我们的结果显示文档能与高封装效率被合并到 nanoparticles (>90%) 。合并文档能以一种持续方式被免除 DOCNP。在 vitro cytotoxicity,研究显示 DOCNP 能有效地杀死 B16 房间并且显示出剂量依赖者和时间依赖者功效。而且, intratumoral 管理表明 DOCNP 比免费文档有显著地更高的 antitumor 效果和更低的毒性到正常房间和纸巾。这些结果建议 DOCNP 可以是在为恶意的黑瘤的治疗的一个有希望的药交货系统。 | Donghui Zheng Xiaolin Li Huae Xu Xiaowei Lu Yong Hu Weixin Fan | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 4 |
| 20 | Hybrid superhydrophilic-superhydrophobic micro/nanostructures fabricated by femtosecond laserinduced forward transfer for sub-femtomolar Raman detection显示文摘Raman spectroscopy plays a crucial role in biochemical analysis.Recently,superhydrophobic surface-enhanced Raman scattering(SERS)substrates have enhanced detection limits by concentrating target molecules into small areas.However,due to the wet transition phenomenon,further reduction of the droplet contact area is prevented,and the detection limit is restricted.This paper proposes a simple method involving femtosecond laser-induced forward transfer for preparing a hybrid superhydrophilic–superhydrophobic SERS(HS-SERS)substrate by introducing a superhydrophilic pattern to promote the target molecules to concentrate on it for ultratrace detection.Furthermore,the HS-SERS substrate is heated to promote a smaller concentrated area.The water vapor film formed by the contact of the solution with the substrate overcomes droplet collapse,and the target molecules are completely concentrated into the superhydrophilic region without loss during evaporation.Finally,the concentrated region is successfully reduced,and the detection limit is enhanced.The HS-SERS substrate achieved a final contact area of 0.013mm2,a 12.1-fold decrease from the unheated case.The reduction of the contact area led to a detection limit concentration as low as 10−16 M for a Rhodamine 6G solution.In addition,the HS-SERS substrate accurately controlled the size of the concentrated areas through the superhydrophilic pattern,which can be attributed to the favorable repeatability of the droplet concentration results.In addition,the preparation method is flexible and has the potential for fluid mixing,fluid transport,and biochemical sensors,etc. | Xiaodan Ma Lan Jiang Xiaowei Li Bohong Li Ji Huang Jiaxing Sun Zhi Wang Zhijie Xu Liangti Qu Yongfeng Lu Tianhong Cui | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
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