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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Electrochemical synthesis of nitric acid from air and ammonia through waste utilization显示文摘Commercial nitric acid(HNO3) and ammonia(NH3) are mostly produced through the Ostwald process and the Haber-Bosch process, respectively. However, high energy demand and enormous greenhouse gas accompy these processes. The development of economical and green ways to synthesize HNO3 and NH3 is highly desirable for solving the global energy and environmental crisis. Here, we present two energy-efficient and environmentally friendly strategies to synthesize HNO3 and NH3 at distributed sources, including the electrocatalytic oxidation of N2 in air to HNO3 and the electrocatalytic reduction of residual NO3- contamination in water to NH3. The isotope-labeling studies combined with theoretical calculation reveal the reaction path of the two proposed strategies, confirming the origin of the electrochemical products. Importantly, the electrooxidation-generated NO3- ions may also serve as reactants for the electroreduction synthesis of NH3 in the future. Our work may open avenues for energy-efficient and green production of HNO3 and NH3 at distributed sources. | Yuting Wang Yifu Yu Ranran Jia Chao Zhang Bin Zhang | 2019 | National Science Review2019，6，4： | 10 |
| 3 | Self-template synthesis of double-layered porous nanotubes with spatially separated photoredox surfaces for efficient photocatalytic hydrogen production显示文摘Improving charge carriers separation to achieve high photoconversion efficiency in heterogeneous photocatalysts is highly desirable.Herein,heterostructured ZnS@CdS double-layered porous nanotubes(PNTs),in which the spatially separated reduction and oxidation reaction sites lie on the outer and inner shell,respectively,are fabricated through a robust self-template conversion strategy.After selective photo-deposition of Ni and CoO_x as dual cocatalysts,Ni nanoparticles as electron collectors and reduction reaction sites are loaded on the outer shell,while CoO_x nanoparticles as hole collectors and oxidation reaction sites are loaded on the inner shells.As a result,a novel CoO_x/ZnS@CdS/Ni photocatalyst is obtained and shows high visible-light-driven photocatalytic hydrogen production activity owing to the synergistic effect of self-template-derived thin mesoporous heterojunctions and photo-depositionderived spatially separated dual cocatalysts,which can significantly provide driving force for the ordered transfer of photogenerated electrons and holes toward opposite direction and promote the surface catalytic reaction.Additionally,the facile strategy can be broadened to the preparation of CoO_x/ZnSe@CdSe/NiPNTs with enhanced photocatalytic activity. | Yani Xin Yi Huang Kui Lin Yifu Yu Bin Zhang | 2018 | Science Bulletin2018，63，10： | 9 |
| 4 | Hydrogen evolution activity enhancement by tuning the oxygen vacancies in self-supported mesoporous spinel oxide nanowire arrays显示文摘到调子的灵巧的策略的发展在转变金属氧化物(TMO ) 的氧空缺(OV ) 内容是首要的获得便宜、稳定的 electrocatalysts,但是仍然高度质问。拿 NiCo 2 O 4作为一个模型系统,我们试验性地建立了灵巧的锻烧和电气化学的激活( EA )方法论戏剧性地增加 OV 的集中并且提供 OV 的集中怎么向电气化学的氢进化反应影响尖晶石 TMO 的表演的理论卓见(她的)。OV 富有的 NiCo 2 O 4 nanowire 数组被发现更高与更少 OV 比它的对应物在碱的媒介展出她的活动和更好的稳定性。她的活动在对在学习样品的 OV 的增加的集中的好同意的 electrocatalytic。360 妈的大当前的密度?? | Dali Liu Chao Zhang Yifu Yu Yanmei Shi Yu Yu Zhiqiang Niu Bin Zhang | 2018 | Nano Research2018，11，2： | 9 |
| 5 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 6 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 7 | Optimization Strategies for Selective CO_(2) Electroreduction to Fuels显示文摘Capturing CO_(2) from the atmosphere and converting it into fuels are an effi cient strategy to stop the deteriorating greenhouse eff ect and alleviate the energy crisis.Among various CO_(2) conversion approaches,electrocatalytic CO_(2) reduction reaction(CO_(2) RR)has received extensive attention because of its mild operating conditions.However,the high onset potential,low selectivity toward multi-carbon products and poor cruising ability of CO_(2) RR impede its development.To regulate product distribution,previous studies performed electrocatalyst modifi cation using several universal methods,including composition manipulation,morphology control,surface modifi cation,and defect engineering.Recent studies have revealed that the cathode and electrolytes infl uence the selectivity of CO_(2) RR via pH changes and ionic eff ects,or by directly participating in the reduction pathway as cocatalysts.This review summarizes the state-of-the-art optimization strategies to effi ciently enhance CO_(2) RR selectivity from two main aspects,namely the cathode electrocatalyst and the electrolyte. | Yangfang Ling Qinglang Ma Yifu Yu Bin Zhang | 2021 | Transactions of Tianjin University2021，27，3： | 6 |
| 8 | Promoting selective electroreduction of nitrates to ammonia over electron-deficient Co modulated by rectifying Schottky contacts显示文摘Developing efficient electrocatalysts for selective nitrate contamination reduction into value-added ammonia is significant.Here,heterostructured Co/CoO nanosheet arrays(Co/CoO NSAs)exhibited excellent Faradaic efficiency(93.8%)and selectivity(91.2%)for nitrate electroreduction to ammonia,greatly outperforming Co NSAs.15N isotope labeling experiments and 1H nuclear magnetic resonance(NMR)quantitative testing methods confirmed the origin of the produced ammonia.Electrochemical in situ Fourier transform infrared(FTIR)spectroscopy,online differential electrochemical mass spectrometry(DEMS)data and density functional theory(DFT)results revealed that the superior performances arose from the electron deficiency of Co induced by the rectifying Schottky contact in the Co/CoO heterostructures.The electron transfer from Co to CoO at the interface could not only suppress the competitive hydrogen evolution reaction,but also increase energy barriers for by-products,thus leading to high Faradaic efficiency and selectivity of ammonia. | Yu Yu Changhong Wang Yifu Yu Yuting Wang Bin Zhang | 2020 | Science China Chemistry2020，63，10： | 2 |
| 9 | Adsorption desulfurization of model gasoline by metal–organic framework Ni3(BTC)2显示文摘This work presented the synthesis of Ni-based metal-organic framework material with a paddle-wheel structure Ni3(BTC)2 (Ni-BTC) and its application in thiophene (TP) adsorption from gasoline distillate by batch method. Adsorption isotherms of TP, cyclohexene, and toluene in cyclohexane onto Ni-BTC were conducted at 298-308 K to interpret the different effect of cyclohexene and toluene on TP adsorption. The results showed that, compared w让h cyclohexene, toluene addition in model gasoline led to a more evident decline in sulfur capacity of Ni-BTC, which is opposite to isostructural HKUST-1. The adsorption isotherms of TP, cyclohexene and toluene fit Langmuir model, S-type model and Temkin model well, respectively, indicating that the adsorption mechanisms of TP and the two competitors are different from one another The adsorption capacities on Ni-BTC followed the order of cyclohexene < toluene < TP at the same equilibrium concentrations, implying the order of the adsorption affinities, which is in good agreement with the different extent of influence by the two competitors. The enthalpy of TP adsorption on Ni-BTC was estimated to be -80.01 kj/mol, almost twice that on HKUST-1. The poor reusability of Ni-BTC in batch experiment, which is owing to its sensitivity to the air, can be prevented from regenerating used Ni-BTC in fixed-bed reactor by N2 flow. The difference between Ni-BTC and HKUST-1 in maximum adsorption capacity (q0),△H of TP adsorption, and stability demonstrates that the central metal in isostructural MOFs plays a key role in adjusting the desulfurization performance, which may open up a potential avenue for the development of MOF-based adsorbents with superior desulfurization performance. | Fuping Tian Qiaofeng Ru Chenxia Qiao Xin Sun Cuiying Jia Yu Wang Yifu Zhang | 2019 | Journal of Energy Chemistry2019，28，5： | 2 |
| 10 | Promoting nitric oxide electroreduction to ammonia over electron-rich Cu modulated by Ru doping显示文摘Electrocatalytic nitric oxide(NO)reduction is a promising strategy to produce ammonia.Developing a facile approach to synthesize efficient catalysts with enhanced NO electroreduction performance is highly desirable.Here,a series of Ru-doped Cu materials are constructed through in situ electroreduction of corresponding metal hydroxides.The optimized Ru_(0.05)Cu_(0.95)exhibits superior electrocatalytic performance for ammonia synthesis by using NO/Ar(1/4,n/n)as the feedstocks(Faradaic efficiency:64.9%,yield rate:17.68μmol cm^(-2)h^(-1)),obviously outperforming Cu counterpart(Faradaic efficiency:33.0%,yield rate:5.73μmol cm^(-2)h^(-1)).Electrochemical in situ Fourier transform infrared(FTIR)spectroscopy and online differential electrochemical mass spectrometry(DEMS)are adopted to detect intermediates and unveil the possible reaction pathway.The downshift of the Cu d-band center induced by Ru doping facilitates the rate-limiting hydrogenation step and decreases the desorption energy of NH_(3),leading to high Faradaic efficiency and yield of ammonia. | Jiangwei Shi Changhong Wang Rong Yang Fanpeng Chen Nannan Meng Yifu Yu Bin Zhang | 2021 | Science China Chemistry2021，64，9： | 2 |
| 11 | Integrating photocatalytic reduction of CO2 with selective oxidation of tetrahydroisoquinoline over InP–In2O3 Z-scheme p-n junction显示文摘The development of a facile strategy to construct stable hierarchal porous heterogeneous photocatalysts remains a great challenge for efficient CO2 reduction.Additionally,hole-trapping sacrificial agents(e.g.,triethanolamine,triethylamine,and methanol)are mostly necessary,which produce useless chemicals,and thus cause costs/environmental concerns.Therefore,utilizing oxidation ability of holes to develop an alternative photooxidation reaction to produce value-added chemicals,especially coupled with CO2 photoreduction,is highly desirable.Here,an in situ partial phosphating method of In2O3 is reported for synthesizing In P–In2O3 p-n junction.A highly selective photooxidation of tetrahydroisoquinoline(THIQ)into value-added dihydroisoquinoline(DHIQ)is to replace the hole driven oxidation of typical sacrificial agents.Meanwhile,the photoelectrons of In P–In2O3 p-n junction can induce the efficient photoreduction of CO2 to CO with high selectivity and stability.The evolution rates of DHIQ and CO are 2 and 3.8 times higher than those of the corresponding In2O3 n-type precursor,respectively.In situ irradiated X-ray photoelectron spectroscopy and electron spin resonance are utilized to confirm that the direct Z-scheme mechanism of In P–In2O3 p-n junction accelerate the efficient separation of photocarriers. | Bohang Zhao Yi Huang Dali Liu Yifu Yu Bin Zhang | 2020 | Science China Chemistry2020，63，1： | 2 |
| 12 | The metabolism of soluble carbohydrates related to chilling injury in peach fruit exposed to cold stress显示文摘 | Ke Wang Xingfeng Shao Yifu Gong Yong Zhu Hongfei Wang Xinglong Zhang Dandan Yu Fang Yu Ziyun Qiu Hao Lu | 2013 | Postharvest Biology and Technology2013，，： | 1 |
| 13 | A General Method for the Synthesis of Hybrid Nanostructures Using MoSe_(2) Nanosheet-Assembled Nanospheres as Templates显示文摘The layered transition metal dichalcogenides(TMDs)and transition metal phosphides are low-cost,earth-abundant,and robust electrocatalysts for hydrogen evolution reaction(HER).Integrating them into hybrid nanostructures is potentially promising to further boost the catalytic activity toward HER based on their synergistic effects.Herein,we report a general method for the synthesis of a series of MoSe_(2)-based hybrid nanostructures,including MoSe_(2)-Ni_(2)P,MoSe_(2)-Co_(2)P,MoSe_(2)-Ni,MoSe_(2)-Co,and MoSe_(2)-NiS,by postgrowth of Ni_(2)P,Co_(2)P,Ni,Co,and NiS nanostructures on the presynthesized MoSe_(2) nanosheet-assembled nanospheres,respectively,via a colloidal synthesis method.As a proof-of-concept application,the as-synthesized hybrid nanostructures are used as electrocatalysts for HER,exhibiting high activity and stability in acidic media.Among them,the MoSe_(2)-Co_(2)P composite shows the highest HER activity with an overpotential of 167 mV at 10 mA cm^(-2). | Shikui Han Kai Zhou Yifu Yu Chaoliang Tan Junze Chen Ying Huang Qinglang Ma Ye Chen Hongfei Cheng Weijia Zhou Hua Zhang | 2019 | Research2019，，1： | 1 |
| 14 | Reduced Graphene Oxide/Carbon Fiber Composite Membrane for Self-floating Solar-thermal Steam Production显示文摘Solar-thermal water evaporation has attracted increasing attention owing to the promising potential to solve the global clean water and energy crisis.But,the development of this strategy is limited by the lack of materials with high solar-thernal conversion efficiency,local heating of superficial water,easy preparation and low cost.Herein,we proposed a facile strategy to prepare a reduced graphene oxide/carbon fiber composite membrane,denoted as RGO/CF membrane.The surface of the RGO/CF membrane was highly hydrophobic,endowing the composite membrane with the self-floating ability on the water without any assistance.The light absorbance ability achieved as high as ca.98%in the wavelength range of 300-1200 nm.The steam evaporation efliciency under the illumination of3-sun was 97%,generating water steam at a rate of 4.54 kg·m^-2·h^-1.Moreover,the solar-thermal steam production rate showed high stability during successive 30 cvcle tests. | MA Aijing CHEN Yaxi LIU Yang GUI Jianzhou YU Yifu | 2020 | Chemical Research in Chinese Universities2020，36，4： | 1 |
| 15 | Domain-confined multiple collision enhanced catalytic soot combustion over a Fe203/ TiO2-nanotnhe array catalyst prepared by light-assisted cyclic magnetic adsorption显示文摘 | Yu Yifu Ren Jiale Liu Dongsheng | 2014 | ACS Catal2014，4，： | 1 |
| 16 | Photoluminescence and photocatalysis of the flower-like nano-ZnO photocatalysts prepared by a facile hydrothermal method with or without ultrasonic assistance显示文摘 | Youlei Lai Ming Meng Yifu Yu Xitao Wang Tong Ding | 2011 | Applied Catalysis B, Environmental2011，，： | 1 |
| 17 | Synthesis and characterization of nanostructured CuFe 2 O 4 anode material for lithium ion battery显示文摘 | Yu Ding Yifu Yang Huixia Shao | 2012 | Solid State Ionics2012，，： | 1 |
| 18 | Effect of titania polymorph on the properties of CuO/TiO2 catalysts for trace methane combustion 显示文摘 | RUI Zebao HUANG Yifu ZHENG Yu | 2013 | Journal of Molecular Catalysis a-Chemical2013，372，： | 1 |
| 19 | Electrocatalytic construction of the C–N bond from the derivates of CO_(2) and N_(2)显示文摘Electrochemical synthesis of C-N bond-containing compounds(e.g.,urea,amino acid,amide,amine,and their derivates)from CO_(2)/N_(2)and their derivates is emerging as a promising sustainable strategy[1-7].CO_(2)and its derived products,CO,HCOOH,(COOH)_(2),etc.,could serve as carbon sources(Figure 1)[8].N_(2),making up 80%of air,is an appealing nitrogen source.However,the low solubility of N2 and the high dissociation energy for the N≡N bond limit its application. | Yanmei Huang Yuting Wang Yongmeng Wu Yifu Yu Bin Zhang | 2022 | Science China Chemistry2022，65，2： | 1 |
| 20 | High capacity ZnFe204 anode material for lithium ion batteries显示文摘 | DING Yu YANG Yifu SHAG Huixia | 2011 | Electrochimica Acta2011，56，： | 1 |
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