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| 1 | Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO显示文摘胃的溃疡(GU ) 是在全世界影响许多人的普通病理。过多的白酒消费是 GU 的主要原因之一;然而,仍然有为 GU 的预防或治疗的有效的药的缺乏。在这研究,我们在老鼠把保护的效果和 kaempferol (KAE ) 的可能的机制与尖锐导致乙醇的损害作比较到胃的 mucosa。Fasted 老鼠口头上地被给车辆(0.9% 盐) , omeprazole (20 mg/kg ) ,或为在在由有绝对乙醇(10 ml/kg ) 的挑战的 GU 模型的建立以前的不同试验性的集合的 1 h 的 KAE (40, 80,或 160 mg/kg ) 。动物是 euthanized 在乙醇吸入以后的 1 h,和他们的血浆和胃纸巾服从于进一步的检查。宏观、显微镜的损害,和免疫学的和生物化学的参数被观察。发炎的效果用下列指示物被调查:肿瘤坏死因素 --(TNF-) , interleukin-1 (IL-1 ) , IL-6, myeloperoxidase (军邮局) ,和氮的氧化物(没有) 。结果证明 KAE 显著地减少了溃疡索引,增加了预防索引,完全保护了 mucosa 免受损害,和保存胃的 mucosal glycoprotein 的伤害。KAE 减少了军邮局活动和支持 inflammatory cytokine (TNF- ,和 IL-1 ) 铺平,并且没改进层次。KAE 的 gastroprotective 活动可能被归因于胃的有粘液的 glycoproteins 层次的保藏,这样由禁止嗜中性的累积和军邮局活动,调整支持 inflammatory cytokines 的层次,并且不改进生产。 | Qinchen Li Xinxin Hu Yanhan Xuan Jianghua Ying Yujia Fei Jielu Rong Yong Zhang Jian Zhang Chunyan Liu Zheng Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 18 |
| 2 | Salt-responsive genes in rice revealed by cDNA microarray analysis显示文摘We used cDNA microarrays containing ~9,000 unigenes to identify 486 salt responsive expressed sequence tags (ESTs) (representing ~450 unigenes) in shoots of the highly salt-tolerant rice variety, Nona Bokra (Oryza sativa L. Ssp.Indica pv. Nona). Some of the genes identified in this study had previously been associated with salt stress. Howeverthe majority were novel, indicating that there is a great number of genes that are induced by salt exposure. Analysis of the salt stress expression profile data of Nona provided clues regarding some putative cellular and molecular processes that are undertaken by this tolerant rice variety in response to salt stress. Namely, we found that multiple transcription factors were induced during the initial salt response of shoots. Many genes whose encoded proteins are implicated in detoxification, protectant and transport were rapidly induced. Genes supporting photosynthesis were repressed and those supporting carbohydrate metabolism were altered. Commonality among the genes induced by salt exposure with those induced during senescence and biotic stress responses suggests that there are shared signaling pathways among these processes. We further compared the transcriptome changes of the salt-sensitive cultivar, IR28, with that of Nona rice. Many genes that are salt responsive in Nona were found to be differentially regulated in IR28. This study identified a large number of candidate functional genes that appear to be involved in salt tolerance and further examination of these genes may enable the molecular basis of salt tolerance to be elucidated. | Dai Yin CHAO Yong Hai LUO Min SHI Da LUO Hong Xuan LIN | 2005 | Cell Research2005，15，10： | 17 |
| 3 | Using Plan-Do-Check-Act Circulation to Improve the Management of Panic Value in the Hospital显示文摘The concept 'panic value' (or critical value) was first brought up by American scholar Lundberg[1] in 1972.It refers to the results of auxiliary examinations that are widely deviating from normal or anticipated results.The occurrence of these abnormal results shows that patients could be in a dangerous situation that their lives might be threatened.If clinicians are able to get the information in time and provide the patients with effective interventions or treatments promptly,lives could be saved.Otherwise,there could be serious consequences and the best opportunities for rescuing the patients might be missing.[2] | Suo-Wei Wu Tong Chen Yong Xuan XJ-Wu Xu Qi Pan Liang-Yu Wei Chao Li Oin Wang | 2015 | Chinese Medical Journal2015，，18： | 16 |
| 4 | Research of Medical Expenditure among Inpatients with Unstable Angina Pectoris in a Single Center显示文摘 | Suo-Wei Wu Qi Pan Tong Chen Liang-Yu Wei Yong Xuan Qin Wang Chao Li Jing-Chen Song | 2017 | Chinese Medical Journal2017，，13： | 15 |
| 5 | Applying Neural-Network-Based Machine Learning to Additive Manufacturing:Current Applications,Challenges,and Future Perspectives显示文摘Additive manufacturing(AM),also known as three-dimensional printing,is gaining increasing attention from academia and industry due to the unique advantages it has in comparison with traditional subtractive manufacturing.However,AM processing parameters are difficult to tune,since they can exert a huge impact on the printed microstructure and on the performance of the subsequent products.It is a difficult task to build a process-structure-property-performance(PSPP)relationship for AM using traditional numerical and analytical models.Today,the machine learning(ML)method has been demonstrated to be a valid way to perform complex pattern recognition and regression analysis without an explicit need to construct and solve the underlying physical models.Among ML algorithms,the neural network(NN)is the most widely used model due to the large dataset that is currently available,strong computational power,and sophisticated algorithm architecture.This paper overviews the progress of applying the NN algorithm to several aspects of the AM whole chain,including model design,in situ monitoring,and quality evaluation.Current challenges in applying NNs to AM and potential solutions for these problems are then outlined.Finally,future trends are proposed in order to provide an overall discussion of this interdisciplinary area. | Xinbo Qi Guofeng Chen Yong Li Xuan Cheng Changpeng Li | 2019 | Engineering2019，5，4： | 11 |
| 6 | Comparison of the 1-year Outcomes of Conbercept Therapy between Two Different Angiographic Subtypes of Polypoidal Choroidal Vasculopathy显示文摘 | Yong Cheng Xuan Shi Jin-Feng Qu Ming-Wei Zhao Xiao-Xin Li | 2016 | Chinese Medical Journal2016，，21： | 10 |
| 7 | The Use of Lipoprotein-Associated Phospholipase A2 in a Chinese Population to Predict Cardiovascular Events显示文摘Objective To explore associations between lipoprotein-associated phospholipase A2(Lp-PLA2)and the risk of cardiovascular events in a Chinese population,with a long-term follow-up.Methods A random sample of 2,031 participants(73.6%males,mean age=60.4 years)was derived from the Asymptomatic Polyvascular Abnormalities Community study(APAC)from 2010 to 2011.Serum Lp-PLA2 levels were determined by enzyme-linked immunosorbent assay(ELISA).The composite endpoint was a combination of first-ever stroke,myocardial infarction(MI)or all-cause death.Lp-PLA2 associations with outcomes were assessed using Cox models.Results The median Lp-PLA2 level was 141.0 ng/m L.Over a median follow-up of 9.1 years,we identified 389 events(19.2%),including 137 stroke incidents,43 MIs,and 244 all-cause deaths.Using multivariate Cox regression,when compared with the lowest Lp-PLA2 quartile,the hazard ratios with95%confidence intervals for developing composite endpoints,stroke,major adverse cardiovascular events,and all-cause death were 1.77(1.24–2.54),1.92(1.03–3.60),1.69(1.003–2.84),and 1.94(1.18–3.18)in the highest quartile,respectively.Composite endpoints in 145(28.6%)patients occurred in the highest quartile where Lp-PLA2(159.0 ng/m L)was much lower than the American Association of Clinical Endocrinologists recommended cut-off point,200 ng/m L.Conclusion Higher Lp-PLA2 levels were associated with an increased risk of cardiovascular event/death in a middle-aged Chinese population.The Lp-PLA2 cut-off point may be lower in the Chinese population when predicting cardiovascular events. | XI Hui CHENG Guan Liang HU Fei Fei LI Song Nan DENG Xuan ZHOU Yong | 2022 | Biomedical and Environmental Sciences2022，35，3： | 8 |
| 8 | Resveratrol protects PC12 cells against OGD/ R-induced apoptosis via the mitochondrial-mediated signaling pathway显示文摘在这研究,我们对导致的氧葡萄糖 deprivation/reoxygenation (OGD/R ) 调查了 resveratrol 的 neuroprotective 潜力在区分得好的 PC12 房间和内在的机制的 apoptotic 损坏。房间当面在正常状况或 OGD/R 下面被孵化或 10 M resveratrol 的缺席。房间生存能力与 methyl-thiazolyl-tetrazolium (MTT ) 被决定试金。Apoptotic 比率与 Hoechst 33342 染色和 Annexin V-FITC/PI 两倍染色被决定。氧化应力被测量细胞内部的反应的氧评估 superoxide dismutase (草皮) 和过氧化氢酶(猫) 的种类(ROS ) , mitochondrial superoxide, malondialdehyde (MDA ) 内容,和这些活动。细胞内部的钙([Ca 2+]i) 被 Fluo-3/AM 估计。mitochondrial 膜潜力(MMP ) 被 5,5,6,6-tetrachloro-1,1,3,3-tetraethyl-benzimidazolyl-carbocyanine 碘化物(JC-1 ) 和玫瑰精评估 123 (Rh123 ) 。mitochondrial 渗透转变毛孔(MPTP ) 的开始被 Calcein/Co 2+-quenching 技术决定。细胞色素 c, Bcl-2, Bax,劈开的 caspase-9,和劈开的 caspase-3 的蛋白质层次被西方的污点分析检测。结果证明 10 M resveratrol 稀释了 OGD/R-induced 房间生存能力损失和房间 apoptosis,它在在 SOD 和猫活动的 MDA 内容和增加与减少被联系。而且,细胞内部的 ROS 和 mitochondrial superoxide 的累积,骚乱[Ca 2+]i 动态平衡, MMP 的减小, MPTP 的开始,和在 OGD/R-injured 房间观察的 mitochondrial 细胞色素 c 的版本,在调停 mitochondrial 的 apoptotic 小径上显示了一个开关,都被 resveratrol 颠倒。这些结果建议 resveratrol 管理可以经由 modulating 起一个 neuroprotective 作用在 OGD/R-induced PC12 房间损害的调停 mitochondrial 的发信号小径。 | Xuan Liu Xiangyang Zhu Miao Chen Qinmin Ge Yong Shen Shuming Pan | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 8 |
| 9 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 10 | Experimental forward and reverse in situ combustion gasification of lignite with production of hydrogen-rich syngas显示文摘This research focused on the feasibility of applying the forward and reverse combustion approach to the in situ gasification of lignite with the production of hydrogen-rich syngas(H_(2)and CO).The so-called forward combustion gasification(FCG)and reverse combustion gasification(RCG)approach in which oxygen and steam are simultaneously fed to the simulated system of underground coal gasification(UCG)was studied.A simulated system of UCG was designed and established.The underground conditions of the coal seam and strata were simulated in the system.The combustion gasification of lignite has been carried out experimentally for almost 6.5 days.The average effective content(H_(2)+CO)of syngas during the FCG phase was 62.31%and the maximum content was 70.92%.For the RCG phase the corresponding figures are 61.33%and 67.91%.Thus,the feasibility of using RCG way for UCG has been demonstrated.The temperature profiles have been provided by using of 85 thermocouples during the model experiment,which portrayed the several nephograms of thermal data in the gasifier were of significance for the prospective gasification processes. | Yong Cui Jie Liang Zhangqing Wang Xiaochun Zhang Chenzi Fan Xuan Wang | 2014 | International Journal of Coal Science & Technology2014，1，1： | 7 |
| 11 | Toxicity of Multi-Walled Carbon Nanotubes,Graphene Oxide,and Reduced Graphene Oxide to Zebrafish Embryos显示文摘Objective This study was aimed to investigate the toxic effects of 3 nanomaterials, i.e. multi-walled carbon nanotubes(MWCNTs), graphene oxide(GO), and reduced graphene oxide(RGO), on zebrafish embryos. Methods The 2-h post-fertilization(hpf) zebrafish embryos were exposed to MWCNTs, GO, and RGO at different concentrations(1, 5, 10, 50, 100 mg/L) for 96 h. Afterwards, the effects of the 3 nanomateria on spontaneous movement, heart rate, hatching rate, length of larvae, mortality, and malformations ls were evaluated. Results Statistical analysis indicated that RGO significantly inhibited the hatching of zebrafish embryos. Furthermore, RGO and MWCNTs decreased the length of the hatched larvae at 96 hpf. No obvious morphological malformation or mortality was observed in the zebrafish embryos after exposure to the three nanomaterials. Conclusion MWCNTs, GO, and RGO were all toxic to zebrafish embryos to influence embryos hatching and larvae length. Although no obvious morphological malformation and mortality were observed in exposed zebrafish embryos, further studies on the toxicity of the three nanomaterials are still needed. | LIU Xiao Tong MU Xi Yan WU Xiao Li MENG Li Xuan GUAN Wen Bi MA Yong Qiang SUN Hua WANG Cheng Ju LI Xue Feng | 2014 | Biomedical and Environmental Sciences2014，27，9： | 6 |
| 12 | Research of admission management standards and working patterns of first class medical technologies显示文摘Medical technologies refers to the measures taken for the purpose of diagnosing and curing diseases,alleviating illnesses,reducing the pain,as well as helping patients restore health and prolonging their lives.According to the regulation on the clinical application of medical technology published by the Ministry of Health in 2009,medical technologies are divided into three classes according to their safety and effectiveness.Comparing with second and third class medical technologies,first class medical technologies are more accurate in their safety and validity.1 Now that the Ministry of Health had made clear requirements for the management of the second and third class technologies,the first class technologies still lack specific standards for their admission as well as development management.2. | Wu Suowei Ge Yuanyuan Xu Xiwu Xuan Yong Chen Tong | 2014 | Chinese Medical Journal2014，，15： | 5 |
| 13 | Inclusion of purified dietary fiber during gestation improved the reproductive performance of sows显示文摘Background: This study aimed to investigate the impacts of guar gum and cellulose as the source of dietary fiber during gestation on the reproductive performance of sows.Methods: A total of 210 sows(parities 3–6) were randomly allocated into six diets(n = 35) throughout gestation to feed graded levels of dietary fiber(DF), including a corn-soybean meal-based control diet with no wheat bran inclusion(CON, 12.5% DF), a wheat bran-rich diet(DF1, 17.4% DF), and another 4 diets(DF2, 17.7% DF;DF3, 18.1%DF;DF4, 18.4% DF;DF5, 18.8% DF) in which wheat bran were equally substituted by 1%, 2%, 3% and 4% purified FIBER MIX(guar gum and cellulose, 1:4). All sows received similar DE and other nutrients throughout gestation.Results: DF treatment during gestation resulted in normal fecal score(1 to 5 with 1 = dry and 5 = watery) in sows compared with those received the CON diet(P < 0.05). The number of total born piglets had a tendency to be affected by dietary treatment(P = 0.07), and correlation analysis revealed a linear response of total born to dietary fiber levels during gestation(P < 0.01). Sows received the DF2, DF3, and DF5 diets during gestation had a greater ADFI during lactation compared with those in the CON group(P < 0.05) without affecting the daily body weight gain of suckling piglets. Gut microbiota compositions were dramatically changed by the gestation stage and some of those were changed by DF inclusion. Fecal acetate, propionate, and butyrate of sows were markedly increased in late gestation, and butyrate contents in feces of gestating sows were significantly affected by DF levels(P < 0.01).Serum concentrations of pro-inflammatory TNF-α were decreased and anti-inflammatory IL-10 was increased on day30 of gestation by DF levels(P < 0.05).Conclusions: In summary, increasing dietary fiber levels by guar gum and cellulose during gestation improved the reproductive performance of sows, which might be related to changes in immunity and gut microbiota of sows. | Yong Zhuo Bo Feng Yuedong Xuan Lianqiang Che Zhengfeng Fang Yan Lin Shengyu Xu Jian Li Bing Feng De Wu | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 4 |
| 14 | Effectiveness of Using Mean Corpuscular Volume and Mean Corpuscular Hemoglobin for Beta-thalassemia Carrier Screening in the Guangdong Population of China显示文摘Beta(β)-thalassemia is one of the most common hemoglobinopathies worldwide,creating major public health problems and social burdens in many regions.Screening forβ-thalassemia carriers is crucial for controlling this condition.To investigate the?effectiveness?of?mean?corpuscular?volume?(MCV)and mean corpuscular hemoglobin(MCH)for screeningβ-thalassemia,retrospective data were analyzed for 6,779β-thalassemia carriers subjected to genetic testing following thalassemia screening in Guangdong province between January 2018 and December 2019. | GU Heng WANG Yong Xia DU Meng Xuan XU Shan Shan ZHOU Bing Yi LI Ming Zhen | 2021 | Biomedical and Environmental Sciences2021，34，8： | 4 |
| 15 | Cytogenetic comparisons between A and G genomes in Oryza using genomic in situ hybridization显示文摘Oryza sativa (一个染色体) 和 O 的 genomic 结构。meyeriana (G 染色体) 比较地在 situ 杂交(GISH ) 用二色的 genomic 被学习。GISH 清楚地能在 O 的染色体之间区别。sativa 和 O。在没有堵住 DNA 的种间的 F1 混血儿的 meyeriana,和合作杂交几乎没被检测。O 的平均有丝分裂的染色体长度。meyeriana 被发现是乘 O 的的 1.69。sativa。染色的 4,6-diamidino-2-phenylindole 的比较出现了 O 的染色体。meyeriana 更广泛地被标记,建议 G 染色体与更重复的序列比被放大一个染色体。在分裂期间原子核, 9-12 多彩石印版中心通常被检测,将近,所有多彩石印版中心组成了 G 染色体特定的 DNA。中心由相应于 G 染色体的染色质压缩形成了的更多和更大的多彩石印版与它的父母相比在混血儿被检测。在 F1 混血儿的 pachytene 期间, A 和 G 的大多数染色体互相,除了 1-2,染色体在他们的手臂的结束配对的触处。在 meiotic 中期我, chromosomal 协会的三种类型,即 O。sativa-O。sativa (A-A ) , O。sativa-O。meyeriana (A-G ) 和 O。meyeriana-O。meyeriana (G-G ) ,在 F1 混血儿被观察。配对配置的 A-G 染色体包括了 bivalents 和 trivalents。结果向学习染色体组织和 O 的进化提供了一个基础。meyeriana。 | Zhi Yong Xiong Guang Xuan Tan Guang Yuan He Guang Cun He Yun Chun Song | 2006 | Cell Research2006，16，3： | 4 |
| 16 | Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis显示文摘Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis.Crosstalk between autophagy deficiency and inflammation response in foam cells(FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized lowdensity lipoprotein(ox-LDL) leads to abnormal crosstalk between autophagy and inflammation,thereby causing aberrant lipid metabolism mediated through a dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4(BRD4) axis. ox-LDL led to macrophage autophagy deficiency along with TFEB cytoplasmic accumulation and increased reactive oxygen species generation. This activated P300 promoted BRD4 binding on the promoter regions of inflammatory genes, consequently contributing to inflammation with atherogenesis. Particularly, ox-LDL activated BRD4-dependent super-enhancer associated with liquid-liquid phase separation(LLPS) on the regulatory regions of inflammatory genes. Curcumin(Cur) prominently restored FCs autophagy by promoting TFEB nuclear translocation, optimizing lipid catabolism, and reducing inflammation. The consequences of P300 and BRD4 on super-enhancer formation and inflammatory response in FCs could be prevented by Cur. Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. The findings identify a novel TFEB-P300-BRD4 axis and establish a new epigenetic paradigm by which Cur regulates autophagy, inhibits inflammation, and decreases lipid content. | Xuesong Li Ruigong Zhu Hong Jiang Quanwen Yin Jiaming Gu Jiajing Chen Xian Ji Xuan Wu Haiping Fu Hui Wang Xin Tang Yuanqing Gao Bingjian Wang Yong Ji Hongshan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 17 | Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis显示文摘Depression is a serious public-health issue.Recent reports have suggested higher susceptibility to viral infections in depressive patients.However,how depression affects antiviral innate immune signaling remains unknown.Here,we revealed a reduction in expression of Abelson helper integration site 1(AHI1)in the peripheral blood mononuclear cells(PBMCs)and macrophages from the patients with major depressive disorder(MDD),which leads to attenuated antiviral immune response.We found that depression-related arginine vasopressin(AVP)induces reduction of AHI1 in macrophages.Further studies demonstrated that AHI1 is a critical stabilizer of basal type-I-interferon(IFN-I)signaling.Mechanistically,AHI1 recruits OTUD1 to deubiquitinate and stabilize Tyk2,while AHI1 reduction downregulates Tyk2 and IFN-I signaling activity in macrophages from both MDD patients and depression model mice.Interestingly,we identified a clinical analgesic meptazinol that effectively stimulates AHI1 expression,thus enhancing IFN-I antiviral defense in depression model mice.Our study promotes the understanding of the signaling mechanisms of depression-mediated antiviral immune dysfunction,and reveals meptazinol as an enhancer of antiviral innate immunity in depressive patients. | Hong-Guang Zhang Bin Wang Yong Yang Xuan Liu Junjie Wang Ning Xin Shifeng Li Ying Miao Qiuyu Wu Tingting Guo Yukang Yuan Yibo Zuo Xiangjie Chen Tengfei Ren Chunsheng Dong Jun Wang Hang Ruan Miao Sun Xingshun Xu Hui Zheng | 2022 | Cell Research2022，32，10： | 3 |
| 18 | Multiresolution Isogeometric Topology Optimisation Using Moving Morphable Voids显示文摘A general and new explicit isogeometric topology optimisation approach with moving morphable voids(MMV)is proposed.In this approach,a novel multiresolution scheme with two distinct discretisation levels is developed to obtain high-resolution designs with a relatively low computational cost.Ersatz material model based on Greville abscissae collocation scheme is utilised to represent both the Young’s modulus of the material and the density field.Two benchmark examples are tested to illustrate the effectiveness of the proposed method.Numerical results show that high-resolution designs can be obtained with relatively low computational cost,and the optimisation can be significantly improved without introducing additional DOFs. | Bingxiao Du Yong Zhao Wen Yao Xuan Wang Senlin Huo | 2020 | Computer Modeling in Engineering & Sciences2020，，3： | 3 |
| 19 | Evaluation of humic acid removal by a flat submerged membrane photoreactor显示文摘A flat submerged membrane combined with a TiO 2 /UV photocatalytic reactor (FSMPR) was employed in batch mode to remove humic acid (HA). HA removal efficiency was characterized by UV 254 absorbance, UV-vis spectra, dissolved organic carbon (DOC) concentration, specific UV absorbance (SUVA), and trihalomethane formation potential (THMFP). The FSMPR process was effective in removing more than 86% of DOC and nearly 100% of UV 254 absorbance, while the THMFPs of samples were reduced to < 19 μ g/L after 150 min of treatment. In addition, changes in transmembrane pressure (TMP) with and without UV were evaluated; TiO 2 /UV was effective at controlling membrane fouling by HA. Analysis of the molecular weight (MW) distributions and three-dimensional excitation-emission matrix (EEM) fluorescence spectra of HAs revealed that the effectiveness in membrane fouling control is a result of changes in HA molecular characteristics. The TiO 2 /UV photocatalytic reactor caused the degradation of high MW, hydrophobic humic-like molecules to low MW, hydrophilic protein-like molecules, although this fraction was not completely removed during 150 min of treatment and was less responsible for membrane fouling. | WEI Yong CHU HuaQiang DONG BingZhi LI Xuan | 2011 | Chinese Science Bulletin2011，56，32： | 3 |
| 20 | Exergy and ecological modelling of lake environment显示文摘1IntroductionIncreasinglyseriouslakeeutrophicationhasbecomeaglobalenvironmentalproblemanddrawngreatatention.InChina,manylakes... | Zhang Yong ze Environmental Engineering Center, Chinese Research Academy of Environmental Sciences, Beijing 100012, China Wang Xuan Institute of Environmental Science, Beijing Normal University, Beijing 100875, China | 1998 | Journal of Environmental Sciences1998，10，4： | 3 |
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