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| 1 | Strata movement controlling effect of waste and fly ash backfillings in fully mechanized coal mining with backfilling face显示文摘A fully mechanized coal mining with backfilling (FMCMB) provides advantages of safety and efficiency for coal mining under buildings, railways, and water bodies. According to the field geological conditions, we analyzed the controlling effect of strata movement by the waste and fly ash backfilling in FMCMB face. Based on the key strata theory, we established the equivalent mining thickness model, and analyzed the action of the bulk factor of backfilling body to the equivalent mining thickness. In addition, we numerically simulated the controlling function of the strata movement by backfilling bodies with differ- ent strength. And the numerical simulation result show that the deformation of stratum and the subsi- dence of surface can be controlled by FMCMB. The result provides references to the effective execution of fully mechanized coal mining with solid waste backfilling in goaf. | Zhang Jixiong Zhang Qiang Huang Yanli Liu Jinwei Zhou Nan Zan Dongfeng | 2011 | Mining Science and Technology2011，21，5： | 27 |
| 2 | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity显示文摘Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases. | Qin Chen Peiliang Shi Yufang Wang Dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 22 |
| 3 | Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation显示文摘Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the pyroptotic process. Here, we also found MMP collapse and ROS generation induced by Nlrp3 inflammasome activation as previous studies reported. The elimination of ROS alleviated the cleavage of Gsdmd, suggesting that Gsdmd cleavage occurs downstream of ROS release. Consistent with this result, hydrogen peroxide treatment augmented the cleavage of Gsdmd by caspase-1. Indeed, four amino acid residues of Gsdmd were oxidized under oxidative stress in macrophages. The efficiency of Gsdmd cleavage by inflammatory caspase-1 was dramatically reduced when oxidative modification was blocked by mutation of these amino acid residues. These results demonstrate that Gsdmd oxidation serves as a de novo mechanism by which mitochondrial ROS promote Nlrp3 inflammasome-dependent pyroptotic cell death. | Yufang Wang Peiliang Shi Qin Chen Zan Huang Dayuan Zou Jingzi Zhang Xiang Gao Zhaoyu Lin | 2019 | Journal of Molecular Cell Biology2019，11，12： | 23 |
| 4 | Recovery of novel bacterial diversity from mangrove sediment显示文摘 | Liang JB Chen YQ Lan CY Tan NFY Zan QJ Huang LN | 2007 | 中国生物学文摘2007，21，7： | 7 |
| 5 | Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1显示文摘瞄准:严重痛苦的感觉神经病经常发生在 paclitaxel 化疗期间。,后来, paclitaxel 能激活桅杆房间和 basophils 橡黄素, polyphenolic flavonoid 在各种各样的植物包含了,它能明确地作为桅杆房间 stabilizer 禁止组织安版本。在这研究,我们探索橡黄素是否能改善导致 paclitaxel 的神经病的疼痛和阐明的位于 \O 下面 mechanisms.Methods:组织安版本上的橡黄素抑制被从白血病(RBL-2H3 ) 房间与 paclitaxel 刺激了的老鼠 basophilic 检测组织安版本在 vitro 验证(10 μ mol/L ) 。在里面在里面 vivo 实验,老鼠和老鼠收到了橡黄素(20, 40 mg·为 40 和 12 d 的 kg -1·d-1) 分别地。同时,动物与 paclitaxel 被注射(2 mg/kg, ip ) d 上的四次 1, 3, 5 和 7。热痛觉过敏和机械 allodynia 在不同时间点被评估。动物是 euthanized 和针的绳索,背面的根中心为分析 PKCε 被收获;并且 TRPV1 表示铺平。血浆组织安层次在 d 上在老鼠被估计 31 .Results:有橡黄素的预告的处理(3, 10, 30 μ mol/L ) 从在 vitro 的刺激 paclitaxel 的 RBL-2H3 房间的 dose-dependently 禁止的过多的组织安版本,和橡黄素管理显著地在对待 paclitaxel 的老鼠压制了高血浆组织安层次。橡黄素管理 dose-dependently 在对待 paclitaxel 的老鼠和老鼠为热痛觉过敏和机械 allodynia 提起了阀值。而且,橡黄素管理 dose-dependently 压制了 PKCε 的增加的表示层次;并且在对待 paclitaxel 的老鼠和老鼠的针的绳索和 DRG 的 TRPV1。而且,橡黄素管理可以禁止了 PKCε 的 translocation;从细胞质到在对待 paclitaxel 的 rats.Conclusion 的针的绳索和 DRG 的膜:我们的结果揭示导致 paclitaxel 的外部神经病的内在的机制并且为对待这个副作用表明橡黄素的治疗学的潜力。 | Wei GAO Yan ZAN Zai-jie Jim WANG Xiao-yu HU Fang HUANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 5 |
| 6 | Method of neural network modulation recognition based on clustering and Polak-Ribiere algorithm显示文摘To improve the recognition rate of signal modulation recognition methods based on the clustering algorithm under the low SNR, a modulation recognition method is proposed. The characteristic parameter of the signal is extracted by using a clustering algorithm, the neural network is trained by using the algorithm of variable gradient correction(Polak-Ribiere) so as to enhance the rate of convergence, improve the performance of recognition under the low SNR and realize modulation recognition of the signal based on the modulation system of the constellation diagram.Simulation results show that the recognition rate based on this algorithm is enhanced over 30% compared with the methods that adopt clustering algorithm or neural network based on the back propagation algorithm alone under the low SNR. The recognition rate can reach 90% when the SNR is 4 d B, and the method is easy to be achieved so that it has a broad application prospect in the modulating recognition. | Faquan Yang Zan Li Hongyan Li Haiyan Huang Zhongxian Pan | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 4 |
| 7 | LyP-1 peptide-functionalized gold nanoprisms for SERRS imaging and tumor growth suppressing by PTT induced-hyperthermia显示文摘Gold-based nanomaterials with plasmonic properties exhibit various potentials for biomedical applications. In this work, gold nanoprisms (GNPs) was synthesized and then modified with LyP-1, a tumor-homing peptide, to improve the affinity of the GNPs to tumor cells, thus, to improve the efficacy of tumor-targeted photothermal therapy. The introduction of NIR dye IR780 not only enabled the GNPs-based nanosystem with the surface-enhanced resonant Raman scattering (SERRS) property, but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation. The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo, which resulted in enhanced tumor-targeting photothermal therapeutic efficacy after laser irradiation. Hence, the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment. | Xi Huang Yanlong Yin Min Wu Wang Zan Qian Yang | 2019 | Chinese Chemical Letters2019，30，6： | 3 |
| 8 | Imaging for thinned perforator flap harvest:current status and future perspectives显示文摘With advances in anatomical knowledge and technology,increased interest has been directed towards reconstruction with enhanced aesthetic and functional outcomes.A myriad of thinned perforator flap harvest approaches have been developed for this purpose;however,concerns about jeopardizing their vascularity remain.To ensure optimum reconstructive outcome without hampering the flap’s microcirculation,it is important to make good use of the existing advanced imaging modalities that can provide clear visualization of perforator branches,particularly in the adipose layer,and an accurate assessment of flap perfusion.Therefore,this review will highlight the imaging modalities that have been utilized for harvesting a thinned perforator flap from these two perspectives,along with future insights into creating both functionally and aesthetically satisfying,yet simultaneously safe,thinned perforator flaps for the best reconstructive outcomes for patients. | Yi Min Khoong Xin Huang Shuchen Gu Tao Zan | 2021 | Burns & Trauma2021，9，1： | 3 |
| 9 | 儿童参与动感舞蹈视频游戏的情景动机、体育活动参与度与愉悦性之间的联系显示文摘目的:调查'劲舞革命'游戏(Dance Dance Revolution,DDR)中儿童的情景动机、体力活动水平和他们感受到的体育活动愉悦性之间的关系。方法:在为期一周的实验中,215名小学生每天玩30 min DDR游戏。研究者测量了受试者对DDR的情境动机(内在动机、认同调控、外部调控和无动机),然后测量了他们玩DDR时由加速度确定的中到重度体育活动水平(MVPA),最后让受试者报告其参与体育活动的愉悦性。结果:只有内在动机与儿童玩DDR时的MVPA和愉悦性成正相关。而其他情境动机与MVPA和愉悦性之间无显著相关。回归分析进一步表明,内在动机是MVPA和愉悦性的重要预测因素。结论:在玩DDR中感到快乐并学到新事物的儿童有效提高了体育运动水平,同时也普遍感受到心理愉悦。 | Zan Gao Leslie Podlog Chaoqun Huang | 2013 | Journal of Sport and Health Science2013，2，2： | 3 |
| 10 | High expression of human serum albumin in milk of trans-genie mice directed by the goat β-casein gene promoter region显示文摘We have constructed a mammary gland expression vector that contained the goat β-casein gene pro-moter, 5’upstream regulatory region, exons 1, 2, intron 1 as well as the human serum albumin (hALB) mini-gene (including the full-long sequences of hALB cDNA and its intron 1). Injection of the vector into mouse tail veins showed that the recombinant construct was expressed only in mammary glands. The vector was microinjected into the mouse fertilized eggs, followed by transferring the eggs into the foster mice. 33 F0 mice were obtained. Of the 33, 8 mice (5 , 3 ) were transgenic with hALB gene integration identified by PCR as well as Southern blot hybridization. The integration rate was 24.2% (8/33). Western blot analysis showed that 3 female transgenic mice had hALB expression in their milk. The hALB contents in milk reached 3.54, 0.21 and 3.03 g/L, respectively. | HUANG Ying, HUANG Ying, HUANG Zan,YAN Jingbin, MA Zhanlu, SHENG Min,REN Zhaorui, ZENG Yitao & HUANG ShuzhenShanghai Institute of Medical Genetics, Shanghai Children’s Hospital, Shanghai 200040, China | 2001 | Chinese Science Bulletin2001，46，7： | 3 |
| 11 | A modified scar model with controlled tension on secondary wound healing in mice显示文摘Pathological scars might cause a distorted appearance and restricted mobility,and the study of scar pathophysiology has been hindered by the absence of a reliable model.In this study,we introduce a model with a modified device to induce controlled tension on a wound healing by secondary intention to overcome the shortcomings of the model generated by Aarabi et al.We investigated and recommend an induction of 0.1 N/mm^(2) tension on day 7 for 14 days to mimic the characteristics of human scars.A 3.5-fold increase in scar tissue and a 2-fold increase in collagen production were induced by the modified model.Histologically,the modified method increased scar thickness.However,no significant difference was found in cell density between the two groups.This modified procedure significantly increased scar tissue,which could be used for further cellular and biomolecular research.The mechanical force applied to the wound became measurable and controllable.This method is more convenient for researchers to observe in realtime and for providing timely adjustments of the tension used in this modified model. | Zi Wang Xin Huang Tao Zan Qingfeng Li Haizhou Li | 2020 | Burns & Trauma2020，8，1： | 2 |
| 12 | CD4+T cells memorize obesity and promote weight regain显示文摘Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obese status.In a weight gain-loss-regain model,we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain.This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice.Surprisingly,such obesity memory was abrogated by dexamethasone treatment,whereas immunodeficient Rag1−/−and H2A−/−mice failed to establish such memory.Rag1−/−mice repossessed the obesity memory when immune cells or CD4+T cells isolated from previously obese mice were transferred.Furthermore,depletion of CD4+T cells led to obesity memory ablation.Taken together,we conclude that CD4+T cells mediate obesity memory and promote weight regain. | Jianghuan Zou Beibei Lai Mingzhu Zheng Qin Chen Shujun Jiang Anying Song Zan Huang Peiliang Shi Xin Tu Di Wang Linrong Lu Zhaoyu Lin Xiang Gao | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 13 | Enhanced simultaneous absorption of NO_(x) and SO_(2) in oxidation-reduction-absorption process with a compounded system based on Na_(2)SO_(3)显示文摘Oxidation of sulfite and competitive absorption existed in Na_(2)SO_(3) solution for simultaneous removal of NO_(x) and SO_(2),inhibited the long-term high-efficiency when used for practical applications.A matching strategy was developed to solve these problems.Antioxidants combination was used to retard the oxidation of antioxidant and enhance inhibition of S(IV)(tetravalent sulfur)oxidation.Hydroquinone(HQ)and sodium thiosulfate(ST)showed a positive synergistic effect on inhibition of S(IV)oxidation.When SO_(2) concentration was 500 and 2000 ppmV,the addition of 0.1 wt.%HQ and 1 wt.%ST decreased the percentage of S(IV)oxidized by oxygen by over 30%and 40%,respectively.Alkali(Na_(2)CO_(3))alleviated the competitive absorption between NO_(x) and SO_(2).Moreover,Na_(2)CO_(3) exhibited an enhancement effect on the absorption of NO_(x) and SO_(2) when coupled with anti-oxidants.While the increase of oxygen pressure accelerated the oxidation of S(IV),the anti-oxidants can retard the oxidation.The measurement of pH suggested the removal efficiency of NO_(x) highly depended on SO_(3)^(2-) concentration rather than pH.The further investigation of the mechanism suggested the match effect was related to the interaction between ST and the intermediate product of HQ.The match strategy holds a potential for application of SO_(3)^(2-) to denitration. | Sichao Li Wenjun Huang Haomiao Xu Kai Liu Jia-nan Wang Yaning Sun Zan Qu Naiqiang Yan | 2022 | Journal of Environmental Sciences2022，34，1： | 2 |
| 14 | A case of scalp avulsion with prolonged ischemic time:indocyanine green angiography can aid in predicting replant survival显示文摘Background:Microsurgical replantation has become the most favorable treatment option for scalp avulsion.However,the accurate prediction of postoperative replant viability remains challenging.Case presentation:In this article,we showed that(indocyanine green angiography,ICGA)can provide a much more precise prediction of replant necrosis than conventional clinical assessment in a rare case of complete scalp avulsion with prolonged ischemia time.Conclusion:Clinical assessment of replant survival may be misleading in cases of complex tissue injuries and prolonged ischemic stress.This case provides insight into the promising utility of ICGA as an important adjuvant tool to better assess tissue perfusion and viability in scalp avulsion and possibly other types of replantation. | Xin Huang Zhichao Wang Caiyue Liu Shuchen Gu Yashan Gao Xiangwen Xu Tao Zan | 2019 | Burns & Trauma2019，7，1： | 2 |
| 15 | Bistable Stochastic Resonance Enhanced 4-ary PAM Signal Detection under Low SNR显示文摘To boost the performance of 4-ary pulse amplitude modulated(PAM) at low signal-to-noise ratio(SNR), bistable stochastic resonance(BSR) system is introduced into digital communications system and get a reliable signal detection scheme. In this paper, we first analyse BSR system for different amplitudes of 4-ary PAM signals. The steadystate of the bistable system will be statistically distinct, and the feasibility of the proposed detection scheme is confirmed. On this basis, we present a detailed study on steady-state transitions of the BSR system, and an explicit expression of the bistable system parameters is derived. By setting the bistable system parameters, bistable system, 4-ary PAM signal, and noise reach the resonance state, and the BSR-based detection scheme is implemented. Moreover, we derive an analytical expression to calculate the symbol error rate(SER) of 4-ary PAM signals with the BSR-based detection under additive white Gaussian noise(AWGN). Finally, the simulation results validate that BSR-based detection scheme can improve the detection performance while efficiently reducing the symbol error rate. | Linlin Liang Nina Zhang Haiyan Huang Zan Li | 2019 | China Communications2019，16，4： | 2 |
| 16 | Credit rating analysis with support vector machines and neural networks显示文摘 | Huang Zan Chen Hsinchun | 2004 | Decision Support Systems2004，37，4： | 1 |
| 17 | Infl- enee of fafliquoring on flammability of leather 显示文摘 | Huang Zan Li Lixin Chen Wuyong | 2006 | JSLTC2006，90，4： | 1 |
| 18 | Performance of flame retardants on leather显示文摘 | Huang Zan Li Lixin Wang Yinghong | 2005 | JSLTC2005，89，： | 1 |
| 19 | Applying associative retrieval tech- niques to alleviate the sparsity problem in collaborative filtering 显示文摘 | Huang Zan Chert H Zeng D | 2004 | ACM Trans on Information Systems2004，22，1： | 1 |
| 20 | Preparation and evaluation of anti-SARS coronavirus IgY from yolks of immunized SPF chickens显示文摘 | Chao-Yang Fu He Huang Xiao-Mei Wang Yong-Gang Liu Zhi-Guo Wang Shang-Jin Cui Hong-Lei Gao Zan Li Jing-Peng Li Xian-Gang Kong | 2006 | Journal of Virological Methods2006，133，： | 1 |
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