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| 1 | The study on the safety and efficacy of amnion graft for preventing the recurrence of moderate to severe intrauterine adhesions显示文摘Transcervical resection of adhesion(TCRA)is the standard treatment for the intrauterine adhesions,but the recurrence of adhesions is a tough problem for the gynecologist.In addition,the therapeutic strategy after TCRA about prevention of recurrence remains controversial especially for the patients with moderate to severe intrauterine adhesions(IUAs).Hence,we designed this study to explore the safety and efficacy of fresh amnion grafts for preventing the recurrence after TCRA for patients with moderate to severe IUAs.One hundred patients with moderate to severe IUAs who presented with a history of hypomenorrhea,amenorrhea and infertility were included in the study from January 2015 to December 2017.Patients were divided into amnion group(52 patients)and chitosan group(48 patients).Fresh amnion grafts or intrauterine injections of chitosan were administered after TCRA.Transvaginal ultrasonography(TVUS)and hysteroscopy were performed at the first and third month after the operation.The surgical procedures for all patients were completed successfully without relevant complications.In amnion group,8 patients exhibited relapse in the first month and 2 patients in three months after surgery;in chitosan group,23 women exhibited relapse in the first month and 18 patients in three months after surgery.Statistical analysis revealed that the recurrence rate of adhesion in amnion group was significantly lower than those of chitosan group in the first and three months after surgery(P1=0.000,P2=0.000).After TCRA,fresh amnion graft plays a significant role in preventing further adhesions than injections of chitosan. | Changjiang Li Aiqi Cai Congcong Sun Benyuan Wu Xinpei Chen Yanhua Mao Yingfeng Zhang Yating Gou Jie Yu Yuhan Wang Huanhuan Yu Jia Wang | 2020 | Genes & Diseases2020，7，2： | 11 |
| 2 | Chemical characteristics of haze particles in Xi'an during Chinese Spring Festival: Impact of fireworks burning显示文摘Fireworks burning releases massive fine particles and gaseous pollutants, significantly deteriorating air quality during Chinese Lunar New Year(LNY) period. To investigate the impact of the fireworks burning on the atmospheric aerosol chemistry, 1-hr time resolution of PM_(2.5) samples in Xi'an during the winter of 2016 including the LNY were collected and detected for inorganic ions, acidity and liquid water content(LWC) of the fine aerosols. PM_(2.5) during the LNY was 167 ± 87 μg/m^3, two times higher than the China National Ambient Air Quality Standard(75 μg/m^3). K^+(28 wt.% of the total ion mass) was the most abundant ion in the LNY period, followed by SO_4^(2-)(25 wt.%) and Cl-(18 wt.%). In contrast, NO_3^-(34 wt.%) was the most abundant species in the haze periods(hourly PM32-2.5> 75 μg/m), followed by SO_4(29.2 wt.%) and NH_4^+(16.3 wt.%), while SO_4^(2-)(35 wt.%) was the most abundant species in the clean periods(hourly PM_(2.5)< 75 μg/m^3), followed by NO_3^-(23.1 wt.%) and NH_4^+(11 wt.%). Being different from the acidic nature in the non-LNY periods, aerosol in the LNY period presented an alkaline nature with a pH value of 7.8 ± 1.3. LWC during the LNY period showed a robust linear correlation with K_2SO_4 and KCl, suggesting that aerosol hygroscopicity was dominated by inorganic salts derived from fireworks burning. Analysis of correlations between the ratios of NO--3/SO_4^(2-) and NH_4^+/SO_4^(2-) indicated that heterogeneous reaction of HNO_3 with NH_3 was an important formation pathway of particulate nitrate and ammonium during the LNY period. | Can Wu Gehui Wang Jiayuan Wang Jianjun Li Yanqin Ren Lu Zhang Cong Cao Jin Li Shuagshuang Ge Yuning Xie Xinpei Wang Guoyan Xue | 2018 | Journal of Environmental Sciences2018，30，9： | 10 |
| 3 | Water-driven photoluminescence reversibility in CsPbBr_(3)/PDMSPUa composite显示文摘Strong ionic character endows all-inorganic perovskite nanocrystals(NCs)with particular optoelectronic features when interacting with common polar solvents,such as water.However,the interaction mechanism of water affecting perovskite NCs is still lack of in-depth understanding.This study systematically explores the roles of water on CsPbBr_(3) nanocrystals(CNCs)by finely controlling the polymer coating degree of polydimethylsiloxane-based polyurea(PDMS-PUa).Through this coating,the effect of water on CNCs is found to experience from“fluorescence quenching”owing to irreversible crystal decomposition towards“forward fluorescence reversibility”by crystal destruction and recrystallization.With gradually enhanced coating,a phenomenon of“reverse fluorescence reversibility”is further observed in that water begins to passivate the CNCs’defect states.Finally,“fluorescent balance”can be achieved with a thick enough coating,where water can hardly contact with the CNCs.Inspired by the fluorescence reversible mechanism discovered,a new wearable intelligent sensing skin is demonstrated by using the CsPbBr_(3)/PDMS-PUa composite as raw material.Both water contact and humidity change can be perceived through photoluminescence(PL)intensity,corresponding to stimuli-responsive sensory nerves of human skin.It is expected that these findings will shed some new lights on perovskite NCs. | Junhu Cai Chenhui Wang Xinpei Hu Yuanyuan Ye Lijuan Zhong Enguo Chen Yun Ye Sheng Xu Jie Sun Qun Yan Tailiang Guo | 2022 | Nano Research2022，15，7： | 4 |
| 4 | Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations显示文摘Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells (NSC/NPCs) activities manifested by decreased proliferation, reduced propensity to produce neurons, and increased differentiation into astrocytes. While gene transcription changes objectively reveal molecular alterations of cells undergoing various biological processes, the search for molecular mechanisms underlying aging of NSC/NPCs has been confronted by the enormous heterogeneity in cellular compositions of the brain and the complex cellular microenvironment where NSC/NPCs reside. Moreover, brain NSC/NPCs themselves are not a homogenous population, making it even more difficult to uncover NSC/NPC sub-type specific aging mechanisms. Here, using both population-based and single cell transcriptome analyses of young and aged mouse forebrain ependymal and subependymal regions and comprehensive “big-data” processing, we report that NSC/NPCs reside in a rather inflammatory environment in aged brain, which likely contributes to the differentiation bias towards astrocytes versus neurons. Moreover, single cell transcriptome analyses revealed that different aged NSC/NPC subpopulations, while all have reduced cell proliferation, use different gene transcription programs to regulate age-dependent decline in cell cycle. Interestingly, changes in cell proliferation capacity are not influenced by inflammatory cytokines, but likely result from cell intrinsic mechanisms. The Erk/Mapk pathway appears to be critically involved in regulating age-dependent changes in the capacity for NSC/NPCs to undergo clonal expansion. Together this study is the first example of using population and single cell based transcriptome analyses to unveil the molecular interplay between different NSC/NPCs and their microenvironment in the context of the aging brain. | Zhanpinq Shi Yanan Geng Jiping Liu Huina Zhang Liqiang Zhou Quan Lin Juehua Yu Kunshan Zhang Jie Liu Xinpei Gao Chunxue Zhang Yinan Yao Chong Zhang Yi E. Sun | 2018 | Protein & Cell2018，9，4： | 3 |
| 5 | Surveillance of pine wilt disease by high resolution satellite显示文摘Pine wilt disease caused by the pinewood nematode Bursaphelenchus xylophilus has led to the death of a large number of pine trees in China.This destructive disease has the characteristics of bring wide-spread,fast onset,and long incubation time.Most importantly,in China,the fatality rate in pines is as high as 100%.The key to reducing this mortality is how to quickly find the infected trees.We proposed a method of automatically identifying infected trees by a convolution neural network and bounding box tool.This method rapidly locates the infected area by classifying and recognizing remote sensing images obtained by high resolution earth observation Satellite.The recognition accuracy of the test data set was 99.4%,and the remote sensing image combined with convolution neural network algorithm can identify and determine the distribution of the infected trees.It can provide strong technical support for the prevention and control of pine wilt disease. | Hongwei Zhou Xinpei Yuan Huanyu Zhou Hengyu Shen Lin Ma Liping Sun Guofei Fang Hong Sun | 2022 | Journal of Forestry Research2022，33，4： | 2 |
| 6 | Coupled electrophysiological recording and single cell transcriptome analyses revealed molecular mechanisms underlying neuronal maturation显示文摘哺乳动物的大脑是异构的,包含形成各种各样的神经电路,感觉,运动,思维,和情感通过产生的触处的十亿个神经原和万亿。大脑的细胞的异质使学习神经电路配线的分子的逻辑困难,修剪,直到最近, transcriptome 与分辨率使基因译码规章的单个房间分析的激活,和粘性联网可能的内在的上述的电路性质。这里,我们在在文化在单个人的神经原上执行 electrophysiological 和整个染色体的 transcriptome 分析报导成功。用加权的基因 Coexpression 网络分析(WGCNA ) ,我们鉴别基因簇高度相关, neuronal 成熟由 electrophysiological 特征判定了。在涉及 ubiquitination 和 mitochondrial 功能的 neuronal 成熟和基因之间的一个紧密的连接被揭示。而且,我们识别了候选人基因的一张表,它能潜在地为 neuronal 成熟用作 biomarkers。联合 electrophysiological 记录和单个房间 transcriptome 分析将在未来用作强大的工具为神经电路功能揭开分子的逻辑。 | Xiaoying Chen Kunshan Zhang Liqiang Zhou Xinpei Gao Junbang Wang Yinan Yao Fei He Yuping Luo Yongchun Yu Siguang Li Liming Cheng Yi E. Sun | 2016 | Protein & Cell2016，7，3： | 2 |
| 7 | Optical Brain Imaging: A Powerful Tool for Neuroscience显示文摘As the control center of organisms,the brain remains little understood due to its complexity. Taking advantage of imaging methods,scientists have found an accessible approach to unraveling the mystery of neuroscience. Among these methods,optical imaging techniques are widely used due to their high molecular specificity and single-molecule sensitivity. Here,we overview several optical imaging techniques in neuroscience of recent years,including brain clearing,the micro-optical sectioning tomography system,and deep tissue imaging. | Xinpei Zhu Yanfang Xia Xuecen Wang Ke Si Wei Gong | 2017 | Neuroscience Bulletin2017，33，1： | 2 |
| 8 | Rabies Virus Pseudotyped with CVS-N2C Glycoprotein as a Powerful Tool for Retrograde Neuronal Network Tracing显示文摘Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseudotyped with the N2 C glycoprotein(SAD-RV(DG)-N2 C(G)) shows strong neuro-tropism in cell culture, but its in vivo efficiency for retrograde gene transduction and neuro-tropism have not been systematically characterized.We compared these features in different mouse brain regions for SAD-RV-N2 C(G) and two other widely-used retrograde tracers, SAD-RV(DG)-B19(G) and r AAV2-retro. We found that SAD-RV(DG)-N2 C(G) enhanced the infection efficiency of long-projecting neurons by^10 times but with very similar neuro-tropism, compared with SAD-RV(DG)-B19(G). On the other hand, SAD-RV(DG)-N2 C(G) had an infection efficiency comparable with r AAV2-retro, but a more restricted diffusion range, and broader tropism to different types and regions of longprojecting neuronal populations. These results demonstrate that SAD-RV(DG)-N2 C(G) can serve as an effective retrograde vector for studying neuronal circuits. | Xutao Zhu Kunzhang Lin Qing Liu Xinpei Yue Huijie Mi Xiaoping Huang Xiaobin He Ruiqi Wu Danhao Zheng Dong Wei Liangliang Jia Weilin Wang Anne Manyande Jie Wang Zhijian Zhang Fuqiang Xu | 2020 | Neuroscience Bulletin2020，36，3： | 2 |
| 9 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 10 | A non‐equal gap distance dielectric barrier discharge:Between cone‐shape and cylinder‐shape electrodes显示文摘A non‐equal gap distance dielectric barrier discharge(DBD)between cone‐shape and a cylinder‐shaped electrodes is reported.The DBD is driven by a nanosecond voltage pulse.When the pulse frequency is 500 Hz or lower,ladder‐shape plasma with multiple plasma layers is generated within the gap,with a distance increasing from 1 to 7 mm.According to high‐speed photographs of the plasma captured by an intensified charge‐coupled camera detector camera,the ladder‐shaped plasma is formed owing to propa-gation of ring‐shaped plasma from the region of the short‐gap distance to the region of long‐gap distance with regular variations in its propagation speed.The propagation speed drops to zero and lasts for about 20-30 ns at the region of each plasma layer,which results in bright plasma layers.The electric field of the plasma layer at the region of the different gap distance is evaluated according to the optical emission intensity ratio R_(391)/_(394)of N_(2)^(+)at 391 nm and N_(2) at 394 nm.The obtained electric field drops from 8.1 to 6.4 kV/mm when the plasma is propagated from regions of gap distance of 2-5 mm.When the pulse frequency is increased to 1 kHz or higher,the discharge changes into a filamentary mode and the multiple‐layer plasma disappears. | Shaohui Jin Zhiyu Li Yubin Xian Lanlan Nie Xinpei Lu | 2022 | High Voltage2022，7，1： | 2 |
| 11 | Investigation on surface insulation strength of machinable ceramic material under pulsed voltage in vacuum显示文摘 | Zhang Guanjun Zhao Wenbin Ma Xinpei | 2007 | Journal of the Vacuum Society of Japan2007，50，5： | 1 |
| 12 | On the charged aerosols generated by atmospheric pressure non‐equilibrium plasma显示文摘Recently,charged aerosols are used widely in many applications,such as fog elimination,inactivation of airborne viruses and so on.Atmospheric pressure non‐equilibrium plasma(APNP)have become an efficient way to generate charged aerosols.Except the traditional pin‐plate or wire‐plate APNP sources,the new APNP sources such as large scale corona discharge system and air plasma jet array are introduced.These sources can increase the ion density in open air and generate adjustable large plasma plume,which are helpful in increasing the charging efficiency on aerosols.Although the interactions between plasma and aerosols is quite complicated,the preliminary study suggests that the diffusion charging dominates aerosols below 0.1μm,field charging dominates aerosols larger than 1μm,and the photo charging also contributes to aerosols charging.These reactive charged aerosols have shown their potential in the artificial rain enhancement,biomedicine,and ma-terial processing.Finally,challenges and opportunities for theoretical,experimental,and application research in related cross‐disciplinary areas are presented to stimulate critical discussions and collaborations in the future. | Yanzhe Zhang He Cheng Haotian Gao Dawei Liu Xinpei Lu | 2021 | High Voltage2021，6，3： | 1 |
| 13 | Effect of nano- to millisecond pulse on dielectric barrier discharges 显示文摘 | Lu Xinpei Xiong Qing Xiong Zilan | 2009 | IEEE Transactions on Plasma Science2009，37，5： | 1 |
| 14 | The high yield synthesis and characterization of gold nanoparticles with superior sta- bility and their catalytic activity 显示文摘 | Jia Han Gao Xinpei Zheng Liqiang | 2012 | Cryst Eng Comm2012，14，22： | 1 |
| 15 | Spark model of pulsed discharge in water 显示文摘 | LU Xinpei PAN Yuan LIU Kefu | 2002 | Journal of Applied Physics2002，91，1： | 1 |
| 16 | Trihalomethane formation in water treated with chlorine dioxide 显示文摘 | LI Junwen YU Zuobin CAI Xinpei | 1996 | Water Res1996，30，10： | 1 |
| 17 | The roles of the various plasma agents in the inactivation of bacteria显示文摘 | Lu Xinpei Ye Tao Cao Yingguang | | 0，，： | 1 |
| 18 | Inactivation of bacteria by the plasma pencil显示文摘 | Laroussi M Tendero C Lu Xinpei | 2006 | Plasma Processes and Polymers2006，3，67： | 1 |
| 19 | Ionization waves in nanosecond pulsed atmospheric pressure plasma jets in argon显示文摘Typical ionization waves(IWs)are observed during the propagation of nanosecond pulsed atmospheric pressure plasma jets(APPJs)with argon flow,combining both the measurement of the axial electric field(Ez)and the temporal resolved optical imaging.The movement of the luminous APPJ head is recognized as the development of the IW front,accompanied with the propagation of the peak electric field.Especially,the radial distribution of Ez transits from a central peak profile before the IW front arrives to a hollow profile after the pass of the IW front.As for the temporal Ez trend,there is a mode transition from the single-peak feature under a low peak voltage to the double-peak feature under a higher peak voltage,indicating the existence of both primary and secondary IWs.The effect of target conditions on the IWs in APPJs is also explored.With a metal target,no residual electric field is observed before imposing the high-voltage pulses.However,with a dielectric target,the residual surface charges generate a back-ground electric field in the opposite direction to that during IW propagation.In the free APPJ(with no target),on the voltage falling edge,a negative electric field drives the electron flow to compensate the positive ions left over during the forward IW propa-gation on the voltage rising edge. | Bangdou Huang Cheng Zhang Wenchao Zhu Xinpei Lu Tao Shao | 2021 | High Voltage2021，6，4： | 1 |
| 20 | Trihalomethanes formation in water treated with chlorine Dioxide 显示文摘 | Jun Wen Li Zuobin Yu Xinpei Cai | 1996 | Water Research1996，30，10： | 1 |
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