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| 1 | Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis显示文摘Many randomized clinical controlled trials have confirmed the efficacy and safety of calcium dobesilate in treating diabetic retinopathy(DR).This systematic review critically evaluated the evidence that links calcium dobesilate to DR.In this fixed-effects meta-analysis,a total of 221 pertinent English-language articles published between January 1975 and October 2013 were identified.Systematic searches of PUBMED,Springer Link and the Cochrane Clinical Trials Database were conducted using the keywords 'diabetic retinopathy' and 'calcium dobesilate'.The extracted information included the study design,inclusion and exclusion criteria,setting,sample size,participant mean age,treatment regime,mean change in best corrected visual acuity,laboratory parameters,capillary fragility,intraocular pressure and fundus manifestations based on the findings of fluorescent angiography.The summary statistics indicated that calcium dobesilate was significantly associated with improving retinal microaneurysms(RR: 0.62,95%CI: 0.42?0.90,P=0.01),retinalhemorrhages(RR: 0.39,95% CI: 0.17?0.88,P=0.02); exudates(RR: 0.31,95% CI: 0.12?0.81,P=0.02),reduction of whole blood viscosity(MD: ?0.57 CP,95% CI: ?0.75 to ?0.38,P<0.001),plasma viscosity(MD: ?0.36 CP,95% CI: ?0.63 to ?0.09,P=0.01) and blood cholesterol(MD: ?0.48 mg m L?1,95% CI: ?0.64?0.33,P<0.00001).Intraocular pressure was also significantly reduced(MD: ?5.59 mm Hg,95% CI: ?6.69 to ?4.50,P<0.00001).The results indicate that calcium dobesilate effectively treats DR at the systematic and local ocular levels. | ZHANG XinYuan LIU Wei WU ShanShan JIN JingLong LI WeiHong Wang NingLi | 2015 | Science China(Life Sciences)2015，58，1： | 54 |
| 2 | Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins显示文摘蛋白质治疗,治疗学的蛋白质在那里被交付对待混乱,为治疗疾病被认为最安全、很直接的途径。然而,它的应用被有效策略的少量高度为在他们的管理以后在 vivo 交付蛋白质和治疗学的蛋白质的快速的清理限制。这里,我们表明能显著地延长治疗学的蛋白质的发行量时间以及最小化他们的 immunogenicity 的新奇策略。这被与抵抗蛋白质吸附的 crosslinked phosphorylcholine 聚合物的薄层包含单个蛋白质分子完成。通过广泛的细胞的研究,我们证明 crosslinked phosphorylcholine 聚合物壳有效地阻止包含的蛋白质是由巨噬细胞的 phagocytosed,它在 vivo 在 nanoparticles 的清理起一个必要作用。而且,聚合物壳阻止包含的蛋白质被有免疫力的房间识别。作为结果,对治疗学的蛋白质的有免疫力的回答有效地被压制。这个工作描述一个可行方法延长循环时间并且减少治疗学的蛋白质的 immunogenicity,它可以在多样的疾病的治疗支持新奇蛋白质治疗的发展和申请。 | Sheng Liang Yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu | 2016 | Nano Research2016，9，4： | 11 |
| 3 | Microstructural evolution and stress state related to mechanical properties of electron beam melted Ti-6Al-4V alloy modified by laser shock peening显示文摘This work characterizes microstructural evolutions of electron beam melted(EBM) Ti-6 Al-4 V alloy modified via laser shock peening(LSP).The depth stress distribution and tensile properties of EBM Ti-6 Al-4 V alloy were measured before and after LSP.The results indicate that microstructure consists of β phase with 7.2%±0.4% vol.% and balance α lamellar in EBM sample,and the α lamella was refined into nano-equiaxed grains and submicro-equiaxed grains after LSP.The dominant refinement mechanism is revealed during LSP.Stacking faults were found in the LSP-treated sample,and their corresponding planes were determined as(0001) basal plane,(1010) prismatic plane,and(1011) pyramidal plane obtained by high resolution transmission electron microscopy.The subgrains and high-angle grains formed during dynamic recrystallization were identified by selected area electron diffraction pattern.The LSP treatment produces a significantly residual compressive stress approximately-380 MPa with the depth of compressive stress layer reaching 450 μm.Strength and elongation of the EBM sample were significantly increased after LSP.The strength and ductility enhancements are attributed to compre s sive stress,grain refinement and grain gradient distribution of α phase. | Liang Lan Xinyuan Jin Shuang Gao Bo He Yonghua Rong | 2020 | Journal of Materials Science & Technology2020，47，15： | 11 |
| 4 | Oligolayered Ti3C2Tx MXene towards high performance lithium/sodium storage显示文摘Nano Research volume 13,pages1659–1667(2020)Cite this article 232 Accesses 3 Citations Metrics details Abstract 2D MXenes are highly attractive for achieving ultrafast and stable lithium/sodium storage due to their good electric conductivity and abundant redox active sites.While,effective strategies for scalable preparation of oligolayered MXenes are still under exploration.Herein,oligolayered Ti3C2Tx MXene is successfully obtained after conventional synthesis of multilayered Ti3C2 and subsequent delamination process via an organic solvent of tetramethyl-ammonium hydroxide(TMAOH).Comprehensive electrochemical study reveals that surface-controlled redox reaction dominated the charge storage behavior of oligolayered Ti3C2Tx with fast reaction kinetics.Impressively,the obtained oligolayered Ti3C2Tx exhibits excellent lithium/sodium storage performance,featured for a high specific capacity of 330 mAhg^−1 at 1.0 Ag^−1 after 800 cycles for lithium storage and 280 mAhg^−1 at 0.5 Ag^−1 after 500 cycles for sodium storage.Such impressive performance will advance the development of oligolayered Ti3C2Tx based materials for lithium/sodium storage and even broaden their application into energy storage. | Xiaolan Song Hui Wang Shengming Jin Miao Lv Ying Zhang Xiaodong Kong Hongmei Xu Ting Ma Xinyuan Luo Hengfeng Tan Dong Hu Chaoyong Deng Xinghua Chang Jianlong Xu | 2020 | Nano Research2020，13，6： | 4 |
| 5 | Versatile synthesis of yolk/shell hybrid nanocrystals via ion-exchange reactions for novel metal/semiconductor and semiconductor/semiconductor conformations显示文摘Yolk/shell (Y-S) hybrid nanoarchitectures, owing to the interior voids createdfor individualized catalyst applications, have emerged as new candidates foreffectively isolating catalytic species. However, the well-defined hollow interiorswith flexible core and shell compositions--such as noble-metal cores, metal-oxidecores, and widespread semiconductor shells--and a flexible anisotropic shapeare far from the requirements. In particular, the introduction of catalytic noblemetals or metal-oxide nanocrystals (NCs) with isotropic or anisotropic shapesinto various hollow semiconductor structures with well-defined morphologieshas been rarely reported but is urgently needed. Herein, we propose a strategyinvolving the careful sulfuration of as-prepared cavity-free core/shell NCs ormetal-oxide NCs followed by phosphine-initialized cation-exchange reactionsfor preparing metal@semiconductor and metal oxide@semiconductor (II-VI) Y-SNCs. The geometry, size, and conformations of the core and shell are fully andindependently considered. New and unprecendented metal@semiconductorand metal oxide@semiconductor (II-VI) Y-S NCs are prepared via widespreadDhosDhine-initialized cation-exchange reactions. | Muwei Ji Xinyuan Li Hongzhi Wang Liu Huang Meng Xu Jia Liu Jiajia Liu Jin Wang Jiatao Zhang | 2017 | Nano Research2017，10，9： | 4 |
| 6 | Temperature dependent conductivity of Bi_4Ti_3O_(12) ceramics induced by Sr dopants显示文摘Bi_4Ti_3O_(12) is an important lead-free ferroelectric material.Doping modification of Bi_4Ti_3O_(12)has attracted great attention to improving its performances.In this work,the effect of Sr dopants on the microstructure,dielectric,and conductivity of Bi_4Ti_3O_(12) ceramic was investigated by XRD,SEM,and AC impedance spectroscopy.Substitution of 1 at%Sr for Bi decreased the grain size,suppressed the dielectric dispersion of Bi_4Ti_3O_(12) ceramic at room temperature,and resulted in different effects on the conductivity of grains and grain boundaries.The conductivity of grains in Bi_4Ti_3O_(12) ceramic was increased by the small amount of Sr dopants in the whole experimental temperature range.While the grain boundaries of 1 at%Sr-doped Bi_4Ti_3O_(12) exhibited lower conductivity than pure Bi_4Ti_3O_(12) below~380℃and higher conductivity above~380℃.The experimental phenomena were interpreted in term of compensating defects for Sr dopants. | Lin WANG Mengqi GUI Hai-Bo JIN Xinyuan HU Yongjie ZHAO Naseer Muhammad ADNAN Jing-Bo LI | 2018 | Journal of Advanced Ceramics2018，7，3： | 3 |
| 7 | Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells显示文摘Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).In addition,suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2(LAMP-2A)in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation,and as expected,LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation.This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10(CXCL10),which recruits inflammatory cells,especially T cells,to MSCs,and inducible nitric oxide synthase(iNOS),which leads to the subsequent inhibition of T cell proliferation via nitric oxide(NO).Mechanistically,CMA inhibition dramatically promoted IFN-γplus TNF-α-induced activation of NF-κB and STAT1,leading to the enhanced expression of CXCL10 and iNOS in MSCs.Furthermore,we found that IFN-γplus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs.More interestingly,CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury.Taken together,our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines nd highlighted a previously unknown function of CMA. | Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 8 | Spatial Distribution of Archaeological Sites in Lakeshore of Chaohu Lake in China Based on GIS显示文摘There are about 19 Neolithic Age sites and 120 Shang-Zhou dynasties sites in the western lakeshore of Chaohu Lake,Anhui Province,China.Based on sites data,topographic data,drainage maps,administrative maps and SPOT5 remote sensing data,spatial analysis methods were introduced into the archaeology of Chaohu Lake Basin with Geographic Information System(GIS).The spatial analysis methods include:1) Point Density Analysis with density model to acquire the shift of the sites;2) Distance Analysis to reveal the spatial structure of the sites;3) 3D Analysis based on Digital Elevation Model to get micro-geomorphologic features of the sites;and 4) Buffer Analysis to discover the relationship between the sites and rivers.The results indicate that the archaeological sites spread from the western lakeshore of Chaohu Lake gradually to the northwest,later to the south,and then symmetrically spread.Controlled by productive forces and other factors,ancient people preferred to reside in those places near water,or in plain and fertile land,which resulted in linear and decentralized distribution of the sites,and presented such disciplines as river valley directivity,terrace directivity and soil directivity.This paper indicates that the distribution of archaeological sites was influenced earlier by natural elements and later by human elements in the study period.The research is important for the integration of GIS and archaeology. | GAO Chao WANG Xinyuan JIANG Tong JIN Gaojie | 2009 | Chinese Geographical Science2009，19，4： | 1 |
| 9 | Influence of multiple laser shock peening treatments on the microstructure and mechanical properties of Ti-6Al-4V alloy fabricated by electron beam melting显示文摘Laser shock peening(LSP)is an attractive post-processing method to tailor surface microstructure and enhance mechanical performances of additive manufactured(AM)components.The effects of multiple LSP treatments on the microstructure and mechanical properties of Ti-6Al-4V part produced by electron beam melting(EBM),as a mature AM process,were studied in this work.Microstructure,surface topography,residual stress,and tensile performance of EBM-manufactured Ti-6Al-4V specimens were systematically analyzed subjected to different LSP treatments.The distribution of porosities in EBM sample was assessed via X-ray computed tomography.The results showed that EBM samples with two LSP treatments possessed a lower porosity value of 0.05%compared to the value of 0.08%for the untreated samples.The strength of EBM samples with two LSP treatments was remarkably raised by 12%as compared with the as-built samples.The grains ofαphase were refined in near-surface layer,and a dramatic increase in the depth and magnitude of compressive residual stress(CRS)was achieved in EBM sample with multiple LSP treatments.The grain refinement ofαphase and CRS with larger depth were responsible for the strength enhancement of EBM samples with two LSP treatments. | Liang Lan Ruyi Xin Xinyuan Jin Shuang Gao Bo He | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，9： | 1 |
| 10 | Supramolecular nanoscale drug-delivery system with ordered structure显示文摘Supramolecular chemistry provides a means to integrate multi-type molecules leading to a dynamic organization.The study of functional nanoscale drug-delivery systems based on supramolecular interactions is a recent trend.Much work has focused on the design of supramolecular building blocks and the engineering of supramolecular integration,with the goal of optimized delivery behavior and enhanced therapeutic effect.This review introduces recent advances in supramolecular designs of nanoscale drug delivery.Supramolecular affinity can act as a main driving force either in the self-assembly of carriers or in the loading of drugs.It is also possible to employ strong recognitions to achieve self-delivery of drugs.Due to dynamic controllable drug-release properties;the supramolecular nanoscale drug-delivery system provides a promising platform for precision medicine. | Xin Jin Lijuan Zhu Bai Xue Xinyuan Zhu Deyue Yan | 2019 | National Science Review2019，6，6： | 1 |
| 11 | Genetic polymorphisms of transforming growth factor-β1 and its receptors and colorectal cancer susceptibility: A population-based case-control study in China显示文摘 | Yongjing Zhang Bing Liu Mingjuan Jin Qin Ni Xia Liang Xinyuan Ma Kaiyan Yao Qilong Li Kun Chen | 2008 | Cancer Letters2008，，： | 1 |
| 12 | Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation显示文摘Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation(AST).However,it remains largely unknown how Lkb1 deficiency dynamically regulates AST.Using the classical AST mouse model(Kras LSL-G12D/+;Lkb1flox/flox,KL),we here comprehensively analyze the temporal transcriptomic dynamics of lung tumors at different stages by dynamic network biomarker(DNB)and identify the tipping point at which the Wnt signaling is abruptly suppressed by the excessive accumulation of reactive oxygen species(ROS)through its downstream effector FOXO3A.Bidirectional genetic perturbation of the Wnt pathway using two different Ctnnb1 conditional knockout mouse strains confirms its essential role in the negative regulation of AST.Importantly,pharmacological activation of the Wnt pathway before but not after the tipping point inhibits squamous transdifferentiation,highlighting the irreversibility of AST after crossing the tipping point.Through comparative transcriptomic analyses of mouse and human tumors,we find that the lineage-specific transcription factors(TFs)of adenocarcinoma and squamous cell carcinoma form a“Yin-Yang”counteracting network.Interestingly,inactivation of the Wnt pathway preferentially suppresses the adenomatous lineage TF network and thus disrupts the“Yin-Yang”homeostasis to lean towards the squamous lineage,whereas ectopic expression of NKX2-1,an adenomatous lineage TF,significantly dampens such phenotypic transition accelerated by the Wnt pathway inactivation.The negative correlation between the Wnt pathway and AST is further observed in a large cohort of human lung adenosquamous carcinoma.Collectively,our study identifies the tipping point of AST and highlights an essential role of the ROS-Wnt axis in dynamically orchestrating the homeostasis between adeno-and squamous-specific TF networks at the AST tipping point. | Zhaoyuan Fang Xiangkun Han Yueqing Chen Xinyuan Tong Yun Xue Shun Yao Shijie Tang Yunjian Pan Yihua Sun Xue Wang Yujuan Jin Haiquan Chen Liang Hu Lijian Hui Lin Li Luonan Chen Hongbin Ji | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 13 | Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis显示文摘Small-cell lung cancer(SCLC)is a recalcitrant cancer characterized by high metastasis.However,the exact cell type contributing to metastasis remains elusive.Using a Rb1^(L/L)/Trp53^(L/L) mouse model,we identify the NCAM^(hi)CD44^(lo/–) subpopulation as the SCLC metastasizing cell(SMC),which is progressively transitioned from the non-metastasizing NCAM^(lo)CD44^(hi) cell(non-SMC).Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex,and knockout of its central component,Brg1,significantly inhibits such phenotypic transition and metastasis.Mechanistically,TAZ is silenced by the SWI/SNF complex during SCLC malignant progression,and its knockdown promotes SMC transition and metastasis.Importantly,ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates metastasis.Single-cell RNA-sequencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis,and immunostaining data show a positive correlation between TAZ and patient prognosis.These data uncover high SCLC plasticity and identify TAZ as the key molecular switch in orchestrating SCLC phenotypic transition and metastasis. | Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman KThomas Kwok-Kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji | 2022 | National Science Review2022，9，7： | 0 |
| 14 | Interfacial engineering of metallic rhodium by thiol modification approach for ambient electrosynthesis of ammonia显示文摘Here we report a vapor-phase reaction approach to fabricate rhodium(I)-dodecanethiol complex coated on carbon fiber cloth(Rh(I)-SC_(12)H_(25)/CFC),followed by low-temperature pyrolysis to achieve dodecanethiol modified Rh(Rh@SC_(12)H_(2)5/CFC)for electrocatalytic nitrogen reduction reaction(NRR).The results demonstrate that after pyrolysis for 0.5 h at 150℃,the obtained Rh@SC_(12)H_(2)5/CFC-0.5 exhibits excellent NRR activity with an NH3 yield rate of 121.2±6.6μg∙h^(−1)∙cm^(−2)(or 137.7±7.5μg∙h^(−1)∙mgRh^(−1))and a faradaic efficiency(FE)of 51.6%±3.8%at−0.2 V(vs.RHE)in 0.1 M Na_(2)SO_(4).The theoretical calculations unveil that the adsorption of dodecanethiol on the hollow sites of Rh(111)plane is thermodynamically favorable,effectively regulating the electronic structure and surface wettability of metallic Rh.Importantly,the dodecanethiol modification on Rh(111)obviously decreases the surface H*coverage,thus inhibiting the competitive hydrogen evolution reaction and concurrently reducing the electrocatalytic NRR energy barrier. | Meng Jin Xinyuan Zhang Xian Zhang Hongjian Zhou Miaomiao Han Yunxia Zhang Guozhong Wang Haimin Zhang | 2022 | Nano Research2022，15，10： | 0 |
| 15 | Electric-controlled pressure relief valve for enhanced safety in liquid-cooled lithium-ion battery packs显示文摘The liquid-cooled battery energy sto rage system(LCBESS) has gained significant attention due to its superior thermal management capacity.However,liquid-cooled battery pack(LCBP) usually has a high sealing level above IP65,which can trap flammable and explosive gases from battery thermal runaway and cause explosions.This poses serious safety risks and challenges for LCBESS.In this study,we tested overcharged battery inside a commercial LCBP and found that the conventionally mechanical pressure relief valve(PRV) on the LCBP had a delayed response and low-pressure relief efficiency.A realistic 20-foot model of an energy storage cabin was constructed using the Flacs finite element simulation software.Comparative studies were conducted to evaluate the pressure relief efficiency and the influence on neighboring battery packs in case of internal explosions,considering different sizes and installation positions of the PRV.Here,a newly developed electric-controlled PRV integrated with battery fault detection is introduced,capable of starting within 50 ms of the battery safety valve opening.Furthermore,the PRV was integrated with the battery management system and changed the battery charging and discharging strategy after the PRV was opened.Experimental tests confirmed the efficacy of this method in preventing explosions.This paper addresses the safety concerns associated with LCBPs and proposes an effective solution for explosion relief. | Yuhang Song Jidong Hou Nawei Lyu Xinyuan Luo Jingxuan Ma Shuwen Chen Peihao Wu Xin Jiang Yang Jin | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 16 | Correction to:Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis显示文摘This is a correction to:Yujuan Jin,Qiqi Zhao,Weikang Zhu,Yan Feng,Tian Xiao,Peng Zhang,Liyan Jiang,Yingyong Hou,Chenchen Guo,Hsinyi Huang,Yabin Chen,Xinyuan Tong,Jiayu Cao,Fei Li,Xueliang Zhu,Jun Qin,Dong Gao,Xin-Yuan Liu,Hua Zhang,Luonan Chen,Roman K Thomas,Kwok-Kin Wong,Lei Zhang,Yong Wang,Liang Hu,Hongbin Ji,Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis,National Science Review,Volume 9,Issue 7,July 2022,nwab232,https://doi.org/10.1093/nsr/nwab232. | Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman KThomas Kwok-Kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji | 2023 | National Science Review2023，10，12： | 0 |
| 17 | DDUC:an erasure-coded system with decoupled data updating and coding显示文摘In distributed storage systems,replication and erasure code(EC)are common methods for data redundancy.Compared with replication,EC has better storage efficiency,but suffers higher overhead in update.Moreover,consistency and reliability problems caused by concurrent updates bring new challenges to applications of EC.Many works focus on optimizing the EC solution,including algorithm optimization,novel data update method,and so on,but lack the solutions for consistency and reliability problems.In this paper,we introduce a storage system that decouples data updating and EC encoding,namely,decoupled data updating and coding(DDUC),and propose a data placement policy that combines replication and parity blocks.For the(N,M)EC system,the data are placed as N groups of M+1 replicas,and redundant data blocks of the same stripe are placed in the parity nodes,so that the parity nodes can autonomously perform local EC encoding.Based on the above policy,a two-phase data update method is implemented in which data are updated in replica mode in phase 1,and the EC encoding is done independently by parity nodes in phase 2.This solves the problem of data reliability degradation caused by concurrent updates while ensuring high concurrency performance.It also uses persistent memory(PMem)hardware features of the byte addressing and eight-byte atomic write to implement a lightweight logging mechanism that improves performance while ensuring data consistency.Experimental results show that the concurrent access performance of the proposed storage system is 1.70–3.73 times that of the state-of-the-art storage system Ceph,and the latency is only 3.4%–5.9%that of Ceph. | Yaofeng TU Rong XIAO Yinjun HAN Zhenghua CHEN Hao JIN Xuecheng QI Xinyuan SUN | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，5： | 0 |
| 18 | Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo显示文摘Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour metastasis.SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic cancer.However,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be discovered.Here,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/L.Moreover,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/L.The allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural analyses.Importantly,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver metastasis.To our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic cancer.It not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer. | Xinyuan Xu Qian Zhang Xufeng Wang Jing Jin Chengwei Wu Li Feng Xiuyan Yang Mingzhu Zhao Yingyi Chen Shaoyong Lu Zhen Zheng Xiaobing Lan Yi Wang Yan Zheng Xuefeng Lu Qiufen Zhang Jian Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 19 | Petroleum enrichment characteristics in Ordovician carbonates in Lunnan area of Tarim Basin显示文摘Lunnan heave had experienced denudation during late Caledonian and Hercynian movements and reconstruction during Indosinian movement. Lunnan heave and its circumference areas are located on the direction of petroleum migration, and experienced three reservoir formation cycles that are divided by wave cycle: The first reservoir formation cycle is characterized by breakage, the second by alteration, and the third by enrichment. Three layers of dissolving-cave developed on the vertical in Lunnan area. Development degree of slit-cave system and their connectivity are important factors to control petroleum enrichment in the weathering crust reservoir. The area where dissolving-caves are communicated by silts and faults was a fine petroleum enrichment area, and water was often encountered in the area with isolation cave while drilling because of no oil and gas origin. The top part of the faulted-horst as a leaking area is bearing water area, and the higher part of slope nearing the top part of the | LU Xiuxiang JIN Zhijun ZHOU Xinyuan YANG Ning WANG Qinghua PAN Wenqing | 2004 | Chinese Science Bulletin2004，49，S1： | 0 |
| 20 | Increased Oxygen Evolution Activity in pH-Universal Electrocatalyst: Urea-Modified NiFeCoCN Medium-Entropy Alloy显示文摘The kinetic process of a slow oxygen evolution reaction (OER) always constrains the efficiency of overall water electrolysis for H2 production.In particular,nonprecious metal electrodes for the OER have difficulty in possessing excellent electrocatalytic activity and stability in pH-universal media simultaneously.In this work,urea is first used as a pore-forming agent and active C/N source to fabricate a nanoporous NiFeCoCN medium-entropy alloy (MEA) by high-temperature sintering based on the nanoscale Kirkendall effect.The NiFeCoCN MEA achieves an overpotential of 432 mV at a current density of 10 mA·cm^(-2) and a lower Tafel slope of 52.4 mV·dec^(-1) compared to the IrO_(2)/Ti electrode (58.6 mV·dec^(-1)) in a 0.5 mol/L H_(2)SO_(4) solution.In a 1 mol/L KOH solution,the NiFeCoCN MEA obtains an overpotential of 175 mV for 10 mA·cm^(-2) and a Tafel slope of 40.8 mV·dec^(-1),which is better than IrO_(2)/Ni foam.This work proves a novel strategy to design and prepare nanoporous MEA materials with desirable C/N species,which provides promising prospects for the industrial production of H2 energy. | Hongwei Lv Zhiguo Ye Feng Pei Xinyuan Peng Juntong Huang Duosheng Li Zhong Jin | 2023 | Chinese Journal of Chemistry2023，41，23： | 0 |
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