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| 1 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 2 | Tectonic types and evolution of Ordovician proto-type basins in the Tarim region显示文摘The Ordovician system is an important target for exploration in the Tarim Basin. Restoration of the Ordovician tectono-depositional environment is a key basis for the study of the structural development history in Tarim block and the prediction of the favorable Ordovician reservoir belts (zones). Based on the surrounding tectonic settings, the litho-facies and sedimentary fill, the palaeo-geography, palaeoclimate and palaeo-ecology, and the structural deformation and magmatic eruptions, in this paper we combine the sedimentary fill in the basin with the development of the surrounding orogenic belts and re-build the proto-type basins of the different Ordovician periods. During the Ordovician period, the Tarim region was characterized by the composite of the interior cratonic depression with the peripheral cratonic depression. The interior cratonic depression in the central and western parts is mainly the depositional area of the platform facies while the peripheral cratonic depression in the eastern part is mainly the zone of deepwater basin facies, with the slope acting as the transition belt between them. During the Late Ordovician period, the closure of the Northern Kunlun Ocean and destruction of the trencharc-basin system in the Altyn Tagh region put the southern part of the Tarim block under compression and uplifting and turned the central and western parts of the carbonate platform into the mixed depositional continental shelf. The eastern region of the basin had the over-compensated flysch sedimentation with huge thickness, marking the drastic turn of the basin nature. The basin tectonic framework turned to the south-north differentiation of the Silurian period from the east-west differentiation of the Ordovician period. | HE DengFa ZHOU XinYuan ZHANG ChaoJun YANG XiaoFa | 2007 | Chinese Science Bulletin2007，52，A01： | 15 |
| 3 | Characteristics of carbonate gas pool and multistage gas pool formation history of Hetianhe gas field, Tarim Basin, Northwest China显示文摘Hetianhe is a big carbonate gas field which isfound and demonstrated in the period of 'Chinese NationalNinth 5-Year Plan'. The proved reserve of Hetianhe gas fieldis over 600 ×10~8 m^3. Its main producing layers are Carbon-iferous bioclastic limestone and Ordovician carbonate com-posed of buried hill. The former is stratified gas pool withwater around its side, and the latter is massive gas pool withwater in its bottom. The gases in the gas pools belong to drygases with normal temperature and pressure systems. Basedon the correlation of gas and source rock, the gases aremainly generated from Cambrian source rocks. According tothe researches on source rock and structure evolution, andthe observations on the thin section to reservoir bitumen andthe studies on homogenization temperature of fluid inclu-sions, the gas pool has been identified and divided into threeformation periods. The first is Late Caledonian when the oilgenerated from the Cambrian source rocks and migratedalong faults, as a form of liquid facies into Ordovician carbonate res-ervoir and accumulated there. After that, the crustuplifted, the oil reservoir had been destroyed. The second isLate Hercynian when condensate gases generated from theCambrian source rocks and migrated into Ordovician res-ervoir, as a form of liquid facies. Since the fractures hadreached P strata, so the trap might have a real poor preser-vation condition, and the large-scale gas pool formation hadnot happened. The third gas reservoir formation period oc-curred in Himalaya. The fractures on both sides of Hetianhegas field developed violently under the forces of compression,and thus the present fault horst formed. The dry gases gen-erated from Cambrian source rocks and migrated upwardsas the form of gas facies into Ordovician and Carboniferousreservoirs, and the large gas pool as discovered at presentwas formed finally. | ZHOU Xinyuan JIA Chengzao WANG Zhaoming WANG Qinghua YANG Wei | 2002 | Chinese Science Bulletin2002，47，S1： | 13 |
| 4 | Transcriptional analysis and histochemistry reveal that hypersensitive cell death and H2O2 have crucial roles in the resistance of tea plant (Camellia sinensis (L.) O. Kuntze) to anthracnose显示文摘Anthracnose causes severe losses of tea production in China.Although genes and biological processes involved in anthracnose resistance have been reported in other plants,the molecular response to anthracnose in tea plant is unknown.We used the susceptible tea cultivar Longjing 43 and the resistant cultivar Zhongcha 108 as materials and compared transcriptome changes in the leaves of both cultivars following Colletotrichum fructicola inoculation.In all,9015 and 8624 genes were differentially expressed between the resistant and susceptible cultivars and their controls(0 h),respectively.In both cultivars,the differentially expressed genes(DEGs)were enriched in 215 pathways,including responses to sugar metabolism,phytohormones,reactive oxygen species(ROS),biotic stimuli and signalling,transmembrane transporter activity,protease activity and signalling receptor activity,but DEG expression levels were higher in Zhongcha 108 than in Longjing 43.Moreover,functional enrichment analysis of the DEGs showed that hydrogen peroxide(H2O2)metabolism,cell death,secondary metabolism,and carbohydrate metabolism are involved in the defence of Zhongcha 108,and 88 key genes were identified.Protein–protein interaction(PPI)network demonstrated that putative mitogen-activated protein kinase(MAPK)cascades are activated by resistance(R)genes and mediate downstream defence responses.Histochemical analysis subsequently validated the strong hypersensitive response(HR)and H2O2 accumulation that occurred around the hyphal infection sites in Zhongcha 108.Overall,our results indicate that the HR and H2O2 are critical mechanisms in tea plant defence against anthracnose and may be activated by R genes via MAPK cascades. | Yuchun Wang Xinyuan Hao Qinhua Lu Lu Wang Wenjun Qian Nana Li Changqing Ding Xinchao Wang Yajun Yang | 2018 | Horticulture Research2018，5，1： | 11 |
| 5 | Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins显示文摘蛋白质治疗,治疗学的蛋白质在那里被交付对待混乱,为治疗疾病被认为最安全、很直接的途径。然而,它的应用被有效策略的少量高度为在他们的管理以后在 vivo 交付蛋白质和治疗学的蛋白质的快速的清理限制。这里,我们表明能显著地延长治疗学的蛋白质的发行量时间以及最小化他们的 immunogenicity 的新奇策略。这被与抵抗蛋白质吸附的 crosslinked phosphorylcholine 聚合物的薄层包含单个蛋白质分子完成。通过广泛的细胞的研究,我们证明 crosslinked phosphorylcholine 聚合物壳有效地阻止包含的蛋白质是由巨噬细胞的 phagocytosed,它在 vivo 在 nanoparticles 的清理起一个必要作用。而且,聚合物壳阻止包含的蛋白质被有免疫力的房间识别。作为结果,对治疗学的蛋白质的有免疫力的回答有效地被压制。这个工作描述一个可行方法延长循环时间并且减少治疗学的蛋白质的 immunogenicity,它可以在多样的疾病的治疗支持新奇蛋白质治疗的发展和申请。 | Sheng Liang Yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu | 2016 | Nano Research2016，9，4： | 11 |
| 6 | High-dimensional orbital angular momentum multiplexing nonlinear holography显示文摘Nonlinear holography has been identified as a vital platform for optical multiplexing holography because of the appearance of new optical frequencies.However,due to nonlinear wave coupling in nonlinear optical processes,the nonlinear harmonic field is coupled with the input field,laying a fundamental barrier to independent control of the interacting fields for holography.We propose and experimentally demonstrate high-dimensional orbital angular momentum(OAM)multiplexing nonlinear holography to overcome this problem.By dividing the wavefront of the fundamental wave into different orthogonal OAM channels,multiple OAM and polarization-dependent holographic images in both the fundamental wave and second-harmonic wave have been reconstructed independently in the spatial frequency domain through a type-II second harmonic generation process.Moreover,this method can be easily extended to cascadedχ2 nonlinear optical processes for multiplexing in more wavelength channels,leading to potential applications in multicasting in optical communications,multiwavelength display,multidimensional optical storage,anticounterfeiting,and optical encryption. | Xinyuan Fang Haocheng Yang Wenzhe Yao Tianxin Wang Yong Zhang Min Gu Min Xiaoa | 2021 | Advanced Photonics2021，3，1： | 8 |
| 7 | N-Acetyl-D-glucosamine improves the intestinal development and nutrient absorption of weaned piglets via regulating the activity of intestinal stem cells显示文摘Early weaning in piglets can cause a series of negative effects.This causes serious losses to the livestock industry.N-Acetyl-D-glucosamine(D-GlcNAc)plays an important role in regulating the homeostasis of the intestine.This study aimed to investigate the effects of D-GlcNAc on the growth performance and intestinal function of weaned piglets.Twenty-four weaned piglets([Yorkshire×Landrace]Duroc,6.58±0.15 kg,n=8)at 21 d old were fed 3 diets supplemented with 0(control),1 and 3 g/kg D-GlcNAc.The intestinal organoid model was used to verify the regulatory mechanism of D-GlcNAc on intestinal epithelial cells.On the whole,supplementation of D-GlcNAc in the piglet diet has no significant effect on the growth performance and diarrhoea of weaned piglets(P>0.05).The apparent digestibility of nutrients and mRNA abundance of nutrient transporters in the 1 g/kg D-GlcNAc group were increased significantly(P<0.05).D-GlcNAc did not affect villus height(VH)and crypt depth(CD)but resulted in a numerically shorter VH and shallower CD,which lead to an increase in ileal VH:CD ratio(P<0.05).Cell shedding rates in the ileum villi increased(P<0.05).The relative length and weight of the small intestine of weaned piglets increased(P<0.05).In vitro studies found that the budding rates of organoids treated with 0.1 mmol/L D-GlcNAc increased on the d 3 and 5(P<0.05).The average budding numbers per budding organoid treated with 0.1 and 10 mmol/L D-GlcNAc increased on d 3(P<0.05).D-GlcNAc upregulated leucine rich repeat containing G protein-coupled receptor 5(Lgr5^(+))and Chromogranin A mRNA abundance in organoids(P<0.05).Mucin 2(Muc2)expression increased when treated with 1 and 10 mmol/L D-GlcNAc(P<0.05).In conclusion,dietary D-GlcNAc cannot improve the growth performance of weaned piglets.However,it can promote the growth and development of the intestinal tract and improve the digestion and absorption capacity of the intestine,which is achieved by affecting the activity of intestinal stem cells. | Zhaobin Wang Jie Hu Xinyuan Yang Lanmei Yin Min Wang Yuebang Yin Jianzhong Li Huansheng Yang Yulong Yin | 2022 | Animal Nutrition2022，，1： | 6 |
| 8 | Prolonging the plasma circulation of proteins by nano- encapsulation with phosphorylcholine-based polymer显示文摘突然在 vivo 循环是到蛋白质治疗学的普遍采纳的一个主要阻碍者。经由显著地展出的一个二拍子的圆舞封装过程与基于 phosphorylcholine 的聚合物的薄层包含蛋白质产生的蛋白质 nanocapsules 延长了血浆半衰期。而且,由与类似的尺寸构造 nanocapsules 但是不同表面费用和化学,我们为延长治疗学的蛋白质的血浆半衰期表明了通用策略。在里面一在里面 vitro 实验,牛的浆液白朊(BSA ) 的四种类型 nanocapsules 在磷酸盐缓冲区与胎儿的牛的浆液(FBS ) 被孵化盐(PBS ) ;由 HeLa 房间的房间举起被监视系统地在循环期间评估表面化学的特征。单个正电子排放计算断层摄影术的断层摄影术(SPECT ) 被采用在静脉内的管理以后在血浆集中的 vivo,以及 quantification 允许 BSA nanoparticle 分发的即时观察。这研究为为临床的使用翻译大量蛋白质提供一个实际方法。 | Linlin Zhang Yang Liu Gan Liu Duo Xu Sheng Liang Xinyuan Zhu Yunfeng Lu Hui Wang | 2016 | Nano Research2016，9，8： | 4 |
| 9 | Fractured reservoir modeling by discrete fracture network and seismic modeling in the Tarim Basin,China显示文摘Fractured reservoirs are an important target for oil and gas exploration in the Tarim Basin and the prediction of this type of reservoir is challenging.Due to the complicated fracture system in the Tarim Basin,the conventional AVO inversion method based on HTI theory to predict fracture development will result in some errors.Thus,an integrated research concept for fractured reservoir prediction is put forward in this paper.Seismic modeling plays a bridging role in this concept,and the establishment of an anisotropic fracture model by Discrete Fracture Network (DFN) is the key part.Because the fracture system in the Tarim Basin shows complex anisotropic characteristics,it is vital to build an effective anisotropic model.Based on geological,well logging and seismic data,an effective anisotropic model of complex fracture systems can be set up with the DFN method.The effective elastic coefficients,and the input data for seismic modeling can be calculated.Then seismic modeling based on this model is performed,and the seismic response characteristics are analyzed.The modeling results can be used in the following AVO inversion for fracture detection. | Sam Zandong Sun Zhou Xinyuan Yang Haijun Wang Yueying WangDi Liu Zhishui | 2011 | Petroleum Science2011，8，4： | 4 |
| 10 | Effects of cerium substitution on phase components, microstructures and magnetic properties of Nd-Fe-Ti-B alloy显示文摘(Nd(1-x)Cex)(12)Fe(77)Ti5B6(x=0,0.2,0.3,0.4,0.6,0.8)alloys were prepared by melt-spinning and annealing techniques.The phase constitutions,microstructures and magnetic properties were investigated by powder X-ray diffraction(XRD),a differential scanning calorimeter(DSC),a vibrating sample magnetometer(VSM)and a transmission electron microscope(TEM).It is found that with the increase of Ce content,the coercivity of the(Nd(1-x)Cex)(12)Fe(77)Ti5B6 alloys reaches maximum first and then decreases.The maximum coercivity reaches 18.5 kOe obtained in the sample of 20%Ce substituted which is 34%higher than the Ce-free sample.TEM results reveal that the micro structure refinement effect is responsible for the coercivity improvement.This phenomenon implies that in some cases,Ce and Ti co-doping is more beneficial to improving of the coercivity than Ti single doping in Nd-Fe-B alloys.With further Ce addition,magnetic properties deteriorate due to the formation of CeFe2 and TbCu7-type phases. | Haijun Peng Yang Luo Yakun Dou Xinyuan Bai Wenlong Yan Dunbo Yu Yuanfei Yang Shulin Diao | 2019 | Journal of Rare Earths2019，37，8： | 4 |
| 11 | OsbZIP60-mediated unfolded protein response regulates grain chalkiness in rice显示文摘Grain chalkiness,an undesirable trait caused by complex factors,has great negative impacts on the quality and economic value of rice.However,little is known about the regulatory mechanism of grain chalkiness,particularly the effect of endoplasmic reticulum(ER)stress.Here,a genome-wide association study(GWAS)reveals that the transcription factor Osb ZIP60 is a vital regulator of rice grain chalkiness.Genetic analysis demonstrates that knockout of Osb ZIP60 results in extremely high grain chalkiness and aberrant structure of storage substances.Notably,the expression of unfolded protein response(UPR)genes,such as OsbZIP50,Os Bi P1,Os Bi P2 and Os Bi P3,is up-regulated in the endosperm cells of osbzip60,and overexpression of all these UPR genes causes various degrees of chalkiness.Furthermore,Osb ZIP60 is found to activate the expression of key genes related to grain chalkiness,such as GPA3,FSE1,FLO7,Chalk5,Os NF-YB1,and Os PK2,whose expression is significantly suppressed in osbzip60 and overexpression lines of Osb ZIP50,Os Bi P1,Os Bi P2,and Os Bi P3.Our study provides novel insights into the function of Osb ZIP60 and the role of the UPR pathway in the formation of grain chalkiness in rice. | Weiping Yang Pengkun Xu Juncheng Zhang Shuo Zhang Zhenwei Li Ke Yang Xinyuan Chang Yibo Li | 2022 | Journal of Genetics and Genomics2022，49，5： | 4 |
| 12 | Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model显示文摘基因类型 1 糖尿病 mellitus 的基于治疗的处理要求能综合并且响应生理的联盟者分泌机能上地活跃的胰岛素的一个代理人贝它房间的发展在周围的葡萄糖层次的相关变化。在这研究,鼠科的 enteroendocrine 房间线 STC-1 被稳定的转染遗传上修改。二个克隆房间被选择(STC-1-2 和 STC-1-14 ) 那在从 0 ~ 157.2 亩 IU/ml/10 (6 ) cells/d 表示胰岛素的 22 克隆之中分泌了胰岛素的高水平。在在文化媒介的葡萄糖集中从 1 公里被增加到 10 公里以后,分泌胰岛素从 40.3 +/- 升起了 0.8 ~ 56.3 +/- 3.2 亩 IU/ml (STC-1-2 ) ,并且从 10.8 +/- 0.8 ~ 23.6 +/- 2.3 亩 IU/ml (STC-1-14 ) 。在 STC-1-14 房间被植入进糖尿病的裸体老鼠以后,他们的血葡萄糖层次被归结为正常。身体重量损失也被改善。我们的数据建议遗传上设计的 K 房间以一种调整葡萄糖的方式分泌活跃胰岛素,并且在 vivo,学习证明多糖症能被房间的培植颠倒,建议到快速的人的胰岛素力量的遗传上设计的 K 房间的使用提供一条调整葡萄糖的途径对待糖尿病的多糖症。 | Yiqun Zhang Liqing Yao Kuntang Shen Meidong Xu Pinghong Zhou Weige Yang Xinyuan Liu Xinyu Qin | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 4 |
| 13 | Increasing prevalence of antibiotic resistance genes in manured agricultural soils in northern China显示文摘Land application of manure tends to result in the dissemination of antibiotic resistance in the environment.In this study,the influence of long-term manure application on the enrichment of antibiotic resistance genes(ARGs)and mobile genetic elements(MGEs)in agricultural soils was investigated.All the analyzed eight ARGs(tetA,tetW,tetX,sull,sulll,ermF,aac(6')-Ib-cr and blaTEM)and two MGEs(intJJ and Tn916/1545)were detected in both the manured and control soils,with relative abundances ranging from 10^-6 to 10^-2 Compared with the control soil,the relative abundances of ARGs and MGEs in manured soils were enriched 1.0-18.1 fold and 0.6-69.1 fold,respectively.High-throughput sequencing analysis suggested that at the phylum level,the bacteria carrying intll and ermF might be mainly affiliated with Proteobacteria and Bacteroides,respectively.The dominant genera carrying intll and ermF cow\d be Pseudomonas and Bacteroides,independent of manure application.Correlation analysis revealed that ARGs had strong links with soil physicochemical properties(TC,TN,and OM),heavy metals(Cu,Zn and Pb)and MGEs,indicating that the profile and spread of ARGs might be driven by the combined impacts of multiple factors.In contrast,soil pH and C/N exhibited no significant relationships with ARGs.Our findings provide evidence that long-term manure application could enhance the prevalence and stimulate the propagation of antibiotic resistance in agricultural soils. | Nan Wu Weiyu Zhang Shiyu Xie Ming Zeng Haixue Liu Jinghui Yang Xinyuan Liu Fan Yang | 2020 | Frontiers of Environmental Science & Engineering2020，14，1： | 3 |
| 14 | Large-scale Tazhong Ordovician Reef-flat Oil-Gas Field in the Tarim Basin of China显示文摘Tazhong 礁石公寓油气体地是在中国发现的第一块大规模奥陶纪器官的礁石类型油气体地。它的器官的礁石在早迟了的奥陶纪 Lianglitag 形成被开发,并且是在中国发现的 coral-stromatoporoid hermatypic 社区的第一大礁石。器官的礁石和站台边缘谷物银行组成礁石公寓建筑群,主要由 biolithites 和谷物石头组成。biolithites 能被分类进 framest 那, bafflest,绑石头等等。建筑群的主要身体从 Tazhong-24 躺在井附近到 Tazhong-82, trending 西北与从 100 ~ 300 m 的厚度,长度大约 220 km 和宽度 5 10 km。它是一座礁石公寓石版印刷逻辑烃水库,与很复杂的烃分布:与本地油水库总体上是一座煤气的冷凝物水库。烃分发被礁石建筑群控制,通常定位了在上面建筑群的 100 200 m 部分,并且主要在沿着建筑群的 banded 形状。在侧面上,水库显示出一个成层的特征,与到西北的从东南的几乎 2200 m 的高度差别。石油累积被石灰岩地区常见的地形水库床和东北罢工滑倒差错带控制。全部的地质的储备在 2007 到达了 297.667 山。 | ZHOU Xinyuan WANG Zhaoming YANG Haijun ZHANG Lijuan HAN Jianfa WANG Zhenyu | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 3 |
| 15 | Magnetic properties enhancement of hot-deformed NdFeB magnets by two different methods of CeNdCu diffusion显示文摘Two different ways were used to control the distribution of cerium for the enhancement of coercivity.One was by coating CeNdCu in the prepared magnet and annealing to make CeNdCu diffuse into the grain boundary to increase the coercivity,the other was by mixing CeNdCu with initial magnetic powders and then preparing the hot-deformed magnet.The SEM-EDS result indicates that cerium diffuses more easily into the main phase by the mixing way,while cerium is mainly distributed in the grain boundary via the coating way.The heat-treatment process may be one of the dominant influencing factors for the distribution of Ce,Multi-steps heat treatment in the mixing way,consisting of hot-pressing,hot-deforming and post heat process,easily introduces Ce into the main phase Nd2 Fe14B,which forms the Ce2 Fe14B shell resulting in the decrease of HA.But the coating way can ensure uniform dispersion of Ce in the grain boundary,which leads to the high coercivity. | Guibing Shi Zilong Wang Xinyuan Bai Wenlong Yan Yang Luo Dunbo Yu | 2020 | Journal of Rare Earths2020，38，12： | 3 |
| 16 | Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells显示文摘Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).In addition,suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2(LAMP-2A)in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation,and as expected,LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation.This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10(CXCL10),which recruits inflammatory cells,especially T cells,to MSCs,and inducible nitric oxide synthase(iNOS),which leads to the subsequent inhibition of T cell proliferation via nitric oxide(NO).Mechanistically,CMA inhibition dramatically promoted IFN-γplus TNF-α-induced activation of NF-κB and STAT1,leading to the enhanced expression of CXCL10 and iNOS in MSCs.Furthermore,we found that IFN-γplus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs.More interestingly,CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury.Taken together,our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines nd highlighted a previously unknown function of CMA. | Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 17 | Computational spectropolarimetry with a tunable liquid crystal metasurface显示文摘While conventional photodetectors can only measure light intensity,the vectorial light field contains much richer information,including polarization and spectrum,that are essential for numerous applications ranging from imaging to telecommunication.However,the simultaneous measurement of multi-dimensional light field information typically requires the multiplexing of dispersive or polarization-selective elements,leading to excessive system complexity.Here,we demonstrate a near-infrared spectropolarimeter based on an electrically-tunable liquid crystal metasurface.The tunable metasurface,which acts as an encoder of the vectorial light field,is tailored to support high-quality-factor guided-mode resonances with diverse and anisotropic spectral features,thus allowing the full Stokes parameters and the spectrum of the incident light to be computationally reconstructed with high fidelity.The concept of using a tunable metasurface for multi-dimensional light field encoding may open up new horizons for developing vectorial light field sensors with minimized size,weight,cost,and complexity. | Yibo Ni Chen Chen Shun Wen Xinyuan Xue Liqun Sun Yuanmu Yang | 2022 | eLight2022，2，1： | 2 |
| 18 | Magnetic properties and microstructures of terbium coated and grain boundary diffusion treated sintered Nd-Fe-B magnets by magnetron sputtering显示文摘Tb coating on the surface of commercial sintered Nd-Fe-B magnet was prepared by DC magnetron sputtering.The secondary heat treatment was used to regulate the microstructure for the enhancement of coercivity,namely diffusion treatment and annealing treatment.The coercivity increases significantly from 18.3 to 28.0 kOe,the remanence decreases slightly from 14.1 to 14.0 kGs,and the comprehensive magnetic properties are higher than 75(Hcj+(BH)_(max)=76.7).SEM results indicate that,on the one hand,950℃is the optimal diffusion temperature.Lower diffusion temperature results in insufficient diffusion of Tb element.Higher diffusion temperature can lead to the main phase grain growth,the decrease of Nd-rich phase,and forming holes in the magnet.On the other hand,500℃is the optimal annealing temperature.Lower annealing temperature can result in the reduction of Nd-rich phase.Higher annealing temperature can generate the non-defined Nd-rich thin layer between grains. | Wei Zhu Yang Luo Zilong Wang Xinyuan Bai Haijun Peng Dunbo Yu | 2021 | Journal of Rare Earths2021，39，2： | 2 |
| 19 | Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma显示文摘 | Guofen Yang Weipeng He Muyan Cai Fei Luo Hsiangfu Kung Xinyuan Guan Yixin Zeng Dan Xie | 2011 | International Journal of Gynecological Cancer2011，，3： | 1 |
| 20 | Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma显示文摘 | Guofen Yang Weipeng He Muyan Cai Fei Luo Hsiangfu Kung Xinyuan Guan Yixin Zeng Dan Xie | 2011 | International Journal of Gynecological Cancer2011，，3： | 1 |
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