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| 1 | Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved. | Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. | 2011 | 南京医科大学学报(自然科学版)2011，31，7： | 123 |
| 2 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 3 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 4 | Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage显示文摘背景发炎和免疫在 subarachnoid 出血(SAH ) 以后在早大脑损害的致病起一个重要作用。原子 factor-kappa B (NF-KB ) 为发炎和免疫调整许多基因必需品并且被像使用费的受体(TLR ) 激活。这研究试图检测在早 SAH 以后在老鼠大脑发信号的像使用费的受体 4/nuclear factor-kappa B (TLR4/NF-KB ) 的表示。老鼠被将斩首的方法和他们的大脑在血的单个注射以后在 0, 2, 4, 6, 12, 24 和 48 个小时被移开进 prechiasmatic 水塘, TLR4 的 mRNA 表示被 immunohistochemistry 并且西方的弄污被 Taqman 即时 RT-PCR,和蛋白质表示测量。肿瘤坏死 factor-alpha (TNF-) 的 NF-KB 活动和集中, interleukin-lbeta (IL-) 和 intedeukin-6 (IL-6 ) 被试金(ELISA ).Results TaqMan 即时 RT-PCR 并且西方的弄污识别了的连接酶的 immunosorbent 测量在在 mRNA 和蛋白质的 TLR4 表示的一个 biphasic 变化:一座起始的山峰(2-6 小时) 和持续举起(12-48 小时) 。染色的 Immunohistochemical 在 glial 房间和脉管的内皮细胞层主要显示出 TLR4-1ike 免疫反应的可诱导的表示。在象 NF-KB-regulated proinflammatory cytokines (TNF- , IL-1 和 IL-6 ) 的生产一样的 NF-KB 子单元 p65 的激活的一个类似的 biphasic 变化被 ELISA 检测。结论这些数据建议试验性的 SAH 导致在早大脑损害发信号的 TLR4 表示和 NF-KB 的重要起来规定。发信号的 TLR4/NF-KB 的激活可以在 SAH 以后调整煽动性的回答。 | MA Chun-xiao YIN Wei-ning CAI Bo-wen WU Jian WANG Jun-yi HE Min SUN Hong DING Jun-li YOU Chao | 2009 | Chinese Medical Journal2009，，13： | 33 |
| 5 | Fringe pattern analysis using deep learning显示文摘In many optical metrology techniques,fringe pattern analysis is the central algorithm for recovering the underlying phase distribution from the recorded fringe patterns.Despite extensive research efforts for decades,how to extract the desired phase information,with the highest possible accuracy,from the minimum number of fringe patterns remains one of the most challenging open problems.Inspired by recent successes of deep learning techniques for computer vision and other applications,we demonstrate for the first time,to our knowledge,that the deep neural networks can be trained to perform fringe analysis,which substantially enhances the accuracy of phase demodulation from a single fringe pattern.The effectiveness of the proposed method is experimentally verified using carrier fringe patterns under the scenario of fringe projection profilometry.Experimental results demonstrate its superior performance,in terms of high accuracy and edge-preserving,over two representative single-frame techniques:Fourier transform profilometry and windowed Fourier transform profilometry. | Shijie Feng Qian Chen Guohua Gu Tianyang Tao Liang Zhang Yan Hu Wei Yin Chao Zuo | 2019 | Advanced Photonics2019，1，2： | 31 |
| 6 | Effects of propofol, dexmedetomidine, and midazolam on postoperative cognitive dysfunction in elderly patients: a randomized controlled preliminary trial显示文摘Background: Postoperative cognitive dysfunction (POCD) is a serious complication after surgery, especially in elderly patients. The anesthesia technique is a potentially modifiable risk factor for POCD. This study assessed the effects of dexmedetomidine, propofol or midazolam sedation on POCD in elderly patients who underwent hip or knee replacement under spinal anesthesia. Methods: The present study was a prospective randomized controlled preliminary trial. From July 2013 and December 2014, a total of 164 patients aged 65 years or older who underwent hip or knee arthroplasty at China-Japan Friendship Hospital and 41 non-surgical controls were included in this study. Patients were randomized in a 1:1:1 ratio to 3 sedative groups. All the patients received combined spinal-epidural anesthesia (CSEA) with midazolam, dexmedetomidine or propofol sedation. The sedative dose was adjusted to achieve light sedation (bispectral index[BIS] score between 70 and 85). All study participants and controls completed a battery of 5 neuropsychological tests before and 7 days after surgery. One year postoperatively, the patients and controls were interviewed over the telephone using the Montreal cognitive assessment 5-minute protocol. Results: In all, 60 of 164 patients (36.6%) were diagnosed with POCD 7 days postoperatively, POCD incidence in propofol group was significantly lower than that in dexmedetomidine and midazolam groups (18.2% vs. 40.0%, 51.9%, χ^2 6.342 and 13.603, P= 0.012 and < 0.001). When the patients were re-tested 1 year postoperatively, the incidence of POCD was not significantly different among the 3 groups (14.0%, 10.6% vs. 14.9%, χ^2 0.016 and 0.382, P= 0.899 and 0.536). Conclusion: Among dexmedetomidine, propofol and midazolam sedation in elderly patients, propofol sedation shows a significant advantage in term of short-term POCD incidence. | Wei-Xia Li Ru-Yi Luo Chao Chert Xiang Li Jing-Sheng AO Yue Liu Yi-Qing Yin | 2019 | Chinese Medical Journal2019，，4： | 28 |
| 7 | Human infection with a novel avian-origin influenza A (H7N9) virus: serial chest radiographic and CT findings显示文摘 | Dai Jian Zhou Xianmei Dong Danjiang Liu Yin Gu Qin Zhu Bin Wu Chao Cai Hourong | 2014 | Chinese Medical Journal2014，，12： | 22 |
| 8 | Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro显示文摘OBJECTIVE: To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. METHODS: MI/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 3 h in rats. After reperfusion, hearts were harvested to assess infarct size, histopathological damages, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Blood samples were col- lected to determine serum levels of creatine kinase-MB (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH). Furthermore, simulatedischemia/reperfusion (SI/R) injury in vitro was established by oxygen and glucose deprivation (OGD) for 2 h followed by 24-hour recovery period in cardiomyocytes. The activity of LDH in the cultured supernatant and the levels of intracellular reactive oxygen species (ROS), SOD and MDA in cardiomyocytes were also measured. Finally, cardiomyocytes apoptosis was determined with flow cytometry. RESULTS: MLB significantly limited infarct size, ameliorated histopathological damages and prevented leakage of CK-MB, cTnI and LDH. Additionally, SOD, CAT, GPx and GSH activities were notably increased by MLB, along with the MDA content decreased as compared with the model group in rats. In vitro study, MLB also decreased LDH activity in the cultured supernatant, increased SOD activity in cardiomyocytes, reduced intracellular ROS and MDA levels, and significantly suppressed cardiomyocytes apoptosis. CONCLUSION: MLB possessed remarkably cardioprotective effects on MI/R injury in vivo and in vitro. The protection of MLB may contribute to its antioxidant properties. | Wei Quan Ying Yin Miaomiao Xi Dan Zhou Yanrong Zhu Yue Guan Chao Guo Yanhua Wang Jialin Duan Aidong Wen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 21 |
| 9 | Relative effects of phylogeny,biological characters and environments on leaf traits in shrub biomes across central Inner Mongolia,China显示文摘Aims Understanding the drivers for leaf traits is critical to improving our predictions on ecosystems'responses to global changes.Geographic patterns of leaf traits are shaped by phylogenetic,biological and environmental factors simultaneously.However,till now few studies have examined how these factors influenced leaf traits together,and how their effects differed at the within-and among-site levels.Methods We sampled leaf traits from a 1100 km shrub-biome transect across central Inner-Mongolia,including leaf mass per area(LMA),mass-based photosynthetic rate,nitrogen(N)and phosphorus(P)concentrations.We examined the effects of phylogenetic,biological(height and growth rate)and environmental(climate and soil)fac-tors on leaf traits with mixed-model analyses of variance.Variation partitioning method was used to separate the joint and independent effects of these three types of factors.Important Findings(i)Climate and soil fertility(total or available nutrient concentra-tions)together explained 11.4-41.4%of among-site variations,with remarkable difference among traits.(i)Height and height growth rate together explained 0.4--31.9%of trait variations(mostly among-site variations).Our results could only weakly support the ability of leaf traits as predictors for whole-plant growth.(ii)LMA was negatively related to height,which was consistent with the resource-use strategy hypothesis but incon-sistent with the hypotheses proposed for coexisting trees,suggest-ing that the LMA--height relationship is shaped by rather different mechanisms between the within-and among-communities lev-els.(iv)The variation partitioning analysis showed that,the rela-tionships between leaf traits and biological characters largely reflected the differences in both leaf traits and biological char-acters among species that occupying different sites.The relative importance of phylogenetic,biological and environmental fac-tors differed remarkably among leaf traits,between the within-and among-communities levels,and between different biomes.(v)Our results strongly suggest the necessity of examining the three types of factors simultaneously,and at both the within-and among-communities levels,for a better understanding of the drivers for leaf traits patterns. | Chao Liu Xiangping Wang Xian Wu Shuang Dai Jin-Sheng He Weilun Yin | 2013 | Journal of Plant Ecology2013，6，3： | 19 |
| 10 | Salt-responsive genes in rice revealed by cDNA microarray analysis显示文摘We used cDNA microarrays containing ~9,000 unigenes to identify 486 salt responsive expressed sequence tags (ESTs) (representing ~450 unigenes) in shoots of the highly salt-tolerant rice variety, Nona Bokra (Oryza sativa L. Ssp.Indica pv. Nona). Some of the genes identified in this study had previously been associated with salt stress. Howeverthe majority were novel, indicating that there is a great number of genes that are induced by salt exposure. Analysis of the salt stress expression profile data of Nona provided clues regarding some putative cellular and molecular processes that are undertaken by this tolerant rice variety in response to salt stress. Namely, we found that multiple transcription factors were induced during the initial salt response of shoots. Many genes whose encoded proteins are implicated in detoxification, protectant and transport were rapidly induced. Genes supporting photosynthesis were repressed and those supporting carbohydrate metabolism were altered. Commonality among the genes induced by salt exposure with those induced during senescence and biotic stress responses suggests that there are shared signaling pathways among these processes. We further compared the transcriptome changes of the salt-sensitive cultivar, IR28, with that of Nona rice. Many genes that are salt responsive in Nona were found to be differentially regulated in IR28. This study identified a large number of candidate functional genes that appear to be involved in salt tolerance and further examination of these genes may enable the molecular basis of salt tolerance to be elucidated. | Dai Yin CHAO Yong Hai LUO Min SHI Da LUO Hong Xuan LIN | 2005 | Cell Research2005，15，10： | 17 |
| 11 | Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage显示文摘Ferroptosis is a form of iron-dependent regulated cell death.Evidence of its existence and the effects of its inhibitors on subarachnoid hemorrhage(SAH)is still lacking.In the present study,we found that liproxstatin-1 protected HT22 cells against hemin-induced injury by protecting mitochondrial functions and ameliorating lipid peroxidation.In in vivo experiments,we demonstrated the presence of characteristic shrunken mitochondria in ipsilateral cortical neurons after SAH.Moreover,liproxstatin-1 attenuated the neurological deficits and brain edema,reduced neuronal cell death,and restored the redox equilibrium after SAH.The inhibition of ferroptosis by liproxstatin-1 was associated with the preservation of glutathione peroxidase 4 and the downregulation of acylCoA synthetase long-chain family member 4 as well as cyclooxygenase 2.In addition,liproxstatin-1 decreased the activation of microglia and the release of IL-6,IL-1 b,and TNF-a.These data enhance our understanding of cell death after SAH and shed light on future preclinical studies. | Yang Cao Yin Li Chao He Feng Yan Jian-Ru Li Hang-Zhe Xu Jian-Feng Zhuang Hang Zhou Yu-Cong Peng Xiong-Jie Fu Xiao-Yang Lu Yuan Yao Yu-Yu Wei Yun Tong Yi-Fu Zhou Lin Wang | 2021 | Neuroscience Bulletin2021，37，4： | 16 |
| 12 | Identification of Rice Ethylene-Response Mutants and Characterization of MHZ71OsEIN2 in Distinct Ethylene Response and Yield Trait Regulation显示文摘乙烯在浸透水的环境在米饭植物的适应生长起必要作用;然而,在米饭的乙烯 signalingpathway 大部分是不清楚的。在这研究,我们在变白的米饭幼苗的特定的乙烯反应显型上报导乙烯反应 mutantsbased 的鉴定和描述,包括禁止乙烯的根生长支持 andethylene 的 coleoptile 延伸,它与乙烯不同在 Arabidopsis 的三倍反应的显型。我们证实为屏蔽和一套米饭异种的一个有效系统被识别了。基因分析 revealsthat 这些异种形成八个互补组。所有异种显示出 insensitivity 或减少的敏感到 ethylenein 根生长,但是在 coleoptile 生长展出微分回答。一变异的组 mhz7 在根和 coleoptile 生长有 insensitivity 到乙烯。我们由基于地图的 cloningmethod 识别了相应基因。MHZ7 编码对 EIN2 相应的膜蛋白质,在 Arabidopsis 发信号的乙烯的一个中央部件。在乙烯处理之上,变白 MHZ7-overexpressing 幼苗展出提高的 coleoptile 延伸,增加的 mesocotyl 生长和极其扭曲的短根,展示在米饭提高了乙烯反应显型。谷物长度在 MHZ7 转基因的植物被支持, 1000 谷物重量在 mhz7 异种被减少。衰老的过程也是的叶由 MHZ7 表示影响了。乙烯发信号的操作可以在 rice.Key 词改进适应生长和收益相关的特点: | Biao Ma Si-Jie He Kai-Xuan Duan Cui-Cui Yin Hui Chen Chao Yang Qing Xiong Qing-Xin Song Xiang LU Hao-Wei Chen dVan-Ke Zhang Tie-Gang Lu Shou-Yi Chen Jin-Song Zhang | 2013 | Molecular Plant2013，6，6： | 15 |
| 13 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 14 | Delayed error verification in quantum key distribution显示文摘Quantum key distribution(QKD)provides an unconditional secure key generation method between two distant legitimate parties Alice and Bob based on the fundamental properties of quantum mechanics,in the presence of an eavesdropper Eve.Since key reconciliation cannot always assure that the reconciled keys between Alice and Bob are identical,error verification is an important step in QKD.In this paper,we propose a scheme of delayed error verification using extra keys gained by privacy amplification with an arbitrarily small failure probability.The proposed scheme simplifies the post-processing procedure in QKD,which can be applied in practical QKD systems. | Chun-Mei Zhang Xiao-Tian Song Patcharapong Treeviriyanupab Mo Li Chao Wang Hong-Wei Li Zhen-Qiang Yin Wei Chen Zheng-Fu Han | 2014 | Chinese Science Bulletin2014，59，23： | 12 |
| 15 | A Facile Synthesis of Monodisperse Au Nanoparticles and Their Catalysis of CO Oxidation显示文摘Monodisperse Au nanoparticles(NPs)have been synthesized at room temperature via a burst nucleation of Au upon injection of the reducing agent t-butylamine-borane complex into a 1,2,3,4-tetrahydronaphthalene solution of HAuCl4·3H2O in the presence of oleylamine.The as-synthesized Au NPs show size-dependent surface plasmonic properties between 520 and 530 nm.They adopt an icosahedral shape and are polycrystalline with multiple-twinned structures.When deposited on a graphitized porous carbon support,the NPs are highly active for CO oxidation,showing 100%CO conversion at-45°C. | Sheng Peng Youngmin Lee Chao Wang Hongfeng Yin Sheng Dai Shouheng Sun | 2008 | Nano Research2008，1，3： | 11 |
| 16 | Investigation of Induced Distortions in a-Si∶H/a-SiN_x∶H Multilayers by Raman Scattering Technique显示文摘The a Si∶H/SiN x ∶H sample series are investigated by means of Raman scattering technique(RST). The result shows that due to the structural mismatch between a Si∶H and a SiN x ∶H, severe induced distortions are produced in the interface of the heterojunction, and these induced distortions tend towards a certain energy state. The ordering of the interface structure depends on the periodic number of multilayer thin films. | CAO Guo rong 1, GUO Shen kang 1, WANG Zhi chao 2, LIU Yin chun 2, SUN Mei xiang 2 (1.Dept. of Phys., Jiangsu University, Zhenjiang 212003, CHN 2.Dept. of Phys., Nanjing University, Nanjing 210093, CHN) | 2002 | Semiconductor Photonics and Technology2002，8，4： | 8 |
| 17 | Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas显示文摘AIM To explore the association between Helicobacter pylori(H. pylori) infection status, intestinal metaplasia(IM), and colorectal adenomas.METHODS We retrospectively reviewed 1641 individuals aged ≥ 40 years who underwent physical examination, laboratory testing, 13C-urea breath testing, gastroscopy, colonoscopy, and an interview to ascertain baseline characteristics and general state of health. Histopathological results were obtained by gastric and colorectal biopsies.RESULTS The prevalence of H. pylori infection and adenomas was 51.5%(845/1641) and 18.1%(297/1641), respectively. H. pylori infection was significantly correlated with an increased risk of colorectal adenomas(crude OR = 1.535, 95%CI: 1.044-1.753, P = 0.022; adjusted OR = 1.359, 95%CI: 1.035-1.785, P = 0.028). Individuals with IM had an elevated risk of colorectal adenomas(crude OR = 1.664, 95%CI: 1.216-2.277, P = 0.001; adjusted OR = 1.381, 95%CI: 0.998-1.929, P = 0.059). Stratification based on H. pylori infection stage and IM revealed that IM accompanied by H. pylori infection was significantly associated with an increased risk of adenomas(crude OR = 2.109, 95%CI: 1.383-3.216, P= 0.001; adjusted OR = 1.765, 95%CI: 1.130-2.757, P = 0.012).CONCLUSION H. pylori-related IM is associated with a high risk of colorectal adenomas in Chinese individuals. | Ye Yan Yi-Na Chen Qian Zhao Chao Chen Chun-Jing Lin Yin Jin Shuang Pan Jian-Sheng Wu | 2017 | World Journal of Gastroenterology2017，23，8： | 8 |
| 18 | Numerical Experiment of the Solid Particle Erosion of Bionic Configuration Blade of Centrifugal Fan显示文摘In this paper, a bionic method was presented to improve the erosion resistance of blade of the centrifugal fan. A numerical investigation of the solid particle erosion on the standard and bionic configuration blade of 4-72N10C centrifugal fan was presented. The numerical study employs computational fluid dynamics (CFD) software, based on a finite volume method, in which the discrete phase model was used to modele the solid particles flow, and the Eulerian conservation equation was adopt to simulate the continuous phase. Moreover, user-defined function was used to define wear equation. The various diameters of the particles were taken into account. The positions of collision of standard and bionic fan blades were discussed, and two kinds of centrifugal fan blade wear were compared. The results show that the particles from the incident source with different positions have different processes of turning and movement when enter into the impeller. The trajectories of flow in the fan channel are significantly different for the particles with different diameters. Bionic fan blade have lower erosion rate than the standard fan blade when the particle size is 20 μm. The anti-erosion mechanism of the bionic fan blade was discussed. | Junqiu ZHANG Zhiwu HAN Wei YIN Huiyuan WANG Chao GE Jialian JIANG | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，1： | 8 |
| 19 | Analyses of nitrobenzene, benzene and aniline in environmental water samples by headspace solid phase micro-extraction coupled with gas chromatography-mass spectrometry显示文摘A headspace solid phase microextrac- tion coupled with gas chromatography mass spec- trometry (HS-SPME/GC-MS) method was estab- lished for analyzing nitrobenzene, benzene and ani- line in environmental water samples simultaneously. Factors affecting extraction efficiency (SPME fiber selection, acidity, temperature, salt addition, extrac- tion time, headspace, etc) were verified. Under opti- mal extraction conditions, the detection limits are 0.50, 0.11 and 1.00 μg/L for nitrobenzene, benzene and aniline, respectively. The results indicate that this method is capable of making sensitive and accuracy analyses on nitrobenzene, benzene and aniline in environmental water samples. | CHEN Ming YIN Yongguang TAI Chao ZHANG Qinghua LIU Jiyan HU Jingtian JIANG Guibin | 2006 | Chinese Science Bulletin2006，51，13： | 8 |
| 20 | Tissue array for Tp53,C-myc,CCND1 gene over-expression in different tumors显示文摘AIM:To rapidly detect molecular alterations in different malignancies and investigate the possible role of Tp53,C-myc,and CCND1 genes in development of tumors in human organs and their adjacent normal tissues,as well as the possible relation between well-and poorly-differentiated tumors.METHODS:A tissue array consisting of seven different tumors was generated.The tissue array included 120 points of esophagus,120 points of stomach,80 points of rectum,60 points of thyroid gland,100 points of mammary gland,80 points of liver,and 80 points of colon.Expressions of Tp53,C-myc,and CCND1 were determined by RNA in situ hybridization.3' terminal digoxin-labeled anti-sense single stranded oligonucleotide and locked nucleic acid modifying probe were used.RESULTS:The expression level of Tp53 gene was higher in six different carcinoma tissue samples than in paracancerous tissue samples with the exception in colon carcinoma tissue samples(P < 0.05).The expression level of CCND1 gene was significantly different in different carcinoma tissue samples with the exception in esophagus and colon carcinoma tissue samples.The expression level of C-myc gene was different in esophagus carcinoma tissue samples(c2 = 18.495,P = 0.000),stomach carcinoma tissue samples(c2 = 23.750,P = 0.000),and thyroid gland tissue samples(c2 = 10.999,P = 0.004).The intensity of signals was also different in different carcinoma tissue samples and paracancerous tissue samples.CONCLUSION:Over-expression of the Tp53,CCND1,and C-myc genes appears to play a role in development of human cancer by regulating the expression of mRNA.Tp53,CCND1 and C-myc genes are significantly correlated with the development of different carcinomas. | Guo-Yan Liu Qi Luo Bin Xiong Chao Pan Ping Yin Hong-Feng Liao Wei-Chun Zhuang Hong-Zhi Gao | 2008 | World Journal of Gastroenterology2008，14，47： | 7 |
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