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| 1 | Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts显示文摘Multiple regulatory mechanisms control osteoblast differentiation and function to ensure unperturbed skeletal formation and remodeling. In this study we identify histone lysine-specific demethylase 1(LSD1/KDM1 A) as a key epigenetic regulator of osteoblast differentiation. Knockdown of LSD1 promoted osteoblast differentiation of human mesenchymal stem cells(hMSCs)in vitro and mice lacking LSD1 in mesenchymal cells displayed increased bone mass secondary to accelerated osteoblast differentiation. Mechanistic in vitro studies revealed that LSD1 epigenetically regulates the expression of WNT7 B and BMP2. LSD1 deficiency resulted in increased BMP2 and WNT7 B expression in osteoblasts and enhanced bone formation, while downregulation of WNT7 B-and BMP2-related signaling using genetic mouse model or small-molecule inhibitors attenuated bone phenotype in vivo. Furthermore, the LSD1 inhibitor tranylcypromine(TCP) could increase bone mass in mice. These data identify LSD1 as a novel regulator of osteoblast activity and suggest LSD1 inhibition as a potential therapeutic target for treatment of osteoporosis. | Jun Sun Joerg Ermann Ningning Niu Guang Yan Yang Yang Yujiang Shi Weiguo Zou | 2018 | Bone Research2018，6，3： | 5 |
| 2 | Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang,China显示文摘The Crimean-Congo hemorrhagic fever virus(CCHFV),a member of the genus Orthonairovirus and family Nairoviridae,is transmitted by ticks and causes severe hemorrhagic disease in humans.To study the epidemiology of CCHFV in different ecosystems in Xinjiang,China,a total of 58,932 ticks were collected from Tarim Basin,Junggar Basin,Tianshan Mountain,and Altai Mountain from 2014 to 2017.Hyalomma asiaticum asiaticum was the dominant tick species in Tarim and Junggar basins,whereas Dermacentor nuttalli and Hyalomma detritum were found in Tianshan Mountain and Altai Mountain,respectively.Reverse transcription-polymerase chain reaction of the CCHFV small(S)genome segment was used for the molecular detection.The CCHFV-positive percentage was 5.26%,6.85%,1.94%,and 5.56% in Tarim Basin,Junggar Basin,Tianshan Mountain,and Altai Mountain,respectively.Sequences of the S segment were used for phylogenetic analysis and the results showed that the newly identified CCHFV strains belonged to two clades.Our study confirms that H.asiaticum asiaticum is the major vector of CCHFV in desert habitats which is consistent with previous studies,and also suggests that H.detritum and D.nuttalli are emerging vectors for CCHFV in Xinjiang.Moreover,this study reports the presence of CCHFV in the mountain habitat of Xinjiang for the first time,suggesting that future surveillance of CCHFV should also include mountainous areas. | Abulimiti Moming Xihong Yue Shu Shen Chenchen Chang Cheng Wang Tao Luo Yanfang Zhang Rong Guo Zhihong Hu Yujiang Zhang Fei Deng Surong Sun | 2018 | Virologica Sinica2018，33，1： | 5 |
| 3 | 3D printing of calcium phosphate bioceramic with tailored biodegradation rate for skull bone tissue reconstruction显示文摘The bone regenerative scaffold with the tailored degradation rate matching with the growth rate of the new bone is essential for adolescent bone repair.To satisfy these requirement,we proposed bone tissue scaffolds with controlled degradation rate using osteoinductive materials(Ca-P bioceramics),which is expected to present a controllable biodegradation rate for patients who need bone regeneration.Physicochemical properties,porosity,compressive strength and degradation properties of the scaffolds were studied.3D printed Ca-P scaffold(3DS),gas foaming Ca-P scaffold(FS)and autogenous bone(AB)were used in vivo for personalized beagle skull defect repair.Histological results indicated that the 3DS was highly vascularized and well combined with surrounding tissues.FS showed obvious newly formed bone tissues.AB showed the best repair effect,but it was found that AB scaffolds were partially absorbed and degraded.This study indicated that the 3D printed Ca-P bioceramics with tailored biodegradation rate is a promising candidate for personalized skull bone tissue reconstruction. | Boqing Zhang Huan Sun Lina Wu Liang Ma Fei Xing Qingquan Kong Yujiang Fan Changchun Zhou Xingdong Zhang | 2019 | Bio-Design and Manufacturing2019，2，3： | 5 |
| 4 | BMSCs-assisted injectable Col I hydrogel-regenerated cartilage defect by reconstructing superficial and calcified cartilage显示文摘The self-healing capacity of cartilage was limited due to absence of vascular,nervous and lymphatic systems.Although many clinical treatments have been used in cartilage defect repair and shown a promising repair result in short term,however,regeneration of complete zonal structure with physiological function,reconstruction cartilage homeostasis and maintaining long-term repair was still an unbridgeable chasm.Cartilage has complex zonal structure and multiple physiological functions,especially,superficial and calcified cartilage played an important role in keeping homeostasis.To address this hurdle of regenerating superficial and calcified cartilage,injectable tissue-induced type I collagen(Col I)hydrogel-encapsulated BMSCs was chosen to repair cartilage damage.After 1 month implantation,the results demonstrated that Col I gel was able to induce BMSCs differentiation into chondrocytes,and formed hyaline-like cartilage and the superficial layer with lubrication function.After 3 months post-surgery,chondrocytes at the bottom of the cartilage layer would undergo hypertrophy and promote the regeneration of calcified cartilage.Six months later,a continuous anatomical tidemark and complete calcified interface were restored.The regeneration of neo-hyaline cartilage was similar with adjacent normal tissue on the thickness of the cartilage,matrix secretion,collagen type and arrangement.Complete multilayer zonal structure with physiological function remodeling indicated that BMSCs-assisted injectable Col I hydrogel could reconstruct cartilage homeostasis and maintain long-term therapeutic effect. | Hanxu Cai PeileiWang Yang Xu Ya Yao Jia Liu Tao Li Yong Sun Jie Liang Yujiang Fan Xingdong Zhang | 2020 | Regenerative Biomaterials2020，7，1： | 4 |
| 5 | A comparative study of autogenous, allograft and artificial bone substitutes on bone regeneration and immunotoxicity in rat femur defect model显示文摘Repair and reconstruction of large bone defect were often difficult,and bone substitute materials,including autogenous bone,allogenic bone and artificial bone,were common treatment strategies.The key to elucidate the clinical effect of these bone repair materials was to study their osteogenic capacity and immunotoxicological compatibility.In this paper,the mechanical properties,micro-CT imaging analysis,digital image analysis and histological slice analysis of the three bone grafts were investigated and compared after different time points of implantation in rat femur defect model.Autogenous bone and biphasic calcium phosphate particular artificial bone containing 61.4% HA and 38.6%β-tricalcium phosphate with 61.64%porosity and 0.8617±0.0068 g/cm^(3) den-sity(d≤2 mm)had similar and strong bone repair ability,but autogenous bone implant materials caused greater secondary damage to experimental animals;allogenic bone exhibited poor bone defect repair ability.At the early stage of implantation,the immunological indexes such as Immunoglobulin G,Immunoglobulin M concentration and CD4 cells'population of allogenic bone significantly increased in compared with those of autologous bone and artificial bone.Although the repair process of artificial bone was relatively inefficient than autologous bone graft,the low immunotoxicological indexes and acceptable therapeutic effects endowed it as an excellent alter-native material to solve the problems with insufficient source and secondary trauma of autogenous bone. | Wen Zou Xing Li Na Li Tianwei Guo Yongfu Cai Xiaoqin Yang Jie Liang Yong Sun Yujiang Fan | 2021 | Regenerative Biomaterials2021，8，1： | 3 |
| 6 | Dynamic mechanical loading facilitated chondrogenic differentiation of rabbit BMSCs in collagen scaffolds显示文摘Mechanical signals have been played close attention to regulate chondrogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).In this study,dynamic mechanical loading simulation with natural frequencies and intensities were applied to the 3D cultured BMSCs–collagen scaffold constructs.We investigated the effects of dynamic mechanical loading on cell adhesion,uniform distribution,proliferation,secretion of extracellular matrix(ECM)and chondrogenic differentiation of BMSCs–collagen scaffold constructs.The results indicated that dynamic mechanical loading facilitated the BMSCs adhesion,uniform distribution,proliferation and secretion of ECM with a slight contraction,which significantly improved the mechanical strength of the BMSCs–collagen scaffold constructs for better mimicking the structure and function of a native cartilage.Gene expression results indicated that dynamic mechanical loading contributed to the chondrogenic differentiation of BMSCs with higher levels of AGG,COL2A1 and SOX9 genes,and prevented of hypertrophic process with lower levels of COL10A1,and reduced the possibility of fibrocartilage formation due to down-regulated COL1A2.In conclusion,this study emphasized the important role of dynamic mechanical loading on promoting BMSCs chondrogenic differentiation and maintaining the cartilage phenotype for in vitro reconstruction of tissue-engineered cartilage,which provided an attractive prospect and a feasibility strategy for cartilage repair. | Wanxu Cao Weimin Lin Hanxu Cai Yafang Chen Yi Man Jie Liang Qiguang Wang Yong Sun Yujiang Fan Xingdong Zhang | 2019 | Regenerative Biomaterials2019，6，2： | 3 |
| 7 | Ni catalysts supported on nanosheet and nanoplate γ-Al_2O_3 for carbon dioxide methanation显示文摘Nanosheet(S) and nanoplate(P) γ-Al_2O_3 were synthesized by simple hydrothermal methods and employed as supports for Ni catalysts in CO_2 methanation.Both of the nanostructured Ni/Al_2O_3 catalysts displayed good activity.In comparison,the Ni/Al_2O_3-S catalyst showed higher CO_2 conversion than the Ni/Al_2O_3-P counterpart at the reaction temperature ranging from 250 to 400 °C.The physical and chemical properties of the catalysts were systematically characterized by N2 sorption,X-ray diffraction(XRD),high resolution-transmission electron microscopy(HR-TEM),hydrogen temperature-programmed reduction(H2-TPR) and CO_2 temperature-programmed desorption(CO_2-TPD) techniques.Higher specific surface area and stronger metal-support interactions were confirmed on the Ni/Al_2O_3-S catalyst,which may lead to smaller particle size of Ni nanoparticles.Moreover,the Ni/Al_2O_3-S catalyst possessed more abundant weak and medium basic sites,which would benefit the activation of CO_2.The smaller Ni size and more suitable basic sites may rationalize the superior activity of the Ni/Al_2O_3-S catalyst.Besides,the Ni/Al_2O_3-S catalyst exhibited excellent stability at 325 °C for 40 h. | Jinwei Sun Yujiang Wang Haikui Zou Xiaoguang Guo Zhou-jun Wang | 2019 | Journal of Energy Chemistry2019，28，2： | 3 |
| 8 | Facile synthesis of Cu2O nanocube/polycarbazole composites and their high visible-light photocatalytic properties显示文摘 | Sun Wei Sun Wendong Zhuo Yujiang | 2011 | Journal of Solid State Chemistry2011，184，7： | 1 |
| 9 | Thiocyanate removal from aqueous solution by a synthetic hydrotalcite sol显示文摘 | Wu Tao Sun Dejun Li Yujiang | 2011 | Journal of Colloid and Interface Science2011，355，1： | 1 |
| 10 | The effect of LyPRP/collagen composite hydrogel on osteogenic differentiation of rBMSCs显示文摘Although platelet-rich plasma(PRP)plays a significant role in the orthopedic clinical application,it still faces two major problems,namely,uncontrollable factors release,frequent preparation and extraction processes as well as the inconvenient form of usage.To overcome these shortcomings,freeze-dried PRP(LyPRP)was encapsulated into bioactive Col I hydrogel to induce osteogenic dif-ferentiation of rabbit bone marrow mesenchymal stem cells(rBMSCs).And PRP/Col I composite hydrogel was prepared as a control.Compared with Col I hydrogel,the introduction of platelets significantly improved the mechanical properties of hydrogels.Meanwhile,platelets were evenly distributed in the composite hydrogels network.The sustainable release of related factors in the composite hydrogels could last for more than 14days to maintain its long-term biological activity.Further cell experiments confirmed that PRP and LyPRP could effectively alleviate the contraction of collagen hydrogel in vitro,and promote the adhesion,proliferation and osteogenesis differentia-tion of rBMSCs.The results of osteogenic gene expression indicated that the 10%LyPRP/Col I composite hydrogel could facilitate the early expression of BMP-2 and late osteogenic associated protein formation with higher expression of alkaline phosphatase and Osteocalcin(OCN).These results might provide new insights for the clinical application of 10%LyPRP/Col I composite hydro-gel as practical bone repair injection. | Manyu Chen Quanying Liu Yang Xu Yuxiang Wang Xiaowen Han Zhe Wang Jie Liang Yong Sun Yujiang Fan Xingdong Zhang | 2021 | Regenerative Biomaterials2021，8，1： | 1 |
| 11 | Hexavalent chromium removal from aqueous solution by adsorption on aluminum magnesium mixed hydroxide显示文摘 | Yujiang Li Baoyu Gao Tao Wu Dejun Sun Xia Li Biao Wang Fengjuan Lu | 2009 | Water Research2009，，12： | 1 |
| 12 | Estimates of HIV prevalence in a highly endemic area of China: Dehong Prefecture, Yunnan Province 显示文摘 | Jia Yujiang Sun Jiangping Fan Lu | 2008 | Int J Epidemiol2008，37，6： | 1 |
| 13 | Prevalence and Correlates of HIV and Syphilis Infections Among Men Who Have Sex With Men in Seven Provinces in China With Historically Low HIV Prevalence显示文摘 | Yan Xiao Jiangping Sun Chunmei Li Fan Lu Katherine L Allen Sten H Vermund Yujiang Jia | 2010 | JAIDS Journal of Acquired Immune Deficiency Syndromes2010，，： | 1 |
| 14 | Advanced application of collagen-based biomaterials in tissue repair and restoration显示文摘In tissue engineering,bioactive materials play an important role,providing structural support,cell regulation and establishing a suitable microenvironment to promote tissue regeneration.As the main component of extracellular matrix,collagen is an important natural bioactive material and it has been widely used in scientific research and clinical applications.Collagen is available from a wide range of animal origin,it can be produced by synthesis or through recombinant protein production systems.The use of pure collagen has inherent disadvantages in terms of physico-chemical properties.For this reason,a processed collagen in different ways can better match the specific requirements as biomaterial for tissue repair.Here,collagen may be used in bone/cartilage regeneration,skin regeneration,cardiovascular repair and other fields,by following different processing methods,including cross-linked collagen,complex,structured collagen,mineralized collagen,carrier and other forms,promoting the development of tissue engineering.This review summarizes a wide range of applications of collagen-based biomaterials and their recent progress in several tissue regeneration fields.Furthermore,the application prospect of bioactive materials based on collagen was outlooked,aiming at inspiring more new progress and advancements in tissue engineering research. | Jiayi Zhu Zhulian Li Yaping Zou Gonggong Lu Alfredo Ronca Ugo D’Amora Jie Liang Yujiang Fan Xingdong Zhang Yong Sun | 2022 | Journal of Leather Science and Engineering2022，4，1： | 0 |
| 15 | Study on Surface States of Zinc Sulfide Electroluminescence Thin Films显示文摘1IntroductionZincsulfideisaⅡ-Ⅳsemiconductorcompoundwithwidebandgap.Thethinfilmshaveexcelentcharactersofelectroluminescence(EL... | LIU Zhaohong, WANG Yujiang, CHEN Mouzhi, SUN Shunong, LIU Ruitang ( Xiamen University, Xiamen 361005,CHN) | 1998 | Semiconductor Photonics and Technology1998，4，4： | 0 |
| 16 | Corrigendum to“Bioinspired supramolecular nanofiber hydrogel through self-assembly of biphenyl-tripeptide for tissue engineering”[Bioact.Mater.8(2022)396-408]显示文摘The authors regret that the published version of the above article contained error in Fig.6F,which was not identified during the proofing stage.The wrong live/dead stain,F-actin stain,and SEM images of BPAA-GFF gel were selected during the assembly of Fig.6F.The images of Fig.6F have been replaced with the correct images as follow.The authors apologize for this error and state that the figure’s correction did not change the scientific conclusions of the article in any way. | Yong Sun Xing Li Mingda Zhao Yafang Chen Yang Xu Kefeng Wang Shaoquan Bian Qing Jiang Yujiang Fan Xingdong Zhang | 2023 | Bioactive Materials2023，，5： | 0 |
| 17 | Influence of AAO Treatment Parameters on Characterizations of Surface Pores on 316L Stainless Steel显示文摘Recently a new kind stent,porous drug-eluting stent,has been developed to overcome the problems of bare metal stent(BMS)and drug-eluting stent(DES),and the clinic results reveal that it combined the advantage of BMS and DES.In this paper,a new method to fabricate surface pores on 316L stainless steel stent using anodic oxidation of aluminum mask film deposited by magnetron sputtering on 316L substrate was reported.The effect of experimental parameters,such as anodization time,anodization voltage,anodization solution and anodization temperature,on the pores'size distribution and density are investigated using SEM.It is found that the pores characterizations strongly depend on anodization time and pores expanding rate through AAO films and on stainless steel surface. | Tang Guangze Wang Yujiang Lin Kaijie Ma Xinxin Sun Mingren | 2012 | 稀有金属材料与工程2012，41，S1： | 0 |
| 18 | Therapeutic sponge prevents postoperative breast cancer recurrence by sustainably dissociating into CD44-targeted nanoplatform显示文摘Locoregional recurrence and distant metastasis of breast cancer still pose a significant risk for patients’survival.To address the clinical challenge,functional absorbable sponges(HA-SH/PP-Dox/Lap/COL I(HCNPs))were constructed by biomimetic extracellular matrix of collagen I/hyaluronic acid complex conjugated with doxorubicin/lapatinib(Dox/Lap)-loaded nanoparticles.The HCNPs sponge exhibited excellent clotting ability and blood absorption rate.Worthily,Dox/Lap-loaded nanoparticles were synchronously endowed with a large number of oligo hyaluronic acid segments after degradation,which thus enhanced the ability of targeting into CD44-overexpressed tumor cells.The implantable HCNPs sponge in resected cavity of postoperative 4T1 models inhibited the spread of scattered tumor cells by absorbing the inevitable bleeding.More importantly,CD44 targeted nanoparticle with suitable Dox/Lap proportion continuously released from sponge to kill tumor cells of surrounding HCNPs and those remaining at surgical margin,thus prevented local recurrence as well as distant metastasis.Therefore,the functional HCNPs sponge might provide a safer and more effective strategy for postoperative treatment of cancer. | Junhui Sui Mingda Zhao Zhihao Guo Jiafeng Li Jie Chen Hongli Chen Jie Liang Yong Sun Xingdong Zhang Yujiang Fan | 2024 | Nano Research2024，17，3： | 0 |
| 19 | Nuclear transfer of goat somatic cells transgenic for human lactoferrin gene显示文摘Transgenic animal mammary gland bioreactors are used to produce recombinant proteins with appropriate post-translational modifications.The nuclear transfer of transgenic somatic cells is a powerful method to produce mammary gland bioreactors.We established an efficient gene transfer and nuclear transfer approach in goat somatic cells.Gene targeting vector pGBC2LF was constructed by cloning human lactoferrin(LF)gene cDNA into exon 2 of the milk goat beta-casein gene and the endogenous start codon was replaced by that of human LF gene.Goat fetal fibroblasts were transfected with lin-earized pGBC2LF and 14 cell lines were positive accord-ing to PCR and Southern blot.The transgenic cells were used as donor cells of nuclear transfer and some of recon-structed embryos could develop into blastocyst in vitro. | Lan LI Wei SHEN Lingjiang MIN Qingyu PAN Yujiang SUN Jixian DENG Qingjie PAN | 2008 | Frontiers in Biology2008，3，3： | 0 |
| 20 | Biofabrication (3D Bioprinting) Laboratory at Sichuan University显示文摘Introduction and research overview Recently,increasing need for organ transplantation and lack of donated organs have led to the rapid development of new technologies for artificial organ biofabrication.In the era of burgeoning breakthroughs around 3D bioprinting technologies,the personalization of organs and medicine is an ongoing nice vision[1–5].As one of the leading laboratories in the interdisciplinary field of materials,manufacturing and bioengineering,the Biofabrication(3D Bioprinting)Research Laboratory at Sichuan University has been engaging in the research on customized regenerativemedicine since 2012. | Changchun Zhou Kefeng Wang Yong Sun Qiguang Wang Qing Jiang Jie Liang Xuan Pei Boqing Zhang Yujiang Fan Xingdong Zhang | 2021 | Bio-Design and Manufacturing2021，4，2： | 0 |
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