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| 1 | Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications显示文摘Major depressive disorder(MDD),also referred to as depression,is one of the most common psychiatric disorders with a high economic burden.The etiology of depression is still not clear,but it is generally believed that MDD is a multifactorial disease caused by the interaction of social,psychological,and biological aspects.Therefore,there is no exact pathological theory that can independently explain its pathogenesis,involving genetics,neurobiology,and neuroimaging.At present,there are many treatment measures for patients with depression,including drug therapy,psychotherapy,and neuromodulation technology.In recent years,great progress has been made in the development of new antidepressants,some of which have been applied in the clinic.This article mainly reviews the research progress,pathogenesis,and treatment of MDD. | Zezhi Li Meihua Ruan Jun Chen Yiru Fang | 2021 | Neuroscience Bulletin2021，37，6： | 13 |
| 2 | The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals显示文摘Dear Editor,Since the middle of December 2019,human-to-human transmission of novel coronavirus pneumonia(NCP,also called COVID-19)has occurred among close contacts[1].After the outbreak on January 21,2020,it was swiftly included among the Class B infectious diseases stipulated in the Law of the People’s Republic of China on the Prevention and Control of Infectious Diseases,and measures for prevention and control of Class A infectious diseases were adopted.At 21:27 on February 12,2020,the China News Network updated information to include epidemic data from the National Health Commission and official channels in Hong Kong,Macao,and Taiwan regions:the highest death rate was in Wuhan City(Table 1).Overload of inpatients at hospitals may play a negative role in the overall therapeutic effect and contribute to the death rate. | Yuncheng Zhu Liangliang Chen Haifeng Ji Maomao Xi Yiru Fang Yi Li | 2020 | Neuroscience Bulletin2020，36，3： | 6 |
| 3 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 4 | Embedding lead halide perovskite quantum dots in carboxybenzene microcrystals improves stability显示文摘铅卤化物 perovskite 量点(PQD ) 的稳定性被在 carboxybenzene microcrystals 嵌入他们改进。结果塑造针的混合 microcrystals 保存了 PQD 的强壮的光致发光。与以前报导的包含聚苯乙烯的 PQD 相比, carboxybenzene 晶体是柔韧的并且保护了点免受潮湿和 photodegradation 的伤害。提高的稳定性被归因于 carboxybenzene microcrystals 的紧密的矩阵,它保护了 PQD 免受潮湿的伤害。这万用的策略保护了各种各样的 QD,包括所有无机的 PQD 和 chalcogenide QD (例如, CdSe/ZnS QD 和 CuInS/ZnS QD ) 。它提供保护 PQD 的一个灵巧、万用的方法并且可以启用应用在固态有象显示,激光,和轻射出二极管那样的高颜色质量要求的系统。 | Wei Xu Zhixiong Cai Feiming Li Jing Dong Yiru Wang Yaqi Jiang Xi Chen | 2017 | Nano Research2017，10，8： | 4 |
| 5 | MICROSTRUCTURE OF INTERFACE BETWEEN HVOF SPRAYED WC-Co COATING AND SPRING STEEL SUBSTRATE显示文摘MICROSTRUCTUREOFINTERFACEBETWEENHVOFSPRAYEDWC-CoCOATINGANDSPRINGSTEELSUBSTRATE￥ShaoBeiling;LiuAnsheng;WangXiaohua;LiYonghong;... | Shao Beiling Liu Ansheng Wang Xiaohua Li Yonghong Zou Linying Wang Jing Zhang Jianguo Shi Changyong Zhou Yiru(General Research institute For Nonferrous Metals,Beijing 100088) | 1996 | 中国有色金属学会会刊:英文版1996，6，4： | 3 |
| 6 | Confined Ni-In intermetallic alloy nanocatalyst with excellent coking resistance for methane dry reforming显示文摘Carbon dioxide and methane are two main greenhouse gases which are contributed to serious global warming.Fortunately,dry reforming of methane(DRM),a very important reaction developed decades ago,can convert these two major greenhouse gases into value-added syngas or hydrogen.The main problem retarding its industrialization is the seriously coking formation upon the nickel-based catalysts.Herein,a series of confined indium-nickel(In-Ni)intermetallic alloy nanocatalysts(In_(x)Ni@SiO_(2))have been prepared and displayed superior coking resistance for DRM reaction.The sample containing 0.5 wt.%of In loading(In_(0.5)Ni@SiO_(2))shows the best balance of carbon deposition resistance and DRM reactivity even after 430 h long term stability test.The boosted carbon resistance can be ascribed to the confinement of core–shell structure and to the transfer of electrons from Indium to Nickel in In-Ni intermetallic alloys due to the smaller electronegativity of In.Both the silica shell and the increase of electron cloud density on metallic Ni can weaken the ability of Ni to activate C–H bond and decrease the deep cracking process of methane.The reaction over the confined InNi intermetallic alloy nanocatalyst was conformed to the Langmuir-Hinshelwood(L-H)mechanism revealed by in situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS).This work provides a guidance to design high performance coking resistance catalysts for methane dry reforming to efficiently utilize these two main greenhouse gases. | Wenming Liu Le Li Sixue Lin Yiwei Luo Zhenghong Bao Yiru Mao Kongzhai Li Daishe Wu Honggen Peng | 2022 | Journal of Energy Chemistry2022，31，2： | 3 |
| 7 | GhKT2: a novel K^+ transporter gene in cotton(Gossypium hirsutum)显示文摘Potassium is an essential nutrient for plant growth and productivity of crops. K+transporters are important for K+uptake and transport in plants. However,information on the function of K+transporters and K+channels in cotton is limited. The KT/KUP/HAK protein family is essential for a variety of physiological processes in plants, including nutrient acquisition and regulation of development. This study, identified a K+transporter gene,Gh KT2, expressed in the roots of cotton(Gossypium hirsutum) cv. Liaomian17. The deduced transcript of Gh KT2 is highly homologous to Cluster II of KUP/HAK/KT K+transporters and is predicted to contain 11 transmembrane domains. Gh KT2 has been localized to the plasma membrane, and its transcripts were detected in roots, stems, leaves and shoot apices of cotton seedlings.Consistently, b-glucuronidase(GUS) expression driven by the Gh KT2 promoter could be detected in roots, mesophyll cells, and leaf veins in transgenic Arabidopsis. In addition,the expression of Gh KT2 was induced by low K+stress in cotton roots and p Gh KT2::GUS-transgenic Arabidopsis seedlings. The Gh KT2-overexpression Arabidopsis lines plants were larger and showed greater K+accumulation than the wild type(WT) regardless of K+concentration supplied. The net K+influx rate, measured by the noninvasive micro-test technique, in root meristem zone of Gh KT2-transgenic Arabidopsis lines was significantly greater than that of WT. Taken together, this evidence indicates that Gh KT2 may participate in K+acquisition from low or high external K+, as well as K+transport and distribution in plants. | Yiru WANG Juan XU Mingcai ZHANG Xiaoli TIAN Zhaohu LI | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 2 |
| 8 | Correction to: Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications显示文摘Correction to:Neurosci.Bull.2021 https://doi.org/10.1007/sl2264-021-00638-3 The original version of this article unfortunately contained two mistakes.1.In the“Acknowledgements”,the“the National Basic Research”should be changed into“the National Key Research”. | Zezhi Li Meihua Ruan Jun Chen Yiru Fang | 2021 | Neuroscience Bulletin2021，37，6： | 2 |
| 9 | A Hybrid Conjugate Gradient Algorithm for Solving Relative Orientation of Big Rotation Angle Stereo Pair显示文摘The fast convergence without initial value dependence is the key to solving large angle relative orientation.Therefore,a hybrid conjugate gradient algorithm is proposed in this paper.The concrete process is:①stochastic hill climbing(SHC)algorithm is used to make a random disturbance to the given initial value of the relative orientation element,and the new value to guarantee the optimization direction is generated.②In local optimization,a super-linear convergent conjugate gradient method is used to replace the steepest descent method in relative orientation to improve its convergence rate.③The global convergence condition is that the calculation error is less than the prescribed limit error.The comparison experiment shows that the method proposed in this paper is independent of the initial value,and has higher accuracy and fewer iterations. | Jiatian LI Congcong WANG Chenglin JIA Yiru NIU Yu WANG Wenjing ZHANG Huajing WU Jian LI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，2： | 2 |
| 10 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 11 | Bone marrow-derived mesenchymal stem cells attenuate phosgene-induced acute lung injury in rats显示文摘 | Junfeng Chen Yiru Shao Guoxiong Xu ChitChoon Lim Jun Li Daojian Xu Jie Shen | 2015 | Inhalation Toxicology2015，，5： | 1 |
| 12 | Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factor-κB Dependent Pathway显示文摘 | Qianhong Li Yiru G Wei T | 2007 | Circulation2007，116，： | 1 |
| 13 | Core-shell-structured Co@Co4N nanoparticles encapsulated into MnO-modified porous N-doping carbon nanocubes as bifunctional catalysts for rechargeable Zn–air batteries显示文摘Designing the highly catalytic activity and durable bifunctional catalysts toward oxygen reduction/evolution reaction(ORR/OER) is paramount for metal–air batteries. Metal–organic frameworks(MOFs)-based materials have attracted a great deal of attention as the potential candidate for effectively catalyzing ORR/OER due to their adjustable composition and porous structure. Herein, we first introduce the Mn species into zeolitic-imidazole frameworks(ZIFs) and then further pyrolyze the Mn-containing bimetallic ZIFs to synthesize core-shell-structured Co@Co4N nanoparticles embedded into MnO-modified porous N-doped carbon nanocubes(Co@Co4N/MnO–NC). Co@Co4N/MnO–NC exhibits the outstanding catalytic activity toward ORR and OER which is attributed to its abundant pyridinic/graphitic N and Co4N,the optimized content of MnO species, highly dispersed catalytic sites and porous carbon matrix. As a result, the Co@Co4N/MnO–NC-based Zn–air battery exhibits enhanced performances, including the high discharge capacity(762 mA h gZn-1), large power density(200.5 mW cm-2), stable potential profile over 72 h, low overpotential(<1.0 V) and superior cycling life(2800 cycles). Moreover, the belt-shaped Co@Co4N/MnO–NC cathode-based Zn–air batteries are also designed which exhibit the superb electrochemical properties at different bending/twisting conditions. | Fengmei Wang Huimin Zhao Yiru Ma Yu Yang Bin Li Yuanyuan Cui Ziyang Guo Lei Wang | 2020 | Journal of Energy Chemistry2020，29，11： | 1 |
| 14 | Impact of residential building heating on natural gas consumption in the south of China:Taking Wuhan city as example显示文摘With the development of social economy,heating in the south of China has been concerned widely.As one of the energy sources of decentralized heating,natural gas(NG)has been used more and more popularly.This paper aimed to study the impact of residential building heating on NG consumption,and took Wuhan city,the representative city needing heating in winter of the south of China due to its location and climate,as an example.Firstly,a typical residential building model was established through DeST software.The heating load was simulated,and the corresponding NG consumption index was calculated.Secondly,appropriate methods were used to forecast the basic data of Wuhan city in 2020,including households and per capita gross national product(GDP),etc.Thirdly,the NG consumption of residential buildings with and without heating were predicted.Finally,the impact of residential building heating on NG consumption was analyzed.The results showed that the average annual household heating consumption of residential building in Wuhan city in 2020 was 2100 kWh/household,and the NG consumption using for residential building heating was 295 Nm 3/household.In addition,the NG consumption of residential building generated by space heating with 100%heating rate was 2.82 times the NG consumption generated by the stove and water heater,showing that residential building heating had a large impact on NG consumption.This study can contribute to choosing appropriate heating method in the southern cities of China,and further planning the gas pipe network in these cities. | Jiankai Dong Yiru Li Wenjie Zhang Long Zhang Yana Lin | 2020 | Energy and Built Environment2020，1，4： | 1 |
| 15 | Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factor-κB Dependent Pathway显示文摘 | Qianhong Li Yiru G Wei T | 2007 | Circulation2007，116，： | 1 |
| 16 | The late phase of preconditioning and its natural clinical application—gene therapy显示文摘 | Roberto Bolli Qian-Hong Li Xian-Liang Tang Yiru Guo Yu-Ting Xuan Gregg Rokosh Buddhadeb Dawn | 2007 | Heart Failure Reviews2007，，3： | 1 |
| 17 | Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factor-κB-Dependent Pathway显示文摘 | Qianhong Li Yiru Guo Wei Tan Qinghui Ou Wen-Jian Wu Diana Sturza Buddhadeb Dawn Greg Hunt Chuanjue Cui Roberto Bolli | 2007 | Circulation2007，，14： | 1 |
| 18 | Intracoronaryadministration of cardiacstem cells in mice: a new, improved technique for cell therapy in murine models显示文摘 | LI Qianghong GUO Yiru QU Qinghui | 2011 | Basic Res Cardiol2011，106，5： | 1 |
| 19 | TNF-α,IL-6 and hs CRP in patients with melancholic,atypical and anxious depression:an antibodyyarrayanalysis related to somatic symptoms显示文摘Background The association between inflammation and major depressive disorder(MDD)remains poorly understood,given the heterogeneity of patients with MDD.Aims We investigated inflammatory markers,such as interleukin(IL)-6,high-sensitivity C reactive protein(hsCRP)and tumour necrosis factor-α.(TNF-α)in melancholic,atypical and anxious depression and explored whether baseline inflammatory protein levels could indicate prognosis.Methods The sample consisted of participants(aged 18-55 years)from a previously reported multicentre randomised controlled trial with a parallel-group design registered with ClinicalTrials.gov,including melancholic(n=44),atypical(n=37)and anxious(n=44)patients with depression and healthy controls(HCs)(n=33).Subtypes of MDD were classified according to the 30-item Inventory of Depressive Symptomatology,Self-Rated Version and the.17-item Hamilton Depression Rating Scale.Blood levels.of TNF-α,IL-6 and hsCRP were assessed using antibody array analysis.Results Patients with MDD,classified according to melancholic,atypical and anxious depression subtypes,and HCs did not differ significantly in baseline TNF-α,IL-6 and hsCRP levels after adjustment.In patients with anxious depression,hsCRP levels increased significantly if they experienced no pain(adjusted(adj.)p=0.010)or mild to moderate pain(adj.p=0.038)compared with those with severe pain.However,the patients with anxious depression and severe pain showed a lower trend in hsCRP levels than patients with atypical depression who experienced severe pain(p=0.022;adj.p=0.155).Baseline TNF-α(adj.p=0.038)and IL-6(adj.p=0.006)levels in patients in remission were significantly lower than those in patients with no remission among the participants with the atypical depression subtype at the eighth-week follow-up.Conclusions This study provides evidence of differences in inflammatory proteins in patients with varied symptoms among melancholic,atypical and anxious depression subtypes.Further studies on the immunoinflammatory mechanism underlying different subtypes of depression are expected for improved individualised therapy. | Hongmei Liu Xiaohui Wu Yun Wang Xiaohua Liu Daihui Peng Yan Wu Jun Chen Yun-Ai Su Jia Xu Xiancang Ma Yi Li Jianfei Shi Xiaodong Yang Han Rong Marta Di Forti Yiru Fang | 2022 | General Psychiatry2022，35，5： | 1 |
| 20 | Control of large linear magnetoelectricity in Co_(3)NiNb_(2)O_(9)显示文摘Magnetoelectric(ME)materials have caught worldwide attentions owing to their potential technological applications in ME switching devices or high-density data storage.However,realizing a sufficiently strong ME effect in one single material is always the key issue.Herein,we systematically investigate the Co_(3)NiNb_(2)O_(9),including the characterization of its crystalline structure,magnetism,specific heat,and pyroelectric properties.It is revealed that Co_(3)NiNb_(2)O_(9) exhibits a remarkable ME response below the magnetic phase transition temperature of TN-32 K.On one hand,the magnetic field-induced electric polarization is observed below TN while it is non-ferroelectric at no magnetic field.The evaluated ME coefficient is as large as 21.2 ps/m.On the other hand,the magnetization is significantly modulated by the applied electric field,with the inverse ME coefficient being 14.1 ps/m.The observed ME responses suggest a stable ME mutual control by the magnetic or electric field in Co_(3)NiNb_(2)O_(9). | Xiang Li Yu Wang Meifeng Liu Yunlong Xie Jiahua Min Xiyu Chen Jingwen Gong Leiyu Li Min Zeng Yiming Xu Yiru Wang Biwen Li Xiuzhang Wang Jun-Ming Liu | 2021 | Journal of Materiomics2021，7，4： | 0 |
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