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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity显示文摘Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases. | Qin Chen Peiliang Shi Yufang Wang Dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 22 |
| 3 | Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing显示文摘Niacin metal-organic frameworks(MOFs)encapsulated microcapsules with alginate shells and copper-/zinc-niacin framework cores were in situ synthesized by using a microfuidic electrospray approach for wound healing.As the alginate shells were bacteriaresponsively degradable,the niacin MOFs encapsulated microcapsules could intelligently,controllably,and programmably release calcium,copper,and zinc ions,depending on the degree of infections.Te released ions could not only kill microbes by destroying their membrane and inducing the outfow of nutrient substance,but also activate copper/zinc superoxide dismutase(Cu/ZnSOD)to eliminate oxygen free radicals and rescue the cells from oxidative stress injury.Furthermore,the simultaneously released niacin could promote hemangiectasis and absorption of functional metal ions.Tus,the niacin MOFs encapsulated microcapsules were imparted with outstanding antibacterial,antioxidant,and angiogenesis properties.Based on an in vivo study,we have also demonstrated that the chronic wound healing process of an infected full-thickness skin defect model could be signifcantly enhanced by using the niacin MOFs encapsulated microcapsules as therapeutic agent.Terefore,the microfuidic electrospray niacin MOFs encapsulated microcapsules are potential for clinical applications. | Guopu Chen Yunru Yu Xiuwen Wu Gefei Wang Guosheng Gu Feng Wang Jianan Ren Huidan Zhang Yuanjin Zhao | 2019 | Research2019，，1： | 21 |
| 4 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 5 | Th17 Cells in autoimmune diseases显示文摘Th17 房间是 CD4 的一个新子集 < 啜 class= “ a-plus-plus ” > 涉及细胞外的病原体和真菌的清理的 + T 房间。积累的证据建议 Th17 房间和他们的签名 cytokines 在多重自体免疫调停的致病有一个枢轴的角色煽动性的疾病。这里,我们在自体免疫的疾病的开发和致病在 Th17 功能上总结最近的研究进步。我们也建议鉴别操作 Th17 的新小分子混合物工作让潜在的治疗学的申请治疗人的自体免疫的疾病,包括风湿性关节炎,全身的豺狼座 erythematosus, Sj ? grens 症候群,煽动性的肠疾病,和多重硬化。 | Lei Han Jing Yang Xiuwen Wang Dan Li Ling Lv Bin Li | 2015 | Frontiers of Medicine2015，9，1： | 9 |
| 6 | Study on the electric property of shaly sand and its interpretation method显示文摘There are so many shaly sand conduction models, and most of them are only used in some local area, and have their limitations. So far, there is no theoretical model that can be used commonly and efficiently .In this paper, based on some existing models, and combining with the knowledge of the researched area, we designed out a new conduction model. The total conductivity of the rock is the combining result from free water in inter granular porous, micro pore water and the clay bound water. It can well describe many electric conduction characteristics of shaly sand. In order to make it useable in practice, we also provide some methods for interpreting the pore components with comprehensive logging data. | Li Zhoubo and Mo Xiuwen (Changchun University of Science and Technology, Changchun, China, 130026) | 1999 | Global Geology1999，4，1： | 8 |
| 7 | A Methodology for Reliability of WSN Based on Software Defined Network in Adaptive Industrial Environment显示文摘As communication technology and smart manufacturing have developed, the industrial internet of things(IIo T)has gained considerable attention from academia and industry.Wireless sensor networks(WSNs) have many advantages with broad applications in many areas including environmental monitoring, which makes it a very important part of IIo T. However,energy depletion and hardware malfunctions can lead to node failures in WSNs. The industrial environment can also impact the wireless channel transmission, leading to network reliability problems, even with tightly coupled control and data planes in traditional networks, which obviously also enhances network management cost and complexity. In this paper, we introduce a new software defined network(SDN), and modify this network to propose a framework called the improved software defined wireless sensor network(improved SD-WSN). This proposed framework can address the following issues. 1) For a large scale heterogeneous network, it solves the problem of network management and smooth merging of a WSN into IIo T. 2) The network coverage problem is solved which improves the network reliability. 3) The framework addresses node failure due to various problems, particularly related to energy consumption.Therefore, it is necessary to improve the reliability of wireless sensor networks, by developing certain schemes to reduce energy consumption and the delay time of network nodes under IIo T conditions. Experiments have shown that the improved approach significantly reduces the energy consumption of nodes and the delay time, thus improving the reliability of WSN. | Ying Duan Wenfeng Li Xiuwen Fu Yun Luo Lin Yang | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，1： | 7 |
| 8 | The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study显示文摘Background:An increasing number of cancer patients die of cardiovascular diseases.The cardiotoxicity of chemo-therapy is particularly important in triple-negative breast cancer(TNBC)with limited therapeutic options.Cardiac autophagy is an important mechanism of cardiotoxicity.This research was aimed to investigate the cardiotoxicity of chemotherapy in TNBC,screen the susceptible population,and determine the relationship between cardiotoxicity and autophagy-related polymorphisms.Methods:From a total of 2450 stage I-III TNBC patients,147 met the inclusion criteria and finally recruited.Electro-cardiography(ECG)was performed before most chemotherapy cycles,and echocardiography(UCG)was performed according to clinical needs.All ECG and UCG records were re-interpreted by cardiologists at the National Center for Cardiovascular Disease,Fuwai Hospital.According to the National Center for Biotechnology Information and the Catalog of Somatic Mutations in Cancer database,we selected 25 single nucleotide polymorphisms(SNPs)related to autophagy and genotyped the 147 TNBC patients.Paired-sample T tests,Chi squared tests,and logistic regression models were employed for the analysis.Results:Only 46(31.3%)patients had normal ECG records after every chemotherapy cycle.Among the 16 patients who underwent UCG,2(12.5%)had a reversible decrease of left ventricular ejection fraction.The use of anthracyclines and excessive alcohol consumption were risk factors of ECG abnormalities.With the continuation of chemotherapy,heart rate gradually increased.Anthracyclines were associated with QRS duration abnormalities(P=0.043).After genotyping for 25 autophagy-related SNPs,we found that the G allele of autophagy-related 13(ATG13)rs10838611 was significantly associated with ECG abnormalities(odds ratio=2.258,95%confidence interval=1.318-3.869;P=0.003).Conclusion:ECG abnormalities caused by chemotherapy are common in the real world.Autophagy-related SNPs are associated with chemotherapy-induced cardiotoxicity,thereby providing new evidence for autophagy as a cause of chemotherapy-induced cardiac damage. | Binliang Liu Tao An Meiying Li Zongbi Yi Chunxiao Li Xiaoying Sun Xiuwen Guan Lixi Li Yanfeng Wang Yuhui Zhang Binghe Xu Fei Ma Yixin Zeng | 2018 | Cancer Communications2018，38，1： | 5 |
| 9 | Structural Changes of Wheat Straw Lignin during Formic Acid Treatment显示文摘The aromatic nature of lignin makes it a potential renewable source of chemicals and other valuable products.Isolation of lignin from lignocellulosic biomass using organic solvents enables the production of high-purity lignin.The use of formic acid in the organosolv pulping and fractionation process has been widely studied.Characterization of lignin is necessary to achieve valueadded applications of lignin.To simplify the isolation of formic acid-treated lignin,herein,milled wheat straw lignin(MWSL) was employed as an archetype for characterization of the structural changes of lignin during formic acid treatment.The results showed that the MWSL was GSH-type(comprising p-hydroxyphenyl(H),guaiacyl(G),and syringyl(S) monolignols) and underwent structural changes during formic acid treatment.Lignin was esterified during the formic acid treatment.The content of alkyl hydroxyl groups in lignin decreased upon formic acid treatment,corresponding to an increase of the number of double bond equivalents(DBE).Lignin units with active reaction sites were liable to slight condensation,which resulted in a moderate increase of the molecular weight.The molecular weight distribution of formic acid-treated MWSL(FMWSL) was wider than that of the MWSL,although the molecular weight of both species did not differ significantly.The β-O-4 linkage in lignin was partially cleaved during formic acid treatment,resulting in the production of new phenolic structures.This improved the solubility of lignin in the cooking liquor and its reactivity for downstream applications. | RuiXue Dong XiuWen Mei Chang Ma MingFei Li YongMing Fan | 2016 | Paper And Biomaterials2016，1，2： | 5 |
| 10 | Biomimetic intestinal barrier based on microfluidic encapsulated sucralfate microcapsules显示文摘Intestinal barriers play an important role in preventing intestinally derived diseases,and maintaining their function is a promising approach to prevent and treat those diseases.Here,inspired by the protection effect of intestinal barriers in live organisms and the mucosa adhesive property of sucralfate,we present a biomimetic intestinal barrier based on microfluidic encapsulated sucralfate microcapsules.Benefiting from the flexible selectivity and precise control of microfluidic electrospray flows,the generated microcapsules were imparted with stomach-tolerant dietary-fibre shells and controllable released sucralfate cores,both of which could contribute to forming a continuous biomimetic intestinal barrier on the intestine.Through in vitro adhesive study,in vivo computed tomography(CT)imaging and in vivo imaging system(IVIS)methods,we have demonstrated that the microcapsule-derived biomimetic intestinal barrier can effectively block food fermentation in the gut,reduce generation of fat,decrease disease risk indexes,and prevent obesity.These features make the microfluidic encapsulated sucralfate microcapsules and their resultant biomimetic intestinal barrier an approach for treating obesity and other intestinal diseases. | Cheng Zhao Yunru Yu Xiaoxuan Zhang Xiuwen Wu Jianan Ren Yuanjin Zhao | 2019 | Science Bulletin2019，64，19： | 4 |
| 11 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 12 | Hybrid-cavity semiconductor lasers with a whispering-gallery cavity for controlling Q factor显示文摘Hybrid cavities composed of a Fabry-P′erot(FP) cavity and a whispering-gallery mode(WGM)microcavity have been proposed and demonstrated for modulating mode Q factor to realize single mode and optical bistable lasers. In this article, we report hybrid cavity lasers with a pentagon microcavity and a square microcavity, respectively. The reflectivity spectra of different microcavities are simulated to select microcavities for hybrid cavities. Mode coupling with mode Q factor enhancement is investigated numerically and experimentally. Stable single mode operations with a high coupling efficiency to a single mode fiber are realized for a hybrid cavity laser with a square microcavity. Furthermore, optical bistability hybrid lasers are investigated as the microcavity is unbiased, due to saturable absorption in the microcavity and mode competition, respectively. All-optical flip-flop is demonstrated using trigger optical pulses with a width of100 ps for mode competition bistability. The stable single mode operation and optical bistability of hybrid cavity lasers may shed light on the applications for photonic integrated circuits and optical signal processing. | Yongzhen HUANG Xiuwen MA Yuede YANG Jinlong XIAO Yun DU | 2018 | Science China(Information Sciences)2018，61，8： | 4 |
| 13 | Novel synthesis of Z-schemeα-Bi2O_(3)/g-C_(3)N_(4) composite photocatalyst and its enhanced visible light photocatalytic performance:Influence of calcination temperature显示文摘In this study,α-Bi2O_(3)/g-C_(3)N_(4) nanocomposite with direct Z-scheme was successfully prepared through calcination of BiOCOOH/g-C_(3)N_(4) precursor at different temperature.Meanwhile,the effect of calcination temperature on the physicochemical properties ofα-Bi2O_(3)/g-C_(3)N_(4) was studied.All results confirmed that calcination tempe rature greatly influences structural,morphology,surface states,photoelectrochemical property and photocatalytic(PC)perfo rmance ofα-Bi2O_(3)/g-C_(3)N_(4) composite.Furthermore,theα-Bi2O_(3)/gC_(3)N_(4) composite was applied as photocatalyst to degrade amido black 10 B dye under visible light irradiation.It was found that the composite synthesized at 400℃exhibited the highest PC performance due to the intense visible light absorbance and high separation efficiency of electron and hole pairs.Besides,the possible PC mechanism was proposed that the photo-generated charge carrier migration inα-Bi2O_(3)/g-C_(3)N_(4) photocatalyst followed a Z-scheme structure.Finally,the stability test also manifest that theα-Bi2O_(3)/g-C_(3)N_(4) composite photocatalyst has good stability and reusability,which was a promising candidate for wastewater treatment. | Bo Li Li-Chao Nengzi Ruonan Guo Yuqi Cui Youxian Zhang Xiuwen Cheng | 2020 | Chinese Chemical Letters2020，31，10： | 3 |
| 14 | A silica-immobilized Pt^(2+) catalyst for the selective,aerobic oxidation of methane via an electron-transfer chain显示文摘磅 2+, benzoquinone 和 NaNO 2 的联合形成电子转移链,它在 CF 32 导致甲烷的氧化 > COOH 水的答案。全面周转数字然而每在 120 ° C 的甲烷的小时(TOF ) 是 0.5 h −1, ,(23%) 仅仅大约四分之一在 CF 3 一种色情的扭摆舞 3 。到在有磅 2+ 种类的催化剂上的公司 2, 的甲烷的在氧化上在硅石底层上作为 ligand 经由 2,2 使 ′-bipyridyl 不能调动,清楚地被压抑。在一样的条件下面,到甲醇的变换统治,并且没有公司 2 被观察由于甲烷的在氧化上,是由同位素实验证实了。 | Zengjian An Xiulian Pan Xiumei Liu Xiuwen Han Xinhe Bao | 2008 | Journal of Natural Gas Chemistry2008，17，2： | 3 |
| 15 | High-adaption locomotion with stable robot body for planetary exploration robot carrying potential instruments on unstructured terrain显示文摘There is a strong demand for Planetary Exploration Mobile robots(PEMRs)that have the capability of the traversability,stability,efficiency and high load while tackling the specialized tasks on planet surface.In this paper,an electric parallel wheel-legged hexapod robot which has high-adaption locomotion on the unstructured terrain is presented.Also,the hybrid control framework,which enables robot to stably carry the heavy loads as well as to traverse the uneven terrain by utilizing both legged and wheeled locomotion,is also proposed.Based on this framework,robot controls the multiple DOF leg for performing high-adaption locomotion to negotiate obstacles via Gait Generator(GG).Additionally,by using Whole-Body Control(WBC)of framework,robot has the capability of flexibly accommodating the uneven terrain by Attitude Control(AC)kinematically adjusting the length of legs like an active suspension system,and by Force/torque Balance Control(FBC)equally distributing the Ground Reaction Force(GRF)to maintain a stable body.The simulation and experiment are employed to validate the proposed framework with the physical system in the planetary analog environments.Particularly,to smoothly demonstrate the performance of robot transporting heavy loads,the experiment of carrying 3-person load of about 240 kg is deployed. | Kang XU Shoukun WANG Junzheng WANG Xiuwen WANG Zhihua CHEN Jinge SI | 2021 | Chinese Journal of Aeronautics2021，34，5： | 3 |
| 16 | Biocompatibility, biodegradation, and neovascularization of human single-unit platelet-rich fibrin glue: an in vivo analysis显示文摘 | Wu Xiuwen Ren Jianan Yao Genhong Zhou Bo Wang Gefei Gu Guosheng Luan Jianfeng | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 17 | Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer显示文摘Background:Breast cancer is a global problem,and a large number of new cases are diagnosed every year.Capecit-abine is effective in patients with metastatic breast cancer(MBC).Hand-foot syndrome(HFS)is a common adverse effect of capecitabine.In this study,we investigated the association between single nucleotide polymorphisms(SNPs)in genes involved in capecitabine metabolism pathways and capecitabine-induced HFS in Chinese patients with MBC to identify some predictive genetic biomarkers.Methods:We selected 3 genes involved in capecitabine metabolism and screened genetic variants in these target genes.We genotyped a total of 22 SNPs in the thymidylate synthase gene(TYMS),the methylene tetrahydrofolate reductase gene(MTHFR),and the ribonucleotide reductase M1 gene(RRM1)in 342 MBC patients treated with capecit-abine-based chemotherapy.The genotype distributions of each SNP in patients with and without HFS were assessed using Pearson’sχ^(2)test,and the relationship between HFS and genotypes of SNPs was determined using logistic regression analysis.The association between SNPs and their corresponding gene expression was analyzed using the Blood expression quantitative trait loci(eQTL)browser online tools.Results:We found 4 positive sites for HFS in the TYMS and MTHFR genes:TYMS rs2606241(P=0.022),TYMS rs2853741(P=0.019),MTHFR rs3737964(P=0.029),and MTHFR rs4846048(P=0.030).Logistic regression analyses showed that the genotype AG of MTHFR rs3737964[odds ratio(OR)=0.54,95%confidence interval(CI)0.31-0.97,P=0.038]and MTHFR rs4846048(OR=0.54,95%CI 0.30-0.98,P=0.042)were protective factors of HFS,whereas the genotype CT of TYMS rs2853741(OR=2.25,95%CI 1.31-3.87,P=0.012)increased the risk of HFS.The association between the genotype GT of TYMS rs2606241(OR=1.27,95%CI 0.73-2.23,P=0.012)and HFS was uncertain.Further eQTL analyses confirmed that the alleles of rs3737964 and rs4846048 affected the gene expression levels of MTHFR in cis.Conclusions:We have identified four potentially useful pharmacogenetic markers,TYMS rs2606241,TYMS rs2853741,MTHFR rs3737964,and MTHFR rs4846048 to predict capecitabine-induced HFS in MBC patients. | Shaoyan Lin Jian Yue Xiuwen Guan Peng Yuan Jiayu Wang Yang Luo Ying Fan Ruigang Cai Qiao Li Shanshan Chen Pin Zhang Qing Li Fei Ma Binghe Xu | 2019 | Cancer Communications2019，39，1： | 3 |
| 18 | Revealing the crystallization process and realizing uniform 1.8 eV MA-based wide-bandgap mixed-halide perovskites via solution engineering显示文摘Wide-bandgap perovskites are recently drawing tremendous attention in the community for high-efficiency all-perovskite tandem solar cells.However,the formamidinium (FA^+) and methylammonium (MA^+) based wide-bandgap mixed halide perovskites suffered from high density of traps and pin-holes,respectively.Fundamental understanding on the crystallization and film formation processes are keys to overcome those challenges but not yet clearly understood.In this study,an in-situ photoluminescence technique was used to investigate the perovskite crystallization during the thermal annealing process.It is found that the crystallization of a mixed halide perovskite with bromide (Br^-) and iodine (I^-) ions following the Ostward ripening crystal growth.Interestingly,it is found that the initial nucleation reaction is quickly completed in the first few seconds,however,leaving the small crystals with inhomogeneous composition.The different aggregation affinities of such inhomogeneous small crystals provoke the formation of pin-holes during the thermal annealing process.By engineering the precursor solution to control the nucleation rate,the chemical composition of the small crystals has become homogenous.Uniform pin-hole free high Br-composited wide-bandgap MA0.9Cs0.1Pb(I0.6Br0.4)3 perovskite films with bandgap energy of 1.8 eV have been realized.The corresponding photovoltaic devices have achieved an encouraging device efficiency of 15.1% with superb photostability. | Yue-Min Xie Chunqing Ma Xiuwen Xu Menglin Li Yuhui Ma Jing Wang Hrisheekesh Thachoth Chandran Chun-Sing Lee Sai-Wing Tsang | 2019 | Nano Research2019，12，5： | 2 |
| 19 | Roles of lncRNAs in Rice: Advances and Challenges显示文摘Long non-coding RNAs(lncRNAs) larger than 200 nucleotides in length are eukaryotic RNAs, and do not encode proteins. lncRNAs are considered to be important regulators in many biological processes in plants. In this review, the latest advances in the roles of lncRNAs in rice were reviewed, and functions of lncRNAs were further summarized and classified. lncRNAs play crucial roles in tolerance to biotic and abiotic stresses such as disease, drought, heat, cold, heavy metal, and starvation of nitrogen and phosphorus in rice. In addition, lncRNAs also regulate various growth and development processes in rice. Finally, the prospect and challenges of rice lncRNA function research in future were proposed. This review will not only help us quickly grasp the frontiers of lncRNAs functional research progresses, but also propose suggestions and ideas for the directions of further lncRNA research in rice. | Gao Caixia Zheng Xiuwen Li Hubo Ussi Ali Mlekwa Gao Yu Xiong Jie | 2020 | Rice science2020，27，5： | 2 |
| 20 | Fractional Modeling and SOC Estimation of Lithium-ion Battery显示文摘This paper proposes a state of charge(SOC) estimator of Lithium-ion battery based on a fractional order impedance spectra model. Firstly, a battery fractional order impedance model is derived on the grounds of the characteristics of Warburg element and constant phase element(CPE) over a wide range of frequency domain. Secondly, a frequency fitting method and parameter identification algorithm based on output error are presented to identify parameters of the fractional order model of Lithium-ion battery. Finally, the fractional order Kalman filter approach is introduced to estimate the SOC of the lithium-ion battery based on the fractional order model. The simulation results show that the fractional-order model can ensure an acceptable accuracy of the SOC estimation, and the error of estimation reaches maximally up to 0.5 % SOC. | Yan Ma Xiuwen Zhou Bingsi Li Hong Chen | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，3： | 2 |
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