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| 1 | Experimental studies on active control of a dynamic system via a time-delayed absorber显示文摘The traditional passive absorber is fully effective within a narrow and certain frequency band.To solve this problem,a time-delayed acceleration feedback is introduced to convert a passive absorber into an active one.Both the inherent and the intentional time delays are included.The former mainly comes from signal acquiring and processing,computing,and applying the actuation force,and its value is fixed.The latter is introduced in the controller,and its value is actively adjustable.Firstly,the mechanical model is established and the frequency response equations are obtained.The regions of stability are delineated in the plane of control parameters.Secondly,the design scheme of control parameters is performed to help select the values of the feedback gain and time delay.Thirdly,the experimental studies are conducted.Effects of both negative and positive feedback control are investigated.Experimental results show that the proper choices of control parameters may broaden the effective frequency band of vibration absorption.Moreover,the time-delayed absorber greatly suppresses the resonant response of the primary system when the passive absorber totally fails.The experimental results are in good agreement with the theoretical predictions and numerical simulations. | Jian Xu Yixia Sun | 2015 | Acta Mechanica Sinica2015，31，2： | 9 |
| 2 | Rapamycin promotes Schwann cell migration and nerve growth factor secretion显示文摘Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of rapamycin and FK506 on Sc hwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration(1.53 nmol/L) more significantly promoted Schwann cell migration than the highest FK506 concentration(100 μmol/L). Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not significantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy. | Fang Liu Haiwei Zhang Kaiming Zhang Xinyu Wang Shipu Li Yixia Yin | 2014 | Neural Regeneration Research2014，9，6： | 6 |
| 3 | Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos显示文摘在在 midblastula 转变(MBT ) 的 zygotic 染色体激活前的动物胚胎的开发是实质上 supportedby 导出鸡蛋的母亲的产品。节的蛋白质在 MBT 以后是为中层和内胚叶正式就职的关键信号。Itremains 不清楚母亲的因素它在 zebrafish 胞胚的 ventrolateral blastodermal 边缘激活节的基因的 zygotic 表示。在这研究,我们显示出母亲的 Eomesodermina (Eomesa ) 的那损失,一个 T 盒子抄写因素,损害节的基因 ndr1 和 ndr2 以及 mesodermal 和 endodermal 标记的 zygotic 表示,在 mesendoderm 显示参与感应。母亲的 Eomesa 是为抄写因素基因 mxtx2 的及时 zygotic 表示的 alsorequired,节的基因表示的一个管理者。Eomesa 直接在激活他们的抄写的 ndr1, ndr2,和 mxtx2 的倡导者或 enhancer 绑在 Eomes 有约束力的地点。而且,节的基因也是的人和老鼠由 Eomes 调整了。进鼠科的胚胎的干细胞的 zebrafish eomesa 的 Transfection 与内长的节的表示的经常的高水平支持 mesendodermal 区别,建议 Eomes 的一个保存函数。一起拿,我们的调查结果在在脊椎动物胚胎调整节的基因表示和 mesendoderm 正式就职揭示母亲的 T-boxtranscription 因素的一个保存角色。 | Pengfei Xu Gaoyang Zhu Yixia Wang Jiawei Sun Xingfeng Liu Ye-Guang Chen Anming Meng | 2014 | Journal of Molecular Cell Biology2014，8，4： | 5 |
| 4 | Diversity Analysis of Chlorophyll, Flavonoid, Anthocyanin, and Nitrogen Balance Index of Tea Based on Dualex显示文摘The chemical compositions of tea(Camellia sinensis)are affected by numerous factors,such as cultivar,climate,leaf position,and cultivation pattern.However,under the same conditions,the chemical compositions are mainly determined by varieties.Therefore,we investigated the genetic diversity of chemical compositions of tea tree resources in China to screen excellent germplasm resources.Three chemical compositions index(including chlorophyll index,flavonoid index,and anthocyanin index)and the nitrogen balance index of tea leaves were measured in 102 tea germplasms planted in Chinese Tea Plants Improved Variety Germplasm Resources Nursery(CTPIVGRN)by Dualex on April 152019.Results showed that the chlorophyll,flavonoid,and anthocyanin contents and the nitrogen balance index significantly differed between the 102 tea germplasms.The genetic diversity index values were 2.005,2.246,1.599,and 1.838,and the average genetic diversity was 1.922.The 102 tea germplasms can be divided into four categories by cluster analysis under the genetic distance threshold of 11.These results suggest that the genetic diversity of tea germplasm resources in China is rich.This study’s results can serve as a basis for the diversified development and utilization of tea plant. | Yifu Liu Jiazhen Wang Yao Xiao Xiongwen Shi Yixia Zeng | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 4 |
| 5 | A novel HBV genotypes detecting system combined with microfluidic chip, loop-mediated isothermal amplification and GMR sensors显示文摘 | Xiao Zhi Min Deng Hao Yang Guo Gao Kan Wang Hualin Fu Yixia Zhang Di Chen Daxiang Cui | 2014 | Biosensors and Bioelectronics2014，，： | 2 |
| 6 | Clinical Study on Ocular Trauma in Children显示文摘Purpose:To investigate the clinical characteristics of ocular trauma in children and put forward the major treatment and prevention of ocular trauma in children.Methods:To analyze the clinical data by 77 eyes in 77 cases of ocular trauma in children from April 1999 to February 20002.Resuts:The male and female were in the ratio of 2.21:1.Right eye ocular traumas were more than left ones.Ocular penetrating trauma was 83.12% and blunt trauma 12.99%.41 cases(53.25%)were injured by themselves while 33 cases by others.90.91% patients came from the countryside.Conclusion:The rate of blindness of children with ocular trauma could be reduced by prompt treatment.The study indicated that ocular trauma preventive pubicity should be faced in the countryside in order to improve the understanding of the severity of ocular trauma and treat it as a social problem. | Zicai Huang, Hongni Li, Yixia Huang, Zhongxia ZhouDepartment of Ophthalmology, Shantou Central Hospital, Shantou 515031, China | 2002 | 眼科学报2002，18，3： | 2 |
| 7 | 3-D Numerical Simulation on the Chip Machining Process of a Metal Block显示文摘In this paper, the cutting process of a metal block is numerically simulated by the dynamic explicit FE code ABAQUS. Taking thermo-mechanical coupling effect into consideration, the simulation presents the variation of temperature, stress and strain distribution in the workpiece and chip. The effective plastic strain failure criterion is applied to modeling the chip separation and plastic formation. And the phenomenon of the contact and friction between the workpiece and the cutting tool are described in the paper. | Yan Yixia Yin Yihui Li Weifen | 2004 | 上海交通大学学报2004，38，z2： | 2 |
| 8 | The Role of Fas Expression on the Occurrence of Immunosuppression in Severe Acute Pancreatitis显示文摘 | Yueqiu Qin Liao Pinhu Yanwu You Suren Sooranna Zhansong Huang Xihan Zhou Yixia Yin Sien Song | 2013 | Digestive Diseases and Sciences2013，，11： | 2 |
| 9 | Mesenchymal stem cells loaded on 3D-printed gradient poly(e-caprolactone)/methacrylated alginate composite scaffolds for cartilage tissue engineering显示文摘Cartilage has limited self-repair ability due to its avascular,alymphatic and aneural features.The combination of three-dimensional(3D)printing and tissue engineering provides an up-and-coming approach to address this issue.Here,we designed and fabricated a tri-layered(superficial layer(SL),middle layer(ML)and deep layer(DL))stratified scaffold,inspired by the architecture of collagen fibers in native cartilage tissue.The scaffold was composed of 3D printed depth-dependent gradient poly(e-caprolactone)(PCL)impregnated with methacrylated alginate(ALMA),and its morphological analysis and mechanical properties were tested.To prove the feasibility of the composite scaffolds for cartilage regeneration,the viability,proliferation,collagen deposition and chondrogenic differentiation of embedded rat bone marrow mesenchymal stem cells(BMSCs)in the scaffolds were assessed by Live/dead assay,CCK-8,DNA content,cell morphology,immunofluorescence and real-time reverse transcription polymerase chain reaction.BMSCs-loaded gradient PCL/ALMA scaffolds showed excellent cell survival,cell proliferation,cell morphology,collagen II deposition and hopeful chondrogenic differentiation compared with three individual-layer scaffolds.Hence,our study demonstrates the potential use of the gradient PCL/ALMA construct for enhanced cartilage tissue engineering. | Yanyan Cao Peng Cheng Shengbo Sang Chuan Xiang Yang An Xiaochun Wei Zhizhong Shen Yixia Zhang Pengcui Li | 2021 | Regenerative Biomaterials2021，8，3： | 2 |
| 10 | The Main Characteristics and Disposal of Municipal Garbage in Changchun City of China显示文摘Based on current situations of Chinese garbage management and disposal, this paper is centered on introduction of some research results of household garbage in Changchun, capital city of Jilin Province, northeast China. From the viewpoint of man the earth system, garbage is characterized by sociality, temporal and spatial differentiation and limitation and other features, which imply that the garbage research being involved with natural science and social science should not only focus on the natural features but also on the social features. Compared to some developed cities, the material composition of garbage in Changchun is typically characterized by high moisture content, low combustion value and minor recyclable materials. Concentration, cycle shaping and self similarity characterize the garbage distribution. The tracing investigation on 683 households ten times shows that three fourths of the total garbage yield in Changchun is derived from non domestic units and that the attention of garbage management, especially source reduction, should be focused on the non domestic units. The GM(1,1) prediction model has been set up and the prediction result shows that the amount of garbage yield of Changchun in 2004 will be up to 1,500,000 tons. Investigation of environmental consciousness to garbage problems have been carried out. Based on the above characteristics of garbage, the disposal countermeasures of Changchun garbage have been suggested. | Su Xiaosi, Zhang Yixia, Yan Jingqi, Jin Wei and Sun Jiapeng (Changchun University of Science and Technology, Changchun,China, 130026) | 1999 | Global Geology1999，4，1： | 2 |
| 11 | Static Image Compression Based on Fractal Theory显示文摘1IntroductionThefractalgeometrywasestablishedatthebeginningofthecentury.Mandelbrotpresentedtwofractaldefinitionsin1982and1984... | Lin Yixia Zhu Quanfan Liu Jun ((School of Automation) | 1998 | Advances in Manufacturing1998，，3： | 1 |
| 12 | miR-30e is negatively regulated by myostatin in skeletal muscle and is functionally related to fiber-type composition显示文摘Myostatin (MSTN ) 否定地调整在哪个 microRNAs (miRNAs ) 也起关键作用的骨胳的 myogenesis。用从 MSTN 大美人的骨胳的肌肉的 miRNA microarrays (MSTN /) 老鼠,我们最近证明 miR-431 被 MSTN 发信号调整。为了识别另外的 miRNAs,由 MSTN 调整了,我们重新分析这些 miRNA 数组并且由量的 RT-PCR 验证了他们的表示。此处,我们证明 miR-30e 是显著地在 MSTN / 老鼠的骨胳的肌肉的 upregulated 与野类型的同窝出生的人的相比。重要地, miR-30e 的预言的目标机能上地涉及 myocyte 区别和纤维类型形成。用酶记者基因试金,我们进一步显示出那 peroxisome 激活 proliferator 的受体 gamma,激活剂 1 alpha (Pgc1 ) ,是 miR-30e 的一个直接目标。在 C2C12 房间的 miR-30e 的 Overexpression 显著地减少了 Pgc1 和增加的类型 II 肌浆球蛋白形成重链基因表示,机能上地建议那 miR-30e 把 myofiber 与 glycolytic 联系形成。因此,我们的数据显示在 MSTN / 鼠标的改变的纤维类型作文对 miR-30e 的 deregulated 表示部分地可归因。 | Haixue Jia Yixia Zhao Tingting Li Yong Zhang Dahai Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 1 |
| 13 | Atom-economic synthesis of an oligomeric P/N-containing fire retardant towards fire-retarding and mechanically robust polylactide biocomposites显示文摘Renewable and biodegradable polylactide (PLA) has excellent mechanical strength but is highly flammable which restricts its practical applications. Many phosphorus/nitrogen (P/N)-based flame retardants are ef- fective in PLA, but their high addition loading usually decreases the mechanical strength of the PLA bulk. For polyphosphoramides, despite high fire-retardant efficiency, their chemical synthesis often generates chemical wastes as byproducts. Herein, we report an atom-economic and highly efficient oligomeric P/N fire retardant (APN) prepared using a mild Michael addition polymerization with no byproducts. Using only 3 wt% APN, the resulting PLA exhibits desired fire retardancy including a UL-94 V-0 rating and a limiting oxygen index of 37.6%. Furthermore, the toughness of the fire-retardant PLA increases by 85% compared to pure PLA, with both tensile strength and thermal stability preserved. This work offers an atom-economic strategy for synthesizing highly efficient P/N fire retardants for use in the creation of fire-resistant PLA with robust mechanical properties. | Jiabing Feng Yixia Lu Hongyan Xie Yan Zhang Siqi Huo Xiaohuan Liu Matt Flynn Zhiguang Xu Paulomi Burey Mark Lynch Hao Wang Pingan Song | 2023 | Journal of Materials Science & Technology2023，，29： | 1 |
| 14 | Cytocompatibility Evaluation of Grafted IKVAV PLEOF Hydrogels with Bone Marrow Mesenchymal Stem Cells显示文摘The novel hydrogels-grafted IKVAV poly(lactide-co-ethylene oxide-co-fumarate)(PLEOF) hydrogels(GIPHs) were developed. The rat bone marrow mesenchymal stem cells(BMMSCs) were employed, and the cell vitality and apoptosis assays were carried out to evaluate the cytocomptibility of GIPHs. Our data demonstrated that the infl uence of GIPHs on the proliferation of BMMSCs was in a concentration and time dependent manner. The proliferative ability of BMMSCs in GIPHs-treated group(100 μg/mL) after 72 h presented a maximum response which was 30.1% more than that of control group. The numbers of apoptotic cells in GIPHs-treated group(100 μg/mL) were just as much as that of control group after 24 h treatment. The GIPHs are able to provide an appropriate environment for BMMSCs survival and proliferation. | 李宾斌 ZHANG Ping YIN Yixia QIU Tong TAO Yuan WANG Xinyu 李世普 | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，4： | 1 |
| 15 | Effects of the Interaction between Hydroxyapatite Nanoparticles and Hepatoma Cells显示文摘To gain a better understanding of the anticancer effects of hydroxyapatite(HAP) nanoparticles in vivo and in vitro, the effects of the interaction of HAP nanoparticles with hepatoma cells were explored. HAP nanoparticles were prepared by homogeneous precipitation and characterized by laser particle analysis and transmission electron microscopy(TEM). HAP nanoparticles were observed to be uniformly distributed, with rod-like shapes and diameters in the range of 42.1-87.1 nm. Overnight attached, suspended, and proliferating Bel-7402 cells were incubated with HAP nanoparticles. Inverted microscopy observation revealed that HAP nanoparticles with a cell membrane showed good adsorption. TEM demonstrated that HAP nanoparticles were present on the surface of cells, continuously taken up by cells through endocytosis, and transported in vesicles close to the nucleus. Fluorescence microscopy showed that the concentrations of intracellular Ca2+ labeled with Fluo-3 calcium fluorescent probe were significantly enhanced. In addition, inverted microscopy observation revealed that suspended cells treated with HAP nanoparticles did not adhere to the culture bottle, resulting in cell death. After the overnight attached cells were treated with HAP nanoparticles for 96 h with increasing doses of HAP nanoparticles, inverted microscopy observation revealed that cell proliferation was slowed and cell–cell adhesion was weakened. Feulgen staining and image analysis indicated that the nuclear DNA content of the cells was markedly reduced, and argyrophilic nucleolar organizer region(AgNOR) staining and image analysis indicated that the number of AgNORs was signifi cantly decreased. Therefore, hepatoma cells brought about the adsorption, uptake, transport and degradation of HAP nanoparticles. In addition, HAP nanoparticles affected hepatoma cells with regard to cell–cell adhesion, cell and extracellular matrix adhesion, and DNA and protein synthesis; thus inhibiting cell proliferation. This understanding of the effects of interaction between HAP nanoparticles and hepatoma cells is useful for further study of the anticancer mechanisms of HAP nanoparticles. | 尹美珍 XU Weiguo CUI Bingcun 戴红莲 HAN Yingchao YIN Yixia LI Shipu | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，3： | 1 |
| 16 | Effect of external loads on the frost resistant properties of mortar with and without silica fume显示文摘 | Zhou Yixia | 1994 | ACI Material Journal1994，91，6： | 1 |
| 17 | Temperature and rate dependent constitutive relationship for vanadium alloy V-SCr-5Ti and failure modes显示文摘 | HUANG Xicheng HU Wenjun YAN Yixia | 2010 | Applied Mechanics and Materials2010，4447，： | 1 |
| 18 | prpf4 is essential for cell survival and posterior lateral line primordium migration in zebrafish显示文摘Prpf4(pre-mRNA processing factor 4),a key component of spliceosome,plays critical roles in pre-mRNA splicing and its mutations result in retinitis pigmentosa due to photoreceptor defects.In this study,we characterized a zebrafishharboring a Tol2 transposon-based gene trap cassette in the third intron of the prpf4 gene.Cells in the brain and spinal cord gradually undergo p53-dependent apoptosis after 28 hpf insuggesting that a widespread function of prpf4 in neural cell survival.In addition,prpf4 is essential for survival of posterior lateral line primordial(pLLP)cells.prpf4 deficiency perturbs Fgf,and chemokine signaling pathways and impairs pLLP migration.RNA-Seq analysis suggests that prpf4 deficiency may impair spliceosome assembly,leading to compensatory upregulation of core spliceosomal genes and alteration of pre-mRNA splicing.Taken together,our studies uncover an essential role of prpf4 in pre-m RNA splicing,cell survival and pLLP migration. | Yixia Wang Yanchao Han Pengfei Xu Shihui Ding Guangyuan Li Hongbin Jin Yaping Meng Anming Meng Shunji Jia | 2018 | Journal of Genetics and Genomics2018，45，8： | 1 |
| 19 | construction of transgenic murine embryonicstemcellclones 显示文摘 | YU YANQIU ZHANG YIXIA DU LILI | 2006 | Tissue Engineering2006，12，4： | 1 |
| 20 | Promotion of peripheral nerve regeneration and prevention of neuroma formation by PRGD/PDLLA/b-TCP conduit:report of two cases显示文摘In the field of nerve repair,one major challenge is the formation of neuroma.However,reports on both the promotion of nerve regeneration and prevention of traumatic neuroma in the clinical settings are rare in the field of nerve repair.One of the reasons could be the insufficiency in the follow-up system.We have conducted 33 cases of nerve repair using PRGD/PDLLA/b-TCP conduit without any sign of adverse reaction,especially no neuroma formation.Among them,we have selected two cases as representatives to report in this article.The first case was a patient with an upper limb nerve wound was bridged by PRGD/PDLLA/b-TCP conduit and a plate fixation was given.After nearly 3-years’follow-up,the examination results demonstrated that nerve regeneration effect was very good.When the reoperation was performed to remove the steel plate we observed a uniform structure of the regenerated nerve without the formation of neuroma,and to our delight,the implanted conduit was completely degraded 23 months after the implantation.The second case had an obsolete nerve injury with neuroma formation.After removal of the neuroma,the nerve was bridged by PRGD/PDLLA/b-TCP conduit.Follow-up examinations showed that the structure and functional recovery were improved gradually in the 10-month follow-up;no end-enlargement and any other abnormal reaction associated with the characteristic of neuroma were found.Based on our 33-case studies,we have concluded that PRGD/PDLLA/b-TCP nerve conduit could both promote nerve regeneration and prevent neuroma formation;therefore,it is a good alternative for peripheral nerve repair. | Yixia Yin Binbin Li Qiongjiao Yan Honglian Dai Xinyu Wang Jifeng Huang Shipu Li | 2015 | Regenerative Biomaterials2015，2，2： | 1 |
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