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| 1 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 2 | Rural vitalization in China:A perspective of land consolidation显示文摘The core objective of rural vitalization is to systemically establish a coupling pattern of various rural development elements including population,land and industry.As one of the prerequisites,land resources is required to be optimally allocated via land consolidation.Con seque ntly,la nd con solidati on con tributes greatly to population agglomeration,industrial developme nt and resources support under the con text of combati ng rural decline.Based on the key eleme nts affecting rural development,this paper elaborates the con no tation of rural vitalization and land consolidation in the new era as well as their relationships.Furthermore,the paper analyzes the alternative paths for achieving rural vitalization via land consolidation,and discusses the future directions of land consolidation and rural vitalization.The conclusions are drawn as follows:(1)To cope with the loss and decline of the intrinsic elements in rural areas,rural vitalization is a development strategy aimed at realizing economic,political,cultural and ecological rejuvenation in rural area by reshaping socio?economic morphology and spatial pattern in rural territory.(2)From the perspective of rural vitalization,land consolidation is endowed with new connotation,which should not only target at activating the key elements of rural development,but also place emphasis on coordimating material space and spirit core as well as integrating the restructuring of the physical space and the rural gov?ernance system.(3)Land consolidation should be compatible with regional natural conditions and the current stage of socio-economic development.According to the principle of regional planning and classification strategy,the appropriate models and paths should be adopted to promote the benign interactions of population,land and industry based on engineering techniques and ecological means.(4)Under the background of national strategy of rural vitaliza?tion,it is n ecessary to reshape the value orientati on of la nd con solidation based on a scie tific understanding of urban-rural relations and rural territorial functions,coordinate land consolidation planning and rural vitalization planning under the unified spatial planning system,and explore the new model combining land consolidation and multifunctional agriculture. | LONG Hualou ZHANG Yingnan TU Shuangshuang | 2019 | Journal of Geographical Sciences2019，29，4： | 33 |
| 3 | Development of land use transitions research in China显示文摘With the introduction of the concept of land use transition into China,related researches have been carried out extensively in the past two decades,which enrich the knowledge of land system science.This paper describes the development of research on land use transitions in China from the perspectives of conceptual connotations,theoretical model,research methods,and research progress and prospects.With the in-depth investigation of land use transitions,the concept and connotations of land use morphology are developed and encapsulated as two kinds,i.e.,dominant morphology and recessive morphology.The dominant morphology refers to the land use structure of a certain region over a certain period of time,with features such as the quantity and spatial pattern of land use types.While the recessive morphology includes the land use features in the aspects of quality,property rights,management mode,input,output and function.Accordingly,the concept of land use transition is further developed,and the theoretical model of regional land use transitions is established.Thereafter,three innovative integrated approaches to study land use transitions are put forward,i.e.,multidisciplinary research framework for recessive land use transition,transect and horizontal comparison.To date,there have been 62 Ph.D.and 166 M.S.dissertations on the topic of'land use transition'in China.During 2002–2019,the National Natural Science Foundation of China has funded 48 research programs on the theme of'land use transition'.As such,the Chinese scholars have adapted the concept derived from western literature to the situations and experiences in China. | LONG Hualou QU Yi TU Shuangshuang ZHANG Yingnan JIANG Yanfeng | 2020 | Journal of Geographical Sciences2020，30，7： | 15 |
| 4 | Diode-pumped power scalable Kerr-lens mode-locked Yb:CYA laser显示文摘Stable 68 fs pulses with the average power of 1.5 W is directly generated from a multimode diode-pumped Kerr-lens mode-locked Yb:CYA laser by separating the gain medium and Kerr medium. The repetition rate is about 50 MHz, resulting in a single pulse energy of 30 n J and a peak power of 0.44 MW. To the best of our knowledge, this is the highest single pulse energy ever produced from a mode-locked Yb:CYA oscillator. Our experimental results show that Yb:CYA crystal is an excellent candidate for multiwatt, sub-100 fs pulse generation in diode-pumped all-solid-state lasers. It is believed that the output power can be scalable to multi-W while the pulse duration is maintained with this simple method. | WENLONG TIAN YINGNAN PENG ZIYUE ZHANG ZIJIAO YU JIANGFENG ZHU XIAODONG XU ZHIYI WEI | 2018 | Photonics Research2018，6，2： | 8 |
| 5 | Benefit of everolimus as a monotherapy for a refractory breast cancer patient bearing multiple genetic mutations in the PI3K/AKT/mTOR signaling pathway显示文摘A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer. | Yehui Shi Wenwen Zhang Yingnan Ye Yanan Cheng Lei Han Pengpeng Liu Weipeng Zhao Zhongsheng Tong Jinpu Yu | 2018 | Cancer Biology & Medicine2018，15，3： | 6 |
| 6 | A Novel Video Reversible Data Hiding Algorithm Using Motion Vector for H.264/AVC显示文摘A novel reversible data hiding algorithm for H.264/AVC videos is proposed.Histogram Shifting(HS) of motion vector values is used efficiently in reversible data hiding to embed data.By designating a specific decoded reference frame,the distortion accumulation effects due to modification of the motion vectors is overcome.All the extracted information can be recovered without loss of the original compressed video carrier.The experimental results show that the proposed algorithm is simple,has higher capacity and invisibility than other existing schemes,and can adjust the relationship between capacity and invisibility according to embedded load. | Ke Niu Xiaoyuan Yang Yingnan Zhang | 2017 | Tsinghua Science and Technology2017，22，5： | 5 |
| 7 | Study of the correlations between main shocks and aftershocks and aftershock synthesis method显示文摘To consider the infl uence of aftershocks in engineering design, the correlations between main shocks and aftershocks should be examined, and an aftershock simulation method with main shock ground motions needs to be developed. In this study, the data on the sequences of main shock–aftershock ground motions and other related parameters were collected. Using these data, correlations between the magnitude, frequency, duration and energy of the main shock–aftershock ground motions were investigated. The results showed that the magnitude of the aftershock can be larger than that of the main shock. The shapes of the Fourier amplitude spectra of main shocks and aftershocks were similar;however, the predominant frequency and high-frequency components of the aftershock tended to be larger. Considering the magnitude diff erence between the main shock and the aftershock, the correlation of durations was explored. Additionally, a new concept, the duration ratio, was defi ned to describe the concentration of seismic energy release, and main shock energy was strongly positively correlated with the energy attenuated during the main shock–aftershock sequence. Finally, based on these results regarding correlation, an aftershock synthesis using recorded main shock ground motions was constructed with the trigonometric series method for seismic design, and some examples are given to analyze the rationality of this synthetic method. | Zhang Yingnan Zhi Xudong Fan Feng | 2019 | Earthquake Engineering and Engineering Vibration2019，18，4： | 4 |
| 8 | Novel Video Steganography Algorithm Based on Secret Sharing and Error-Correcting Code for H.264/AVC显示文摘In this paper, we analyze the video steganography technique, which is used to ensure national security and the confidentiality of the information of governmental agencies and enterprises. Videos may be used to transmit secrets and conduct covert communication. As such, we present an algorithm based on a secret sharing scheme and an Error-Correcting Code(ECC), which combines Grey Relational Analysis(GRA) with a partition mode in video compression standard H.264/AVC. First, we process secret information by secret sharing, and then use an ECC to process the obtained information. Moreover, we choose the Discrete Cosine Transform(DCT) blocks using GRA, and then use rules to hide the pretreated information in DCT coefficients of the video frames. Experimental results indicate that our algorithm has good invisibility, better robustness, good anti-steganalysis ability, and little influence on the bit rate of the video carrier. In addition, the bit error rate is low after attacks such as noise, filtering,or frame loss in the simulation environment. | Yingnan Zhang Minqing Zhang Xiaoyuan Yang Duntao Guo Longfei Liu | 2017 | Tsinghua Science and Technology2017，22，2： | 4 |
| 9 | Probing the fractional topological charge of a vortex light beam by using dynamic angular double slits显示文摘Vortex beams with fractional topological charge(FTC) have many special characteristics and novel applications.However, one of the obstacles for their application is the difficulty of precisely determining the FTC of fractional vortex beams. We find that when a vortex beam with an FTC illuminates a dynamic angular double slit(ADS), the far-field interference patterns that include the information of the FTC of the beam at the angular bisector direction of the ADS vary periodically. Based on this property, a simple dynamic ADS device and data fitting method can be used to precisely measure the FTC of a vortex light beam with an error of less than 5%. | Jing Zhu Pei Zhang Dongzhi Fu Dongxu Chen Ruifeng Liu Yingnan Zhou Hong Gao Fuli Li | 2016 | Photonics Research2016，4，5： | 4 |
| 10 | Adsorption of cesium from aqueous solution using agricultural residue – Walnut shell: Equilibrium, kinetic and thermodynamic modeling studies显示文摘 | Dahu Ding Yingxin Zhao Shengjiong Yang Wansheng Shi Zhenya Zhang Zhongfang Lei Yingnan Yang | 2013 | Water Research2013，，： | 4 |
| 11 | OS1 functions in the allocation of nutrients between the endosperm and embryo in maize seeds显示文摘Uncovering the genetic basis of seed develop-ment will provide useful tools for improving both crop yield and nutritional value, However, the genetic regulatory networks of maize (Zea mays) seed development remain largely unknown. The maize opaque endosperm and small germ 1 (osl) mutant has opaque endosperm and a small embryo,Here, we cloned OSi1 and show that it encodes a putative transcription factor containing an RWP-RK domain-Transcriptional analysis indicated that OSi1 expression is elevated in early endosperm development, especially in the basal endosperm transfer layer (BETL), conducting zone (CZ), and central starch endospcrm (CSE) cells. RNA sequencing (RNA-Seq) analysis of the osi mutant revealed sharp downregulation of certain genes in specific cell types, including ZmMRP-1 and Megl in BETL cells and a majority of zein-and starch-related genes in CSE cells. Using a haploid induction system, we show that wild-type endosperm could rescue the smaller size of osi embryo, which suggests that nutrients are allocated by tho wild type endosperm. Therefore, our dsta imply that the network regulated by 051 accomplishes a key step in nutrient allocation between endosperm and embryo within maize seeds. Identification of this network will help uncover the mechanisms regulating the nutritional balance between endosperm and embryo. | Weibin Song Jinjie Zhu Haiming Zhao Yingnan Li Jiangtao Liu Xiangbo Zhang Liangliang Huang Jinsheng Lai | 2019 | Journal of Integrative Plant Biology2019，61，6： | 3 |
| 12 | Advanced Biotechnology for Cell Cryopreservation显示文摘Cell cryopreservation has evolved as an important technology required for supporting various cell-based applications,such as stem cell therapy,tissue engineering,and assisted reproduction.Recent times have witnessed an increase in the clinical demand of these applications,requiring urgent improvements in cell cryopreservation.However,cryopreservation technology suff ers from the issues of low cryopreservation effi ciency and cryoprotectant(CPA)toxicity.Application of advanced biotechnology tools can signifi cantly improve post-thaw cell survival and reduce or even eliminate the use of organic solvent CPAs,thus promoting the development of cryopreservation.Herein,based on the diff erent cryopreservation mechanisms available,we provide an overview of the applications and achievements of various biotechnology tools used in cell cryopreservation,including trehalose delivery,hydrogel-based cell encapsulation technique,droplet-based cell printing,and nanowarming,and also discuss the associated challenges and perspectives for future development. | Jing Yang Lei Gao Min Liu Xiaojie Sui Yingnan Zhu Chiyu Wen Lei Zhang | 2020 | Transactions of Tianjin University2020，26，6： | 2 |
| 13 | Model test and discrete element method simulation of shield tunneling face stability in transparent clay显示文摘The stability of the shield tunneling face is an extremely important factor affecting the safety of tunnel construction.In this study,a transparent clay with properties similar to those of Tianjin clay is prepared and a new transparent clay model test apparatus is developed to overcome the“black box”problem in the traditional model test.The stability of the shield tunneling face(failure mode,influence range,support force,and surface settlement)is investigated in transparent clay under active failure.A series of transparent clay model tests is performed to investigate the active failure mode,influence range,and support force of the shield tunneling face under different burial depth conditions,whereas particle flow code three-dimensional numerical simulations are conducted to verify the failure mode of the shield tunneling face and surface settlement along the transverse section under different burial depth conditions.The results show that the engineering characteristics of transparent clay are similar to those of soft clay in Binhai,Tianjin and satisfy visibility requirements.Two types of failure modes are obtained:the overall failure mode(cover/diameter:C/D£1.0)and local failure mode(C/D≥2.0).The influence range of the transverse section is wider than that of the longitudinal section when C/D≥2.0.Additionally,the normalized thresholds of the relative displacement and support force ratio are 3%-6%and 0.2-0.4,respectively.Owing to the cushioning effect of the clay layer,the surface settlement is significantly reduced as the tunnel burial depth increases. | Huayang LEI Yajie ZHANG Yao HU Yingnan LIU | 2021 | Frontiers of Structural and Civil Engineering2021，15，1： | 2 |
| 14 | Analysis of Expression Profiles of Long Noncoding RNAs and mRNAs in A549 Cells Infected with H3N2 Swine Influenza Virus by RNA Sequencing显示文摘Long noncoding RNAs(lncRNAs)participate in regulating many biological processes.However,their roles in influenza A virus(IAV)pathogenicity are largely unknown.Here,we analyzed the expression profiles of lncRNAs and mRNAs in H3N2-infected cells and mock-infected cells by high-throughput sequencing.The results showed that 6129 lncRNAs and 50,031 mRNA transcripts in A549 cells displayed differential expression after H3N2 infection compared with mock infection.Among the differentially expressed lncRNAs,4963 were upregulated,and 1166 were downregulated.Functional annotation and enrichment analysis using gene ontology and Kyoto Encyclopedia of Genes and Genomes databases(KEGG)suggested that target genes of the differentially expressed lncRNAs were enriched in some biological processes,such as cellular metabolism and autophagy.The up-or downregulated lncRNAs were selected and further verified by quantitative real-time polymerase chain reaction(RT-qPCR)and reverse transcription PCR(RT-PCR).To the best of our knowledge,this is the first report of a comparative expression analysis of lncRNAs in A549 cells infected with H3N2.Our results support the need for further analyses of the functions of differentially expressed lncRNAs during H3N2 infection. | Yina Zhang Tianqi Yu Yingnan Ding Yahui Li Jing Lei Boli Hu Jiyong Zhou | 2020 | Virologica Sinica2020，35，2： | 2 |
| 15 | Au@Pt core-shell nanoparticles supported on multiwalled carbon nanotubes for methanol oxidation显示文摘 | Yangyang Xu Yingnan Dong Jin Shi Mingli Xu Zhengfu Zhang Xikun Yang | 2011 | Catalysis Communications2011，，： | 1 |
| 16 | Behavior of autotrophic denitrification and heterotrophic denitrification in an intensified biofilm-electrode reactor for nitrate-contaminated drinking water treatment显示文摘 | Yingxin Zhao Baogang Zhang Chuanping Feng Fangyuan Huang Peng Zhang Zhenya Zhang Yingnan Yang Norio Sugiura | 2011 | Bioresource Technology2011，，： | 1 |
| 17 | Inhibition of the growth of two blue-green algae species ( Microsystis aruginosa and Anabaena spiroides ) by acidification treatments using carbon dioxide显示文摘 | Xin Wang Chunbo Hao Feng Zhang Chuanping Feng Yingnan Yang | 2011 | Bioresource Technology2011，，10： | 1 |
| 18 | Cadmium accumulation and oxidative burst in garlic ( Allium sativum )显示文摘 | Haiyan Zhang Yingnan Jiang Zhenyan He Mi Ma | 2005 | Journal of Plant Physiology2005，，9： | 1 |
| 19 | Detecting particle swarm optimization显示文摘 | ZHANG Yingnan TENG Hongfei | 2009 | Concurrency and Computation Practice and Experience2009，21，4： | 1 |
| 20 | CdS magic-size clusters exhibiting one sharp ultraviolet absorption singlet peaking at 361 nm显示文摘We report,for the first time,the synthesis of CdS magic-size clusters (MSCs) which exhibit a single sharp absorption peaking at ~ 361 nm,along with sharp band edge photoemission at ~ 377 nm and broad trap emission peaking at ~ 490 nm.These MSCs are produced in a singleensemble form without the contamination of conventional quantum dots (QDs) and/or other-bandgap clusters.They are denoted as MSC-361.We present the details of several controlled syntheses done in oleylamine (OLA),using C,d(NO3)2 or C,d(OAc)2 as a C,d source and thioacetamide (TAA) or elementary sulfur (S) as a S source.A high synthetic reproducibility of the reaction of Cd(NO3)2 and TAA to single-ensemble MSC-361 is achieved,the product of which is not contaminated by other bandgap clusters and/or QDs.In some cases,the reaction product exhibits an additional absorption peak at ~ 322 nm.We demonstrate that the two peaks,at 361 and 322 nm,do not evolve synchronously.Therefore,the 322 nm peak is not a higher order electronic transition of MSC-361,but due to the presence of another ensemble,namely MSC-322.The present study suggests that there is an outstanding need for the development of a physical model to narrow the knowledge gap regarding the electronic structure in these colloidal semiconductor CdS MSCs. | Junbin Tang Juan Hui Meng Zhang Hongsong Fan Nelson Rowell Wen Huang Yingnan Jiang Xiaoqin Chen Kui Yu | 2019 | Nano Research2019，12，6： | 1 |
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