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| 1 | Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study显示文摘Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system.Previous studies identified either regional or network alterations in patients with asthma,but inconsistent results were obtained.A key question remains unclear:are the regional and neural network deficits related or are they two independent characteristics in asthma?Answering this question is the aim of this study.By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls,brain functional measures including regional activity(amplitude of low-frequency fluctuations)and neural network function(degree centrality(DC)and functional connectivity)were calculated to systematically characterize the functional alterations.Patients exhibited regional abnormities in the left angular gyrus,right precuneus,and inferior temporal gyrus within the default mode network.Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes.Altered DC in the lingual gyrus was correlated with the degree of airway obstruction.This study elucidated different patterns of regional and network changes,thereby suggesting that the two parameters reflect different brain characteristics of asthma.These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma. | Siyi Li Peilin Lv Min He Wenjing Zhang Jieke Liu Yao Gong Ting Wang Qiyong Gong Yulin Ji Su Lui | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 2 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 3 | Microfluidics for cell-cell interactions: A review显示文摘Microfluidic 薄片在各种各样的生物的域里被使用了由于它的试剂,高产量,能流动的可控制性和正直低消费。设计得好的 microscale 中间人为房间生物学的学习也是理想的。特别地, microfluidic 薄片对更好理解房间房间相互作用有用。最近的出版物的一般调查将帮助与不同特征概括合作文化薄片的图案。与机灵并且 combinational 利用,薄片便于高度以一个不同空间、时间的方法被担心的一些特殊 coculture 模型的实现。 | Rui Li Xuefei Lv Xingjian Zhang Omer Saeed Yulin Deng | 2016 | Frontiers of Chemical Science and Engineering2016，10，1： | 2 |
| 4 | Efficient CO2 to CO conversion at moderate temperatures enabled by the cobalt and copper co-doped ferrite oxygen carrier显示文摘Chemical looping technology holds great potential on efficient CO2 splitting with much higher CO production and CO2 splitting rate than photocatalytic processes.Conventional oxygen carrier requires high temperature(typically 850–1000°C)to ensure sufficient redox activity,but the stable and high CO2 conversion is favored at a lower temperature,leading to the degrading on the reaction kinetics as well as the low CO production and CO2 splitting rate.In this paper,we prepared several ternary spinels and demonstrated their performance for chemical looping CO2 splitting at moderate temperatures.Using the promotion effect of Cu to cobalt ferrite reduction and reversible phase change of the reduced metals,Cu0.4 Co0.6 Fe2 O4 exhibits high CO2 splitting rate(144.6μmol g–1 min–1)and total CO production(9100μmol g–1)at 650°C.The high performance of this earth-abundant spinel material is also consistent in repeated redox cycles,enabling their potential in industrial use. | Yu Qiu Li Ma Dewang Zeng Min Li Dongxu Cui Yulin Lv Shuai Zhang Rui Xiao | 2020 | Journal of Energy Chemistry2020，29，7： | 2 |
| 5 | Cathode infiltration with enhanced catalytic activity and durability for intermediate-temperature solid oxide fuel cells显示文摘To lower the operation temperature and increase the durability of solid oxide fuel cells(SOFCs), increasing attentions have been paid on developing cathode materials with good oxygen reduction reaction(ORR)activity at intermediate-temperature(IT, 500-750 ℃) range. However, most cathode materials exhibit poor catalytic activity, or they thermally mismatch with SOFC electrolytes and undergo severe degeneration. Infiltrating catalysts on existing backbone materials has been proved to be an efficient method to construct highly active and durable cathodes. In this mini-review, the advantages of infiltration-based cathode compared with new material-based cathodes are summarized. The merits and drawbacks of different backbones are illustrated. Different types of catalysts for infiltration are depicted in detail. Suggestions on the material/structure optimization of the infiltrated cathodes of IT-SOFC are provided. | Yinghua Niu Weirong Huo Yuandong Yu Wenjun Li Yulin Chen Weiqiang Lv | 2022 | Chinese Chemical Letters2022，33，2： | 1 |
| 6 | Improved methodology for efficient establishment of the myocardial ischemia-reperfusion model in pigs through the median thoracic incision显示文摘To investigate the feasibility and effectiveness of establishing porcine ischemia-reperfusion models by ligating the left anterior descending(LAD)coronary artery,we first randomly divided 16 male Bama pigs into a sham group and a model group.After anesthesia,we separated the arteries and veins.Subsequently,we rapidly located the LAD coronary artery at the beginning of its first diagonal branch through a mid-chest incision.Then,we loosened and released the ligation line after five minutes of pre-occlusion.Finally,we ligated the LAD coronary artery in situ two minutes later and loosened the ligature 60 min after ischemia.Compared with the sham group,electrocardiogram showed multiple continuous lead ST-segment elevations,and ultrasound cardiogram showed significantly lower ejection fraction and left ventricular fractional shortening at one hour and seven days post-operation in the model group.Twenty-four hours after the operation,cardiac troponin T and creatine kinase-MB isoenzyme levels significantly increased in the model group,compared with the sham group.Hematoxylin and eosin staining showed the presence of many inflammatory cells infiltrating the interstitium of the myocardium in the model group but not in the sham group.Masson staining revealed a significant increase in infarct size in the ischemia/reperfusion group.All eight pigs in the model group recovered with normal sinus heart rates,and the survival rate was 100%.In conclusion,the method can provide an accurate and stable large animal model for preclinical research on ischemia/reperfusion with a high success rate and homogeneity of the myocardial infarction area. | Liuhua Zhou Jiateng Sun Tongtong Yang Sibo Wang Tiankai Shan Lingfeng Gu Jiawen Chen Tianwen Wei Di Zhao Chong Du Yulin Bao Hao Wang Xiaohu Lu Haoliang Sun Meng Lv Di Yang Liansheng Wang | 2023 | The Journal of Biomedical Research2023，37，4： | 1 |
| 7 | Investigation into the epidemiology,genetic characteristics,and clinical manifestations of the first monkeypox outbreak in Shenzhen,China显示文摘This paper comprehensively analyses the first-ever monkeypox outbreak in Shenzhen,China,encompassing clinical symptomatology,therapeutic approaches,epidemiological research,and comprehensive laboratory tests,aiming to establish a robust reference for future monkeypox mitigation and management strategies.The investigation involved a thorough investigation of all identified positive cases,including extensive molecular analysis by nucleic acid detection and whole-genome sequencing of the monkeypox virus.Contact tracing and containment of the infected individuals were also undertaken.Three distinct monkeypox cases were identified in this unique outbreak,exhibiting mild and atypical clinical manifestations,primarily fever and rash.All cases were associated with a single transmission chain,primarily facilitated through close contact and homosexual behavior,indicative of a high-risk factor for monkeypox transmission. | Jia Wan Xiaomin Zhang Jing Qu Bo Peng Dongfeng Kong Jianhua Lu Qinghua Hu Zhifeng Zhou Haiduan Lin Xiangjie Yao Yulin Fu Qing Xu Ying Lin Yan Yang Jinzhen Tang Lin Lin Huimin Li Ziquan Lv Zhen Zhang Xuan Zou Xiaolu Shi | 2023 | Biosafety and Health2023，5，5： | 0 |
| 8 | Low-cost dual-stage offset-cancelled sense amplifier with hybrid read reference generator for improved read performance of RRAM at advanced technology nodes显示文摘In this work,two process-variation-tolerant schemes for a current-mode sense amplifier(CSA)of RRAM were proposed:(1)hybrid read reference generator(HRRG)that tracks process-voltage-temperature(PVT)variations and solve the nonlinear issue of the RRAM cells;(2)a two-stage offset-cancelled current sense amplifier(TSOCC-SA)with only two capacitors achieves a double sensing margin and a high tolerance of device mismatch.The simulation results in 28 nm CMOS technology show that the HRRG can provide a read reference that tracks PVT variations and solves the nonlinear issue of the RRAM cells.The proposed TSOCC-SA can tolerate over 64% device mismatch. | Qiao Wang Donglin Zhang Yulin Zhao Chao Liu Xiaoxin Xu Jianguo Yang Hangbing Lv | 2021 | Journal of Semiconductors2021，42，8： | 0 |
| 9 | Ex utero intrapartum therapy in infants with congenital diaphragmatic hernia:a propensity score matching analysis显示文摘Objective Previous studies have shown that ex utero intrapartum therapy(EXIT)is safe and feasible for newborns with congenital diaphragmatic hernia(CDH).This study reports our experience with EXIT in fetuses with CDH in an attempt to explore the efficacy of EXIT on the survival rate of this population.Methods A retrospective analysis of the clinical data of 116 children with CDH was conducted.The children were assigned to EXIT and non-EXIT groups.Propensity score matching(PSM)toward clinical data was performed,and the clinical characteristics and outcomes were compared.Taking survival at discharge as the main outcome,logistic regression analysis was carried out to explore the efficacy of EXIT on survival.Results During the study period,30 of 116 children received EXIT.After PSM,the survival rates of the EXIT group and the non-EXIT group were 82.76%(24/29)and 48.28%(14/29),respectively(p=0.006).EXIT(OR=0.083,95%CI=0.013to 0.525,p=0.008),liver herniation(OR=16.955,95%CI=2.342 to 122.767,p=0.005),and gestational age at diagnosis(OR=0.662,95%CI=0.497 to 0.881,p=0.005)were independent mortality-related risk factors of all children with CDH.Ninety-nine of 116 children underwent surgery.After PSM,the postoperative survival rates of the EXIT group and non-EXIT group were 84.6%(22/26)and 76.9%(20/26),respectively(p=0.754).Liver herniation(OR=10.451,95%CI=1.641 to 66.544,p=0.013)and gestational age at diagnosis(OR=0.736,95%CI=0.577 to 0.938,p=0.013)were independent mortality-related risk factors of children after surgery.Conclusion EXIT can be performed safely for selected prenatally diagnosed CDH neonates with potentially better survival and does not cause more maternal complications compared with traditional cesarean section. | Yunlong Zhao Ying Wang Chao Liu Yulin Jiang Yandong Wei Hua Meng Shan Jian Xiting Zhu Lijian Pei Xiaochen Bai Feng Feng Yan Lv Xiya Zhou Qingwei Qi Jingna Li Lishuang Ma | 2022 | World Journal of Pediatric Surgery2022，5，4： | 0 |
| 10 | Determination of the total concentration of casein and ?-lactoglobulin by indirect competitive ELISA in milk and dairy products显示文摘The main purpose of this work was to develop an assay as a means of quality control in milk and dairy products. As specific and high abundant proteins in milk and diary products, casein and b-lactoglobulin were chosen as the targets, and an indirect competitive enzyme-linked immunosorbent assay(ELISA) was developed for determination of the total concentration of casein and b-lactoglobulin. The detection limit of the assay was 79.07 ng/mL,and a working range of the calibration curve was from140.6 to 36,000 ng/mL. The intra-assay and inter-assay coefficients of variations were 4.7 % and 6.5 %, respectively. The recoveries ranged from 94.1 % to 106.6 %. The developed ELISA assay was used to detect the total concentration of casein and b-lactoglobulin in liquid milk and milk powder. The results indicated that the developed assay was very specific, and the addition of nonprotein nitrogen(such as melamine, cyanuric acid, and urea) and vegetable protein did not affect the detection. The good performance of the assay makes it suitable for use in the quality control of milk and dairy products. | Xuefei Lv Xuena Hu Yan Man Yulin Deng | 2014 | Chinese Science Bulletin2014，59，27： | 0 |
| 11 | A Hf_(0.5)Zr_(0.5)O_(2)ferroelectric capacitor-based half-destructive read scheme for computing-in-memory显示文摘The emerging non-volatile memories(NVMs),including resistive random access memory(RRAM)[1],phase-change memory(PCM)[2],and ferroelectric random access memory(Fe RAM)[3],have broad application prospects owing to their non-volatility and near-zero static energy consumption.Compared to other NVMs,ferroelectric capacitors(Fe CAPs)ofer advantages in energy consumption and endurance.However,the destructive read operation of capacitors(e.g.,DRAMs and Fe CAPs)destroys the stored data. | Yulin ZHAO Yuan WANG Donglin ZHANG Zhongze HAN Qiao HU Xuanzhi LIU Qingting DING Jinhui CHENG Wenjun ZHANG Yue CAO Ruixi ZHOU Qing LUO Jianguo YANG Hangbing LV | 2023 | Science China(Information Sciences)2023，66，5： | 0 |
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