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| 1 | The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice显示文摘Hepatic ischemia/reperfusion injury(HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein, we investigated the potential contribution of gut microbes to HIRI.Ischemia/reperfusion surgery was performed to establish a murine model of HIRI. 16 S r RNA gene sequencing and metabolomics were used for microbial analysis. Transcriptomics and proteomics analysis were employed to study the host cell responses. Our results establish HIRI was significantly increased when surgery occurred in the evening(ZT12, 20:00) when compared with the morning(ZT0, 08:00);however, antibiotic pretreatment reduced this diurnal variation. The abundance of a microbial metabolite3,4-dihydroxyphenylpropionic acid was significantly higher in ZT0 when compared with ZT12 in the gut and this compound significantly protected mice against HIRI. Furthermore, 3,4-dihydroxyphenylpropionic acid suppressed the macrophage pro-inflammatory response in vivo and in vitro. This metabolite inhibits histone deacetylase activity by reducing its phosphorylation. Histone deacetylase inhibition suppressed macrophage pro-inflammatory activation and diminished the diurnal variation of HIRI. Our findings revealed a novel protective microbial metabolite against HIRI in mice. The potential underlying mechanism was at least in part, via 3,4-dihydroxyphenylpropionic acid-dependent immune regulation and histone deacetylase(HDAC) inhibition in macrophages. | Rui Li Li Xie Lei Li Xiaojiao Chen Tong Yao Yuanxin Tian Qingping Li Kai Wang Chenyang Huang Cui Li Yifan Li Hongwei Zhou Neil Kaplowitz Yong Jiang Peng Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 2 | The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization显示文摘Objective:Macrophages are a major component of the tumor microenvironment.M1 macrophages secrete pro-inflammatory factors that inhibit tumor growth and development,whereas tumor-associated macrophages(TAMs)mainly exhibit an M2 phenotype.Our previous studies have shown that the interleukin-33/ST2(IL-33/ST2)axis is essential for activation of the M1 phenotype.This study investigates the role of the IL-33/ST2 axis in TAMs,its effects on tumor growth,and whether it participates in the mutual conversion between the M1 and M2 phenotypes.Methods:Bone marrow-derived macrophages were extracted from wildtype,ST2 knockout(ST2-/-),and Il33-overexpressing mice and differentiated with IL-4.The mitochondrial and lysosomal number and location,and the expression of related proteins were used to analyze mitophagy.Oxygen consumption rates and glucose and lactate levels were measured to reveal metabolic changes.Results:The IL-33/ST2 axis was demonstrated to play an important role in the metabolic conversion of macrophages from OXPHOS to glycolysis by altering mitophagy levels.The IL-33/ST2 axis promoted enhanced cell oxidative phosphorylation,thereby further increasing M2 polarization gene expression and ultimately promoting tumor growth(P<0.05)(Figure 4).This metabolic shift was not due to mitochondrial damage,because the mitochondrial membrane potential was not significantly altered by IL-4 stimulation or ST2 knockout;however,it might be associated with the m TOR activity.Conclusions:These results clarify the interaction between the IL-33/ST2 pathway and macrophage polarization,and may pave the way to the development of new cancer immunotherapies targeting the IL-33/ST2 axis. | Huadan Xu Dong Li Jiaoyan Ma Yuanxin Zhao Long Xu Rui Tian Yanan Liu Liankun Sun Jing Su | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 3 | Active control of circular cylinder flow by affiliated rotating cylinders显示文摘This study puts forward an active control method for circular cylinder flow by placing two small affiliated rotating cylinders adjacent to the main cylinder,and their effects on the drag and lift forces acting on the main cylinder as well as the heat transfer effectiveness are numerically investigated.According to the diameter of the main cylinder the Reynolds number is chosen as Re=200.The well-proven finite volume method is employed for the calculation.The code is validated by comparing the present computed results of flow passing an isolated rotating cylinder with those available from the literature.To describe the present control model,two parameters are defined:the rotation direction of the two small cylinders(including co-current rotation and counter-current rotation) and the dimensionless rotation rate.In the simulation,the rotation rate varies from 0 to 2.4.The results indicate that the optimum rotation direction of the subsidiary cylinders,which is beneficial to both drag reduction and heat transfer enhancement,is the co-current rotating(the upper affiliated cylinder spins clockwise and the lower affiliated cylinder spins counter-clockwise).We observe noticeable suppression of the vortex shedding and favorable reduction of the fluid forces acting on the main cylinder as the rotation rate increases.Besides,the pressure and viscous components of the drag force are analyzed.Energy balance between energy cost for activating the rotating cylinders and energy saving by the momentum injection is considered.In addition,the influence of the affiliated rotating cylinders on heat transfer is also investigated.The average Nusselt number is found to increase with the rotation rate. | WANG JianSheng XU YuanXin TIAN YongSheng | 2013 | Science China(Technological Sciences)2013，56，5： | 3 |
| 4 | A cooperative fast annealing coevolutionary algorithm for protein motif extraction显示文摘By integrating the cooperative approach with the fast annealing coevolutionary algorithm (FAEA), a so-called cooperative fast annealing coevolutionary algorithm (CFACA) is presented in this paper for the purpose of solving high-dimensional problems. After the partition of the search space in CFACA, each smaller one is then searched by a separate FAEA. The fitness function is evaluated by combining sub-solutions found by each of the FAEAs. It demonstrates that the CFACA outperforms the FAEA in the domain of function optimization, especially in terms of convergence rate. The current algorithm is also applied to a real optimization problem of protein motif extraction. And a satisfactory result has been obtained with the accuracy of prediction achieving 67.0%, which is in agreement with the result in the PROSITE database. | CHEN Chao TIAN YuanXin ZOU XiaoYong CAI PeiXiang MO JinYuan | 2007 | Chinese Science Bulletin2007，52，3： | 2 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 6 | Predicting protein structural class with pseudo-amino acid composition and support vector machine fusion network 显示文摘 | CHEN Chao ZHOU Xibin TIAN Yuanxin | 2006 | Analy Biochem2006，357，1： | 1 |
| 7 | Prediction of protein secondary structure content using support vector maehine显示文摘 | Chen Chao Tian Yuanxin Zou Xiaoyong | 2007 | Talanta2007，71，5： | 1 |
| 8 | Aromatic Carbon Coated Tin Composites as Anode Materials for Lithium Ion Batteries显示文摘Aromatic carbon coated tin composites(A/Sn) have been prepared by thermal decomposition of the stannous 1,8-naphthalenedicarboxylate precursors,which is a reformative preparation method.Sugar carbon coated tin composites(S/Sn) also are prepared as a contrast with the A/Sn composites.The morphology and composition of the products were characterized by Scanning Electricity Microscopy(SEM) and X-Ray Diffraction(XRD).Their electrochemical performance as anode materials for lithium ion batteries were investigated;the results indicated that these materials exhibited good performance,and the cycle stability of A/Sn composites is especially superior to the S/Sn composites due to its special carbon resource. | AI Changchun HU Yi LIU Yang SUN Jutang TIAN Qifeng WU Yuanxin | 2013 | Wuhan University Journal of Natural Sciences2013，18，3： | 0 |
| 9 | Formation conditions and reservoir-forming models of the Ordovician buried hill reservoirs in the Jizhong depression显示文摘The buried hill in the Jizhong depression contains abundant petroleum reserves and are important production areas.The Ordovician buried hill has restricted the discovery of new oil and gas exploration targets because of its strong reservoir heterogeneity and complex reservoir-controlling factors.Based on a large volume of core,thin section,logging,seismic,and geochemical data and numerous geological analyses,the reservoir-forming conditions and modes were systematically analyzed to guide the exploration and achieve important breakthroughs in the Yangshuiwu and Wen an slope buried hills.The study revealed that three sets of source rocks of the third and fourth members of the Shahejie Formation from the Paleogene and Carboniferous-Permian were developed in the Jizhong depression,providing sufficient material basis for the formation of buried hill oil and gas reservoirs.The reservoir control mechanism involving the three major factors of“cloud-karst-fault”was clarified,and karst cave,fracture fissure-pore,and cloud pore type reservoir models were established,thereby expanding the exploration potential.Controlled by the superposition of multi-stage tectonic processes during the Indosinian,Yanshanian,and Himalayan,two genetic buried hill trap types of uplift-depression and depression-uplift were formed.Based on the analysis of reservoir-forming factors of the Ordovician buried hill,three buried hill oil and gas reservoir-forming models were identified:low-level tectonic-lithologic composite quasi-layered buried hill,medium-level paleo-storage paleo-block buried hill,and high-level paleo-storage new-block buried hill.Comprehensive evaluations indicate that the reservoir-forming conditions of the low-level tectonic-lithologic composite quasi-layered buried hill in the northern portion of the Jizhong depression are the most favorable and that the Sicundian and Xinzhen buried hills are favorable areas for future exploration. | ZHANG Ruifeng TIAN Jianzhang HUANG Yuanxin TIAN Ran REN Yi BIAN Yingying WANG Yuanjie CHEN Ling LU Shan | 2023 | 地学前缘2023，30，1： | 0 |
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