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| 1 | Deep carbon cycles constrained by a large-scale mantle Mg isotope anomaly in eastern China显示文摘Although deep carbon recycling plays an important role in the atmospheric CO_2 budget and climate changes through geological time,the precise mechanisms remain poorly understood.Since recycled sedimentary carbonate through plate subduction is the main light-δ^(26)Mg reservoir within deep-Earth,Mg isotope variation in mantle-derived melts provides a novel perspective when investigating deep carbon cycling.Here,we show that the Late Cretaceous and Cenozoic continental basalts from 13 regions covering the whole of eastern China have low δ^(26)Mg isotopic compositions,while the Early Cretaceous basalts from the same area and the island arc basalts from circum-Paciic subduction zones have mantle-like or heavy Mg isotopic characteristics.hus,a large-scale mantle low δ^(26)Mg anomaly in eastern China has been delineated,suggesting the contribution of sedimentary carbonates recycled into the upper mantle,but limited into the lower mantle.his large-scale spatial and temporal variation of Mg isotopes in the mantle places severe constraints on deep carbon recycling via oceanic subduction. | Shu-Guang Li Wei Yang Shah Ke Xunan Meng Hengci Tian Lijuan Xu Yongsheng He Jian Huang Xuan-Ce Wang Qunke Xia Weidong Sun Xiaoyong Yang Zhong-Yuan Ren Haiquan Wei Yongsheng Liu Fancong Meng Jun Yan | 2017 | National Science Review2017，4，1： | 23 |
| 2 | Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix metalloproteinase-9 expression显示文摘Objective:To explore the molecular mechanisms of antitumor properties of triptolide,a bioactive component isolated from the Chinese herb Tripterygium wolfordii Hook F.Methods:Human fibrosarcoma HT-1080 cells were treated with different doses of triptolide for 72 h.Then the expression and activity of matrix metalloproteinase(MMP)-2 and -9 were measured and the invasiveness of triptolide-treated HT-1080 cells was compared with that of anti-MMP-9- treated HT-1080 cells.Results:18 nmol/L triptolide inhibited the gene expression and activity of MMP-9,but not those of MMP-2,in HT-1080 cells.In addition,both 18 nmol/L triptolide and 3μg/mL anti-MMP-9 significantly reduced the invasive potential of HT-1080 cells,by about 50%and 35%, respectively,compared with the control.Whereas there was no significant difference between the effect of 18 nmol/L triptolide and that of anti-MMP-9 on invasive potential of HT-1080 cells. Conclusions:These data suggest that triptolide inhibits tumor cell invasion partly by reducing MMP-9 gene expression and activity. | Shengbo Yang Can Gu Guiying Zhang Jian Kang Haiquan Wen QianJin Lu Jinhua Huang | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 3 |
| 3 | Building Extraction from LIDAR Based Semantic Analysis显示文摘Extraction of buildings from LIDAR data has been an active research field in recent years. A scheme for building detection and reconstruction from LIDAR data is presented with an object-oriented method which is based on the buildings’ semantic rules. Two key steps are discussed: how to group the discrete LIDAR points into single objects and how to establish the buildings’ semantic rules. In the end, the buildings are reconstructed in 3D form and three common parametric building models (flat, gabled, hipped) are implemented. | YU Jie YANG Haiquan TAN Ming ZHANG Guoning | 2006 | Geo-Spatial Information Science2006，9，4： | 2 |
| 4 | Exact cone beam reconstruction for a saddle trajectory显示文摘 | Yang Haiquan Li Meihua Koizumi K | 2006 | Phys Med Biol2006，51，： | 1 |
| 5 | A Fast Approach for Predicting Aerodynamic Noise Sources of High-Speed Train Running in Tunnel显示文摘The aerodynamic noise of high-speed trains passing through a tunnel has gradually become an important issue.Numerical approaches for predicting the aerodynamic noise sources of high-speed trains running in tunnels are the key to alleviating aerodynamic noise issues.In this paper,two typical numerical methods are used to calculate the aerodynamic noise of high-speed trains.These are the static method combined with non-reflective boundary conditions and the dynamic mesh method combined with adaptive mesh.The fluctuating pressure,flow field and aerodynamic noise source are numerically simulated using the abovemethods.The results showthat the fluctuating pressure,flow field structure and noise source characteristics obtained using different methods,are basically consistent.Compared to the dynamic mesh method,the pressure,vortex size and noise source radiation intensity,obtained by the static method,are larger.The differences are in the tail car and its wake.The two calculation methods show that the spectral characteristics of the surface noise source are consistent.The maximum difference in the sound pressure level is 1.9 dBA.The static method is more efficient and more suitable for engineering applications. | Deng Qin Tian Li Honglin Wang Jizhong Yang Yao Jiang Jiye Zhang Haiquan Bi | 2022 | Computer Modeling in Engineering & Sciences2022，，3： | 1 |
| 6 | Spectrum sensing in cognitive radio using goodness of fit testing显示文摘 | WANG Haiquan YANG Enhui ZHAO Zhijin | 2009 | IEEE Transaction on Wireless Commu- nication2009，8，11： | 1 |
| 7 | Spec- trum sensing in cognitive radio using goodness of fit tes- ting 显示文摘 | Wang Haiquan Yang Enhui Zhao Zhijin | 2009 | IEEE Transactions on Wireless Communica- tions2009，8，11： | 1 |
| 8 | Exact cone beam recomtruction for a saddle trajectory 显示文摘 | Yang Haiquan LiMeihua Kazuhito K | 2006 | Phys Med Biol2006，51，： | 1 |
| 9 | Spec- trum Sensing in Cognitive Radio Using Goodness of Fit Tes- ting显示文摘 | WANG Haiquan YANG Enhui ZHAO Zhijin | 2009 | IEEE Transactions on Wireless Communications2009，8，11： | 1 |
| 10 | Pattern of lymphatic spread in thoracic esophageal squamous cell carcinoma: A single-institution experience显示文摘 | Bin Li Haiquan Chen Jiaqing Xiang Yawei Zhang Chenguang Li Haichuan Hu Yang Zhang | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，4： | 1 |
| 11 | Adenovirus Ad-p53AIP1-mediated gene therapy and its regulation of p53-MDM2interactions显示文摘 | Yunbo Jiang Huihua Chen Haiquan Jia Yuanji Xu Gang Liu Yan Wang Xiaohe Yang Yinglin Lu | 2010 | Experimental and Therapeutic Medicine2010，，2： | 1 |
| 12 | Spectrum sensing in cognitive radio using goodness of fit testing显示文摘 | Wang Haiquan Yang E Zhao Zhijin | 2009 | IEEE transaction on Wireless Communications2009，8，11： | 1 |
| 13 | The anti-EGFR antibody cetuximab sensitizes human head and neck squamous cell carcinoma cells to radiation in part through inhibiting radiation-induced upregulation of HIF-1α显示文摘 | Haiquan Lu Ke Liang Yang Lu Zhen Fan | 2012 | Cancer Letters2012，，1： | 1 |
| 14 | Enhancing thermostability and activity of sucrose phosphorylase for high-level production of 2-O-α-d-glucosylglycerol显示文摘Sucrose phosphorylase(SPase)can transfer the glucosyl group of sucrose to different compounds and has been widely used in industry.To overcome the low thermostability of the sucrose phosphorylase from Leuconostoc mesenteroides ATCC 12291(LmSP),a method named PROSS was used to construct mutants with increased thermostability.All variants were screened by measuring their residual activities after heating at 50℃.Then,a single point mutant and a combined mutant with improved thermostability and activity were obtained.The half-lives of mutants at 50℃ were approximately twice as high as those of the wild type.In addition,2-O-α-d-glucosylglycerol(αGG)was synthesized by the wild type and the two improved variants,and the reaction conditions were optimized.Under the conditions of glycerol concentration of 3.2 mol/L,sucrose concentration of 1.2 mol/L,and enzyme concentration of 40 U/mL at 37℃ for 60 h,the yield ofαGG reached the maximum,and the sucrose conversion rate of the wild type,the mutant V23L and the combined mutant V23L/S424R were 62.3%,70.7%and 76.3%,respectively.In this study,SPase mutants with higher activity and stability were obtained,and achieved high-level production ofαGG. | Linli Yang Lukasz Peplowski Yujuan Shen Haiquan Yang Xianzhong Chen Wei Shen Yuanyuan Xia | 2022 | Systems Microbiology and Biomanufacturing2022，2，4： | 1 |
| 15 | Design and analysis of optimal noisy channel quantization with random index assignment显示文摘 | YU XIANG WANG HAIQUAN YANG EN-HUI | 2010 | IEEE Transactions on Information Theory2010，56，11： | 1 |
| 16 | Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing显示文摘Dear Editor,Aberrant DNA methylation gets involved in cancer initiation,progression,and recurrence,which in turn makes it an ideal cancer biomarker.Various methylation markers or their panels have been developed in diverse cancer types.However,the model-constructing based marker mining strategy and incompatibility of application have greatly impeded their ways to clinic.Thus,single methylation marker applicable to all/most cancer types and multiple clinical scenarios is desperately needed.The hope came from the unexpected observation that HIST1H4F was universally hypermethylated in all 17 cancer types;thus,we raised the concept of“Universal Cancer Only Marker(UCOM)”and established a paradigm for discovery and clinical application of UCOM.1 Recently,a novel UCOM,hypermethylated PCDHGB7,was identified and found to advance cervical cancer(CC)screening to the precancerous stage.2 During the screening of UCOM,we discerned a bunch of cancer cell-differentially methylated regions.1 Among them,sine oculis(SIX)homeobox family of transcription factors,which were found to function as tumorigenesis regulator by promoting epithelial-to-mesenchymal transition and metastasis recently in addition to their traditional roles in tissue formation and organogenesis,3 sparked our special attention.Herein,we interrogate whether SIX6 methylation could serve as a novel UCOM and its potential applications. | Shihua Dong Zhicong Yang Peng Xu Wanxiang Zheng Baolong Zhang Fangqiu Fu Zhanrui Mao Jianlin Yuan Haiquan Chen Wenqiang Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 1 |
| 17 | Spectrum Sensing in Cognitive Radio Using Goodness of Fit Testing 显示文摘 | Haiquan Wang En-hui Yang Zhijin Zhao Wei Zhang | 2009 | IEEE Transaction on Wireless Communication2009，，： | 1 |
| 18 | Spec- trum Sensing in Cognitive Radio Using Goodness of Fit Testing显示文摘 | WANG Haiquan YANG Enhui ZHAO Zhijin | 2009 | IEEE Transactions on Wireless Communica- tions2009，8，11： | 1 |
| 19 | Mechanical Properties of PPV Film in Thermal Elimination Process显示文摘 | LI Qlngsong YANG Qingxiang ZHANG Haiquan | 2014 | Chemical Research in Chinese Universities2014，30，4： | 0 |
| 20 | Statistical modeling and optimization for enhanced hyaluronic acid production by batch culture of Sreptococcus zooepidemicus via the supplement of uracil显示文摘This work is aimed to achieve the optimal hyaluronic acid(HA)production by batch culture of Streptococcus zooepidemicus via the supplement of nucleotide bases using response surface methodology(RSM).First,the influence of nucleotide bases(adenine,guanine,cytosine,thymine,and uracil)on microbial HA production was investigated using fractional factorial design(FFD).By a 2^(5-2)FFD,uracil was found to be the most significant factor for cell growth and HA production,while the other nucleotide bases were shown to have no significant effects on cell growth and HA production.Also,the impact of uracil on cell growth and HA production was further investigated by RSM,where two variables were considered:uracil concentration and supplement time.The optimal uracil concentration and supplement time were found to be 0.051 g/L and 7 h,respectively,and the predicted maximal HA production reached 6.42 g/L.The maximal HA production increased from 5.0 g/L of the control without uracil supplement to 6.31 g/L at the optimal conditions in validation experiments. | Long LIU Haiquan YANG Miao WANG Guocheng DU Jian CHEN | 2009 | Frontiers of Chemical Science and Engineering2009，3，4： | 0 |
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