|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Tuning the selectivity of photoreduction of CO2 to syngas over Pd/layered double hydroxide nanosheets under visible light up to 600 nm显示文摘Photocatalytic reduction of CO2 with H2 O to syngas is an effective way for producing high value-added chemical feedstocks such as methanol and light olefins in industry.Nevertheless,the precise control of CO/H2 ratio from photocatalytic CO2 reduction reaction still poses a great challenge for the further application.Herein,we prepared a series of highly efficient heterostructure based on highly dispersed palladium supported on ultrathin Co Al-layered double hydroxide(LDH).In conjunction with a Ru-complex sensitizer,the molar ratios of CO/H2 can be tuned from 1:0.74 to 1:3 under visible-light irradiation(λ>400 nm).More interestingly,the syngas can be obtained under light irradiation atλ>600 nm.Structure characterization and density functional theory calculations revealed that the remarkable catalytic activity can be due to the supported palladium,which improved the charge transfer efficiency.Meanwhile,more H atoms were used to generate H2 on the supported palladium for further tunable CO/H2 ratio.This work demonstrates a new strategy for harnessing abundant solar-energy to produce syngas from a CO2 feedstock. | Xian Wang Zelin Wang Ya Bai Ling Tan Yanqi Xu Xiaojie Hao Jikang Wang Abdul Hanif Mahadi Yufei Zhao Lirong Zheng Yu-Fei Song | 2020 | Journal of Energy Chemistry2020，29，7： | 5 |
| 3 | Study on Shaopu Liu, the resonance ttering spectra of the interactionsof hydrochloride and chlorpromazinehydrochloride with 12-tungstophosphoric acid and their analytical applications显示文摘 | Pei Zhongfang Liu nonlinear sca promethazine li Chen and Yanqi Xiaoli Hu Song | 2010 | Spectrochimica ncta Part A:2010，77，1： | 1 |
| 4 | Study on the resonance nonlinear scattering spectra of the interactions of promethazine hydrochloride and chlorpromazine hydrochloride with 12-tungstophosphoric acid and their analytical applications显示文摘 | Peili Chen Xiaoli Hu Shaopu Liu Zhongfang Liu Yanqi Song | 2010 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2010，，1： | 1 |
| 5 | Improved prediction of differential subsidence caused by underground mining显示文摘 | Ximin Cui Xiexing Miao Jin’an Wang Shuo Yang Huide Liu Yanqi Song Hong Liu Xikuan Hu | 2000 | International Journal of Rock Mechanics and Mining Sciences2000，，4： | 1 |
| 6 | Theoretical and numerical calculation of stress field in cracked mass model 显示文摘 | SONG Yanqi ZHOU Honggang LI Ming | 2014 | Journal of Liaoning Technical University (Natural Science)2014，33，9： | 1 |
| 7 | Resonance ray leigh scattering spectra, nonlinear scattering spectra of malachite green-12-tungstophosphoric acid system and its analytical application in fish显示文摘 | Song Yanqi Liu Shaopu Liu Zhongfang | 2011 | Spectrochimica Acta2011，78，： | 1 |
| 8 | Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice显示文摘Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue,and poses a huge health burden. Precision medicine provides more treatment options for prostate cancer patients, but its popularity, drug resistance, and adverse reactions still need to be focused on. Chinese herbal medicines(CHMs) have been widely accepted as an alternative therapy for cancer, with the advantages of multiple targets, multiple pathways, and low toxicity. We searched the experimental research and clinical practice of CHMs for prostate cancer treatment published in Pub Med, Embase, and Web of Science in the last five years. We found five CHM formulas and six single CHM extracts as well as 12 CHM-derived compounds, which showed induction of apoptosis, autophagy, and cell cycle arrest, suppression of angiogenesis, proliferation, and migration of prostate cancer cells, reversal of drug resistance,and enhancement of anti-tumor immunity. The mechanisms of action include the PI3K/Akt/mTOR, AR,EGFR and Wnt/β-catenin signaling pathways, which are commonly implicated in the development of prostate cancer. We also summarized the advantages of CHMs in patients with hormone-sensitive and castration-resistant prostate cancer and provided ideas for their further experimental design and application. | Fanming Kong Chaoran Wang Jing Zhang Xiaoqun Wang Binxu Sun Xian Xiao Haojian Zhang Yanqi Song Yingjie Jia | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 9 | The design and implementation of GECAM satellite payload performancemonitoring software显示文摘Background The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)is primarily designed to spot gamma-ray bursts corresponding to gravitational waves.In order to achieve stable observations from various astronomical phenomena,the payload performance need to be monitored during the in-orbit operation.Method This article describes the design and implementation of GECAM satellite payload performance monitoring(GPPM)software.The software extracts the payload status and telescope observations(light curves,energy spectrums,characteristic peak fitting of energy spectrums,etc)from the payload data.Considering the large amount of payload status parameters in the engineering data,we have designed a method of parameter processing based on the configuration tables.This method can deal with the frequent changes of the data formats and facilitate program maintenance.Payload status and performance are monitored through defined thresholds and monitoring reports.The entire software is implemented in python language and the huge amount of observation data is stored in MongoDB.Conclusion The design and implementation of GPPM software have been completed,tested with ground and in-orbit payload data.The software can monitor the performance of GECAM payload effectively.The overall design of the software and the data processing method can be applied to other satellites. | Peng Zhang Xiang Ma Yue Huang Shaolin Xiong Shijie Zheng Liming Song Ge Ou Yanqi Du Jing Liang Hong Wu | 2022 | Radiation Detection Technology and Methods2022，6，1： | 0 |
| 10 | Timing fluctuation correction for the front end of a 100-PW laser显示文摘The development of high-intensity ultrafast laser facilities provides the possibility to create novel physical phenomena and matter states.The timing fluctuation of the laser pulses is crucial for pump–probe experiments,which is one of the vital means to observe the ultrafast dynamics driven by intense laser pulses.In this paper,we demonstrate the timing fluctuation characterization and control of the front end of a 100-PW laser that is composed of a high-contrast optical parametric amplifier(seed)and a 200-TW optical parametric chirped pulse amplifier(preamplifier).By combining the timing jitter measurement with a feedback system,the laser seed and preamplifier are synchronized to the reference with timing fluctuations of 1.82 and 4.48 fs,respectively.The timing system will be a key prerequisite for the stable operation of 100-PW laser facilities and provide the basis for potential pump–probe experiments performed on the laser. | Hongyang Li Keyang Liu Xinliang Wang Xingyan Liu Xianze Meng Yanqi Liu Liwei Song Yuxin Leng Ruxin Li | 2023 | High Power Laser Science and Engineering2023，11，4： | 0 |
| 11 | Boron quantum dots all-optical modulator based on efficient photothermal effect显示文摘All-optical devices without external electronic components have drawn extraordinary attentions in all-optical communication.In this work,boron quantum dots(BQDs)were synthesized by a facile liquid-phase exfoliation method.The as-prepared BQDs showed good structural homogeneity and crystallinity,broadband optical absorption as well as excellent photothermal properties.Femtosecond-resolved transient absorption further revealed the short carrier relaxation time of BQDs.Inspired by the outstanding photothermal properties and ultrafast carrier dynamic of BQDs,we fabricated BQDsbased all-optical modulator.The phase shift with a slope efficiency of 0.032π/m W and response time of 0.97 ms can be achieved.The modulator was used in laser resonance cavity to achieve all-optical actively Q-switched laser operation with control repetition rate.This prototypical BQDs-based all-optical modulator shows a great potential to be applied in all-optical information processing and communication. | Cong Wang Qianyuan Chen Hualong Chen Jun Liu Yufeng Song Jie Liu Delong Li Yanqi Ge Youning Gong Yupeng Zhang Han Zhang | 2021 | Opto-Electronic Advances2021，4，7： | 0 |
| 12 | Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: Single-cell transcriptome analysis显示文摘Osseointegration seems to be a foreign body reaction equilibrium due to the complicated interactions between the immune and skeletal systems.The heterogeneity of the osteoimmune microenvironment in the osseointegration of implant materials remains elusive.Here,a single-cell study involving 40043 cells is conducted,and a total of 10 distinct cell clusters are identified from five different groups.A preliminary description of the osteoimmune microenvironment revealed the diverse cellular heterogeneity and dynamic changes modulated by implant properties.The increased immature neutrophils,Ly6C+CCR2hi monocytes,and S100a8hi macrophages induce an aggressive inflammatory response and eventually lead to the formation of fibrous capsule around the stainless steel implant.The enrichment of mature neutrophils,FcgR1hi and differentiated immunomodulatory macrophages around the titanium implant indicates favorable osseointegration under moderate immune response.Neutrophil-depletion mice are conducted to explore the role of neutrophils in osseointegration.Neutrophils may improve bone formation by enhancing the recruitment of BMSCs via the CXCL12/CXCR3 signal axis.These findings contribute to a better knowledge of osteoimmunology and are valuable for the design and modification of‘osteoimmune-smart’biomaterials in the bone regeneration field. | Jia Li Congrui Zhao Yangbo Xu Lu Song Yanqi Chen Yuzi Xu Yang Ma Siyuan Wang Antian Xu Fuming He | 2023 | Bioactive Materials2023，，4： | 0 |
| 13 | Novel aerosol detection platform for SARS–CoV–2:Based on specific magnetic nanoparticles adsorption sampling and digital droplet PCR detection显示文摘The SARS–CoV–2 virus is released from an infectious source(such as a sick person)and adsorbed on aerosols,which can form pathogenic microorganism aerosols,which can affect human health through airborne transmission.Efficient sampling and accurate detection of microorganisms in aerosols are the premise and basis for studying their properties and evaluating their hazard.In this study,we built a set of sub-micron aerosol detection platform,and carried out a simulation experiment on the SARS–CoV–2 aerosol in the air by wet-wall cyclone combined with immunomagnetic nanoparticle adsorption sampling and ddPCR.The feasibility of the system in aerosol detection was verified,and the influencing factors in the detection process were experimentally tested.As a result,the sampling efficiency was 29.77%,and extraction efficiency was 98.57%.The minimum detection limit per unit volume of aerosols was 250 copies(102copies/m L,concentration factor 2.5). | Hui Chen Xinye Ma Xinyu Zhang Gui Hu Yan Deng Song Li Zhu Chen Nongyue He Yanqi Wu Zhihong Jiang | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 14 | Research progress of severe acute respiratory syndrome coronavirus 2 on aerosol collection and detection显示文摘The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in late 2019 has negatively affected people's lives and productivity.Because the mode of transmission of SARS-CoV-2 is of great concern,this review discusses the sources of virus aerosols and possible transmission routes.First,we discuss virus aerosol collection methods,including natural sedimentation,solid impact,liquid impact,centrifugal,cyclone and electrostatic adsorption methods.Then,we review common virus aerosol detection methods,including virus culture,metabolic detection,nucleic acid-based detection and immunology-based detection methods.Finally,possible solutions for the detection of SARS-CoV-2 aerosols are introduced.Point-of-care testing has long been a focus of attention.In the near future,the development of an instrument that integrates sampling and output results will enable the real-time,automatic monitoring of patients. | Xinyu Zhang Yuting Chen Yueying Pan Xinye Ma Gui Hu Song Li Yan Deng Zhu Chen Hui Chen Yanqi Wu Zhihong Jiang Zhiyang Li | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员