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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Aerobic Oxidation of Benzyl Alcohol Catalyzed by Cu-Mn Mixed Oxides and 2,2,6,6-Tetramethyl-piperidyl-1-oxyl显示文摘异构的 Cu-Mn 混合了氧化物能调停由在中立状况下面的分子的氧的本甲基酒精的催化速度的选择氧化,并且是 recyclable。在超过 1 的 Cu 和 Mn 的摩尔比率的情况中,在 Cu-Mn 内的高度分散的 CuO 混合了氧化物为在催化氧化的好表演负责。给词调音:Cu-Mn 氧化物;2,2,6,6-tetramethyl-piperidyl-l-oxyl;氧气的氧化; | Yanchun Guo Junfeng Zhao Jinxia Xu Wei Wang Fengshou Tian Guanyu Yang Maoping Song | 2007 | Journal of Natural Gas Chemistry2007，16，2： | 6 |
| 3 | High N-doped hierarchical porous carbon networks with expanded interlayers for efficient sodium storage显示文摘Sodium-ion batteries (SIBs) have been attracting considerable attention as a promising candidate for large-scale energy storage because of the abundance and low-cost of sodium resources. However, lack of appropriate anode materials impedes further applications. Herein, a novel self-template strategy is designed to synthesize uniform flowerlike N-doped hierarchical porous carbon networks (NHPCN) with high content of N (15.31 at.%) assembled by ultrathin nanosheets via a self-synthesized single precursor and subsequent thermal annealing. Relying on the synergetic coordination of benzimidazole and 2-methylimidazole with metal ions to produce a flowerlike network, a self-formed single precursor can be harvested. Due to the structural and compositional advantages, including the high N doping, the expanded interlayer spacing, the ultrathin two-dimensional nano-sized subunits, and the three-dimensional porous network structure, these unique NHPCN flowers deliver ultrahigh reversible capacities of 453.7 mAh·g^−1 at 0.1 A·g^−1 and 242.5 mAh·g^−1 at 1 A·g^−1 for 2,500 cycles with exceptional rate capability of 5 A·g^−1 with reversible capacities of 201.2 mAh·g^−1. The greatly improved sodium storage performance of NHPCN confirms the importance of reasonable engineering and synthesis of hierarchical carbon with unique structures. | Dongqin Su Man Huang Junhao Zhang Xingmei Guo Jiale Chen Yanchun Xue Aihua Yuan Qinghong Kong | 2020 | Nano Research2020，13，10： | 5 |
| 4 | Zephyranthes-like Co2NiSe4 arrays grown on 3D porous carbon frame-work as electrodes for advanced supercapacitors and sodium-ion batteries显示文摘Developing suitable electrode materials for electrochemical energy storage devices by biomorph assisted design has become a fascinating topic due to the fantastic properties derived from bio-architectures.Herein,zephyranthes-like Co_(2)NiSe_(4)arrays grown on butterfly wings derived three-dimensional(3D)carbon framework(Z-Co_(2)NiSe_(4)/BWC)is fabricated via hydrothermal assembly and further conversion method.Benefiting from its unique structure and multi-components,the obtained Z-Co_(2)NiSe_(4)/BWC electrode for supercapacitor delivers an excellent specific capacitance of 2,280 F·g^(-1)at 1 A·g^(-1).Impressively,the constructed asymmetric supercapacitor using Co_(2)NiSe_(4)/BWC as positive electrode and activated butterfly wings carbon as negative electrode acquires a high energy density of 42.9 Wh·kg^(-1)at a power density of 800 W·kg^(-1)with robust stability of 94.6%capacitance retention at 10 A·g^(-1)after 5,000 cycles.Moreover,the Z-Co_(2)NiSe_(4)/BWC as anode for sodium-ion batteries exhibits a high specific capacity of 568 mAh·g^(-1)at 0.1 A·g^(-1)and high cycling stability(maintaining 80.1%of the second cycle after 100 cycles).The outstanding electrochemical performances are ascribed to that the synergistic effect of bimetallic selenides and N-doped carbon improves electrochemical activities and conductivity.One-dimensional(1D)nanoneedles grown on 3D porous framework increase the exposure of redox-active sites,endow adequate transmission channels of electrons/ions,and guarantee stability of the electrode during charge/discharge processes.This study will shed light on the avenue towards extending such nanohybrids to excellent energy storage applications. | Yanchun Xue Xingmei Guo Mengrong Wu Jiale Chen Mengting Duan Jing Shi Junhao Zhang Fu Cao Yuanjun Liu Qinghong Kong | 2021 | Nano Research2021，14，10： | 3 |
| 5 | A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery显示文摘SARS-CoV-2 causes the pandemic of COVID-19 and no effective drugs for this disease are available thus far.Due to the high infectivity and pathogenicity of this virus,all studies on the live virus are strictly confined in the biosafety level 3(BSL3)laboratory but this would hinder the basic research and antiviral drug development of SARS-CoV-2 because the BSL3 facility is not commonly available and the work in the containment is costly and laborious.In this study,we constructed a reverse genetics system of SARS-CoV-2 by assembling the viral cDNA in a bacterial artificial chromosome(BAC)vector with deletion of the spike(S)gene.Transfection of the cDNA into cells results in the production of an RNA replicon that keeps the capability of genome or subgenome replication but is deficient in virion assembly and infection due to the absence of S protein.Therefore,such a replicon system is not infectious and can be used in ordinary biological laboratories.We confirmed the efficient replication of the replicon by demonstrating the expression of the subgenomic RNAs which have similar profiles to the wild-type virus.By mutational analysis of nsp12 and nsp14,we showed that the RNA polymerase,exonuclease,and cap N7 methyltransferase play essential roles in genome replication and sgRNA production.We also created a SARS-CoV-2 replicon carrying a luciferase reporter gene and this system was validated by the inhibition assays with known anti-SARS-CoV-2 inhibitors.Thus,such a one-plasmid system is biosafe and convenient to use,which will benefit both fundamental research and development of antiviral drugs. | Yun-Yun Jin Hanwen Lin Liu Cao Wei-Chen Wu Yanxi Ji Liubing Du Yiling Jiang Yanchun Xie Kuijie Tong Fan Xing Fuxiang Zheng Mang Shi Ji-An Pan Xiaoxue Peng Deyin Guo | 2021 | Virologica Sinica2021，36，5： | 2 |
| 6 | Neuroprotection of phenolic alkaloids from Menispermum dauricum versus melatonin against oxygen-glucose-serum-deprivation-mediated injury显示文摘BACKGROUND: Recent studies have demonstrated that phenolic alkaloids from Menispermum dauricum (PAMD) can protect the heart and brain from ischemia/reperfusion injury, and promote neuron survival by inhibiting neuronal Bax and upregulating Bcl-2 expression following ische- mia/reperfusion. OBJECTIVE: To investigate the neuroprotective effects of PAMD versus exogenous melatonin against ischemia/reperfusion injury. DESIGN, TIME AND SETTING: Observation and comparison experiments at a cellular level were performed at the Department of Biochemistry and Molecular Biology, Tongji Medical College of Huazhong University of Science and Technology between February 2007 and February 2008. MATERIALS: PAMD (95% purity) was provided by Kunming Institute of Botany, Chinese Academy of Sciences; melatonin was provided by Sigma, USA. METHODS: N2a mouse neuroblastoma cells were cultured in vitro deprived of glucose, serum and oxygen for 90 minutes, then cultured in normal medium containing different concentrations of PAMD (0.1, 1.0, 10 mg/L) or melatonin (1, 10, and 100 μmol/L). Cells cultured in normal conditions served as a control. MAIN OUTCOME MEASURES: The culture solution was collected to determine the content of ex- citatory neurotransmitters such as glutamic acid and aspartic acid; cell viability was detected by MTT methods; reactive oxygen species production was determined by fluorescence spectroscopy; mito- chondrial transmembrane potential (?Ψm) was detected by laser confocal scanning; cytochrome C was measured by western blotting; and caspase-3 activity was determined by visible spectropho- tometry. RESULTS: Melatonin and PAMD both promoted oxygen-glucose-serum deprivation-mediated N2a cell survival (P < 0.01) and inhibited glutamic acid release (P < 0.01), but melatonin did not inhibit aspartic acid production. The protective effects were the strongest using melatonin 100 μmol/L and PAMD 10 mg/L, so subsequent experiments were the performed at those doses. Although PAMD could no longer maintain mitochondrial transmembrane potential 6 hours after reperfusion, its in- hibitory effects on cytochrome C release from mitochondria and scavengers of reactive oxygen species were stronger than those of melatonin (P < 0.01). However, its inhibitory effect on caspase-3 activity was weaker than that of melatonin: PAMD could inhibit caspase-3 activity 12 hours after reperfusion (P < 0.01), but melatonin inhibited caspase-3 activity 28 hours after reperfusion (P < 0.01). CONCLUSION: The results show that melatonin and PAMD have neuroprotective effects, but that the mechanisms are varied. Melatonin can maintain mitochondrial transmembrane potential, but its inhibitory effects on cytochrome C release, caspase-3 activity, and reactive oxygen species scav-enging are different from those of PAMD. | Zhongqiang Wang Jianfei Wang Yanchun Guo Tao Lu Ximing Wang Qiuhong Duan | 2009 | Neural Regeneration Research2009，4，1： | 2 |
| 7 | KOH-assisted aqueous synthesis of bimetallic metal-organic frameworks and their derived selenide composites for efficient lithium storage显示文摘To solve low efficiency,environmental pollution,and toxicity for synthesizing zeolitic imidazolate frameworks(ZIFs)in organic solvents,a KOH-assisted aqueous strategy is proposed to synthesize bimetallic ZIFs polyhedrons,which are used as precursors to prepare bimetallic selenide and N-doped carbon(NC)composites.Among them,Fe–Co–Se/NC retains the three-dimensional(3D)polyhedrons with mesoporous structure,and Fe–Co–Se nanoparticles are uniform in size and evenly distributed.When assessed as anode material for lithium-ion batteries,Fe–Co–Se/NC achieves an excellent initial specific capacity of 1165.9 m Ah·g^(-1)at 1.0 A·g^(-1),and the reversible capacity of Fe–Co–Se/NC anode is 1247.4 m Ah·g^(-1)after 550 cycles.It is attributed to that the uniform composite of bimetallic selenides and N-doped carbon can effectively tune redox active sites,the stable 3D structure of Fe–Co–Se/NCs guarantees the structural stability and wettability of the electrolyte,and the uniform distribution of Fe–Co–S nanoparticles in size esuppresses the volume expansion and accelerates the electrochemical reaction kinetics. | Shuya Zhang Yanchun Xue Yutang Zhang Chengxing Zhu Xingmei Guo Fu Cao Xiangjun Zheng Qinghong Kong Junhao Zhang Tongxiang Fan | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，4： | 2 |
| 8 | Co-producing hydrogen and methane from higher-concentration of corn stalk by combining hydrogen fermentation and anaerobic digestion显示文摘 | Guo Yanchun Dai Yang Bai Yanxia | 2014 | International Journal of Hydrogen Energy2014，39，14： | 1 |
| 9 | Surface strengthening of Ti 3 SiC 2 through magnetron sputtering Cu and subsequent annealing显示文摘 | Haiping Guo Jie Zhang Fangzhi Li Yi Liu Jinjie Yin Yanchun Zhou | 2008 | Journal of the European Ceramic Society2008，，10： | 1 |
| 10 | Research progress on resource utilization of leather solid waste显示文摘Leather making is the process of converting raw hides into leather.Amounts of solid waste containing hazardous and high value components are generated during this process.Therefore,the elimination of the potential pollution and resource utilization of leather solid waste are the primary research hotspots.Herein,we comprehensively review the recent advances in the resource utilization of leather solid waste generated from chrome tanning including the utilization of tannery hair waste,untanned solid waste,chrome-containing leather solid waste,tannery sludge and finished leather waste,emphasizing on the general and novel utilization approaches.Finally,the remaining challenges and perspectives were summarized,in order to accelerate the development of resource utilization of leather solid waste. | Yanchun Li Ruijun Guo Wenhui Lu Deyi Zhu | 2019 | Journal of Leather Science and Engineering2019，1，1： | 1 |
| 11 | Forward modeling and inversion of the relation model between the gas content of plume and its seismic attribute显示文摘The methane bubble plume attracts interest because it offers direct evidence of seafloor gas leakage and plays an indirect role in the exploration and identification of natural gas hydrate.In this study,based on established plume models and their migration sections,three amplitude-class attributes were extracted from three formations for the migration sections of five plumes,and the correlation between the gas content and seismic attribute was obtained.As the gas content increases,the amplitude attribute correspondingly increases,and the linear correlation is relatively good.Moreover,correlation coefficients between gas content and amplitude attributes are close to 1.0.By using linear fitting,the relation model between the gas content of the plume and the seismic attribute was obtained.The relation model was subsequently used to invert the gas content from a real databearing plume.Comparison of the gas content section of the plume with the attribute section and real seismic section reveals common distribution characteristics,namely,the color of the section in the lower right corner is dark.If the amplitude value is large in the seismic section of the real plume,the amplitude attribute value is also large in the corresponding attribute section,and the inverted value of the gas content is also large(because gas content and amplitude are linearly correlated),which indicates that the plume bubbles of the section in the lower right corner is intensively distributed.Finally,the obtained gas content section of the plume can reflect the distribution of the plume bubble content more simply and intuitively,from which the distribution law of seafloor bubbles can be deduced,and this lays a foundation for the further estimation of the gas content of the plume and hydrate reserves. | Canping Li Jiachun You Yanchun Tan Fengying Chen Yilin Liu Zihao Guo Xinyu Tian | 2021 | Acta Oceanologica Sinica2021，40，5： | 1 |
| 12 | In vitro & in vivo targeting behaviors of biotinylated Pluronic F127/poly (lactic acid) nanoparticles through biotin-avidin interaction显示文摘 | Xiang Xiangyuan Guo Liang Gong Yanchun | 2012 | European Journal of Pharmaceutical Sciences2012，46，5： | 1 |
| 13 | On the additive k-power complements 显示文摘 | Guo Yanchun | 2008 | Scientia Magna2008，4，2： | 1 |
| 14 | KOH-assisted aqueous synthesis of ZIF-67 with high-yield and its derived cobalt selenide/carbon composites for high-performance Li-ion batteries显示文摘To solve the environmental pollution and low yield during the sythesis of zeolitic imidazolate frameworks(ZIFs)and their derived materials,a KOH-assisted aqueous strategy is proposed to synthesize cobalt zeolitic imidazolate framework(ZIF-67)polyhedrons,which are used as precursors to prepare cobalt selenide/carbon composites with different crystal phases(Co_(0.85)Se,CoSe_2).When evaluated as anode material for lithium ion batteries,Co_(0.85)Se/C composites deliver a reversible capacity of 758.7 m A·h·g^(-1)with a capacity retention rate of 90.5%at 1.0 A·g^(-1)after 500 cycles,and the superior rate capability is 620 m A·h·g^(-1)at 2.0 A·g^(-1).The addition of KOH accelerates the production of ZIF-67 crystals by boosting deprotonation of dimethylimidazole,resulting in rapid growth and structures transition from two-dimensional to three-dimensional of ZIF-67 in aqueous solution,which greatly promotes the application of MOFs in the field of energy storage and conversion. | Kai Xue Yanchun Xue Jing Wang Shuya Zhang Xingmei Guo Xiangjun Zheng Fu Cao Qinghong Kong Junhao Zhang Zhong Jin | 2023 | Chinese Journal of Chemical Engineering2023，57，5： | 0 |
| 15 | Synthesis and Evaluation of Photophysical Properties of C-3 Halogenated Derivatives of 2-Phenylimidazo[1,2-a]pyridine显示文摘A CuX-mediated regioselective halogenation reaction of 2-phenylimidazo[1,2-a]pyridine in the presence of oxygen is introduced in this paper.This reaction provides an effective method for the production of C-3 halogenated 2-phenylimidazo[1,2-a]pyridines with a yield of up to 96%.A plausible mechanism for the formation of title compounds via 2-phenylimidazo[1,2-a]pyridine–CuX complex intermediate is proposed.The structure of representative compounds is established by the single crystal XRD method.The electronic structure,corroborated by Hirshfeld surface analysis and DFT calculations,rationalizes characters of relevant absorptions and emission as well as large Stokes shifts. | Hong Chen Yanyan Wang Qingjie Liu Yanchun Guo Shuxia Cao Yufen Zhao | 2022 | Chinese Journal of Chemistry2022，40，19： | 0 |
| 16 | Special issue: Near-net shaping technology显示文摘 | Dequn LI Dongming GUO Qingxue HUANG Yanchun LOU | 2018 | Frontiers of Mechanical Engineering2018，13，1： | 0 |
| 17 | Investigation of Reaction Mechanism of Amino Acids and Phosphorus Trichloride by 31P NMR and ESI-MS/MS显示文摘在 THF 的氨基酸和磷 trichloride 的反应被跟踪的 31P NMR 和 ESI-MS/MS 学习。一系列 hydridophoranes 和周期的 dipeptides 被获得。反应介绍了有趣的差异,反应机制被建议。机制建议那磷在氨基酸 hydridophorane 和周期的 dipeptides 的合成起一个重要作用。结果也证明 31P NMR 和 ESI-MS/MS 是为反应机制的调查的有用工具。 | Guo, Yanchun Cao Shuxia Xie, Yali Zong, Xiangkun Zhao, Yufen | 2011 | Chinese Journal of Chemistry2011，29，6： | 0 |
| 18 | Association of variants in the KIF1A gene with amyotrophic lateral sclerosis显示文摘Background:Amyotrophic lateral sclerosis(ALS)is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and the spinal cord.As in many other neurodegenerative disorders,the genetic risk factors and pathogenesis of ALS involve dysregulation of cytoskeleton and neuronal transport.Notably,sen-sory and motor neuron diseases such as hereditary sensory and autonomic neuropathy type 2(HSAN2)and spastic paraplegia 30(SPG30)share several causative genes with ALS,as well as having common clinical phenotypes.KIF1A encodes a kinesin 3 motor that transports presynaptic vesicle precursors(SVPs)and dense core vesicles and has been reported as a causative gene for HSAN2 and SPG30.Methods:Here,we analyzed whole-exome sequencing data from 941 patients with ALS to investigate the genetic association of KIF1A with ALS.Results:We identified rare damage variants(RDVs)in the KIF1A gene associated with ALS and delineated the clini-cal characteristics of ALS patients with KIF1A RDVs.Clinically,these patients tended to exhibit sensory disturbance.Interestingly,the majority of these variants are located at the C-terminal cargo-binding region of the KIF1A protein.Functional examination revealed that the ALS-associated KIF1A variants located in the C-terminal region preferentially enhanced the binding of SVPs containing RAB3A,VAMP2,and synaptophysin.Expression of several disease-related KIF1A mutants in cultured mouse cortical neurons led to enhanced colocalization of RAB3A or VAMP2 with the KIF1A motor.Conclusions:Our study highlighted the importance of KIF1A motor-mediated transport in the pathogenesis of ALS,indicating KIF1A as an important player in the oligogenic scenario of ALS. | Panlin Liao Yanchun Yuan Zhen Liu Xiaorong Hou Wanzhen Li Jin Wen Kexuan Zhang Bin Jiao Lu Shen Hong Jiang Jifeng Guo Beisha Tang Zhuohua Zhang Zhonghua Hu Junling Wang | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
| 19 | A Large Acute Gastroenteritis Outbreak Associated with Both Campylobacter coli and Human Sapovirus—Beijing Municipality,China,2021显示文摘Summary What is already known about this topic?Campylobacter is a significant foodborne pathogen that leads to global outbreaks of acute gastroenteritis(AGE)usually affecting less than 30 individuals.Human sapovirus(HuSaV)is an enteric virus responsible for sporadic cases and outbreaks of AGE worldwide.In a study conducted in Beijing,HuSaV detection ranked second after norovirus.What is added by this report?We present a discussion of the first large-scale outbreak of AGE caused by both Campylobacter coli(C.coli)and HuSaV.The outbreak involved a total of 996 patients and exhibited two distinct peaks over a period of 17 days.Through case-control studies,we identified exposure to raw water from a secondary water supply system as a significant risk factor.Among 83 patients,49 samples tested positive for C.coli,39 samples tested positive for HuSaV,and 27 samples tested positive for both pathogens using real-time polymerase chain reaction detection.Furthermore,whole-genome sequencing of 17 C.coli isolates obtained from 17 patients revealed that all isolates belonged to a highly clonal strain of C.coli.What are the implications for public health practice?Outbreaks of AGE resulting from multiple pathogen infections warrant increased attention.This report emphasizes the significance of ensuring the safety of drinking water,particularly in secondary supply systems. | Lin Zou Ying Li Guilan Zhou Zhenzhou Huang Changyan Ju Chunyan Zhao Xiang Gao Bojun Zhen Ping Zhang Xiaochen Guo Jing Zhang Yang Zhang Bo Liu Shaolei Zhou Aixia Yan Ying Kang Yanchun Wang Hongmei Ma Xiaohui Li Maojun Zhang | 2023 | China CDC weekly2023，5，52： | 0 |
| 20 | Author Correction:Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prog nosis in esophageal squamous cell carcinoma显示文摘Correction to:Cell Research https://doi.org/10.1038/s41422-020-0333-6,published online 12 May 2020 In the initial published version of this article,there was an error in the Supplementary information,Table S1.Row 463 and row 80 have the same sample id BDESCC-01-838.After checking the original id of these two samples,we found that they were actually two different samples.This error was caused by Excel random numbering when we assigned the external id to each sample.Thus,we re-assigned a new id BDESCC-01-839 to the row 4P3 sample to fix this issue. | Yongping Cui Hongyan Chen Ruibin Xie Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qi min Zhan Yanhong Li Zhihua Liu | 2022 | Cell Research2022，32，4： | 0 |
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