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| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | Estimation of biomass in wheat using random forest regression algorithm and remote sensing data显示文摘Wheat biomass can be estimated using appropriate spectral vegetation indices.However,the accuracy of estimation should be further improved for on-farm crop management.Previous studies focused on developing vegetation indices,however limited research exists on modeling algorithms.The emerging Random Forest(RF) machine-learning algorithm is regarded as one of the most precise prediction methods for regression modeling.The objectives of this study were to(1) investigate the applicability of the RF regression algorithm for remotely estimating wheat biomass,(2) test the performance of the RF regression model,and(3) compare the performance of the RF algorithm with support vector regression(SVR) and artificial neural network(ANN) machine-learning algorithms for wheat biomass estimation.Single HJ-CCD images of wheat from test sites in Jiangsu province were obtained during the jointing,booting,and anthesis stages of growth.Fifteen vegetation indices were calculated based on these images.In-situ wheat above-ground dry biomass was measured during the HJ-CCD data acquisition.The results showed that the RF model produced more accurate estimates of wheat biomass than the SVR and ANN models at each stage,and its robustness is as good as SVR but better than ANN.The RF algorithm provides a useful exploratory and predictive tool for estimating wheat biomass on a large scale in Southern China. | Li'ai Wang Xudong Zhou Xinkai Zhu Zhaodi Dong Wenshan Guo | 2016 | The Crop Journal2016，4，3： | 30 |
| 3 | Pokemon reduces Bcl-2 expression through NF-κ Bp65:a possible mechanism of hepatocellular carcinoma显示文摘Objective:To investigate the relationship among Pokemon,NF-κB p65 and Bcl-2 in hepatoma cells.Methods:HCC cell HepG2,SMMC7721 and human fetal liver cell line L02 cells were used,and expression of Pokemon,NF-κB p65 and Bcl-2 in three cells were detected by realtime PCR and western blot.Then siRNA of Pokemon was applied to inhibit the expression of Pokemon and NF-κB p65 and apoptotic rate was determined by flow cytometric analysis. Results:Expressions of Pokemon,NF-κB p65 and Bcl-2 in human hepatoma cell HepG2, SMMC7721 expression were significantly higher than those in human embryonic stem cells L02. siRNA of Pokemon inhibited the expression of Pokemon,NF-κB p65 and Bcl-2 in liver cancer cells,and significantly increased apoptosis of liver cells.While siRNA of NF-κB n65 inhibited the expression of NF-κB p65 and Bcl-2,but Pokemon expression in hepatoma cells had no significant change.Conclusions:The proto-oncogene Pokemon can inhibit PI4ARF by specific transcription regulation of cell cycle and can induce tumors.In addition,Pokemon can regulate NF-κB p65 through the expression of apoptosis repressor,and promote the development of liver cancer.It suggests signal network in the liver include the regulation of new non-classical NF-κB regulatory pathway. | Xinkai Zhao Qiaoming Ning Xiaoning Sun De'an Tian | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 11 |
| 4 | Flexible self-charging power units for portable electronics based on folded carbon paper显示文摘对便携式的电子学的迫切要求支持了高效率、持续、甚至可拉长的自我控告的力量来源的发展。在这个工作,我们建议为从人的运动和力量便携式计算机电子学收获机械精力基于合拢的碳(FC ) 统一纸的灵活自我控告的力量。现在的单位主要由摩擦电 nanogenerator (FC-TENG ) 和 supercapacitor (FC-SC ) 组成,基于合拢的复写纸精力 harvester 和存储设备分别地。这个有利几何图案向高幼仔模量复写纸提供优秀 stretchability 并且使力量单位能甚至在严重变丑下面工作,扭动,并且滚动,例如弯曲。另外,张力的紧张能被调节合拢三角的复写纸的合拢的角度最大化。而且,包装设备的防水性质使它可洗,保护它免受人的汗的伤害,并且使它能在严厉环境工作。最后,同样准备的自我控告的力量单位被把它放在人的身体上从手拍,踩的脚,并且手臂接触成功地驱动一块电子手表收获机械精力测试。这个工作表明可拉长的自我控告的力量单位的出色的潜力,它将进一步为便携 / 便携式的电子学支持高幼仔模量材料的发展。 | Changjie Zhou Yanqin Yang Na Sun Zhen Wen Ping Cheng Xinkai Xie Huiyun Shao Qingqing Shen Xiaoping Chen Yina Liu Zhong Lin Wang Xuhui Sun | 2018 | Nano Research2018，11，8： | 9 |
| 5 | Effects of anaerobic composting on tetracycline degradation in swine manure显示文摘Oxytetracycline(OTC) and tetracycline(TC) are the most common TC antibiotics used in human and veterinary medicine.Residual amounts of these antibiotics in manure pose a potential threat to public and ecological health as a result of the potential for them to be released to the environment following land application of manure from animals treated with antibiotics.We investigated the degradation of OTC and TC during anaerobic composting.We tested the effects of temperature and antibiotic concentration on degradation rates in a control and in manure spiked with TCs.We examined changes in p H,biological degradation material(BDM),and moisture corresponding with antibiotic degradation of TCs in the swine manure.Results showed that the OTC and TC concentrations decreased by between 68.54% and 95.50% in all nine treatments following 14 days of anaerobic composting,and the highest removal ef ficiencies were observed at an incubation temperature of 55°C and initial concentrations of 10.36 μg·g^(-1),and 5.96 μg·g^(-1) of OTC and TC,respectively,which were degraded by 95.50%,and 90.06%.During composting at 55 °C and at added concentrations of 5 μg·g^(-1),OTC decreased rapidly,and the time required for50% and 90% degradation was 4.1 and 9.8 days,respectively;for TC,these values were 4.4 and 14.0 days,respectively.Removal ef ficiencies for all TCs correlated well with moisture content of the manure.These results show that composting may be a practical and useful means to reduce concentrations of OTC and TC in swine manure prior to its land application. | Yixuan Chu Chengran Fang Hua Wang Xinkai Wu Yijie Gu Ji Shu | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 6 |
| 6 | Finite-time command filtered adaptive control for nonlinear systems via immersion and invariance显示文摘This paper investigates the problem of finite-time adaptive output tracking control for strictfeedback nonlinear systems with parametric uncertainties. Command signals and their derivatives are generated by a new command filter based on a second-order finite-time differentiator, which attenuates the chattering phenomenon. The parameter estimations are achieved by an immersion and invariance approach without requiring the certainty equivalence principle. The finite-time adaptive controller is constructed via a backstepping design method, a finite-time command filter, and a modified fractional-order error compensation mechanism. The proposed control strategy guarantees the finite-time boundedness of all signals in the closed-loop system, and the tracking error is driven into an arbitrarily small neighborhood of the origin in finite time. Finally, the new design technique is validated in a simulation example of the electromechanical system. | Jinpeng YU Peng SHI Xinkai CHEN Guozeng CUI | 2021 | Science China(Information Sciences)2021，64，9： | 4 |
| 7 | Adaptive Pseudo Inverse Control for a Class of Nonlinear Asymmetric and Saturated Nonlinear Hysteretic Systems显示文摘This paper aims at eliminating the asymmetric and saturated hysteresis nonlinearities by designing hysteresis pseudo inverse compensator and robust adaptive dynamic surface control(DSC)scheme.The'pseudo inverse'means that an on-line calculation mechanism of approximate control signal is developed by applying a searching method to the designed temporary control signal where the true control signal is included.The main contributions are summarized as:1)to our best knowledge,it is the first time to compensate the asymmetric and saturated hysteresis by using hysteresis pseudo inverse compensator because the construction of the true saturated-type hysteresis inverse model is very difficult;2)by designing the saturated-type hysteresis pseudo inverse compensator,the construction of true explicit hysteresis inverse and the identifications of its corresponding unknown parameters are not required when dealing with the saturated-type hysteresis;3)by combining DSC technique with the tracking error transformed function,the'explosion of complexity'problem in backstepping method is overcome and the prespecified tracking performance is achieved.Analysis of stability and experimental results on the hardware-inloop platform illustrate the effectiveness of the proposed adaptive pseudo inverse control scheme. | Xiuyu Zhang Ruijing Jing Zhiwei Li Zhi Li Xinkai Chen Chun-Yi Su | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，4： | 4 |
| 8 | Future vehicles:interactive wheeled robots显示文摘Owing to the lack of variety of interactions in automatic driving,the interactive cognition and evolution growth of self-driving vehicles in uncertain and complex environments have been proposed,making future vehicles interactive wheeled robots. | Nan MA Deyi LI Wen HE Yue DENG Jiahong LI Yue GAO Hong BAO Huan ZHANG Xinkai XU Yuansheng LIU Zhixuan WU Li CHEN | 2021 | Science China(Information Sciences)2021，64，5： | 4 |
| 9 | Effect of rotationally accelerated shot peening on the microstructure and mechanical behavior of a metastableβtitanium alloy显示文摘Microstructural evolution and deformation mechanism of a metastableβalloy(Ti-10 V-2 Fe-3 Al)processed by rotationally accelerated shot peening(RASP)were systematically investigated with optical microscopy,X-ray diffraction,electron backscatter diffraction and transmission electron microscopy.Different gradient hierarchical microstructures(gradients inα″martensite andβphase,and hierarchical twins range from the nanoscale to microscale)can be fabricated by RASP via changing the shot peening time.The hardening behavior and tensile mechanical properties of gradient hierarchical microstructure were systematically explored.Novel deformation twinning systems of{112}α″and{130}<310>α″in the kinkedα″martensite were revealed during the tensile deformation.It was found that stress-induced martensitic transformation,twinnedα″martensite and the related dynamic grain refinement contribute to hardness and work hardening ability.Simultaneous improvement of strength and ductility of the metastableα″titanium alloy can be achieved by introducing a gradient hierarchical microstructure. | Xinkai Ma Zhuo Chen Dongling Zhong SNLuo Lei Xiao Wenjie Lu Shanglin Zhang | 2021 | Journal of Materials Science & Technology2021，，16： | 4 |
| 10 | Dacrycarpus pattern shedding new light on the early floristic exchange between Asia and Australia显示文摘The recent discovery of mummified Dacrycarpus remains from the Miocene Erzitang Formation of the Guiping Basin,Guangxi,southern China,essentially contests our concepts of floristic exchange between Australia and China.East Asia has several biodiversity hotpots and is a key region for understanding the origin and evolution of the biodiversity in the N orthern Hemisphere[1].Most Gondwanan elements in East Asia are those formerly distributed across much wide areas in the Southern Hemisphere,but their modern distributions are the results of complex geological and climatic changes.Understanding the biogeographical history of Gondwanan taxa,and the mechanism underpinning their current distributions,help in understanding and conserving extant biodiversity. | Xinkai Wu Xiaoyan Liu Tatiana Kodrul Cheng Quan Jianhua Jin | 2019 | National Science Review2019，6，6： | 3 |
| 11 | Modelling-based evaluation of the effect of quarantine control by the Chinese government in the coronavirus disease 2019 outbreak显示文摘Dear Editor,The recent outbreak of novel coronavirus disease 2019(COVID-19)has already become a global-scale epidemic.Since the case from China was reported on Dec 30th,2019(Huang et al.,2020;Li et al.,2020),the pathogen was soon identified as a new coronavirus on Jan 7th. | Xinkai Zhou Zhigui Wu Ranran Yu Shanni Cao Wen Fang Zhen Jiang Fang Yuan Chao Yan Dijun Chen | 2020 | Science China(Life Sciences)2020，63，8： | 3 |
| 12 | KEY OPTIMIZATION TECHNIQUES IN JPEG-LS IP CORE DESIGN显示文摘This paper presents the key optimization techniques for an efficient accelerator implementation in an image encoder IP core design for real-time Joint Photographic Experts Group Lossless(JPEG-LS) encoding.Pipeline architecture and accelerator elements have been utilized to enhance the throughput capability.Improved parameters mapping schemes and resource sharing have been adopted for the purpose of low complexity and small chip die area.Module-level and fine-grained gating measures have been used to achieve a low-power implementation.It has been proved that these hardware-oriented optimization techniques make the encoder meet the requirements of the IP core implementation.The proposed optimization techniques have been verified in the implementation of the JPEG-LS encoder IP,and then validated in a real wireless endoscope system. | Zhang Xiaoyu Chen Xinkai Li Xiaowen Jiang Hanjun Zhang Chun Wang Zhihua | 2010 | Journal of Electronics(China)2010，27，1： | 3 |
| 13 | Analytical Analysis and Performance Characterization of Brushless Doubly Fed Induction Machines Based on General Air-gap Field Modulation Theory显示文摘Air-gap magnetic field modulation has been widely observed in electric machines.In this study,we present an analytical analysis and performance characterization of brushless doubly fed induction machines(BDFIMs)fed by two independent converters from the perspective of air-gap field modulation.The spiral-loop winding is studied in detail as an example to show the generalized workflow that can also be used to analyze other short-circuited rotor winding types,such as nested-loop and multiphase double-layer windings.Magnetic field conversion factors are introduced to characterize the modulation behavior of special rotor windings and facilitate their comparison in terms of cross-coupling capability,average torque,and harmonic content of the air-gap flux density waveforms.The stator magnetomotive force(MMF),rotor MMF,and resultant air-gap MMF are considered,based on which the closed-form inductance formulas are derived,and the torque equation is obtained along with the optimal current angle for maximum torque operation by using the virtual work principle.The design equations are then developed for the initial sizing and geometry scaling of the BDFIMs.Transient finite element analysis and experimental measurements are performed to validate the analysis. | Peng Han Ming Cheng Xinkai Zhu Zhe Chen | 2021 | Chinese Journal of Electrical Engineering2021，7，3： | 3 |
| 14 | Establishment of two-dimensional gel electrophoresis for soybean protein isolate and its application显示文摘To optimize the conditions for the establishment of two-dimensional gel electrophoresis(2-DE)of soybean protein isolate(SPI),we investigated Ampholine mixture,anodic and cathodic electrolytes,loading amount of sample,acrylamide concentration,p H gradient and gel staining method in twodimensional gel electrophoresis to optimize the protein imaging conditions in two-dimensional gel.The results of mixed-level design experiments showed that Ampholine,loading amount and gel staining method had significant effect(P<0.05)on 2-DE of SPI.The optimal conditions were Ampholine mixture(pH 3–10+pH 5–7 or pH 4–6+pH 5–7),loading amount of 2 mg sample and silver staining.Although the acrylamide concentration of the gel,the p H gradient,the anodic and cathodic electrolyte solutions had significant statistical effects on the protein separation degree,the complexity of the protein composition and the visibility of the gel images were more inclined to the 12%gel,the 3–10 pH gradient and the H3PO4/NaOH electrolyte.According to the established conditions,the hydrolyzed products of SPI emulsion were determined by 2-DE,and the dynamic changes of protein in the process of enzymatic hydrolysis were described. | Xinkai Lu Yaoming Cui Junjun Guan Xue Liu Hao Zhu Xuyang Ji Jianzhang Zheng Yunlong Cheng Xiaofei Fu | 2020 | Grain & Oil Science and Technology2020，3，3： | 2 |
| 15 | Multi-omics analysis reveals gut microbiota-induced intramuscular fatdeposition via regulating expression of lipogenesis-associated genes显示文摘The gut microbiome has great effects on the digestion, absorption, and metabolism of lipids. However,the microbiota composition that can alter the fat deposition and the meat quality of pigs remains unclear.Here, we used Laiwu (LW) pigs (a native Chinese breed with higher intramuscular fat) compared withcommercial crossbreed Duroc×(Landrace×Yorkshire) (DLY) pigs to investigate the effects of microbiotaon meat quality, especially in intramuscular fat content. A total of 32 DLY piglets were randomly allottedto 4 groups and transplanted with fecal microbiota from healthy LW pigs. The results indicated that thehigh dose of fecal microbiota transplantation (HFMT) selectively enhanced fat deposition in longissimusdorsi (P < 0.05) but decreased backfat thickness (P < 0.05) compared with control group. HFMT significantlyaltered meat color and increased feed conversation ratio (P < 0.05). Furthermore, the multi-omicsanalysis revealed that Bacteroides uniformis, Sphaerochaeta globosa, Hydrogenoanaerobacterium saccharovorans,and Pyramidobacter piscolens are the core species which can regulate lipid deposition. A total of140 male SPF C57BL/6j mice were randomly allotted into 7 groups and administrated with these 4 microbesalone or consortium to validate the relationships between microbiota and lipid deposition.Inoculating the bacterial consortium into mice increased intramuscular fat content (P < 0.05) comparedwith control mice. Increased expressions of lipogenesis-associated genes including cluster of differentiation36 (Cd36), diacylglycerol O-acyltransferase 2 (Dgat2), and fatty acid synthase (FASN) wereobserved in skeletal muscle in the mice with mixed bacteria compared with control mice. Together, ourresults suggest that the gut microbiota may play an important role in regulating the lipid deposition in the muscle of pigs and mice. | Chunlin Xie Junyong Teng Xinkai Wang Baoyang Xu Yaorong Niu Libao Ma Xianghua Yan | 2022 | Animal Nutrition2022，，2： | 2 |
| 16 | MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway显示文摘 | Jianqiang Bao Ding Li Li Wang Jingwen Wu Yanqin Hu Zhugang Wang Yan Chen Xinkai Cao Cizhong Jiang Wei Yan Chen Xu | 2012 | Journal of Biological Chemistry2012，，26： | 2 |
| 17 | Real-time queue length estimation for congested signalized intersections显示文摘 | Liu H X Wu Xinkai Ma Wenteng | 2009 | Transportation Research Part C:Emerging Technologies2009，17，4： | 1 |
| 18 | Reverse Apolipoprotein A-I Mimetic Peptide R-D4F Inhibits Neointimal Formation Following Carotid Artery Ligation in Mice显示文摘 | Lin Du Xinkai Qu Haixia Zhen Rujun Li Jun Wang Mingxing Chen Pei Zhao Zhengang Zhang Kaizheng Gong | 2013 | The American Journal of Pathology2013，，： | 1 |
| 19 | Robust output tracking control for the systems with uncertainties 显示文摘 | Chen Xinkai Su Chunyi | 2002 | International Journal of Systems Science2002，33，4： | 1 |
| 20 | Simultaneous biosorption of cadmium (II) and lead (II) ions by pretreated biomass of Phanerochaete chrysosporium显示文摘 | Qingbiao Li Songtao Wu Gang Liu Xinkai Liao Xu Deng Daohua Sun Yuelin Hu Yili Huang | 2003 | Separation and Purification Technology2003，，1： | 1 |
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