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| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | SERK Family Receptor-like Kinases Function as Co-receptors with PXY for Plant Vascular Development显示文摘 | Heqiao Zhang Xiaoya Lin Zhifu Han Jizong Wang Li-Jia Qu Jijie Chai | 2016 | Molecular Plant2016，9，10： | 11 |
| 3 | Arabidopsis trichome research sheds light on cotton fiber development mechanisms显示文摘Aerial surfaces of most land plants have epidermal hairs (trichomes).Both Arabidopsis thaliana trichomes and cotton fibers (seed hairs) are nonglandular hairs with unicellular structure.Here we out-line the recent progress on molecular dissection of Arabidopsis trichome development,including the transcription factors regulating trichome initiation,phytohormones influencing trichome density,and the cytoskeleton formation system governing trichome morphogenesis.There is increasing evidence showing that these processes also control cotton fiber production.As several cotton fiber genes are able to rescue the Arabidopsis trichome mutants,we discuss the conservation between Arabidopsis trichome and cotton fiber development. | GUAN XueYing YU Nan SHANGGUAN XiaoXia WANG Shui LU Shan WANG LingJian CHEN XiaoYa | 2007 | Chinese Science Bulletin2007，52，13： | 10 |
| 4 | Gossypol: phytoalexin of cotton显示文摘Sesquiterpenoids are a class of 15-carbon secondary metabolites that play diverse roles in plant adaptation to environment.Cotton plants accumulate a large amount of sesquiterpene aldehydes(including gossypol)as phytoalexins against pathogens and herbivores.They are stored in pigment glands of aerial organs and in epidermal layers of roots.Several enzymes of gossypol biosynthesis pathway have been characterized,including 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMGR)and farnesyl diphosphate synthase(FPS)that catalyze the formation of the precursor farnesyl diphosphate(FPP),(+)-δ-cadinene synthase(CDN)which is the first enzyme committed to gossypol biosynthesis,and the downstream enzymes of CYP706B1 and methyltransferase.Expressions of these genes are tightly regulated during cotton plants development and induced by jasmonate and fungi elicitors.The transcription factor Ga WRKY1 has been shown to be involved in gossypol pathway regulation.Recent development of new genomic platforms and methods and releases of diploid and tetraploid cotton genome sequences will greatly facilitate the elucidation of gossypol biosynthetic pathway and its regulation. | Xiu Tian Juxin Ruan Jinquan Huang Xin Fang Yingbo Mao Lingjian Wang Xiaoya Chen Changqing Yang | 2016 | Science China(Life Sciences)2016，59，2： | 10 |
| 5 | Water chemistry controlled aggregation and photo-transformation of silver nanoparticles in environmental waters显示文摘The inevitable release of engineered silver nanoparticles(Ag NPs) into aquatic environments has drawn great concerns about its environmental toxicity and safety. Although aggregation and transformation play crucial roles in the transport and toxicity of Ag NPs, how the water chemistry of environmental waters influences the aggregation and transformation of engineered Ag NPs is still not well understood. In this study, the aggregation of polyvinylpyrrolidone(PVP) coated Ag NPs was investigated in eight typical environmental water samples(with different ionic strengths, hardness, and dissolved organic matter(DOM) concentrations) by using UV–visible spectroscopy and dynamic light scattering. Raman spectroscopy was applied to probe the interaction of DOM with the surface of Ag NPs. Further, the photo-transformation and morphology changes of Ag NPs in environmental waters were studied by UV–visible spectroscopy, inductively coupled plasma mass spectrometry, and transmission electron microscopy. The results suggested that both electrolytes(especially Ca2+and Mg2+) and DOM in the surface waters are key parameters for Ag NP aggregation, and sunlight could accelerate the morphology change, aggregation, and further sedimentation of Ag NPs. This water chemistry controlled aggregation and photo-transformation should have significant environmental impacts on the transport and toxicity of Ag NPs in the aquatic environments. | Yongguang Yin Xiaoya Yang Xiaoxia Zhou Weidong Wang Sujuan Yu Jingfu Liu Guibin Jiang | 2015 | Journal of Environmental Sciences2015，27，8： | 9 |
| 6 | Coupling analysis of social-economic water consumption and its effects on the arid environments in Xinjiang of China based on the water and ecological footprints显示文摘In arid areas,ecological degradation aroused by over-exploitation of fresh water,expansion of artificial oasis and shrinkage of natural oasis,has drawn attention of many scholars and officials.The water and ecological footprints can be used to quantitatively evaluate the water consumption of social-economic activities and their influence on the eco-environments.In addition,increase of the water footprint indicates the expansion of artificial oasis,and the influence on the natural oasis could be reflected by the variation of the ecological footprint.This study was conducted to answer a scientific question that what is the quantitative relationship between the expansion of the artificial oasis and the degradation of the natural oasis in the arid environments of Xinjiang,China.Thus,based on the social-economic data,water consumption data and meteorological data during 2001–2015,we calculated the water and ecological footprints to express the human-related pressure exerted on the water resources and arid environments in Xinjiang(including 14 prefectures and cities),and explore the relationship between the water and ecological footprints and its mechanism by using the coupling analysis and Granger causality test.The results show that both the water and ecological footprints of Xinjiang increased significantly during 2001–2015,and the increasing rate of the ecological footprint was much faster than that of the water footprint.The coupling degree between the water and ecological footprints was relatively high at the temporal scale and varied at the spatial scale.Among the 14 prefectures and cities examined in Xinjiang,the greater social-economic development(such as in Karamay and Urumqi)was associated with the lower coupling degree between the two footprints.Increases in the water footprint will cause the ecological footprint to increase,such that a 1-unit increase in the consumption of water resources would lead to 2–3 units of ecological degradation.The quantitative relationship between the increases of the water and ecological footprints,together with the intensities of water consumption both in the natural and artificial oases of Tarim River Basin,have approved the fact that the formation and expansion of 1 unit of the artificial oasis would bring about the degradation of 2 units of the natural oasis.These conclusions not only provide a technical basis for sustainable development in Xinjiang,but also offer a theoretical guide and scientific information that could be used in similar arid areas around the world. | ZHANG Pei DENG Mingjiang LONG Aihua DENG Xiaoya WANG Hao HAI Yang WANG Jie LIU Yundong | 2020 | Journal of Arid Land2020，12，1： | 8 |
| 7 | Crosslinking strategies for preparation of extracellular matrix-derived cardiovascular scaffolds显示文摘Heart valve and blood vessel replacement using artificial prostheses is an effective strategy for the treatment of cardiovascular disease at terminal stage.Natural extracellular matrix(ECM)-derived materials(decellularized allogeneic or xenogenic tissues)have received extensive attention as the cardiovascular scaffold.However,the bioprosthetic grafts usually far less durable and undergo calcification and progressive structural deterioration.Glutaraldehyde(GA)is a commonly used crosslinking agent for improving biocompatibility and durability of the natural scaffold materials.However,the nature ECM and GA-crosslinked materials may result in calcification and eventually lead to the transplant failure.Therefore,studies have been conducted to explore new crosslinking agents.In this review,we mainly focused on research progress of ECM-derived cardiovascular scaffolds and their crosslinking strategies. | Bing Ma Xiaoya Wang Chengtie Wu Jiang Chang | 2014 | Regenerative Biomaterials2014，1，1： | 6 |
| 8 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 9 | Impact Analysis of Solar Irradiance Change on Precision Orbit Determination of Navigation Satellites显示文摘Solar radiation pressure is the main driving force and error source for precision orbit determination of navigation satellites.It is proportional to the solar irradiance,which is the'sun constant'.In regular calculation,the'solar constant'is regard as a constant.However,due to the existence of sunspots,flares,etc.,the solar constant is not fixed,the change in the year is about 1%.To investigate the variation of solar irradiance,we use interpolation and average segment modeling of total solar irradiance data of SORCE,establishing variance solar radiation pressure(VARSRP)model and average solar radiation pressure(AVESRP)model based on the built solar pressure model(SRPM)(constant model).According to observation data of global positioning system(GPS)and Beidou system(BDS)in 2015 and comparing the solar pressure acceleration of VARSRP,AVESRP and SRPM,the magnitude of change can reach 10-10 m/s^2.In addition,according to the satellite precise orbit determination,for GPS satellites,the results of VARSRP and AVESRP are slightly smaller than those of the SRPM model,and the improvement is between 0.1 to 0.5 mm.For geosynchronous orbit(GEO)satellites of BDS,The AVESRP and VARSRP have an improvement of 3.5 mm and 4.0 mm,respectively,based on overlapping arc,and SLR check results show the AVESRP model and the VARSRP model is improved by 2.3 mm and 3.5 mm,respectively.Moreover,the change of inclined geosynchronous orbit(IGSO)satellites and medium earth orbit(MEO)satellites is relatively small,and the improvement is smaller than 0.5 mm. | ZHANG Yan WANG Xiaoya XI Kewei SHAO Fan | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，6： | 4 |
| 10 | Selective adsorption of silver ions from aqueous solution using polystyrene-supported trimercaptotriazine resin显示文摘Trimercaptotriazine-functionalized polystyrene chelating resin was prepared and employed for the adsorption of Ag(I)from aqueous solution.The adsorbent was characterized according to the following techniques:Fourier transform infrared spectroscopy,elemental analysis,scanning electron microscopy and the Brunauer-Emmet-Teller method.The effects of initial Ag(I)concentration,contact time,solution pH and coexisting ions on the adsorption capacity of Ag(I)were systematically investigated.The maximum adsorption capacity of Ag(I)was up to 187.1 mg/g resin at pH 0.0 and room temperature.The kinetic experiments indicated that the adsorption rate of Ag(I)onto the chelating resin was quite fast in the first 60 min and reached adsorption equilibrium after 360min.The adsorption process can be well described by the pseudo second-order kinetic model and the equilibrium adsorption isotherm was closely fitted by the Langmuir model.Moreover,the chelating resin could selectively adsorb more Ag(I)ions than other heavy metal ions including:Cu(II),Zn(II),Ni(II),Pb(II)and Cr(III)during competitive adsorption in the binary metal species systems,which indicated that it was a highly selective adsorbent of Ag(I)from aqueous solution. | Shiming Wang Hongling Li Xiaoya Chen Min Yang Yanxing Qi | 2012 | Journal of Environmental Sciences2012，24，12： | 4 |
| 11 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 12 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 13 | Clinical Analysis of 240 Patients with HLA-B27 Associated Acute Anterior Uveitis显示文摘Purpose: To analyze the prevalence of HLA-B27 associated acute anterior uveitis and to identify its clinical features. Methods: A total of 240 patients with HLA-B27 associated acute anterior uveitis,who were admitted to Zhejiang Ophthalmologic Hospital between December 2006 and October 2012, were retrospectively analyzed.The age of onset,sex,affected eyes,HLA-B27 antigen detection,recurrence,joint involvement, and surgical complications were investigated. Results:The average age of onset was 37.0 ±12.0 years and the ratio of male to female patients was 2.4:1. Most cases had alternate unilateral or bilateral involvement. Among all participants, 234 cases (97.5%) were HLA-B27 positive, and 124 cases (51.7%) had spondyloarthropathies (SpA), dominated by 108 cases with ankylosing spondylitis. (AS,45.0%),and mostly seen in male subjects(P<0.05).Six patients were HLA-B27 negative(2.5%)and on statistical significance was noted between male and female patients (P >0.05).A total of 193 cases (80.4%) presented with complications, mainly fibrinous exudation, posterior synechia, and vitreous opacity. Conclusion: HLA-B27 that is associated acute anterior uveitis with a relatively high incidence and recurrence presents with more severe clinical features than does idiopathic acute anterior uveitis,and it often accompanies systemic arthritic diseases. HLA-B27 antibody detection is associated with the diagnosis and treatment of acute anterior uveitis. | Yuqin Wang Xiaoya Lu Yulin Wang Liping Mao Yunfeng Gu Pengfei Chen Meiqin Zheng | 2012 | Eye Science2012，27，4： | 3 |
| 14 | Effect of integrated Traditional Chinese and Western Medicine on Gout显示文摘OBJECTIVE:To evaluate the curative effect of integrated Traditional Chinese and Western Medicine on gout,and to investigate the therapy timing and exact treatment options of integrated medicine.METHODS:Totally 860 patients were enrolled,including 460 patients with intermittent gout,200 patients with active Traditional Chinese Medicine(TCM)syndrome(TCM syndrome score≥6)and200 patients with stable TCM syndrome(score<6).They were randomly divided into intervention and control groups.The control group was treated according to Western Medicine guidelines.The intervention group was treated with integrated Traditional Chinese and Western Medicine.The efficacy of TCM syndrome,joint pain score,joint swelling score,ESR,C-reactive protein,serum uric acid,liver and kidney function,and the duration of remission of TCM syndrome were compared between the two groups before and after treatments.RESULTS:For the patients with stable TCM syndrome,there was no significant difference in the effective rate and inefficiency between the intervention group and the control group.For the active type,the effective rate of the intervention group is better than the control group significantly.For the stable type,there was no significant difference between the intervention group and the control group in improving the scores of joint pain and swelling,reducing the level of ESR,C-reactive protein,serum uric acid and improving liver and kidney function.For the active type,the differences between the two groups were significant.The stable stage of gout in the intervention group was longer than the control group.CONCLUSION:For the gout patients with stable TCM syndrome in the acute stage of gout,we can use TCM treatment or Western Medicine alternatively;for the patients with active TCM syndrome,the scheme of combination of Traditional Chinese and Western Medicine can be applied,with the better curative effect than any medicine alone. | LIU Wei WU Yuanhao XUE Bin JIN Yue ZHANG Shumin LI Peihao XIE Qing WANG Aihua GAO Jingyue CAI Yue ZHANG Bo LIU Xiaoya WANG Yi DUAN Ran | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 3 |
| 15 | Background of crustal movement of Chinese mainland显示文摘Based on GPS data during May 1995-March 1998 of 12 IGS stations located in the Chinese mainland and its surrounding areas, the horizontal displacement rates of these IGS stations have been determined. The result can be available to study the background of the crustal tectonic motion in the chinese mainland. | Wenyao Zhu Zongyi Cheng Xiaoya Wang Yongqing Xiong | 2000 | Chinese Science Bulletin2000，45，6： | 3 |
| 16 | Comparative toxicity study of a novel non-ionic surfactant,vanillin ethoxylates, and nonylphenol ethoxylates in Chinese hamster ovary cells in vitro显示文摘Surfactants such as alkylphenol polyethoxylates(APEOs) and nonylphenol ethoxylates(NPEOs) are commonly used worldwide, but the majority of these compounds, together with their metabolites, have been reported to induce severe biological toxicity. Here, we evaluated for the first time the cytotoxicity,genotoxicity and mitochondrial damage in Chinese hamster ovary(CHO-K1) cells caused by a novel non-ionic surfactant, vanillin ethoxylates(VAEOs), an alternative to APEOs. In parallel, the same in vitro bioassays were conducted on NPEOs along with their metabolic byproducts 4-nonylphenol(4-NP) and vanillin. The results showed that the cytotoxic potency order was NPEOs > 4-NP > VAEOs>vanillin using CCK-8 assays. Also, 4-NP showed potential direct DNA damage in SOS/umu tests, whereas NPEOs, VAEOs and vanillin showed no positive result with and without S9 addition. In addition, none of the test compounds showed obvious genotoxic effects with low olive tail moment value using comet assays. However, all test compounds were shown to cause mitochondrial impairment by increasing mitochondrial mass and decreasing mitochondrial membrane potential in a concentration-dependent manner. And further analysis of reactive oxygen species(ROS) and mitochondrial superoxide(MNSOD)measurement showed that mitochondrial impairment was induced by oxidative stress with intracellular ROS and MNSOD overproduction. It's worth noting that VAEOs and vanillin cause relative lower cytotoxic, genotoxic and mitochondrial damage effects than NPEOs and 4-NP, indicating that VAEOs have the potential to substitute NPEOs as suitable surfactants. Take together, this study elucidates the toxicity profiles of VAEOs and NPEOs relatively comprehensively, and further toxicity analyses are suggested in the population, community and ecosystem. | Shengwu Yuan Xiaoya Ji Mei Ma Fengmei Ding Kaifeng Rao Zijian Wang Rong Yang Yihong Liu | 2019 | Journal of Environmental Sciences2019，31，8： | 3 |
| 17 | Hormonal changes throughout puberty in boys:an observational study on the treatment outcome of congenital hypogonadotropic hypogonadism显示文摘To the Editor:It is difficult to capture the exact time of initiation of puberty in normal children,such as when breasts in girls and testicles in boys begin to grow,especially in boys.As a result,research on the detailed patterns of physical development during puberty and the cut-off values and changes of hormones at the initiation of puberty and developmental maturation is rare.It is generally believed that hormonal changes during puberty are a direct result of the stimulating effect of luteinizing hormone(LH)on initiation of puberty;[1]thus,LH is widely accepted as an indicator to evaluate initiation of puberty.However,researchers have not yet reached an agreement on the cut-off value of LH,especially in boys. | Xiaoya Ren Yuanyuan Tian Guoshuang Feng Yi Wang Beibei Zhang Bingyan Cao Jiajia Chen Chunxiu Gong | 2022 | Chinese Medical Journal2022，，3： | 2 |
| 18 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 19 | Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure显示文摘Asthenozoospermia is the most common cause of male infertility.Dynein protein arms play a crucial role in the motility of both the cilia and flagella,and defects in these proteins generally impair the axoneme structure and cause primary ciliary dyskinesia.But relatively little is known about the influence of dynein protein arm defects on sperm flagella function.Here,we recruited 85 infertile patients with idiopathic asthenozoospermia and identified bi-allelic mutations in DNAH7(NM_018897.3)from three patients using whole-exome sequencing.These variants are rare,highly pathogenic,and very conserved.The spermatozoa from the patients with DNAH7 bi-allelic mutations showed specific losses in the inner dynein arms.The expression of DNAH7 in the spermatozoa from the DNAH7-defective patients was significantly decreased,but these patients were able to have their children via intra-cytoplasmic sperm injection treatment.Our study is the first to demonstrate that bi-allelic mutations in DNAH7 may impair the integrality of axoneme structure,affect sperm motility,and cause asthenozoospermia in humans.These findings may extend the spectrum of etiological genes and provide new clues for the diagnosis and treatment of patients with asthenozoospermia. | Xiaoli Wei Yanwei Sha Zijie Wei Xingshen Zhu Fengming He Xiaoya Zhang Wensheng Liu Yifeng Wang Zhongxian Lu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 2 |
| 20 | A comprehensive overview of cotton genomics,biotechnology and molecular biological studies显示文摘Cotton is an irreplaceable economic crop currently domesticated in the human world for its extremely elongated fiber cells specialized in seed epidermis,which makes it of high research and application value.To date,numerous research on cotton has navigated various aspects,from multi-genome assembly,genome editing,mechanism of fiber development,metabolite biosynthesis,and analysis to genetic breeding.Genomic and 3D genomic studies reveal the origin of cotton species and the spatiotemporal asymmetric chromatin structure in fibers.Mature multiple genome editing systems,such as CRISPR/Cas9,Cas12(Cpf1)and cytidine base editing(CBE),have been widely used in the study of candidate genes affecting fiber development.Based on this,the cotton fiber cell development network has been preliminarily drawn.Among them,the MYB-b HLH-WDR(MBW)transcription factor complex and IAA and BR signaling pathway regulate the initiation;various plant hormones,including ethylene,mediated regulatory network and membrane protein overlap fine-regulate elongation.Multistage transcription factors targeting Ces A 4,7,and 8 specifically dominate the whole process of secondary cell wall thickening.And fluorescently labeled cytoskeletal proteins can observe real-time dynamic changes in fiber development.Furthermore,research on the synthesis of cotton secondary metabolite gossypol,resistance to diseases and insect pests,plant architecture regulation,and seed oil utilization are all conducive to finding more high-quality breeding-related genes and subsequently facilitating the cultivation of better cotton varieties.This review summarizes the paramount research achievements in cotton molecular biology over the last few decades from the above aspects,thereby enabling us to conduct a status review on the current studies of cotton and provide strong theoretical support for the future direction. | Xingpeng Wen Zhiwen Chen Zuoren Yang Maojun Wang Shuangxia Jin Guangda Wang Li Zhang Lingjian Wang Jianying Li Sumbul Saeed Shoupu He Zhi Wang Kun Wang Zhaosheng Kong Fuguang Li Xianlong Zhang Xiaoya Chen Yuxian Zhu | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
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