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| 1 | Simultaneous mineralization of CO_2 and recovery of soluble potassium using earth-abundant potassium feldspar显示文摘CO2 capture and storage(CCS) is an important strategy in combatting anthropogenic climate change.However,commercial application of the CCS technique is currently hampered by its high energy expenditure and costs.To overcome this issue,CO2 capture and utilization(CCU) is a promising CO2 disposal method.We,for the first time,developed a promising method to mineralize CO2 using earth-abundant potassium feldspar in order to effectively reduce CO2 emissions.Our experiments demonstrate that,after adding calcium chloride hexahydrate as an additive,the K-feldspar can be transformed to Ca-silicates at 800 C,which can easily mineralize CO2 to form stable calcium carbonate and recover soluble potassium.The conversion of this process reached 84.7%.With further study,the pretreatment temperature can be reduced to 250 C using hydrothermal method by adding the solution of triethanolamine(TEA).The highest conversion can be reached 40.1%.The process of simultaneous mineralization of CO2 and recovery of soluble potassium can be easily implemented in practice and may provide an economically feasible way to tackle global anthropogenic climate change. | XIE HePing WANG YuFei JU Yang LIANG Bin ZHU JiaHua ZHANG Ru XIE LingZhi LIU Tao ZHOU XiangGe ZENG HongMei LI Chun LU HouFang | 2013 | Chinese Science Bulletin2013，58，1： | 16 |
| 2 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 3 | Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus显示文摘The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis. | Yan Li Kun Wang Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong Zhou Wenyuan Shi Liying Xiao Changqing Lu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 8 |
| 4 | Genome-wide identification and co-expression network analysis of the Os NF-Y gene family in rice显示文摘Nuclear factor Y(NF-Y) is a ubiquitous transcription factor that regulates important physiological and developmental processes. In this study, we identified 34 Os NF-Y genes in rice, including 6 newly identified genes. Expression profile analysis covering the whole life cycle revealed that transcripts of Os NF-Y differentially accumulated in a tissue-specific,preferential or constitutive manner. In addition, gene duplication studies and expression analyses were performed to determine the evolutionary origins of the Os NF-Y gene family.Nine Os NF-Y genes were differentially expressed after treatment of seedlings with one or more abiotic stresses such as drought, salt and cold. Analysis of expression correlation and Gene Ontology annotation suggested that Os NF-Y genes were co-expressed with genes that participated in stress, accumulation of seed storage reserves, and plant development.Co-expression analysis also revealed that Os NF-Y genes might interact with each other,suggesting that NF-Y subunits formed complexes that take part in transcriptional regulation. These results provide useful information for further elucidating the function of the NF-Y family and their regulatory pathways. | Wenjie Yang Zhanhua Lu Yufei Xiong Jialing Yao | 2017 | The Crop Journal2017，5，1： | 7 |
| 5 | Passive Localization of Signal Source Based on UAVs in Complex Environment显示文摘For the influence caused by multipath fading and non-line-of-sight(NLOS)transmission,it is challenging to accurately localize a moving signal source in complex environment by using the wireless sensor network(WSN)on the ground.In this paper,we establish a special WSN in the sky to address this challenge,where each sensor is loaded on an unmanned aerial vehicle(UAV)and the operation center of all the UAVs is fixed on the ground.Based on the analyzing of the optimal distribution and the position error calibration of all the sensors,we formulate the localization scheme to estimate the position of the target source,which combines the time difference of arrival(TDOA)method and the frequency difference of arrival(FDOA)method.Then by employing the semidefinite programming approach,we accurately obtain the position and velocity of the signal source.In the simulation,the validity of the proposed method is verified through the performance comparison. | Pengwu Wan Qiongdan Huang Guangyue Lu Jin Wang Qianli Yan Yufei Chen | 2020 | China Communications2020，17，2： | 5 |
| 6 | A novel aminated polymeric adsorbent for removing refractory dissolved organic matter from landfill leachate treatment plant显示文摘Refractory dissolved organic matter (DOM) from landfill leachate treatment plant was with high dissolved organic carbon (DOC) content. An aminated polymeric adsorbent NDA-8 with tertiary amino groups and sufficient mesopore was synthesized, which exhibited high adsorption capacity to the DOM (raw water after coagulation). Resin NDA-8 performed better in the uptake of the DOM than resin DAX-8 and A100. Electrostatic attraction was considered as the decisive interaction between the adsorbent and adsorbate. Special attention was paid to the correlation between porous structure and adsorption capacity. The mesopore of NDA-8 played a crucial role during uptake of the DOM. In general, resin in chloride form performed a higher removal rate of DOC. According to the column adsorption test, total adsorption capacity of NDA-8 was calculated to 52.28 mg DOC/mL wet resin. 0.2 mol/L sodium hydroxide solution could regenerate the adsorbent efficiently. | ZHANG Long, LI Aimin, WANG Jinnan, LU Yufei, ZHOU Youdong State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. | 2009 | Journal of Environmental Sciences2009，21，8： | 5 |
| 7 | Dual-mode emission of single-layered graphene quantum dots in confined nanospace: Anti-counterfeiting and sensor applications显示文摘为 graphene 量点(GQD ) 的光性质的工程提出二庞大的挑战:1 ) GQD 的 bandgap 被结构的缺点(sp 2 和 sp 3 领域的尺寸,形状,和部分) 主要决定,它导致 non-stoichiometric 自然;2 ) 准备方法限制 GQD 的精确化学结构的成就,在在结构的缺点和 bandgaps 之间的关系上导致许多争论解释。这里,有准确结构的单人赛分层的 GQD 被获得由在原处在分层的双氢氧化物(LDH ) 的限制 nanospace 的设置的先锋的反应。随后,结构性质关系被揭开,表明提高的荧光并且激活同样准备的 GQDs-LDHs 的房间温度磷光,它从 synergistic 效果发源:1 ) 强壮的监禁由 LDH 的 nanospace 提供了;2 ) 源于 LDH 的 GQD 的表面上的富有的包含 O 功能的组催化作用。而且,无色性质和 GQDs-LDHs 的双排放的特征为保护珍贵文件作为伪造反的标记满足前提(钞票,商业发票,等等) 。特别地由于 GQD 和 LDH 的可食的性质的低毒性, GQDs-LDHs/gelatin 囊能是食物和药的地里的潜在的绿伪造反的材料的新一代。 | Liqian Bai Ning Xue Yufei Zhao Xinrui Wang Chao Lu Wenying Shi | 2018 | Nano Research2018，11，4： | 4 |
| 8 | Niacin alters the ruminal microbial composition of cattle under high-concentrate condition显示文摘To understand the effects of niacin on the ruminal microbial ecology of cattle under high-concentrate diet condition, Illumina MiSeq sequencing technology was used. Three cattle with rumen cannula were used in a 3 x 3 Latin-square design trial. Three diets were fed to these cattle during 3 periods for 3 days, respectively: high-forage diet(HF; forage-to-concentrate ratio = 80:20), high-concentrate diet(HC;forage-to-concentrate ratio=20:80), and HC supplemented with 800 mg/kg niacin(HCN). Ruminal pH was measured before feeding and every 2 h after initiating feeding. Ruminal fluid was sampled at the end of each period for microbial DNA extraction. Overall, our findings revealed that subacute ruminal acidosis(SARA) was induced and the a-diversity of ruminal bacterial community decreased in the cattle of HC group. Adding niacin in HC could relieve the symptoms of SARA in the cattle but the ruminal pH value and the Shannon index of ruminal bacterial community of HCN group were still lower than those of HF group. Whatever the diet was, the ruminal bacterial community of cattle was dominated by Bacteroidetes,Firmicutes and Proteobacteria. High-concentrate diet significantly increased the abundance of Prevotella,and decreased the abundance of Paraprevotella, Sporobacter, Ruminococcus and Treponema than HF.Compared with HC, HCN had a trend to decrease the percentage of Prevotella, and to increase the abundance of Succiniclasticum, Acetivibrio and Treponema. Increasing concentrate ratio could decrease ruminal pH value, and change the ruminal microbial composition. Adding niacin in HC could increase the ruminal pH value, alter the ruminal microbial composition. | Dan Luo Yufei Gao Youyou Lu Mingren Qu Xiaowen Xiong Lanjiao Xu Xianghui Zhao Ke Pan Kehui Ouyang | 2017 | Animal Nutrition2017，，2： | 4 |
| 9 | Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis显示文摘Dysregulated crosstalk between different signaling pathways contributes to tumor development,including resistance to cancer therapy.In the present study,we found that the mitogen-activated extracellular signal-regulated kinase(MEK)inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway,while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase(ERK)signaling.In particular,the most prominent enhancement of the anti-proliferative effect resulted from the concurrent blockage of the JAK2/STAT3 and ERK signaling pathways.Furthermore,the combination of the two inhibitors resulted in a reduced tumor burden in mice.Our evidence suggests novel crosstalk between JAK2/STAT3 and ERK signaling in gastric cancer(GC)and pancreatic ductal adenocarcinoma(PDAC)cells and provides a therapeutic strategy to overcome potential resistance in gastrointestinal cancer. | Xi WANG Chunyan DAI Yifei YIN Lin WU Weiyang JIN Yufei FU Zhe CHEN Ke HAO Bin LU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 4 |
| 10 | Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy显示文摘Background:The goal was to investigate changes of the inner intra-retinal layer thicknesses and retinal capillary density(RCD)around the macula in thyroid-associated ophthalmopathy(TAO)patients with or without dysthyroid optic neuropathy(DON).Methods:Forty-four TAO patients including 23 non-DON and 21 DON patients,and 38 healthy participants were enrolled.Spectral domain optical coherence tomography equipped with Angiovue was used to obtain threedimensional retinal thickness maps and microvascular images of the superficial and deep retinal capillary layers(SRCL and DRCL,respectively)around the macula.Quantitative analyses were performed using a custom automated algorithm.Results:The thicknesses of the nerve fiber layer,ganglion cell layer+inner plexiform layer,and ganglion cell complex(GCC)as well as the RCDs in the SRCL and DRCL in both TAO groups were significantly decreased compared to the controls.In addition,the RCDs in DRCL of the DON group were further decreased compared to the non-DON group.GCC thickness in both TAO groups was positively correlated with the RCDs of the SRCL in the total annular zone and in the temporal,inferior,and nasal sectors.The areas under the receiver operating characteristic curves for the GCC thickness combined with the RCD were generally larger than those of each single indicator.Conclusions:Thinned inner intra-retinal layers and decreased RCDs in the TAO patients without DON revealed that morphological changes might precede visual dysfunction.The composite index of the retinal structure and the microvascular density might be valuable in the diagnosing,monitoring,and intervention for early DON. | Yufei Wu Yunhai Tu Chaoming Wu Lulu Bao Jianhua Wang Fan Lu Meixiao Shen Qi Chen | 2020 | Eye and Vision2020，7，1： | 3 |
| 11 | CRISPR/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome显示文摘Genetic manipulation of mitochondrial DNA(mtDNA)could be harnessed for deciphering the gene function of mitochondria;it also acts as a promising approach for the therapeutic correction of pathogenic mutation in mtDNA.However,there is still a lack of direct evidence showing the edited mutagenesis within human mtDNA by clustered regularly interspaced short palindromic repeats-associated protein 9(CRISPR/Cas9).Here,using engineered CRISPR/Cas9,we observed numerous insertion/deletion(InDel)events at several mtDNA microhomologous regions,which were triggered specifically by double-strand break(DSB)lesions within mtDNA.InDel mutagenesis was significantly improved by sgRNA multiplexing and a DSB repair inhibitor,iniparib,demonstrating the evidence of rewiring DSB repair status to manipulate mtDNA using CRISPR/Cas9.These findings would provide novel insights into mtDNA mutagenesis and mitochondrial gene therapy for diseases involving pathogenic mtDNA. | Bang Wang Xiujuan Lv Yufei Wang Zhibo Wang Qi Liu Bin Lu Yong Liu Feng Gu | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 12 | High valence metals engineering strategies of Fe/Co/Ni-based catalysts for boosted OER electrocatalysis显示文摘Electrocatalysis for the oxygen evolution reactions(OER)has attracted much attention due to its important role in water splitting and rechargeable metal-air batteries.Therefore,designing highly efficient and low-cost catalysts for OER process is essential as the conventional catalysts still rely on precious metals.Transition metal-based compounds have been widely investigated as active OER catalysts,and renewed interest in the high valence metals engineered compounds has been achieved for superior catalytic activity and stability.However,an in-depth understanding of the construction strategies and induced effects for the high valence metals engineered catalysts is still lacking and desired.In this review,we have summarized the construction strategies of high valence metals as dopants or formed heterostructures with the iron/cobalt/nickel(Fe/Co/Ni)-based catalysts.Then the induced effects on Fe/Co/Ni-based catalysts by incorporating high valence metals,e.g.,accelerating the surface reconstruction,forming amorphous structure,generating vacancies/defects,and acting as stabilizers,are highlighted.The impacts of high valence metals on OER performance are elucidated based on different elements,including molybdenum(Mo),tungsten(W),cerium(Ce),vanadium(V),chromium(Cr),manganese(Mn),niobium(Nb),zirconium(Zr).The correlations of construction strategies,induced effects,catalytic activity and OER reaction pathways are elaborated.Finally,the remaining challenges for further enhancements of OER performance induced by high valence metals are presented. | Lu Li Xianjun Cao Juanjuan Huo Junpeng Qu Weihua Chen Chuntai Liu Yufei Zhao Hao Liu Guoxiu Wang | 2023 | Journal of Energy Chemistry2023，，1： | 3 |
| 13 | A core-shell structured COYID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity显示文摘Although inoculation of COVID-19 vaccines has rolled out globally,there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries.Here,we report on the development of a highly efficacious mRNA vaccine,SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core-shell structured lipopolyplex(LPP)nanoparticles.SWOT 23 is easy to produce using a large-scale microfluidics-based apparatus.The unique core-shell structured nanoparticle facilitates vaccine uptake and demonstrates a high colloidal stability,and a desirable biodistribution pattern with low liver targeting effect upon intramuscular administration.Extensive evaluations in mice and nonhuman primates revealed strong immunogenicity of SW0123,represented by induction of Th1-polarized T cell responses and high levels of antibodies that were capable of neutralizing not only the wild-type SARS-CoV-2,but also a panel of variants including D614G and N501Y variants.In addition,SW0123 conferred effective protection in both mice and non-human primates upon SARS-CoV-2 challenge.Taken together,SW0123 is a promising vaccine candidate that holds prospects for further evaluation in humans. | Ren Yang Yao Deng Baoying Huang Lei Huang Ang Lin Yuhua Li Wenling Wang Jingjing Liu Shuaiyao Lu Zhenzhen Zhan Yufei Wang Ruhan A Wen Wang Peihua Niu Li Zhao Shiqiang Li Xiaopin Ma Luyao Zhang Yujian Zhang Weiguo Yao Xingjie Liang Jincun Zhao Zhongmin Liu Xiaozhong Peng Hangwen Li Wenjie Tan | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 3 |
| 14 | Mechanical activation of spike fosters SARS-CoV-2 viral infection显示文摘The outbreak of SARS-CoV-2(SARS2)has caused a global COVID-19 pandemic.The spike protein of SARS2(SARS2-S)recognizes host receptors,including ACE2,to initiate viral entry in a complex biomechanical environment.Here,we reveal that tensile force,generated by bending of the host cell membrane,strengthens spike recognition of ACE2 and accelerates the detachment of spike’s S1 subunit from the S2 subunit to rapidly prime the viral fusion machinery.Mechanistically,such mechano-activation is fulfilled by force-induced opening and rotation of spike’s receptor-binding domain to prolong the bond lifetime of spike/ACE2 binding,up to 4 times longer than that of SARS-S binding with ACE2 under 10 pN force application,and subsequently by force-accelerated S1/S2 detachment which is up to~103 times faster than that in the no-force condition.Interestingly,the SARS2-S D614G mutant,a more infectious variant,shows 3-time stronger force-dependent ACE2 binding and 35-time faster force-induced S1/S2 detachment.We also reveal that an anti-S1/S2 non-RBD-blocking antibody that was derived from convalescent COVID-19 patients with potent neutralizing capability can reduce S1/S2 detachment by 3×106 times under force.Our study sheds light on the mechano-chemistry of spike activation and on developing a non-RBD-blocking but S1/S2-locking therapeutic strategy to prevent SARS2 invasion. | Wei Hu Yong Zhang Panyu Fei Tongtong Zhang Danmei Yao Yufei Gao Jia Liu Hui Chen Qiao Lu Tenny Mudianto Xinrui Zhang Chuxuan Xiao Yang Ye Qiming Sun Jing Zhang Qi Xie Pei-Hui Wang Jun Wang Zhenhai Li Jizhong Lou Wei Chen | 2021 | Cell Research2021，31，10： | 2 |
| 15 | Electrochemical Carbon Dioxide Reduction to Ethylene:From Mechanistic Understanding to Catalyst Surface Engineering显示文摘Electrochemical carbon dioxide reduction reaction(CO_(2)RR)provides a promising way to convert CO_(2)to chemicals.The multicarbon(C_(2+))products,especially ethylene,are of great interest due to their versatile industrial applications.However,selectively reducing CO_(2)to ethylene is still challenging as the additional energy required for the C–C coupling step results in large overpotential and many competing products.Nonetheless,mechanistic understanding of the key steps and preferred reaction pathways/conditions,as well as rational design of novel catalysts for ethylene production have been regarded as promising approaches to achieving the highly efficient and selective CO_(2)RR.In this review,we first illustrate the key steps for CO_(2)RR to ethylene(e.g.,CO_(2)adsorption/activation,formation of~*CO intermediate,C–C coupling step),offering mechanistic understanding of CO_(2)RR conversion to ethylene.Then the alternative reaction pathways and conditions for the formation of ethylene and competitive products(C_1 and other C_(2+)products)are investigated,guiding the further design and development of preferred conditions for ethylene generation.Engineering strategies of Cu-based catalysts for CO_(2)RR-ethylene are further summarized,and the correlations of reaction mechanism/pathways,engineering strategies and selectivity are elaborated.Finally,major challenges and perspectives in the research area of CO_(2)RR are proposed for future development and practical applications. | Junpeng Qu Xianjun Cao Li Gao Jiayi Li Lu Li Yuhan Xie Yufei Zhao Jinqiang Zhang Minghong Wu Hao Liu | 2023 | Nano-Micro Letters2023，15，10： | 1 |
| 16 | A generic framework of user attention model and its application in video summarization 显示文摘 | MA Yufei HUA Xiansheng LU Lie | 2005 | IEEE Transactions on Multimedia2005，7，5： | 1 |
| 17 | Characterization and removal of dissolved organic matter (DOM) from landfill leachate rejected by nanofiltration显示文摘 | Long Zhang Aimin Li Yufei Lu Lei Yan Sheng Zhong Conglin Deng | 2008 | Waste Management2008，，3： | 1 |
| 18 | A generic framework of user attention model and its application in video summarization显示文摘 | MA YUFEI HUA XIANSHENG LU LIE | 2005 | IEEE Transactions on Multimedia2005，7，5： | 1 |
| 19 | Characterization and removal of dissolved organic matter (DOM) from landfill leachate rejected by nanofiltration显示文摘 | Long Zhang Aimin Li Yufei Lu Lei Yan Sheng Zhong Conglin Deng | 2008 | Waste Management2008，，3： | 1 |
| 20 | A Generic Framework of User Attention Model and Its Application in Video Summarization 显示文摘 | MA Yufei HUA Xiansheng LU Lie | 2005 | IEEE Transaction on Multimedia(S1520-9210)2005，7，5： | 1 |
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