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| 1 | Correlation between BRAF^(V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma显示文摘In adults, the presence of the BRAF^(V600E) mutation in papillary thyroid cancer(PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF^(V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF^(V600E) mutation in48 pediatric patients with PTC, aged 3–13 years. Of these patients, 41 were diagnosed with classic PTC, five were found to have a follicular variant of PTC, and two to exhibit a diffuse sclerosing PTC variant. The BRAF^(V600E) mutation was identified to be present in 35.4% of the 48 analyzed patients, and in 41.5% of the patients diagnosed with classical PTC. Furthermore, the presence of the BRAF^(V600E) mutation was found to be associated with a patient age at diagnosis of less than ten years(P=0.011), the performance of a thyroidectomy(P=0.03), exhibited tumor multifocality(P=0.02) and/or extra-thyroidal invasion(P=0.003), and both a low MACIS(Metastases, Age, Completeness of resection, Invasion, Size)(P=0.036) and AMES(Age, Metastasis, Extent of tumor,Size)(P=0.001)score. Together, these data suggest that the presence of the BRAF^(V600E) mutation may be negatively correlated with partial aggressive clinicopathological features of pediatric PTC. | Jiangqiao Geng Huanmin Wang Yuanhu Liu Jun Tai Yaqiong Jin Jie Zhang Lejian He Libing Fu Hong Qin Yingluan Song Jinzhu Su Aiying Zhang Xin Wen Yongli Guo Xin Ni | 2017 | Science China(Life Sciences)2017，60，7： | 9 |
| 2 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 3 | Natural orifice transluminal endoscopic surgery in urology: The Chinese experience显示文摘Objective:To describe the Chinese experience of natural orifice transluminal endoscopic surgery(NOTES)in urology.Methods:From December 2008 to May 2017,35 animal experiments and 305 clinical surgeries of NOTES or natural orifices specimen extractions(NOSE)were performed in China.The animal experiments included five kidney biopsies,24 nephrectomies and six partial nephrectomies.The clinical surgeries included 12 transvaginal NOSE(TV-NOSE),266 hybrid transvaginal NOTES(TV-NOTES)and 27 pure TV-NOTES.The TV-NOSE procedure was performed in five transumbilical laparoendoscopic single-site(U-LESS)nephrectomies,four suprapubic-assisted laparoendoscopic single-site surgery(SA-LESS)nephroureterectomies,and three laparoscopic radical cystectomies.The hybrid TV-NOTES procedure included 210 nephrectomies,31 adrenalectomies,eight nephroureterectomies,13 partial nephrectomies,and four heminephrectomies.The pure TV-NOTES procedure included five renal cyst decortications and 22 nephrectomies.Results:A total of 29 animal experiments were successfully performed.One partial nephrectomy was converted to standard laparoscopic surgery.Two kidney biopsies and two nephrectomies were unsuccessful.A total of 297 clinical surgeries were successfully performed.Six patients who underwent hybrid TV-NOTES were converted to open surgery.Two patients who underwent pure TV-NOTES were converted to SA-LESS.There were 22 major complications,16 occurred intraoperatively and six postoperatively.The mean visual analog score(VAS)of 48 h after the operation was 2.5 points in TV-NOSE,2.3 points in hybrid TV-NOTES and 1.7 points in pure TV-NOTES.The mean follow-up of 50.6(3.0-87.0)months showed that all patients were in good condition.The umbilicus scars were nearly invisible in TV-NOSE and hybrid TV-NOTES.The vaginal incision healed well.Conclusions:TV-NOSE and TV-NOTES are feasible,safe,and effective with little injury,low pain,fast recovery,and good cosmetic outcomes in properly selected patients.They are worth consideration for urological clinical practice. | Xiaofeng Zou Guoxi Zhang Tianpeng Xie Yuanhu Yuan Rihai Xiao Gengqing Wu Xiaoning Wang Hui Xu Folin Liu Yuting Wu Yunfeng Liao Quanliang Liu Yinghao Sun Bo Yang Linhui Wang Chuanliang Xu Xiaofeng Gao | 2020 | Asian Journal of Urology2020，7，1： | 5 |
| 4 | Correlation between TERT C228T and clinic-pathological features in pediatric papillary thyroid carcinoma显示文摘The aims of the present study were to reveal the prevalence of the TERT C228 T mutation in pediatric papillary thyroid carcinoma(PPTC) and to further investigate the role of the TERT C228 T mutation in PPTC. We also tested another TERT mutation, TERT C250 T, although this was not detected in PPTC patients. In this study, 48 patients with PPTC(41 with classic PPTC) were enrolled. DNA was extracted from PPTC tissues and TERT C228 T mutation analysis was performed. Chi-squared analysis,Fisher’s exact test, and a t-test were applied to test the significance of differences. The TERT C228 T mutation presented in 13(27.1%) of the 48 PPTC patients and 10(24.4%) of the 41 classical PPTC patients. There were significant differences between PPTC patients with the TERT C228 T mutation and those without in terms of modified radical neck dissection, multifocality,capsular invasion, extrathyroidal invasion, and American Joint Committee on Cancer(AJCC) tumor stage(P<0.05). In classical PPTC, there were additional significant differences in other clinic-pathological features, such as AJCC nodal stage(P=0.009)and American Thyroid Association(ATA) PPTC stage(P=0.021) between patients with and without the TERT C228 T mutation.These findings indicate that the TERT C228 T mutation is significantly correlated with certain aggressive clinic-pathological features of PPTC. | Jiangqiao Geng Yuanhu Liu Yongli Guo Huanmin Wang Jun Tai Yaqiong Jin Jie Zhang Yongbo Yu Shengcai Wang Yingluan Song Xin Ni | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 5 | Pediatric cancer surveillance in China:A hospital-based introduction显示文摘Background In recent years,increasing numbers of families have been affected by childhood cancer.According to data from the International Agency for Research on Cancer(IARC)of the World Health Organization,approximately 279000 new cases of cancer were predicted in children and adolescents aged 0–19 years worldwide in 2020.The global incidence of childhood cancer is 10.9 per 100000(global standard rate)and the mortality rate is 4.2 per 100000.1 According to data from the China National Cancer Center,the incidences of cancer in 2017 were 9.9 per 100000 in children aged 0–14 years and 11.5 per 100000 in adolescents aged 15–19 years.2 There are estimated to be approximately 22000 new cases of childhood cancer in China each year,and the incidence of malignant tumors in children aged 0–14 years has increased by 2.5%annually in the past decade. | Zhe Li Rongshou Zheng Xin Xu Yuanhu Liu Chenguang Jia Guoshuang Feng Xiao Zhang Xinping Li Guoliang Bai Xin Ni | 2021 | Pediatric Investigation2021，5，2： | 3 |
| 6 | Effects of substance P on growth of fibroblast-like cells derived from bile duct: an in vitro cell culture study显示文摘 | Tian Yuanhu Yang Guangyun Zhang Xiaoqing Shen Wei Dong Jiahong Xu Zhi | 2014 | Chinese Medical Journal2014，，17： | 3 |
| 7 | RAVL1 Activates IDD3 to Negatively Regulate Rice Resistance to Sheath Blight Disease显示文摘Sheath blight disease (ShB) has a severe impact on the production of rice. ABI3/VP1-like 1(RAVL1) negatively regulated the rice defense mechanism against ShB, however, this regulatorymechanism is not clearly understood. In this study, we identified that indeterminate domain 3 (IDD3) waspositively regulated by RAVL1. Further, chromatin immunoprecipitation (ChIP) assay, yeast one-hybridassay and transient expression assay indicated a direct binding between RAVL1 and the IDD3 promoterregion. IDD3 was ubiquitously expressed in different tissues and at different stages, and its expressionwas significantly enhanced by Rhizoctonia solani infection. IDD3 exhibited transcription activation activityin yeast and IDD3-GFP was found to be localized in the nucleus. IDD3 mutants exhibited no significantdifferences in response to ShB, while IDD3 overexpressors were more susceptible to ShB compared withwild type (WT) plants. Furthermore, IDD3 repressors were less susceptible to R. solani than WT plants.Interestingly, the expression of brassinosteroid-related genes (D2, D11 and BRI1) was lower in IDD3repressors and higher in IDD3 overexpressors compared with WT. However, the ChIP assay revealedthat IDD3 did not directly bind to the D2 and D11 promoters. Overexpression of IDD3 in BRI1 mutantd61-1 inhibited the activity of IDD3, reducing its susceptibility to ShB compared with IDD3 overexpressorand WT plants, indicating that IDD3 negatively regulated the rice defense mechanism against ShB by activatingthe BR signaling pathway. Thus, our analyses provided information to enhance the understanding of therice defense mechanism against ShB. | SUN Qian YANG Shuo GUO Xiaofan WANG Siting JIA Xintong LI Shuang XUAN Yuanhu | 2021 | Rice science2021，28，2： | 2 |
| 8 | Considerable impacts of litter inputs on soil nematode community composition in a young Acacia crassicapa plantation显示文摘Aboveground litter inputs and root exudates provide basal resources for soil communities,however,their relative contributions to soil food web are still not well understood.Here,we conducted a field manipulative experiment to differentiate the effects of litter inputs and living root on nematode community composition of surface and subsoils in a young Acacia crassicapa plantation in southern China.Our results showed that both litter addition and root presence significantly enhanced soil nematode abundance by 17.3%and 35.3%,respectively.Litter addition altered nematode trophic group composition,decreased fungivore to bacterivore ratio,and enhanced maturity index and structure index,which led to a bacterial-based energy channel and a more complex food web structure.However,root presence had a limited impact on the nematode community composition and ecological indices.Despite nematodes surface assembly,soil depth did not affect nematode trophic group composition or ecological index.Our findings highlight the importance of litter inputs in shaping soil nematode community structure and regulating soil energy channel. | CANCAN ZHAO YIN LI CHENLU ZHANG Yuan Miao Mengzhou Liu Wanlin Zhuang Yuanhu Shao Weixin Zhang Shenglei Fu | 2021 | Soil Ecology Letters2021，3，2： | 2 |
| 9 | Experimental study on the influence of diffuser and inlet guide vane for the performance of centrifugal compressor显示文摘 | ZHOU Li XI Guang CAI Yuanhu | 2008 | Experimental Techniques2008，32，5： | 1 |
| 10 | Role of the carrier gas flow rate in monolayer MoS2 growth by modified chemical vapor deposition显示文摘单层铝二硫化物(因为潜在的应用的变化,瞬间 2) 吸引了许多注意。然而,它的控制生长仍然是大挑战。这里,我们报导一个修改化学蒸汽免职方法种单层瞬间 2 。我们观察到瞬间 2 晶体的质量能被在加热阶段期间调节搬运人气体流动率极大地改进。这微妙的修正阻止在先锋之间的控制不了的反应,为高质量的单层瞬间 2 的生长的一个关键因素。基于优化煤气的流动率,瞬间 2 范围和薄片尺寸能被调整生长时间控制。 | Hengchang Liu Yuanhu Zhu Qinglong Meng Xiaowei Lu Shuang Kong Zhiwei Huang Peng Jiang Xinhe Bao | 2017 | Nano Research2017，10，2： | 1 |
| 11 | Suprapubic‐assisted laparoendoscopic single‐site surgery ( LESS ) in urology: our experience显示文摘 | Xiaofeng Zou Guoxi Zhang Yijun Xue Yuanhu Yuan Rihai Xiao Gengqing Wu Xiaoning Wang Yuting Wu Dazhi Long Jun Yang Hui Xu Folin Liu Xu Zhang | 2013 | BJU Int2013，，2： | 1 |
| 12 | Lumi-nescent properties of a new long afterglow Eu2+and Dy3+ac-tivated Ca3MgSi2O8phosphor显示文摘 | LIN Yuanhu ZHANG Zhongtai TANG Zilong | 2001 | J European Ceramic Soci-ty2001，21，： | 1 |
| 13 | Lumi-nescence of Eu2+and Dy3+activated R3MgSi2O8-based(R=Ca,Sr,Ba)phosphors显示文摘 | LIN Yuanhu ZHANG Zhongtai TANG Zilong | 2003 | J Alloys and Componds2003，348，： | 1 |
| 14 | In vitro antioxidant activities of fruits and leaves of pomegranate显示文摘 | Zhang Lihua Li Linglling Zhang Yuanhu etal | 2008 | Ac ta Hortieuhure2008，765，： | 1 |
| 15 | In Vitro Antioxidant Activities of Fruits and Leaves of Pomegranate显示文摘 | Zhang Lihua Li Lingling Zhang Yuanhu | 2008 | Acta Horticulturae2008，765，3： | 1 |
| 16 | Energy efficiency and potentials of cassava fuel ethanol in Guangxi region of China 显示文摘 | Du Dai Zhi Yuanhu Geng Qiangpu | 2006 | Energy Conversion and Management2006，47，1314： | 1 |
| 17 | In vitro antioxidant activities of fruits and leaves of pomegranate显示文摘 | Zhang Lihua Li Lingling Zhang Yuanhu | | 0，，03： | 1 |
| 18 | Simultaneous determination of malachite green, gentian violet and their leuco-metabolites in shrimp and salmon by liquid chromatography–tandem mass spectrometry with accelerated solvent extraction and auto solid-phase clean-up显示文摘 | Yanfei Tao Dongmei Chen Xiaoqin Chao Huan Yu Pan Yuanhu Zhenli Liu Lingli Huang Yulian Wang Zonghui Yuan | 2011 | Food Control2011，，8： | 1 |
| 19 | Microbial desulfurization of ground tire rubber by Thiobacillus ferrooxidans 显示文摘 | Yuanhu Li Suhe Zhao Yaqin Wang | 2011 | Polymer Degradation and Stability2011，96，9： | 1 |
| 20 | Simple synthesis of ordered cubic mesoporous graphitic carbon nitride by chemical vapor deposition method using melamine显示文摘 | YANGANG W FEI W YUANHU! Z | 2014 | Materials Letters2014，136，： | 1 |
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